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Aptamer‐aptamer linkage based aptasensor for highly enhanced detection of small molecules
Nguyen, Van‐,Thuan,Lee, Bang Hyun,Kim, Sang Hoon,Gu, Man Bock WILEY‐VCH Verlag 2016 BIOTECHNOLOGY JOURNAL Vol.11 No.6
<P><B>Abstract</B></P><P>The multi‐target colorimetric aptasensors can be easily fabricated by using two different aptamer sequences. However, there have been no research reports about improvement or enhancing of colorimetric signals based on the aggregation properties of AuNPs. Herein, we report a simple and efficient method to control and enhance the function of the multi‐target aptasensor using an aptamer‐aptamer linkage method. The aptasensor was developed for highly sensitive multiple‐target detection of small molecules. The extension of aptamer DNA sequences using this method resulted in the enhanced analytical sensitivity of this aptasensor in sensing applications for two small molecule targets. Furthermore, the mechanism of the interaction between DNA aptamer and AuNPs was studied by measuring the zeta potential to explain the enhancement of the sensitivity of this multi‐target aptasensor. The limit of detection of this multi‐target aptasensor was found to be 1 nM and 37 nM for kanamycin (KAN) and chlortetracycline (CHLOR), respectively. It is 25‐fold lower than in the previous report using an AuNP‐based sensor for defining the limit of detection (LOD) of KAN and five times lower than the LOD for CHLOR. This aptasensor has great potential in the simultaneous detection of a wide range of KAN and CHLOR concentrations.</P>
Analysing Productivity in Vietnamese Seafood Processing Firms: A Control Function Approach
NGUYEN, Van,TRAN, Thuan Duc,MAI, Thanh Khac Korea Distribution Science Association 2021 The Journal of Asian Finance, Economics and Busine Vol.8 No.2
This study aims to estimate the production function and total factor productivity (TFP) of Vietnamese seafood processing firms. At the same time, the study analyses the impact of internal factors of firms and the quality of economic institutions on the TFP of the Vietnamese seafood processing industry. The study uses the Function Control (FC) approach in TFP estimation and the Feasible Generalized Least Squares (FGLS) regression model in the analysis of factors affecting TFP. The study was carried out on the census data of enterprises of the Vietnamese seafood processing industry collected by the Vietnamese General Statistics Office and Provincial Competitiveness Index data of Vietnam Chamber of Commerce and Industry in the period from 2013 to 2018. Estimated results from the models show that: i) Vietnamese seafood processing firms are, currently, mainly labor-intensive, the TFP contribution and output is only about 2.258. ii) Factors such as the firm's age, firm's size, and the firm's ownership affect TFP. In which, firms that have few numbers of years of operation, small and medium firms, and private firms have low TFP. iii) Institutional quality and the provincial business environment have a positive impact on the TFP of Vietnamese seafood processing firms in this period.
A Review of SnSe: Growth and Thermoelectric Properties
NGUYENVAN QUANG,김정대,조성래 한국물리학회 2018 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.72 No.8
SnSe is a 2D semiconductor with an indirect energy gap of 0.86 - 1 eV; it is widely used in solar cell, optoelectronics, and electronic device applications. Recently, SnSe has been considered as a robust candidate for energy conversion applications due to its high thermoelectric performance (ZT = 2.6 in p-type and 2.2 in n-type), which is assigned mainly to its anhamornic bonding leading to an ultralow thermal conductivity. In this review, we first discuss the crystalline and electronic structures of SnSe and the source of its p-type characteristic. Then, some typical single crystal and polycrystal growth techniques, as well as an epitaxial thin film growth technique, are outlined. The reported thermoelectric properties of SnSe grown by using each technique are also reviewed. Finally, we will describe some remaining issues concerning the use of SnSe for thermoelectric applications.
구엔반동 ( Nguyenvan Dong ),이창주 ( Lee Chang Ju ),백건휘 ( Baek Geon Hwi ),장성규 ( Chang Seong Kyu ),김두기 ( Kim Doo Kie ) 한국구조물진단유지관리공학회 2018 한국구조물진단유지관리공학회 학술발표대회 논문집 Vol.22 No.1
The mechanical behavior of the fasting system on the clamping forces has not been fully studied because of structural complexity. The goal of this research is studying the effect of nonlinear of the rail fastening system on the clamping forces in the railway bridges. A numerical model is proposed to analyze the problem of fasteners. The model is conducted by using a code in FORTRAN. In this study, fasteners are modelled as springs. The calculated results show a good agreement with values referred from manufacturer. As a result, the numerical simulation is believed to indicate an approximate value of clamping force considering the nonlinear behavior of fastening system.
