일사부재리 위반을 이유로 한 각하 심결에 대한 취소소송의 심리범위

강명수 ( Kang¸ Myungsoo ) 한국지식재산연구원 2020 지식재산연구 Vol.15 No.4

특허법 제163조의 일사부재리 제도는 오스트리아 입법을 계수한 일본 법규정을 받아들인 것인데, 오스트리아는 헌법재판소의 위헌 결정으로 동 규정이 폐지되었고, 일본은 2011년 개정을 통해 제3자효를 제외시켰다. 이와 달리 우리나라는 입법 당시와 실질적인 변화 없이 현재에 이르고 있는바, 이러한 특징을 고려하여 해석론을 전개할 필요가 있다. 최근 대법원 2020. 4. 9. 선고 2018후11360 판결에서는 일사부재리 원칙의 판단기준은 심결시라고 하면서 심결취소소송 단계에서의 새로운 주장은 허용되지 않는다고 하였다. 하지만 일사부재리 원칙의 제도적 취지와 특징, 분쟁의 일회적 해결 도모, 심결취소소송의 심리범위에 대한 무제한설 등을 고려해 볼 때 일사부재리 위반을 이유로 한 각하심결에 대해서만 달리 볼 이유는 없다. 선행 심결의 확정시기를 심판청구시로 본 판례에 대해 제3자의 권리 제한을 최소화하기 위하여 부득이하게 선행 심결의 확정과 관련해서만 그 기준 시점을 정한 것이라고 해석한 것을 고려해 볼 때, 일사부재리 위반에 대한 심결취소소송단계에서 새로운 사실을 주장하거나 증거를 제출할 수 있고 이에 따라 그 하자가 치유된다고 보아야 할 것이다. Article 163 of the Patent Act is the acceptance of Japanese law provisions that counted Austrian legislation. The rule was abolished in Austria due to the Constitutional Court’s unconstitutional decision, and Japan excluded the third effect by revising the law in 2011. However Korea has reached the present subjective scope and objective scope without any actual changes from the time of legislation. The recent Supreme Court Decision 2018Hu11360 stated that the standard for judging of the non bis in idem principle is at the time of the trial ruling, and that new claims in the lawsuit for cancellation are not allowed. The purpose of the principle of non bis in idem and an efficient resolution of relevant dispute, there is no reason to deny such new claims in the lawsuit. Considering unlimited hearing scope of revocation action of administrative decision and the supreme court decision regarding the final and conclusive of the preceding ruling is a request the administrative trial is inevitably set only to minimize the limitation of the rights of third parties, new facts or evidence should be submitted in the lawsuit for cancellation of a decision on the grounds for breach of non bis in idem.

여성노인의 저항운동 시 세트구성 방법의 차이가 Myokine에 미치는 영향

김명수 ( Kim¸ Myung-soo ),이승환 ( Lee¸ Sung-hwan ),민병남 ( Min¸ Byung-nam ),김재훈 ( Kim¸ Jae-hoon1 ),방현석 ( Bang¸ Hyun-seok ),김성희 ( Kim¸ Sung-hee ) 한국융합과학회(구 한국시큐리티융합경영학회) 2020 한국융합과학회지 Vol.9 No.4

연구목적: 본 연구는 여성노인을 대상으로 저항운동 시 사용되는 set구성 방법에 중 ascending set, descending set, drop set를 각각 적용시켜 Myokine의 변화를 알아보고자 하였다. 연구방법: 연구대상은 노인복지시설을 이용하고 있는 만 65-72세 사이의 여성노인 32명을 대상으로 ascending set, 8명, descending set 8명, drop set 8명, control group 8명으로 구분하였다. 자료처리는 반복측정에 의한 이원변량분석(two-way ANOVA with repeated measure)을 사용하였으며, 유의도는 .05로 하였다. 결론: 운동프로그램은 12주간 주 3회 실시하였으며, 신체구성과 IL-15, BDNF, VEGF, Irisin의 변화를 관찰하였다. 연구결과 신체구성의 체중, 체지방률, 제지방량 모두 유의한 차이가 없었다. IL-15와 BDNF는 운동 전·후의 비교결과 Descending set와 Drop set에서 운동 후 유의하게 증가하였고, 집단 간의 차이에서 Descending set와 Drop set 집단이 대조집단에 비하여 높게 나타났다. VEGF는 운동 전·후의 비교결과 Descending set와 Drop set 집단이 유의하게 증가하였으며, 집단 간의 차이에서 Descending set와 Drop set가 Ascending set와 control group 보다 높게 나타났다. Irisin은 집단 간 차이는 없었지만 Ascending, Descending, Drop set집단에서 운동 전에 비하여 운동 후 유의한 차이로 증가하였다.. Purpose: The purpose of this study is to identify the change of Myokine by applying ascending set, descending set, and drop set which are set composition used during elderly women’s resistance training. Method: 32 participants aged 65 to 72 who were users of welfare facilities for the aged were divided into 4 groups. They were ascending set group of 8, descending set group of 8, drop set group of 8, and control group of 8. The training program was conducted 3 times a week for 12 weeks and the change of body composition, IL-15(interleukin-15), BDNF(brain derived neurotrophic factor), VEGF(Vascular endothelial growth factor) and Irisin was observed. Two-way ANOVA with repeated measure was used for data processing. Result: The result of this study is as follows. Weight, %fat, and LBM(lean body mass) without fat showed no significant change. IL-15 and BDNF increased significantly after training in Descending set group(p<.05; p<.01)and Drop set group(p<.01; p<.05). VEGF significantly increased in descending set group(p<.01) and drop set group(p<.05). Among groups, VEGF was higher in descending set and drop set groups than ascending set and control groups. Irisin showed no difference between groups, but it showed significant increase after training in ascending(p<.05), descending(p<.05), and drop set groups(p<.05).

