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Hong, Myeng Chan,Choi, Myung Chan,Chang, Young Wook,Lee, Yongwoo,Kim, Jongsik,Rhee, Hakjune WILEY‐VCH Verlag 2012 Advanced Synthesis & Catalysis Vol.354 No.7
<P><B>Abstract</B></P><P>Palladium nanoparticles were immobilized on PNIPAM:4‐VP hydrogels. The resultant püalladium catalysts showed high activities for Suzuki–Miyaura coupling reactions in water. The recyclability of the catalysts was improved by using 4‐VP as a co‐monomer in the hydrogels due to reduced Pd leaching during the reactions.</P>
Palladium-Catalyzed Benzylation of Arylboronic Acids with <i><i>N,N</i></i>-Ditosylbenzylamines
Yoon, Sangeun,Hong, Myeng Chan,Rhee, Hakjune American Chemical Society 2014 Journal of organic chemistry Vol.79 No.9
<P>The palladium-catalyzed coupling of <I><I>N,N</I></I>-ditosylbenzylamines with arylboronic acids has been investigated, and the resulting diarylmethanes were obtained in high yields. Conversion of the amine to a <I><I>N,N</I></I>-ditosylimide group provided an efficient leaving group for the Pd-catalyzed benzylation of arylboronic acids.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/joceah/2014/joceah.2014.79.issue-9/jo500462n/production/images/medium/jo-2014-00462n_0008.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/jo500462n'>ACS Electronic Supporting Info</A></P>
국방획득에서 SE기반의 운용요구서(ORD) 적용 개선방안 연구
김흥빈,정찬영,양명희,Kim, Heung Bin,Jung, Chan Young,Yang, Myeng Hee 한국시스템엔지니어링학회 2022 시스템엔지니어링학술지 Vol.18 No.1
This paper relates to the improvement application of operation requirements documents(ORD) on which empirical researches are not sufficient. The application of ORD was drawn up and operated in the acquisition phase, and recently it was decided to apply it in the requirements planning phase. However, the reality is that there are deficiencies in the performance of works, such as the classification of works among related organizations. Therefore, this study analyzed the cases of writing ORD that have been promoted so far, and Its status was enhanced by reflecting it in laws and regulations. In addition, the concept was redefined, and improvement measures such as the level of writing ORD were suggested for each acquisition stages. Above all, it is desirable to incrementally supplement and develop from preliminary conceptual research in the planning stage and drafting at the military level. In addition, the relevant legal system should be supplemented so that such ORD application can be flexibly established in defence acquisition.
대한약전 시험법에 관한 연구(Ⅲ) : 연질캅셀의 붕해시험에 관한 연구 Evaluation of Disintegration test of Soft Capsules
최명신,장성재,강찬순,최보경,박상애,강명희,홍정희,김길수,박승희 식품의약품안전청 2000 식품의약품안전청 연보 Vol.4 No.-
연질캅셀에서 경환가 력해에 영향을 미치는 것으로 보고되고 있어 연질캅셀의 경차의 정도와 붕해와의 관계 및 붕해액의 차치에 따른 붕해시간을 비교 검토하고, 시판품에 적용하여 여러 붕해액에 대한 타당성을 연구하고자 '하였다. 또한 지름 20.Onhn 이상인 연질캅셀에 대하여 유리관의 지름o) 다른 대한약전 붕해시험기와 USP 붕해시함기 묘를 비교하여 타당한 시험기를 설정하고자 하였다. 연질캅셀을 0.05%, 0.3% 및 0.5% 포름알데히드를 사웅하여 가교결합시키고 가교결합이 일어난 연질 캅셀에 대하여 물, 약전 붕해 제1액 및 USP Simulated gastric fluid를 시험액으로 연질캅셀의 붕해시 험을 하였다. 포름알데히드의 농도가 높을수록 가교결합이 많이 일어나서 연질캅셀의 붕해는 느려졌다. 물을 시함액으로 하였을 때는 가교결합 정도의 차이에 따른 붕해시간의 차이가 컸으나 USP Sim띨ated gastric fluid를 시험액으로 하였을 때는 가교결합의 정도에 따른 붕해시간의 차이가 적었다. 시판품에 패하여 적용f'1였을 패 물, 약전 붕해 제1액 및 USP Simulated gastric fluid에 대한 붕해 시간은 차이가 적었칠 모두 약전 붕해기준에 적합하였다. 지름 20.Omm 이상인 변질캅셀의 시판품을 대상으로 약전 붕해시험기와 USP 붕해시험기 B에 대한 붕해시간은 차이가 적었고 모두 약전 붕해기준에 적합하였다. 그러므로, 연질캅셀의 렴해시험은 현 약전 붕해시험법과 같이 물을 시험액으로 하고 지름 20.Omm 이상인 연질캅셀은 약전 붕해시험기를 사용하여 시험하는 것이 타당한 것으로 사료된다. The crosslinking process in gelatin causes formation of a swollen, rubbery, water insoluble gelatin ?resulting in increasing disintegration time, The effect of crosslinking anddisintegration medium on disintegration time and the effect of disintegration apparatus on(iisintegration of soft capsules exceeding 20.Omm in diameter were studied.Soft capsules frfre filled with three solutions of aqueous formaldehyde in PEG(0.05, 0.3,0.5%), stored at ambient conditions for 96 hr, emptied, disinteEration tested scanned in hRspectrophotometer. The more increased concentration of formaldehyde, the more increaseddisintegration time in fFater, KP disintegration medium I and USP simulated gastric fluid. Butin USP simulated gastric fluid, the differences of disintegration time among crosslinkingamounts were less than in water.In the case of marketed samples, the differences of disintegration time in each test solutionwere not different and clisintegration thne met KP disintegration test criteria.We conducted disintrgration test with KP apparatus and USP apparatus B in the softcaps'lies of which diamcter was over 20.0 mm. The disintegration time between KP apparatusand USP apparatus B were not different and accepted by IfP disintegration test criteria.So, the disintegration test in soft capsules is applicable In present KP Osintegration test.
