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Seismic Behavior of Liquid Storage Tanks Using Complex and Simple Analytical Models
Nabin Raj Chaulagain,Sun Chang Ho,Kim Ick Hyun 한국지진공학회 2018 한국지진공학회논문집 Vol.22 No.7
Performance-based seismic evaluation is usually done by considering simplified models for the liquid storage tanks therefore, it is important to validate those simplified models before conducting such evaluation. The purpose of this study is to compare the seismic response results of the FSI (fluid-structure interaction) model and the simplified models for the cylindrical liquid storage tanks and to verify the applicability of the simplified models for estimating failure probability. Seismic analyses were carried out for two types of storage tanks with different aspect ratios (H/D) of 0.45 and 0.86. FSI model represents detailed 3D fluid-structure interaction model and simplified models are modeled as cantilever mass-spring model, frame type mass-spring model and shell type mass-spring model, considering impulsive and convective components. Seismic analyses were performed with modal analysis followed by time history analysis. Analysis results from all the models were verified by comparing with the results calculated by the code and literature. The results from simplified models show good agreement with the ones from detailed FSI model and calculated results from code and literature, confirming that all three types of simplified models are very valid for conducting failure probability analysis of the cylindrical liquid storage tanks.
Rayamajhi, Nabin,Jung, Byeong Yeal,Cha, Seung Bin,Shin, Min Kyung,Kim, Aeran,Kang, Min Su,Lee, Kang Mu,Yoo, Han Sang American Society for Microbiology 2010 Applied and environmental microbiology Vol.76 No.14
<B>ABSTRACT</B><P>Fifteen nonrepetitive ampicillin-resistant <I>Salmonella</I> spp. were identified among 91 <I>Salmonella</I> sp. isolates during nationwide surveillance of <I>Salmonella</I> in waste from 131 chicken farms during 2006 and 2007. Additional phenotyping and genetic characterization of these 15 isolates by using indicator cephalosporins demonstrated that resistance to ampicillin and reduced susceptibility to cefoxitin in three isolates was caused by TEM-1 and DHA-1 β-lactamases. Plasmid profiling and Southern blot analysis of these three DHA-1-positive <I>Salmonella</I> serovar Indiana isolates and previously reported unrelated clinical isolates of DHA-1-positive <I>Salmonella</I> serovar Montevideo, <I>Klebsiella pneumoniae</I>, and <I>Escherichia coli</I> from humans and swine indicated the involvement of the large-size plasmid. Restriction enzyme digestion of the plasmids from the transconjugants showed variable restriction patterns except for the two <I>S</I><I>almonella</I> serovar Indiana isolates identified in this study. To the best of our knowledge, this is the first report of the presence of the DHA-1 gene among <I>Salmonella</I> spp. of animal origin.</P>
Quercetin Induces Mitochondrial Biogenesis through Activation of HO-1 in HepG2 Cells
Rayamajhi, Nabin,Kim, Seul-Ki,Go, Hiroe,Joe, Yeonsoo,Callaway, Zak,Kang, Jae-Gu,Ryter, Stefan W.,Chung, Hun Taeg Hindawi Publishing Corporation 2013 Oxidative medicine and cellular longevity Vol.2013 No.-
<P>The regeneration of mitochondria by regulated biogenesis plays an important homeostatic role in cells and tissues and furthermore may provide an adaptive mechanism in certain diseases such as sepsis. The heme oxygenase (HO-1)/carbon monoxide (CO) system is an inducible cytoprotective mechanism in mammalian cells. Natural antioxidants can provide therapeutic benefit, in part, by inducing the HO-1/CO system. This study focused on the mechanism by which the natural antioxidant quercetin can induce mitochondrial biogenesis in HepG2 cells. We found that quercetin treatment induced expression of mitochondrial biogenesis activators (PGC-1<I><I>α</I></I>, NRF-1, TFAM), mitochondrial DNA (mtDNA), and proteins (COX IV) in HepG2 cells. The HO inhibitor SnPP and the CO scavenger hemoglobin reversed the effects of quercetin on mitochondrial biogenesis in HepG2 cells. The stimulatory effects of quercetin on mitochondrial biogenesis could be recapitulated <I>in vivo</I> in liver tissue and antagonized by SnPP. Finally, quercetin conferred an anti-inflammatory effect in the liver of mice treated with LPS and prevented impairment of mitochondrial biogenesis by LPS <I>in vivo</I>. These salutary effects of quercetin <I>in vivo</I> were also antagonized by SnPP. Thus, our results suggest that quercetin enhances mitochondrial biogenesis mainly via the HO-1/CO system <I>in vitro</I> and <I>in vivo</I>. The beneficial effects of quercetin may provide a therapeutic basis in inflammatory diseases and sepsis.</P>