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Efficacy of an oral hyaluronate and collagen supplement as a preventive treatment of elbow dysplasia
Simón Martí-Angulo,Núria García-López,Ana Díaz-Ramos 대한수의학회 2014 Journal of Veterinary Science Vol.15 No.4
One hundred and five Labrador dogs were randomlydivided into two groups to determine the number of animalsthat develop elbow dysplasia when treated with an oralsupplement compared to untreated ones. Efficacy of the oraltreatment was also evaluated once illness was diagnosed. The supplement (Hyaloral) contained hyaluronic acid,hydrolysed collagen, glucosamine, chondroitin sulphate,and gamma oryzanol. Clinical evaluation of the elbow jointswas completed at months 3, 6, 12, and 20 by orthopaedicevaluations, radiography, serologic and blood analysis, andveterinarian evaluation of dysplasia symptoms. All sideeffects were recorded. In the control group, 33.3% of thedogs developed radiographic evidence of elbow dysplasiacompared to 18.5% in the treated group. Symptoms ofdysplasia at 12 months differed between the treated (12.5%)and control (61.5%) animals, and were significantlydifferent at 20 months (p < 0.05). Differences in lamenessalong with movement and swelling of the elbows betweengroups were observed after 12 months. The treated grouphad improved significantly by the last visit (p < 0.05). Noadverse side effects were reported. In conclusion, oraltreatment with Hyaloral may have a potential cumulativeaction that provides protection against dysplasia and significantly improves symptoms of elbow dysplasia.
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Verónica Perea,Xavier Urquizu,Maite Valverde,Marina Macias,Anna Carmona,Esther Esteve,Gemma Escribano,Nuria Pons,Oriol Giménez,Teresa Gironés,Andreu Simó-Servat,Andrea Domenech,Núria Alonso-Carril,Car 대한당뇨병학회 2022 Diabetes and Metabolism Journal Vol.46 No.6
Background: This study aimed to evaluate the influence of maternal diabetes in the risk of neurodevelopmental disorders in offspring in the prenatal and postnatal periods.Methods: This cohort study included singleton gestational diabetes mellitus (GDM) pregnancies >22 weeks’ gestation with live newborns between 1991 and 2008. The control group was randomly selected and matched (1:2) for maternal age, weeks of gestation and birth year. Cox regression models estimated the effect of GDM on the risk of attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), and maternal type 2 diabetes mellitus (T2DM). Moreover, interaction between maternal T2DM and GDM-ADHD relationship was evaluated.Results: Children (<i>n</i>=3,123) were included (1,073 GDM; 2,050 control group). The median follow-up was 18.2 years (interquartile range, 14.2 to 22.3) (<i>n</i>=323 with ADHD, <i>n</i>=36 with ASD, and <i>n</i>=275 from women who developed T2DM). GDM exposure was associated with ADHD (hazard ratio [HR]<sub>crude</sub>, 1.67; 95% confidence interval [CI], 1.33 to 2.07) (HR<sub>adjusted</sub>, 1.64; 95% CI, 1.31 to 2.05). This association remained significant regardless of the treatment (diet or insulin) and diagnosis after 26 weeks of gestation. Children of mothers who developed T2DM presented higher rates of ADHD (14.2 vs. 10%, <i>P</i>=0.029). However, no interaction was found when T2DM was included in the GDM and ADHD models (<i>P</i>>0.05). GDM was not associated with an increased risk of ASD (HR<sub>adjusted</sub>, 1.46; 95% CI, 0.74 to 2.84).Conclusion: Prenatal exposure to GDM increases the risk of ADHD in offspring, regardless of GDM treatment complexity. However, postnatal exposure to maternal T2DM was not related to the development of ADHD.
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Agustín V. Ruiz Vega,Consuelo Riaño Gil 글로벌지식마케팅경영학회 2014 Global Marketing Conference Vol.2014 No.9
The present research analyzes the influence of positive and negative emotions towards consumer satisfaction and buying intentions of PDO Rioja wine. Results suggest that only positive emotions have a significant effect, in consumer satisfaction but also in future buying intentions because consumers search (positive) pleasure when taste foods and drinks.
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Sara Hernández-Ortega,Abril Sánchez-Botet,Eva Quandt,Núria Masip,Laura Gasa,Gaetano Verde,Javier Jiménez,Rebecca S. Levin,Florentine U. Rutaganira,Alma L. Burlingame,Don Wolfgeher,Mariana P. C. Ribeir 생화학분자생물학회 2019 Experimental and molecular medicine Vol.51 No.-
CDK16 (also known as PCTAIRE1 or PCTK1) is an atypical member of the cyclin-dependent kinase (CDK) family that forms an active complex with cyclin Y (CCNY). Although both proteins have been recently implicated in cancer pathogenesis, it is still unclear how the CDK16/CCNY complex exerts its biological activity. To understand the CDK16/ CCNY network, we used complementary proteomic approaches to identify potential substrates of this complex. We identified several candidates implicating the CDK16/CCNY complex in cytoskeletal dynamics, and we focused on the microtubule-associated protein regulator of cytokinesis (PRC1), an essential protein for cell division that organizes antiparallel microtubules and whose deregulation may drive genomic instability in cancer. Using analog-sensitive (AS) CDK16 generated by CRISPR-Cas9 mutagenesis in 293T cells, we found that specific inhibition of CDK16 induces PRC1 dephosphorylation at Thr481 and delocalization to the nucleus during interphase. The observation that CDK16 inhibition and PRC1 downregulation exhibit epistatic effects on cell viability confirms that these proteins can act through a single pathway. In conclusion, we identified PRC1 as the first substrate of the CDK16/CCNY complex and demonstrated that the proliferative function of CDK16 is mediated by PRC1 phosphorylation. As CDK16 is emerging as a critical node in cancer, our study reveals novel potential therapeutic targets.
