장기간 숙성에 따른 죽초 및 목초액의 이화학적 변화

구창섭,문성필,박상범,권수덕 한국목재공학회 2002 목재공학 Vol.30 No.4

졸참나무, 맹종죽 및 소나무로부터 제조한 미정제 죽초 및 목초액을 약 1년 간 저장하고, 이들의 이화학적 변화를 주기적으로 분석하였다. pH, 유기산·용해타르 함량 및 비중은 전 숙성기간 중 큰 변화가 관찰되지 않았다. 그러나 색차의 경우 7∼10개월 사이에서 현저한 변화를 나타내었다. 또한 이 기간동안에 이들 죽초 및 목초액의 색깔은 연한 노랑 띤 오렌지색에서 자주색과 오렌지색으로 크게 변화하였다. 죽초 및 목초액 중 유기산 및 중성 성분(dihydro-2(3H)-furanone, furfural, furfuryl alcohol, 2-hydroxy-1-methyl-1-cyclopenten-3-one, 1-hydroxy-2-propanone, methanol)들의 함량은 3개월 간격으로 주기적인 증감을 나타내었다. 특히 유기산류와 중성 성분들의 관계는 0.92 정도의 높은 상관관계를 나타내었다. 페놀류의 함량은 비록 유사한 주기적인 증감이 관찰되었으나, 그 함량의 경우 숙성 전 기간에 걸쳐 감소하였다. Three different kinds of the crude vinegars obtained from oak(Quercus serrata), bamboo(Phyllostachys pubescens) and pine(Pinus densiflora) species were stored for approximately one year and periodically analyzed to monitor their physicochemical changes. Small changes in physical properties, such as the pH, specific gravity and amount of organic acids as well as water-soluble tar were observed in the entire course of aging period. However, the color difference of the vinegars showed a remarkable change between 7 and 10 months. In addition, these vinegars' colors changed from light yellowish orange to much deeper purple and orange during this period. The amount of organic acids and neutral compounds(dihydro-2(3H)-furanone, furfural, furfuryl alcohol, 2-hydroxy-1-methyl-1-cyclopenten-3-one, 1-hydroxy-2-propanone and methanol) in the vinegars increased or decreased periodically every three months. A good linear relationship (correlation coefficient of ca. 0.92) was obtained between the amount of organic acids and the amount of neutral compounds in such changes. However, although the amount of phenols increased or decreased periodically, its amount was decreased over the entire aging period.

Graves 병 환자에서 항갑상선제 투여에 의한 TSH 수용체 항체의 변동에 관한 연구 : 치료 용량 및 기간에 따른 차이 및 임상상과의 관계 its relation to dose and duration of treatment~and clinical features

이문호,조보연,문대혁,고창순,민헌기,서교일 대한내과학회 1986 대한내과학회지 Vol.30 No.3

We undertook a prospective study of 59 patients with Graves' disease in order to clarify the influence of antithyroid drug on the immunological indices and to determine the association of the changes of TSH receptor antibodies activities with drug dosage, duration of treatment and clinical features according to mode of antitbyroid drugs treatment. Patients were divided into two groups. High dose group included 28 patients and conventional dose group 31 patients. We measured TBII activities, antimicrosomal antibodies, and the size of goiter every 3 months, comparing them with clinical features and laboratory findings. TBII activities declined from R months until 9 months following drug treatment. Therafter no significant change of TBII activities were observed. Antimicrosomal antibodies showed the same pattern of change. There was no statistically significant difference of declining rate of TBII activities, antimicrosomal antibodies, and reduction of size of thyroid between two treatment groups. TBII activities fell into normal range in 15 patients among those 44 patients who had been followed for more than 9 months (8 high dose group, 7 conventional dose group). In those 15 patients, TBII activities and frequency of exophthalmos were less than those whose TBII activity did not normalized. We conclude that TSH receptor antibodies activities and antithyroid autoantibodies are diminished by antithyroid drug treatment in patients with Graves disease and there is no relationship between dose of drug and declining of TBII activities. We suggest that changing levels of TBII activities might be secondary phenomenon which can be achieved by control of thyroid function by antithyroid drug rather than direct immunosuppressive effect of antithyroid drug per se.