NGUYENTHIYEN,NGUYENVAN THU,Bing Tian Zhao,Jae Hyun Lee,김정아,손종근,Jae Sui Choi,우은란,우미희,민병선 대한화학회 2014 Bulletin of the Korean Chemical Society Vol.35 No.7
To provide the scientific corroboration of the traditional uses of Akebia quinata (Thunb.) Decne., a detailed analytical examination of A. quinata stems was carried out using a reversed-phase high performance liquid chromatography (RP-HPLC) method coupled to photodiode array detector (PDA) for the simultaneous determination of four phenolic substances; cuneataside D (1), 2-(3,4-dihydroxyphenyl)ethyl-O-β-D-glucopyranoside (2), 3-caffeoylquinic acid (3) and calceolarioside B (4). Particular attention was focused on the main compound, 3-caffeoylquinic acid (3), which has a range of biological functions. In addition, 2-(3,4- dihydroxyphenyl)ethyl-O-β-D-glucopyranoside (2) was considered as a discernible marker of A. quinata from its easy confuse plants. The contents of compounds 2 and 3 ranged from 0.72 to 2.68 mg/g and from 1.66 to 5.64 mg/g, respectively. The validation data indicated that this HPLC/PDA assay was used successfully to quantify the four phenolic compounds in A. quinata from different locations using relatively simple conditions and procedures. The pattern-recognition analysis data from 53 samples classified them into two groups, allowing discrimination between A. quinata and comparable herbs. The results suggest that the established HPLC/PDA method is suitable for quantitation and pattern-recognition analyses for a quality evaluation of this medicinal herb.
Duong Van Thiet,NGUYENVAN QUANG,Nguyen Thi Minh Hai,Nguyen Thi Huong,조성래,Duong Anh Tuan,Dang Duc Dung,트란반탐 한국물리학회 2018 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.72 No.8
In this work, we report on the structural and thermoelectric properties of Sb2Te3 films deposited on GaSb(111) substrates by using molecular beam epitaxy. The effects of the growth temperature on the microstructure and thermoelectric properties of the films were investigated. The results show that Sb2Te3 films grow on GaSb(111) along (00l) axis normal to the substrate and have a hexagonal structure with a layer-by-layer growth mode in growth temperature range from 200 to 250 °C while at 175 and 300 °C, the films show an island growth mode. Te and Sb2Te3 phases coexist at a growth temperature of 175 °C. The films exhibit a metallic behavior for growth temperatures below 250 °C and a semiconductor behavior at 300 °C. By changing growth temperature, we were able to vary the carrier density from 9.96×1018 to 4.55×1019 cm −3. At room temperature, the Seebeck coefficients are 110, 146, and 138 μV/K for growth temperatures of 175, 200 and 250 °C, respectively, and a large value of the power factor 61.67 μW/cm-K2 is achieved for the film grown at 250 °C.
Cytotoxic Triterpenoids from the Fruiting Bodies of Ganoderma lucidum
Nguyen The Tung,우미희,Tran Thi Thu Trang,TODAO CUONG,NGUYENVAN THU,민병선 한국생약학회 2014 Natural Product Sciences Vol.20 No.1
Twelve triterpenoids (1 - 12) were isolated from CHCl3-soluble fraction of fruiting bodies of Ganoderma lucidum. Extensive spectroscopic and chemical studies established the structures of these compounds as butyl lucidenate P (1), butyl lucidenate E2 (2), butyl lucidenate D2 (3), butyl lucidenate Q (4), ganoderiol F (5), methyl ganoderate H (6), methyl ganoderate J (7), lucidumol B (8), ganodermanondiol (9), methyl lucidenate N (10), methyl lucidenate A (11) and butyl lucidenate N (12). All of the compounds were examined for their cytotoxic activity against HL-60, HeLa, and MCF-7 cancer cell lines. Among them, compounds 4 and 8 showed cytotoxic activity with IC50 values of 6.6 and 1.6 ?M against HL-60, respectively. In addition, compound 8 also showed cytotoxic activity with IC50 values of 2.0 ?M against HeLa cancer cell line, other compounds were moderate or inactive.
Compounds from the Seeds of Myristica fragrans and Their Cytotoxic Activity
TODAO CUONG,Chae Jin Lim,Tran Thi Thu Trang,Yoon Ho Bae,NGUYENVAN THU,Nguyen The Tung,Tran Manh Hung,우미희,최재수,민병선 한국생약학회 2012 Natural Product Sciences Vol.18 No.2
Six lignan compounds, 1-(17,21-dihydroxyphenyl)-9-(12,13-dihydroxyphenyl)-1-nonanone (malabaricone C) (1), 7'-(3',4'-methylenedioxyphenyl)-8,8'-dimethyl-7-(3,4-dihydroxyphenyl)-butane (2), 7'-(3',4'-dimethoxyphenyl)-8,8'-dimethyl-7-(3-methoxy-4-hydroxyphenyl)-butane (3), 7-(4-hydroxy-3-methoxyphenyl)-7′-(3′,4′-methylenedioxyphenyl)-8,8′-lignan-7-methyl ether (4), (+)-erythro-(7S,8R)-Δ8′-7-hydroxy-3,4,3′,5′-tetramethoxy-8-O-4′-neolignan (5), and (+)-erythro-(7S,8R)-Δ8′-7-acetoxy-3,4,3′,5′-tetramethoxy-8-O-4′-neolignan (6), were isolated from the seeds of Myristica fragrans. The chemical structures of these compounds were determined on the basis of spectroscopic analyses including 2D NMR. Compounds 1 - 6 were evaluated for their cytotoxic activity against the HL-60, MCF-7, and A549 cancer cell lines in in vitro.