신현철,유백근,주명찬,이금원,조태승,신영우,배동한 대한부인종양 콜포스코피학회 1993 Journal of Gynecologic Oncology Vol.4 No.1
Leiomyomatosis peritonealis disseminat,a is a rare non-neoplastic proliferation of histologically benign smooth muscle that occurs in the alxlominal cavity of women during the reproductive years of life, often giving rise to false choical impression of d.isseminated carcinomatosis grossly. In 1952 Wilson & Peale described a condition which they called $quot;multiple peritoneal leiomyomas$quot;. Taubert et al(1965) clearly delinated the features of the lesion and named it leiomyomatosis peritonealis disseminata(LPD). We report a case of leiomyomatosis peritonealis disseminata with a brief review of literatures.
이권해,남계현,주명찬,김희범,조태호 순천향대학교 1992 논문집 Vol.15 No.4
The retrospective study was performed including 13 cases of nonimmunologic hydrops fetalis who were delivered at the Department of Obstetrics and Gynecology, Soonchunhyang University, College of Medicine from Jan. 1990 to June 1992 during the period of 3years. The results were as follows 1. The incidence of NIH was 0.24%. 2. Average maternal age was 28years. Average gravida and parity were 2.2 and 0.7. Average gestational weeks was 26.8weeks. 3. The sex ratio of male to female was 1:1.25/ 4. Frequency of maternal condition associated with NIH were hypoalbuminemia (37.5%), anemia(30.8%), poly or oligohydramnios(30.8%), maternal disease(15.4%), syphilis(7.7%) and drug medication in early pregnancy(7.7%). 5. Associated fetal anomaly were gastroschisis(7.7%), omphalocele(7.7%), hydrocephalus(7.7%), cord anomaly(7.7%) and anatrophic dwarfism(7.7%). 6. The result of chromosomal study in the 3 cases of NIH were normal; 2 cases (46, XX), 1 case (46,XY). 7. Complications in 13 involved pregnancies were poly or oligohydramnios(30.8%), preterm labor(7.7%), placenta previa(7.7%), breech presentation(23.1%), transverse lie(7.7%). 8. Maternal serum α-fetoprotein was checked in ten of total cases. Maternal serum α-fetoprotein were increased in 5 cases (50.0%). 9. Amniotic fluid α-fetoprotein was checked in 4 of total cases. Amniotic fluid α-fetoprotein were increased in 2 cases (50.0%) 10. Gestational age at ultrasonographic diagnosis of NIH was 20-25weeks (53.8%), 26-30weeks(23.1%), 31-35 weeks (15.4%) and 36-40weeks(7.7%). 11. Ultrasonographic findings of NIH were fetal ascites (100%), edema on scalp or abdomen(76.9%), fetal hydrothorax(61.5%), poly or oligohydramnios (30.8%), intrauterine growth retardation (23.1%), large placenta(15.4%). 12. Management associated gestational weeks were bougination (76.9%), normal spontaneous vaginal delivery (15.4%), cesarean section(7.7%). 13. Autopsy finding were generalized edema (100%), marked extramedullary hematopoiesis in liver, spleen(75.0%), fetal ascites (100%), hydrothorax(75.0%), severe anasarca(50.0%), lung hypoplasia (85%), congestion of liver and spleen (50.0%), infarction of adrenal gland (12.5%). 14. Neonatal death rate was 100%.