환축부 불안정성에 대한 굴곡신전 자기공명 영상

장한,김윤수,정창훈,이재문 대한척추외과학회 1994 대한척추외과학회지 Vol.1 No.1

The atlantoaxial joint, provided with a relatively wide range of motion, is secured and supported chiefly by soft tissue such as ligaments and articular capsule with lit- tle bony support. Thus, relaxation or rupture of the soft tissue structures due to rheumatoid inflammation or trauma may easily cause instability or subluxation, resulting in compression of the spina cord and various degree of neurologic symp- toms. Although the degree of atlantoaxial instability can be assessed conveniently by flex- ion/extension lateral radiogram, it is difficult to recognize the cause of instability and quantify the cord compression during flexion/extension motion. This study has been carried out to prospectively diagnostic tool of atlantoaxial instability. We reviewed 17 patients with atlantoaxial instability who were taken MRI examina- tion and treated at St. Mary's Hospital, Catholic University Medical College between June,1991 and December,1993 and the following results were obtained: 1.Seventeen patients consisted of 5 men and 12 women aged 21 to 68 years(mean, 43 years) 2.Of 17 patients, 11 were rheumatoid arthritis; 4,trauma; one Os odontoideum; one dens nonunion. 3.The 11 patients with atlantoaxial instability of rheumatoid etiology could be clas- sified into three groups according to the cause of the instability and cord compres- sion as revealed by flexion/extension axial MRI: The first group (n=6) characterized by compression of the cord in flexion with relief in extension, was caused by lax transverse ligaments. In the second group (n=2), despite the instability from erosion of the dens, there was no direct cord compression because the transverse ligaments were intact. The third group (n=3) showed retrodental granulation tissue in addition to erosions in the dens and/ or ligaments laxity with resultant cord compression. 4.In the traumatic group, there were four patients with instability from lax or rup- tured transeverse ligaments and one case with cord compression due to instability accompanied by nonunion of the dens. 5.In the great majority of the patients, the degree of cord compression was propor- tional to atlantodental interval(ADI) both on flexion/extension lateral radiogram and MRI despite of the widening of ADI on radiogram. On the other hand, in group Ⅲ Rheumatoid arthritis, a marked cord compression was noted due to retrodental gran- ulation tissues in the absence of significant ADI change. In conclusion, flexon/extension sagittal and axial MRI was useful tor a qualitative and quantitative evaluation of atlantoaxial instability by noting the degree and cause of instability and cord compression on cervical motion.

사염화탄소 투여 흰쥐에서 간섬유화 진행에 따른 Propranolol 의 약동학적 지표들의 변화

이민호,강주섭,강문수,윤병철,이오영,함준수,변재원,윤창옥 대한간학회 2001 Clinical and Molecular Hepatology(대한간학회지) Vol.7 No.2

Background/Aims : This study was designed to determine the effect of hepatic fibrotic severity on pharmacokinetics of propranolol in CC1q - treated rats. Methods - 1 mL/kg of 10% CC14 in olive oil was injected intramuscularly to rats twice weekly for 4, 6, 8 and 10 weeks, respectively (n=6). Control (n=6) was a sham - injected equal dose of olive oil for 10 weeks. After intravenous bolus injection of 2 mg/kg propranolol to rats, the serum propranolol concentrations were analyzed for 4 hours at various time points by a HPLC - fluorimetric system, and pharmacokinetic parameters such as Co, MRT, AUC, Vdss, tl/2(p) and CLp were determined. Then, a small amount of hepatic tissue was obtained and subjected to determination of the hepatic 4 - hydroxyproline content, which confirmed the hepatic fibrotic severity. Results : The serum concentrations of propranolol at 0.5, 1, 2 and 4 hours were significantly increased in CC1q-treated rats (p$lt;0.01). In proportion to the duration of CC4 treatment, Co and AUC were significantly increased, and Vdss and CLp were significantly decreased (p$lt;0.001). But MRT and t1/2(β) were not significantly changed. The hepatic 4 -hydroxyproline content was gradually increased in CC4-treated rats (p$lt;0.001). Conclusion - Gradual changes in pharmacokinetic parameters of propranolol were seen to be dependent on the hepatic fibrotic severity. We suggest that gradual dosage modification, according to their hepatic fibrotic severity, is necessary for many drugs administered to patients with chronic liver disease.(Korean J Hepatol 2001;7:181-188)