Granuloma annulare in a patient with chronic Epstein-Barr virus infection

( Myungsoo Jun ),( Eung Ho Choi ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.1

Granuloma annulare (GA) is a common autoimmune disorder typically characterized by a ring of beaded papules on the extremities. As various etiologic factors have been suggested, careful inspection on the possible cause should be carried out along with treatment. A 4-year-old female patient presented with coin-shaped and flesh-colored plaques on her left lower calf which have lasted for 6 months. The patient had a history of mycoplasma infection and recurrent acute tonsillarpharyngitis, which resulted in adenoidectomy and tonsillectomy. Laboratory tests were all within normal ranges, except that Epstein-Barr nuclear antigen (EBNA) was positive. A punch biopsy revealed dense mucin deposition in the mid dermis accompanied with dense lymphohistiocytic infiltration. An immunohistochemical stain of her adenoid tissue as for EBNA was positive, whereas it was negative on the skin. After the diagnosis of granuloma annulare was established, systemic acyclovir was administrated and skin lesion was cleared without recurrence. Granuloma annulare is commonly provoked by viral infection, and Epstein-Barr virus (EBV) is known to be associated with various skin and systemic disease including granuloma annulare. Herein we report a case of granuloma annulare concurrent with EBV infection and relapsing acute tonsilarpharyngitis, to suggest EBV as an etiologic factor of pediatric granuloma annulare patient.

MODULER FLAT CONNECTOR

Myungsoo Kim(김명수) 한국디자인학회 2018 한국디자인학회 국제초대전도록 Vol.2018 No.6

Acute localized exanthematous pustulosis: secondary to amoxicillin/clavulanate

( Myungsoo Jun ),( Eung Ho Choi ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.1

Acute localized exanthematous pustulosis(ALEP) is a rare variant of acute generalized exanthematous pustulosis(AGEP), characterized by multiple pustules confined within localized area. A 41-year-old male presented with pustules on the face and chest, accompanied by fever, chill and myalgia for 3 days. The patient had diabetes mellitus, and laboratory tests showed elevated erythrocyte sedimentation rate and serum C-reactive protein level with neutrophilia. The punch biopsy on the chest revealed subcorneal pustules of neutrophils, superficial dermal edema, and intra- and perivascular histiocyte infiltration. Oral amoxicilline/clavulanate had been taken 3 days prior to the patient’s visit, because of high fever and leukocytosis. After the discontinuation of amoxicilline/clavulanate, systemic cefazolin, levofloxafin and acetaminophen was administrated with saline soaking dressing 3 times a day on the crusts of face. The pustules and the crusts were completely recovered in 2 weeks without involvement of body parts other than face and chest. ALEP is differenciated from AGEP in that it is confined within localized area. In most of the cases, systemic administration of antibiotics causes ALEP. Yet it has relatively good prognosis in that it only involves regional skin area, it cannot be guaranteed that disease progress into AGEP would not occur. Herein we report a case of ALEP, occurred after the administration of amoxiciline/clavulanate.