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Salvatore Rudilosso,José Ríos,Alejandro Rodríguez,Meritxell Gomis,Víctor Vera,Manuel Gómez-Choco,Arturo Renú,Núria Matos,Laura Llull,Francisco Purroy,Sergio Amaro,Mikel Terceño,Víctor Obach,Joaquim Se 대한뇌졸중학회 2021 Journal of stroke Vol.23 No.3
Background and Purpose In real-world practice, the benefit of mechanical thrombectomy (MT) is uncertain in stroke patients with very favorable or poor prognostic profiles at baseline. We studied the effectiveness of MT versus medical treatment stratifying by different baseline prognostic factors. Methods Retrospective analysis of 2,588 patients with an ischemic stroke due to large vessel occlusion nested in the population-based registry of stroke code activations in Catalonia from January 2017 to June 2019. The effect of MT on good functional outcome (modified Rankin Score ≤2) and survival at 3 months was studied using inverse probability of treatment weighting (IPTW) analysis in three pre-defined baseline prognostic groups: poor (if pre-stroke disability, age >85 years, National Institutes of Health Stroke Scale [NIHSS] >25, time from onset >6 hours, Alberta Stroke Program Early CT Score <6, proximal vertebrobasilar occlusion, supratherapeutic international normalized ratio >3), good (if NIHSS <6 or distal occlusion, in the absence of poor prognostic factors), or reference (not meeting other groups’ criteria). Results Patients receiving MT (n=1,996, 77%) were younger, had less pre-stroke disability, and received systemic thrombolysis less frequently. These differences were balanced after the IPTW stratified by prognosis. MT was associated with good functional outcome in the reference (odds ratio [OR], 2.9; 95% confidence interval [CI], 2.0 to 4.4), and especially in the poor baseline prognostic stratum (OR, 3.9; 95% CI, 2.6 to 5.9), but not in the good prognostic stratum. MT was associated with survival only in the poor prognostic stratum (OR, 2.6; 95% CI, 2.0 to 3.3). Conclusions Despite their worse overall outcomes, the impact of thrombectomy over medical management was more substantial in patients with poorer baseline prognostic factors than patients with good prognostic factors.
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Martina Aida Angeles,Federico Migliorelli,Sergi Vidal-Sicart,Adela Saco,Jaume Ordi,Cristina Ros,Pere Fusté,Meritxell Munmany,Sílvia Escura,Núria Carreras,Nuria Sánchez-Izquierdo,Jaume Pahisa,Aureli To 대한부인종양학회 2021 Journal of Gynecologic Oncology Vol.32 No.4
Objective: We aimed to evaluate the accuracy of sentinel lymph node (SLN) mapping with transvaginal ultrasound-guided myometrial injection of radiotracer (TUMIR) to detect lymph node (LN) metastases, in patients with intermediate and high-risk endometrial cancer (EC), focusing on its performance to detect paraaortic involvement. Methods: Prospective study including women with preoperative intermediate or high-risk EC, according to ESMO-ESGO-ESTRO consensus, who underwent SLN mapping using the TUMIR approach. SLNs were preoperatively localized by planar and single photon emission computed tomography/computed tomography images, and intraoperatively by gamma-probe. Immediately after SLN excision, all women underwent systematic pelvic and paraaortic lymphadenectomy by laparoscopy. Results: The study included 102 patients. The intraoperative SLN detection rate was79.4% (81/102). Pelvic and paraaortic drainage was observed in 92.6% (75/81) and 45.7% (37/81) women, respectively, being exclusively paraaortic in 7.4% (6/81). After systematic lymphadenectomy, LN metastases were identified in 19.6% (20/102) patients, with 45.0% (9/20) showing paraaortic involvement, which was exclusive in 15.0% (3/20). The overall sensitivity and negative predictive value (NPV) of SLNs by the TUMIR approach to detect lymphatic involvement were 87.5% and 97.0%, respectively; and 83.3% and 96.9%, for paraaortic metastases. After applying the MSKCC SLN mapping algorithm, the sensitivity and NPV were 93.8% and 98.5%, respectively. Conclusion: The TUMIR method provides valuable information of endometrial drainage in patients at higher risk of paraaortic LN involvement. The TUMIR approach showed a detection rate of paraaortic SLNs greater than 45% and a high sensitivity and NPV for paraaortic metastases in women with intermediate and high-risk EC.