일반논문 : 준정부조직의 기관유형별 학습조직 특성에 관한 실증분석: 탈관료제의 맥락에서

조창현 ( Chang Hyon Jo ),박문수 ( Mun Su Park ) 서울대학교 한국행정연구소 2011 行政論叢 Vol.49 No.1

본 연구는 최근에 글로벌 경제구조와 지식기반사회에서 정부 서비스의 집행과 전달의 주요조직인 준정부(Quasi-government) 조직을 대상으로 학습조직 메커니즘의 특성 및 수준을 파악하여 탈관료제의 수준을 실증 분석하며, 창의적이며 혁신적인 변화를 주도할 수 있는 학습조직 문화를 형성하기 위한 정책적 시사점을 제시하고자 한다. 분석결과를 종합하면, 시장 수요에 민감한 준정부조직의 학습조직이 환경변화에 적절히 대응하기 위해 폭넓게 확산되어 있었으며, 곧 상대적으로 높은 탈관료화를 성취한 것으로 보인다. 반면, 관리형 준정부조직은 조직의 기능과 역할의 특성상 학습조직의 확산의 편차를 크게 보이고, 전반적으로 낮은 학습조직 수준을 보인다. 이는 부분적으로 탈관료제화가 확산되었고, 일부 부분에서 탈관료제화가 더딘 상황이라는 것을 확인할 수 있다. 정책적 시사점으로는 첫째, 관료제의 문제를 완화 및 해소하기 위한 방안으로 환경과의 개방성을 높이고 지속적인 교류를 보장해야 하는 것이 필요하다. 둘째, 학습조직의 수준차이를 심하게 보이는 대졸 학력, 중간관리자·사원대리 직급, 일반행정직에서 자율적인 학습활동 여건을 실질적으로 제공해야 한다. 따라서 학습조직 활성화를 위한 교육과 업무방식 전환, 세미나, 자체 워크숍 등 다양한 형태의 학습조직 활성화 지원이 추진될 필요가 있다. 마지막으로 소통과 협력의 부족으로 조직내에 의견을 반영하지 못하는 낮은 직급과 여성에게 조직 차원에서 의사소통을 위한 다양한 제도가 실질적으로 운영되어야 할 것이다. This study aimed to analyze empirically the level of the debureaucratization by examining the traits and degrees of learning organization in quasi-government organizations that are primary institutions recently delivering and implementing governmental services in global economic structures and in information-basis society, and secondly to suggest policy implications for establishing a culture of learning organizations that leads to creative and innovative changes. According to the results, learning organizations more sensitive to the market among the quasi-government organizations has spread more in an appropriate response to environmental changes, and also show that it has achieved relatively high debureaucratization. On the other hand, the more management-oriented quasi-government organization shows various differences in dissemination of the traits of learning organizations because of the role and the function of the organization and generally shows a low level of learning organization. Several policy implications are suggested. First, continuous interaction with the organizational environment and expanding openness to the environment are necessary for the purpose of alleviating and resolving the problems of bureaucratic organizations. Secondly, leaders of organizations should supply opportunities and conditions of autonomous learning activity to general administrators, to middle-class managers and low-class employees, and to those who have graduated from university, showing deeply different levels of learning organization traits. It is necessary to back up different learning activities such as workshops, seminars, and to change work and educational methods. Third, different institutions for communication should be operated within an organizational level for women and for grades who cannot express their opinion enough intheir organization because of a shortage of cooperation and communication.