White hair regrowth and alopecia areata: hair-related demographic parameter assessment

( Myungsoo Jun ),( Young Bin Lee ),( Won-soo Lee ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.2

Background: It has been reported that there are patients with white hair regrowth (poliosis) in the treatment of Alopecia areata (AA). Objectives: To identify the relevance between poliosis and AA. Methods: Medical records of 258 AA patients who visited Wonju Severance Christian Hospital from March 2017 to June 2017 were retrospectively assessed. Demographic data of AA patients with or without poliosis were compared. Results: Poliosis was observed in 13 patients (5.04%). When the poliosis group and the control group without poliosis were compared, the mean age and the onset age was higher in poliosis group (47.1 vs 36.7, 43.2 vs. 35.1, respectively), with stastical significance only in mean age (p < 0.05). Sex, disease duration, smoking or drinking history, body mass index showed no significant difference between two groups. Notably, the history of diabetes mellitus (DM) in the Poliosis group was five times higher than in the control group (p < 0.05). Paternal AA history was less frequent (0.0% vs. 3.7%) and maternal AA history was more frequent (7.7% vs. 3.3%) in poliosis group, without statistical significance (p > 0.05). Conclusion: Poliosis group showed no significant difference in most AA-related demographic and disease-related data compared to control group. As DM history was 5-times higher than that of the control group, there is room for further investigation of the relationship between poliosis and endocrine disease.

Unusual presentation of localized scleroderma

( Myungsoo Jun ),( Won Soo Lee ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.1

Localized scleroderma is an autoimmune disorder characterized by inflammation and fibrosis of skin, and possible systemic involvement. A 35-year-old female presented with indurated patches that have lasted 5 months on both arms. The patient was generally healthy except a history of recovered lymph node tuberculosis. Despite the initial punch biopsy showed mucin deposition in upper dermis only, thickening of collagen bundles was observed in follow up biopsy. After 3 years, the patient re-visited our department with aggravated skin lesions, accompanied by mild stiffness on her left arm. The punch biopsy on her left upper arm revealed more aggressive collagen bundle thickening throughout the whole dermis. Thorough inspections of systemic involvement showed negative, and oral prednisolone, pentoxyphyline and D-penicillamine were prescribed. The patient is being followed up in the mild and stable status after the discontinuation of systemic corticosteroid. The possibility of scleroderma is easily overlooked even with histopathological evaluation in the initial status. Besides, because of the possible aggravation into systemic sclerosis, repeated histopathological evaluation and a keen monitoring of disease progress is necessary. We report a case of unusual presentation of localized scleroderma, to discuss its atypical progress and unusual response to the conventional medication.

Mondor`s disease appeared on the flank area

( Myungsoo Jun ),( Jaewoong Choi ),( Sung Ku Ahn ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.1

Mondor’s disease is a rare condition of sclerosing thrombophlebitis of the subcutaneous veins of chest wall. Because of its rare occurrence, and its nature of the sudden appearance of subcutaneous fibrotic cord on the chest wall, the possibility of Mondor’s disease can be easily overlooked. A 59-year-old female patient presented with a linear subcutaneous fibrotic band on her left flank, which have lasted for 3 months. The patient was generally healthy other than the history of herpes zoster on her right thigh and hepatitis C virus infection. The fibrotic band had no symptom except stiffness. The punch biopsy revealed deep subcutaneous phlebitis, inflammatory cell infiltration in the tunica media, thrombus formation and capillary recanalization. Elastic Van Gieson stain shows mild elastic fiber deposition around the vessel. After the diagnosis of Mondor’s disease was established, the patient have been followed up without disease aggravation using oral pentoxyfylline. Although the association of Mondor’s disease and trauma or breast cancer has been suggested, the exact pathogenesis and causing factors have not been unrevealed yet. Herein we report a case of Mondor’s disease, a rare condition of sclerosing thrombophlebitis of subcutaneous veins occurred in flank area.

Therapeutic effect of superficial cryotherapy on alopecia areata: a prospective, split-scalp study

( Myungsoo Jun ),( Won-soo Lee ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.2

Background: Alopecia areata (AA) results in non-scarring hair loss. Since its introduction, superficial cryotherapy with liquefied nitrogen has been used as one of a possible therapeutic modality for AA. Objectives: To clarify the therapeutic efficacy and safety of superficial cryotherapy for treatment of AA. Methods: In 15 patients with AA patches who successfully completed their treatment course ≥4 months, superficial cryotherapy was performed on the right side every 2 weeks. Prednicarbate 0.25% solution was applied to both sides. On every visit, clinical improvement was estimated using the SALT (Severity of Alopecia Tool) score by 3 different dermatologists. The changes in terminal and vellus hair count and hair thickness were analyzed by phototrichogram. Results: After 4 months of treatment, clinical improvement was observed in 73.3%, including complete recovery in 13.3%. Mean terminal hair count on the treated scalp was 1.6-fold increased (p<0.01), while on the control scalp it showed no significant change (p=0.29). Mean SALT score decrease on the treated was 4-fold greater than that on the control (40.7% and 9.6%). Vellus hair count and hair thickness did not show significant changes. No remarkable adverse event was observed. Conclusion: Superficial cryotherapy is an efficacious treatment modality with advantages of simplicity and noninvasiveness. It can be considered as a primary therapeutic modality, especially in mild to moderate AA.

