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Jin-Joo Hue,Myak Miga,Bong Su Kang,Jong-Soo Kim,Sang Yoon Nam,Byeongwoo Ahn,Young Won Yun,Beom Jun Lee 한국실험동물학회 2009 Laboratory Animal Research Vol.25 No.1
There are accumulating evidences that high levels of dietary iron may play a role in colon carcinogenesis. Phytic acid (PA), a natural antioxidant, has chelating and reducing properties on many divalent transition metals. The effects of PA on colon carcinogenesis were investigated in Fe-overloaded ICR male mice. Fiveweek old mice were acclimated for one week and fed on iron-normal diet (35 ppm Fe) or iron-overloaded diet (350 ppm Fe) for 8 weeks. Animals received three (0-2<SUP>nd</SUP> weeks after starting experiment) injections of azoxymethane (AOM; 10 mg/kg b.w.) to induce colonic aberrant crypt foci (ACF). There were five experimental groups including normal control, AOM only, AOM+high Fe, AOM+high Fe+0.5% PA, and AOM+high Fe+2% PA groups. PA was given by drinking water for 8 weeks. The total numbers of ACF and aberrant crypt (AC) were measured in the colonic mucosa after staining with methylene blue. The effects of PA during colon carcinogenesis were analyzed by measuring the total number of aberrant crypt (AC) and ACF in the colonic mucosa, and the hematological and serum biochemical values. High-iron diet induced a significant high in iron content in the livers of mice (P<0.05). Iron-overload diet did not change hematological and serum chemical values compared with normal-diet in ICR mice. There were no significant differences in relative organ weights of mice among experimental groups. High-iron diet increased ACF (82.9±11.5) and AC (96.0±12.3) formation, compared with normal-diet (72.4±15.4 ACF/colon and 90.3±20.1 AC/colon). PA reduced the number of ACF and AC per colon in a dose-dependent manner. 0.5% and 2% PA significantly decreased the numbers of ACF per colon by about 47.5% (43.5±7.2) and 54.3% (37.9±5.5), respectively (P<0.05). The numbers of AC were also significantly reduced by the treatments of PA (P<0.05). These results suggest that phytic acid can be a chemopreventive agent for colon cancer in animals and humans even with iron-overloaded status.
Effects of Carnosine on Exercise Capacity in ICR Mice
Ki-Nam Lee,Jin-Joo Hue,Myak Miga,Bong Su Kang,Jong-Soo Kim,Sang Yoon Nam,Young Won Yun,Jae-Hwang Jeong,Beom Jun Lee 한국실험동물학회 2008 Laboratory Animal Research Vol.24 No.4
Carnosine is a dipeptide (β-alanyl-L-histidine) found in mammalian skeletal muscle at high concentrations. Its biological functions in the muscle include antioxidant and buffering activities. The aim of this study was to evaluate the effect of carnosine on treadmill exercise capacity in mice. Fifty-six male ICR mice were divided into four groups including the control (vehicle) and oral carnosine-treated groups at the doses of 5, 50, and 500 ㎎/㎏/day for 4 weeks. All mice were acclimated to treadmill exercise for 4 weeks by running at 20-40 ㎝/sec for 10-30 min/day. At 2 and 4 weeks, endurance running time was measured. After 4 week, the activities of citrate synthase (CS), lactate dehydrogenase (LDH), and superoxide dismutase (SOD) were determined in gatrocnemius and soleus muscles. At 2 weeks after treatments, the endurance running time in the carnosine-treated groups (50 and 500 ㎎/㎏) was significantly shorter than those in the control group (P<0.05). However, there were no statistically differences in endurance running time at 4 weeks between the control and carnosine-treated groups. CS activity was not markedly different between the control and the carnosine-treated groups. LDH activity was significantly reduced in the carnosine-treated group (500 ㎎/㎏). SOD activity was also significantly reduced in the carnosinetreated groups (50 and 500 ㎎/㎏). These results indicate that carnosine may decrease the exercise capacity in certain physiological conditions.