體型別 Harvard Step Test後 血液有形成分의 變化

閔昌基,金文根 忠南大學校體育科學硏究所 1983 體育科學硏究誌 Vol.1 No.1

The purpose of this study was to see the change of the formed elements of blood according to the Somatotypes after the Harvard step test. Six male students of D middle school in Dae ton were served as subjects. They were classified into Endomorphy, Mesomorphy, and Ectomorphy by Sheldon’s anthropometric method. Being based on before and after Harvard step test for 5 minutes, the F ratio of change of the formed elements of blood according to the Somatotype groups obtained the Conclusions as following; 1. The formed elements of blood according to Somatotypes in normal state had no remarkable difference. 2. After Harvard step test, each of the Somatotype group marked increase of the formed elements of blood. 3. After Harvard step test, Mesomorphy was lower than Endomorphy and Ectomorphy in concentration rate of the formed elements of blood. 4. In Hemoglobin, only Endomorphy group had increcesed significantly.

Cronkhite-Canada 증후군 1예

이수걸,문창형,김무영,최성호,여동승,강필중,송철수,조몽,양웅석,허윤,문한규 대한내과학회 1992 대한내과학회지 Vol.42 No.2

저자들은 Cronkhite-Canada 증후군 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다. Cronkhite-Canada syndrome is a disease entity, including such characteristics as gastrointestinal polyposis associated with ectodermal changes-alopecia, hyperpigmentation of the skin and atrophy of the nails. But it has no familial tendency. In 1955, a report of 2 patients by Cronkhite and Canada established this entity as clinically distinct from any of the other known forms of gastrointestinal polyposis. Since that time, at least 53 similar casas has been described in the world literature, but no case has been reported in Korea.

연구개 및 구개수에 발생한 편평세포암종

이승호,이성훈,김기영,김창룡,박문성,류선열,조규승 大韓顎顔面成形再建外科學會 1996 Maxillofacial Plastic Reconstructive Surgery Vol.18 No.4

Carcinoma of the mouth accounts for approximately 5% of all carcinomas occurring in man. Carcinoma of the oral cavity develops as a result of invasion of malignant epithelial cells through the normally intact basal cell layer into subcutaneous and submucosal tissuse. The sofe palate and uvula may be involved in oral cancer but are not common sites. Early lesions of soft palate carcinoma appear as red, white, or mixed changes in the mucosa. The earliest symptom is mild sore throat. Advanced lesions interfer with swallowing and may cause a voice change. Although surgical method of soft palate carcinoma is successful, prognosis is relatively poor to swallowing and speech problem. Occasionally marginal recurrence may be developed. This article reports a case of squamous cell carcinoma occurred unusually in the soft palate and uvula. The case was treated with neoadjuvant chemotherapy, local radicalexcision and postoperative irradiation. Patient was followed up for 2 years. There was no tumor recurrence. The overall result including function was satisfactory.

A Comparative Proteomics Survey of Proteins Responsive to Phosphorous Starvation in Roots of Hydroponically-grown Rice Seedlings

( Sang Gon Kim ),( Yi Ming Wang ),( Chang Hoon Lee ),( Bong Gyu Mun ),( Pil Joo Kim ),( Sang Yeol Lee ),( Yong Chul Kim ),( Kyu Young Kang ),( Randeep Rakwal ),( Ganesh Kumar Agrawal ),( Sun Tae Kim ) 한국응용생명화학회 2011 Applied Biological Chemistry (Appl Biol Chem) Vol.54 No.5