Role of Alveolar Macrophages in Productions of Prostaglandin D₂ and E₂ in the Inflamed Lung

Myungsoo Joo(주명수) 한국생명과학회 2010 생명과학회지 Vol.20 No.6

프로스타글란딘 D2 (PGD2)와 E2 (PGE2)는 COX-2로부터 유래되는 주요 프로스타노이드로서, 슈도모나스에 의한 폐감염이 발생하였을 경우 폐에서 합성되어 슈도모나스 세균감염을 조절할 수 있음을 밝힌바 있음. 본 연구에서는 두 프로스타노이드의 생성 비율을 조절하는 기전을 연구하고자함. 마크로파아지에 의해 PGD2/PGE2 비율이 결정되는 지 조사하기 위해, 마우스의 허파로부터 마크로파아지를 분리하고 LPS로 처리할 경우, COX-2, PGD2합성 효소인 L-PGDS, PGE2의 합성효소인 mPGES-1 등의 발현이 두 프로스타노이드의 생성 비율에 미치는 영향을 조사하였음. 또한 이 효소들의 발현이 일차 허파 마크로파아지에 특이적인지의 여부를 조사하기 위해, 허파 마트로파이지 세포주인 MH-S와 비교 조사하였음. COX-2가 프로스타글린딘 비율에 미치는 영향을 조사하기 위해, COX-2 특이적 siRNA릉 이용하여 COX-2의 발현을 억제하고 L-PGDS, mPGES-1 등의 발현을 조사하였음. 결과에 따르면, 일차 허파 마트로파아지는 MH-S과는 달리 많은 양의 PGE2를 생성하나, 두 세포간 COX-2, L-PGDS, mPGES-1의 발현에는 큰 차이가 없었음. 이는 이들 효소 외에 다른 인자들이 두 프로스타노이드의 비율을 결정하는데 관여함을 제시함. LPS의 처리에 의해 폐염증을 발생시키고 허파에서의 PGD2/PGE2 비율을 조사한 결과, LPS에 의해 폐염증이 발생할 경우 LPS를 처리한 일차 허파 마크로파아지와 유사하게 PGE2의 발현이 PGD2에 비해 상당히 높았음. 결과적으로 본 연구의 결과는, 허파에서의 PGD2/PGE2 비율은, COX-2, L-PGDS, mPGES-1 등 PGD2나 PGE2의 합성에 직접적인 영향을 주는 효소에 의해 결정되지 않으며, 허파마크로파아지의 PGD2/PGE2 비율을 반영할 가능성을 제시함. Our previous study showed that lungs infected by Pseudomonas, a gram-negative bacteria, produce prostaglandin D₂ (PGD₂) and prostaglandin E2 (PGE₂), the two major prostanoids generated by cyclooxygenase-2 (COX-2), and that the ratio of PGD₂ and PGE₂ can affect the outcome of the bacterial lung infection. In this study, we sought to uncover the mechanism that determines the ratio of PGD₂ and PGE₂ produced in lung inflammation. When treated with lipopolysaccharide (LPS), primary alveolar macrophages, extracted from mouse lung, more PGE₂ was produced than PGD₂, whereas MH-S, a murine alveolar macrophage cell line, produced more PGD₂ than PGE₂ in a similar experiment. Western blot analyses showed that the kinetics of COX-2 expression in both cell types is similar and epigenetic silencing of COX-2 expression did not affect expressions of lipocalin-PGD synthase (L-PGDS) and PGE synthase (mPGES-1), major enzymes synthesizing PGD₂ and PGE₂ in inflammation, respectively, indicating no effect of COX-2 on expressions of the two enzymes. Expressions of L-PGDS and mPGES-1 were also similar in both cell types, suggesting no effect of the two key enzymes in determining the ratio of PGD₂ and PGE₂ in these cells. A single intraperitoneal injection of LPS to C57BL/6 mice induced COX-2 expression and, similar to alveolar macrophages, produced more PGE₂ than PGD₂ in the lung. These results suggest that the differential expressions of PGD₂ and PGE₂ in the lung reflect those in alveolar macrophages and may not be directly determined by the enzymes responsible for PGD₂ and PGE₂ synthesis.