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Agust?n V. Ruiz Vega,Consuelo Ria?o Gil 글로벌지식마케팅경영학회 2014 Global Marketing Conference Vol.2014 No.7
The present research analyzes the influence of positive and negative emotions towards consumer satisfaction and buying intentions of PDO Rioja wine. Results suggest that only positive emotions have a significant effect, in consumer satisfaction but also in future buying intentions because consumers search (positive) pleasure when taste foods and drinks.
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Raw Drone Milk of Honeybees Elicits Uterotrophic Effect in Rats: Evidence for Estrogenic Activity
Adrienn B. Seres,Eszter Ducza,Ma´ria Ba´thori,Attila Hunyadi,Zolta´n Be´ni,Miklo´s De´ka´ny,Ro´bert Ga´spa´r 한국식품영양과학회 2013 Journal of medicinal food Vol.16 No.5
Numerous honeybee products are used in medicine, but the literature furnishes no information concerning the effects of the drone milk (DM), although drone brood, which is similar to DM, was reported to elicit a hormone-like strengthening effect. In certain countries, DM is traditionally used to treat infertility and to promote vitality in both men and women. The aim of this study was to determine the putative estrogen hormone–like effect of raw DM in rats and to identify the effective compounds. Uterotrophic assays revealed that DM increased the relative weight of the immature rat uterus. This effect was confirmed by reverse transcription polymerase chain-reaction and Western blot methods, in which the mRNA and protein expression of the estrogen-dependent peptide complement component C3 was determined. Column chromatography and uterotrophic assays were used to fractionate and check bioactivity, respectively. The active compound after the last fractionation was identified by the nuclear magnetic resonance and mass spectrometry techniques as E-dec-2-enedioic acid, which is very similar to the fatty acids with estrogenic activity that were previously isolated from royal jelly. These results lead us to suppose that E-dec-2-enedioic acid is responsible for the estrogen-like effect of DM. This appears to be the first report on the pharmacological effects of DM and E-dec-2-enedioic acid in mammals.
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Herrando-Moraira, Sonia,Calleja, Juan Antonio,Carnicero, Pau,Fujikawa, Kazumi,Galbany-Casals, Mercè,Garcia-Jacas, Nú,ria,Im, Hyoung-Tak,Kim, Seung-Chul,Liu, Jian-Quan,Ló,pez-Alvarado Elsevier 2018 Molecular phylogenetics and evolution Vol.128 No.-
<P><B>Abstract</B></P> <P>Target enrichment is a cost-effective sequencing technique that holds promise for elucidating evolutionary relationships in fast-evolving lineages. However, potential biases and impact of bioinformatic sequence treatments in phylogenetic inference have not been thoroughly explored yet. Here, we investigate this issue with an ultimate goal to shed light into a highly diversified group of Compositae (Asteraceae) constituted by four main genera: <I>Arctium</I>, <I>Cousinia</I>, <I>Saussurea</I>, and <I>Jurinea</I>. Specifically, we compared sequence data extraction methods implemented in two easy-to-use workflows, PHYLUCE and HybPiper, and assessed the impact of two filtering practices intended to reduce phylogenetic noise. In addition, we compared two phylogenetic inference methods: (1) the concatenation approach, in which all loci were concatenated in a supermatrix; and (2) the coalescence approach, in which gene trees were produced independently and then used to construct a species tree under coalescence assumptions. Here we confirm the usefulness of the set of 1061 COS targets (a nuclear conserved orthology loci set developed for the Compositae) across a variety of taxonomic levels. Intergeneric relationships were completely resolved: there are two sister groups, <I>Arctium</I>-<I>Cousinia</I> and <I>Saussurea</I>-<I>Jurinea</I>, which are in agreement with a morphological hypothesis. Intrageneric relationships among species of <I>Arctium</I>, <I>Cousinia</I>, and <I>Saussurea</I> are also well defined. Conversely, conflicting species relationships remain for <I>Jurinea</I>. Methodological choices significantly affected phylogenies in terms of topology, branch length, and support. Across all analyses, the phylogeny obtained using HybPiper and the strictest scheme of removing fast-evolving sites was estimated as the optimal. Regarding methodological choices, we conclude that: (1) trees obtained under the coalescence approach are topologically more congruent between them than those inferred using the concatenation approach; (2) refining treatments only improved support values under the concatenation approach; and (3) branch support values are maximized when fast-evolving sites are removed in the concatenation approach, and when a higher number of loci is analyzed in the coalescence approach.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Target enrichment resolved relationships among the four genera of the Cardueae. </LI> <LI> Bioinformatic choices can largely affect the phylogenetic reconstructions. </LI> <LI> Filtering strategies improve support values only under concatenation analyses. </LI> <LI> The coalescence approach yields higher topological robustness than concatenation. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
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