Rice takes up phosphorous (P) as major nutrient source for its growth and development when grown under anaerobic water-logged soil conditions. To better understand the underlying mechanisms and to develop potential protein biomarkers of P-starvation, hydroponically-grown rice seedlings in the complete media and phosphorus absence (P-starvation) of phosphorous nutrient solutions were investigated for physiological and proteome changes. The P-starvation manifested significant reduction in root growth in three-week-old seedlings compared to respective complete media. Furthermore, P-starvation also showed increased activity of acid phosphatase in roots of one- and three-week-old seedlings, suggesting that experimental design is suitable for proteomics survey of P-starvation responsive proteins. Two-dimensional gel electrophoresis coupled with matrix-assisted laser desorption/ionization-time of flight (MALDI-TOF) mass spectrometry analysis of total root protein from three-week-old seedlings identified 10 P-starvation responsive protein spots out of 140 high-quality protein spots. Identified 10 proteins were involved in metabolism and defense/stress response. Out of 10, 2 and 8 protein spots were found to be up and down-regulated, respectively. Semi-quantitative reverse transcription polymerase chain reaction (RT-PCR) analysis of corresponding genes of four randomly selected proteins, including putative glyceraldehydes-3-phophate dehydrogenase (G3PDH, spot R1), S-adenosyl-L-methionine synthetase (SAMS, spot R4), ATP synthase subunit alpha (spot R6), and root-specific pathogenesisrelated protein 10 (PR-10, spot R8), showed that just as protein abundance, these proteins are also regulated at the transcript level. Results suggest identified P-starvation responsive proteins are involved in maintaining nutrient homeostasis and/or associated with changes in root physiology under the absence of P.

Hypersensitivity Reaction Incidence Patterns and Risk Factors of Iodinated Contrast Media

김동휘(Dong-Hwi Kim),문종현(Jong-Hyeon Mun),김준환(Jun-Hwan Kim),윤승완(Seung-Wan Yun),박환상(Hwan-Sang Park),김창곤(Chang-Kon Kim),김영덕(Yeong-Deok Kim) 대한CT영상기술학회 2023 대한CT영상기술학회지 Vol.25 No.1

본 연구의 조사 대상은 본 원 에서 요오드화 조영제를 정맥으로 투여받고 CT 검사를 시행한 72,910명과 과거 조영제 과민반응을 겪었던 환자 2,798명을 대상으로 후향적 조사를 시행하였다. 나이, 성별, 과민반응 증상, 조영제 과민반응 기왕력 환자 전처치방법, 사용한 조영제 등을 분석하였다. 조영제 과민반응 발생은 여성과 60대 미만에서 발생 위험이 높고 과거 조영제 과민반응기왕력이 있더라도 적절한 전처치 약물 투여, 조영제 성분 변경을 시행하면 과민반응 발생 위험이 감소한다. 조영제 성분별과민반응 발생률은 Iopromide가 유의하게 과민반응 발생률이 높았고, Iohexol과 Ioversol이 낮은 발생률을 보였다. 조영제 과민반응 재발을 예방하기 위해서는 전처치 약물 단독 사용보다 선행적으로 원인 조영제를 재사용하지 않고 다른 성분의 조영제로 변경하여 사용하는 것이 우선적으로 시행되어야 하고 더불어 전처치 약물 투여와 함께하는 것이 재발을 예방할 수 있을 것이다. The subjects of this study were 2,798 patients who experienced hypersensitivity reaction of contrast media among 72,910 who had had iodinated contrast media administered intravenously and CT examination at our hospital. Retrospective survey was conducted with these subjects. Their age, gender, hypersensitivity reaction symptoms, prepare methods for the patients who had previous hypersensitivity reaction of contrast media, and contrast media administered were analyzed. When it came to the hypersensitivity reaction incidence of contrast media, women and patients aged less than 60 had the high risk of the reaction. Even if patients had previous contrast media hypersensitivity reaction, their hypersensitivity reaction incidence risk was reduced as they had an appropriate premedication drug administered and contrast media were changed. Regarding the hypersensitivity reaction incidence rate by contrast media, Iopromide’s hypersensitivity reaction incidence rate was significantly high, whereas Iohexol and Ioversol had low incidence rates. In order to prevent contrast media hypersensitivity reaction recurrence, it is preferentially necessary to change a contrast media to a different one without reuse of causative contrast media, rather than to use a premedication drug only. Along with that, it is necessary to administer a premedication drug.