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VapB as a regulator of osteoclastogenesis via modulation of PLCγ2-Ca<sup>2+</sup>-NFAT signaling
Choi, Sik-Won,Yeon, Jeong-Tae,Park, Kie-In,Lee, Chang Hoon,Youn, Byung Soo,Oh, Jaemin,Lee, Myeung Su Elsevier 2012 FEBS letters Vol.586 No.3
<P><B>Highlights</B></P><P>► We investigate the role of VapB in RANKL-induced osteoclast differentiation. ► Knock-down of VapB suppressed osteoclastogenesis. ► Over-expression of VapB accelerated RANKL-mediated osteoclast differentiation by induction of NFATc1. ► VapB regulates RANKL-mediated osteoclastogenesis via PLCγ2-Ca<SUP>2+</SUP>-NFAT signaling.</P> <P><B>Abstract</B></P><P>VapB has been shown to regulate calcium homeostasis in amyotrophic lateral sclerosis. Calcium signaling is also important in metabolic bone diseases, but the role of VapB in the generation of osteoclasts for bone resorption during osteoclastogenesis is not known. Therefore, we investigated the role of VapB in RANKL-induced osteoclast differentiation. Interestingly, VapB is induced during osteoclastogenesis, and regulates osteoclast differentiation by modulating NFATc1. The results also suggest that VapB regulates osteoclastogenesis via PLCγ2-Ca<SUP>2+</SUP>-NFAT signaling. The involvement of PLCγ2-Ca<SUP>2+</SUP>-NFAT signaling in VapB-regulated osteoclastogenesis was confirmed by a pharmacological study. Taken together, the results indicate that VapB positively regulates RANKL-mediated osteoclastogenesis via PLCγ2-Ca<SUP>2+</SUP>-NFAT signaling.</P>
김완식,최대경,김기령,고춘명 대한마취과학회 1971 Korean Journal of Anesthesiology Vol.4 No.1
One of the important anesthetic problems is cross-infection in anesthetic macbines in operating rooms. This study is an attempt to determine the transfer of organisms through anesthetic apparatus. The bacteriological experiments were based on selective culture with blood agar media(Difco, U.S.A.) in the operating theater, recovery room and in anesthetic apparatus which was either sterilized with chemicals or without sterilization. Furthermore, nasopharyngeal culture also determined in normal healthy patients. The hypersensitivity test was performed by Kolmer's method. The results are as follows; 1) Most of the organisms in the operating room were Staphylococcus and Baeillus subtilis, (table 1.) 2) Bacteriological examination of unsterilized anesthetic acessories showed Staphylococcus, Streptococcus and Gram negative bacillus. (table 2) The sterilizaiton of anesthetic apparatus with Benzalkonium chloride solution for 40 minutes was superior to that with our standard Sterilized solution for one and half hours. (table 3.) 3) Tbe majority of colonies responded to Albamycine, Erythromycine, Kanamycine and Achromycine. (table4, 4-a.) 4) Strep.nonhemolyticus (37.0%) was the most common bacterial flora of the nasopharynx isolated from healthy persons. (table 5.) In conclusion, it is most important to check the bacteriological examination of operating roon s and anesthetic apparatus at regular intervals and to clean hands before and after anesthesia.
바이러스성 피부질환의 치료에 대한 인터페론(Interferon) 연고의 이중 맹검 연구 : 공동 연구 Multicenter Truals
송도식,김명남,노병인,장진요 대한화학요법학회 1985 대한화학요법학회지 Vol.3 No.1
Authors performed a double blind study to evaluate the therapeutic effect of interferon ointment on the viral skin diseases. Totally 256 patients including 110 herpes simplex patients(herpes labialis: 55 patients, herpes progenitalis: 15 patients, and others of herpes simplex: 40 patients), 127 herpes zoster patients, and 19 varicella patients were studied by topical application of interferon ointment (experimental group) or placebo ointment(contro1 group) on the early lesion of each diseases. The estimation of therapeutic effect of interferon ointment was done by the measurement of time interval from the first day of treatment to the day of crust formation. The results were as follows: 1. Herpes simplex; In the experimental group, the percentage of herpes simplex patients who showed crust formation within the second day of treatment was 37.9% and those of the control group was 13.676. The time of crust fortmation of experimental group was shorter than those of control group(p<0.01). 2. Herpes zoster; In the experimental group, the percentage of herpes zoster patients who showed crust formation within 4th day of treatment was 52.3% and those of the control group was 11.T96. The time of crust formation of experimental group was shorter than those of control group(p<0.01). 3. Varicella; In the experimental group, the percentage of varicella patients who showed crust formation within second day of treatment was 40.0% and those of the control group was 25.0%. Therefore we have impressed that interferon ointment is an effective topical therapeutic agent for viral skin diseases.
Prednisolone과 Cyclosporin A가 Superoxide Radical에 의한 Guinea Pig 피부 염증에 미치는 영향
송도식,김명남,노병인 중앙대학교 의과대학 의과학연구소 1990 中央醫大誌 Vol.15 No.4
The purpose of this study was to investigate the effects of prednisolonc (PDL) and cyclosporin A(C-(S)A) on the inflammation induced by superoxide radicals. Experimentally inflammatory reaction was produced by intradermal injection of xanthine oxidase (XOD) and hypoxanthine (HPX) (control) into guinea pig skin. The authors observed changes in activities of superoxide dismutase (SOD) and catalase, and the production of superoxide radicals in the groups injected intraperitoneally of PDL (group A) and CsA (group B) concomitantly. The results were as follows: 1. Activities of total SOD in group A and group B were increased compared with control, and significantly higher (p<0.01) at the 12 hour and 24 hour points. But there were no significant differences between group A and B in SOD activity. 2. The time course changes of catalase activity in group A and B were similar to those of SOD. In group A and B, catalase activities were significantly higher (p<0.01) at 3 hour point than control, and remained significantly up to 48 hours. In group B, significant increase of catalase activity was observed at 12 hour point (p<0.01) and significant reduce at 48 hour point (p<0.01). 3. The time course of change in the superoxide radical production was contrast to those of SOD and catalase activities. The significant reduces were observed 12 hours after injection in group A (p<0.01) and 3 hours after injection in group B (p<0.05). In group B, superoxide radical production was significantly higher than group A only at the 12 hour point after injection (p<0.01). These findings suggest that PDL and CsA lead to the increased production of SOD and catalase activities in the early phase of inflammation produced by superoxide radical, and that PDL suppress the production of superoxide radical more rapidly than CsA.
이정식,조광명,변종각 한국물환경학회 1994 한국물환경학회지 Vol.10 No.1
An adequate treatment is required for leachates from municipal solid waste landfills because they contain a high concentration of organics. This research was performed to investigate the effects of ozonation on removal of organics, especially refractory, in leachates. Ozonation of a raw leachate showed that both COD and BOD decreased during the first 2 hr contact period, then increased, and finally decreased again after 4 hr contact. Ozonation of an effluent, containing almost nonbiodegradable organics, from a batch activated sludge treatment resulted in increase in COD and BOD during a 4 hr contact period, and then the concentrations decreased. In addition, treatments of raw and ozonated leachates by an activated sludge process with a F /M ratio of approximately 0.1㎏ BOD/㎏ MLSS-day showed only a difference of 2∼3% in COD or BOD removal efficiencies. Most of the biodegradable organics formed from refractory organics during ozonation could he biologically removed. Therefore, it could be concluded that part of the refractory organics in leachates could be biologically removed after ozonation and that it would be more effective to ozonate leachate after an biological process.