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민명희,황현철,김상우 인제대학교 1991 仁濟醫學 Vol.12 No.3
β -thalassemia는 국내에서 매우 희귀하다. 본 예는 β -thalassemia intermedia의 예로서 PCR을 이용하여 진단하였는데, β-globin에 대한 β-haplotype만이 변이(β-globin gene의 codon 32/32 또는 33/34의 3개의 염기의 결손)를 일으켰음에도 불구하고 증상을 나타내었다. 이같은 예는 β-thalassemia 중에서도 매우 희귀한 일이다. A Case of Dominant 70-thalassemia β-thalassemia in Korea is very rare. We experianced a case of β-thalassemia presenting clinical symptoms with a three-base pair deletion in one haplotype of β-globin gene. A 7-year-old boy has been suffered from anemia, jaundice, and hepatosplenomegaly since neonatal period. His hemograms were hemoglobin 7.6g/dl, hematocrit 23vol%, and reticulocyte 7.5%. RBC indices were MCV 61 fl, MCH 19 pg, and MCHC 32g/dl. Peripheral blood smear showed hypochromic and microcytic RBC with anisocytosis, poikilocytosis and moderate basophilic stippling. Iron studios were normal. All of the hemolytic anemia studies were negative. Hemoglobin electrophoresis revealed Hb A 94.7 %, and Hb A2 5.3 %. Bone marrow study showed moderate erythroid hyperplasia with slight eosinophilla. β-globin gene analysis revealed a spontaneous three base pair deletion within codons 32/33 or 33/34 in exon 2 of the one haplotype of β-globin gene. As a result, synthesized β-globin is defective missing one valine, either of β33 or β34 position which is important to make a hemoglobin tetramer between and β-subunit. Therefore, hemoglobin tetramer made of mutated β-globin is so unstable that the hemoglobin is rapidly destructed after being synthesized.
Ultra Precision Machining of the Winston Cone Baffle for Space Observation Camera
Yang, Sun Choel,Kim, Geon Hee,Huh, Myung Sang,Lee, Sang Yong,Kim, Sang Hyuk,Lee, Gil Jae Trans Tech Publications, Ltd. 2012 Key Engineering Materials Vol.516 No.-
<P>The Winston cone baffle was developed for the space observation camera of the MIRIS (Multi-purpose Infrared Imaging System) which is the main payload of STSAT-3 (Science and Technology Satellite). The Winston cone baffle reduces the orbital heat load to the STSAT-3 and is thermally connected to the radiator to cool down. The jig and ultra precision machining jig was designed using a 3D modelling program and analyzed using a computer aided engineering program (ANSYS). The reasons for designing the jig for the baffle were to enhance the stability of the machining and improve the form accuracy of the baffle. The strength, weight and barycentre of the jig are investigated to find the optimized ultra precision machining conditions. To maintain the weight balance of the baffle at high speed rotation, there are lots of holes that can be inserted by heavier bolts. Vibration of the natural diamond bite tool is reduced by using thin copper pipe and urethane silicone. Using this bite tool, we could decrease patterns on the surface of the Winston cone baffle. The results of the simulation using ANSYS show that maximum deformation of the baffle is less than the tolerance limit. Surface roughness of the fabricated Winston cone baffle is machined with the jig and the machining tool is under 5 nm. The Winston cone baffle is plated with gold after being electroless plated with nickel. This baffle is applied to the flight model of the MIRIS.</P>
토끼안구 전방에 유령세포 주입후 섬유주에서의 유령세포의 역할
신정철,고명규,최준규 한양대학교 의과대학 1993 한양의대 학술지 Vol.13 No.1
This study was performed to confirm whether ghost cell in the anterior chamber could block the outflow pathway to lead the increase of the intraocular pressure. Autologous ghost cell was injected into the anterior chamber to observe the fate of the ghost cell was injected into the anterior chamber to observe the fate of the ghost cell in 6 pigmented rabbits within normotensive ocular pressure. The fresh blood from the 6 pigmented rabbits was aspirated to make ghost cell, which was formed in the incubator under the two weeks-incubation. The eyeball was enucleated on 3 days, 7 days and 14 days after infection of ghost cell into the anterior chamber respectively to observe the trabecular meshwork under the transmission electron microscopy. Ghost cells and red cellular debris are observed within the cytoplasm fo the macrophage and endothelial cells of the trabecular meshwork. The nuclear membrane of the trabecular endothelial cell was also markedly indented to indicate the increased activity of the endothelial cell. These findings suggest that ghost cells and red cellular debris may be eliminated through the processes of the phagocytosis and digestion by the trabecular endothelial cell as the biologic filter. Ghost cell within the trabecular meshwork may be a minor role in the elevation of the intraocular pressure.