컴퓨터보조수업을 위한 소프트웨어 설계에 관한 연구

설문규 진주교육대학교 1994 論文集 Vol.1994 No.38

Computer Assisted Instruction is a system which produces answers for the learner's level. This study suggested the factors that had to be considered according to the step in the development of software. And with them, the hierachical structure and logical structure of software arround user were desiged. The purpose of this thesis, is to computer assisted instruction system available for individual lessons.

실과교과 평가방법의 퍼지응용에 관한 연구

설문규 진주교육대학교 1995 論文集 Vol.39 No.1

In this paper, we apply fuzzy theory to evaluation modulo which is the practical arts course. Although the CAI (Computer Assisted Instruction) System and the other educational technologies have been developed, the fuzziness exists concerning our decision to many educational evaluations. We propose to analyze such a problem by appling fuzzy sets and furzy reasonings. Finally, we define fu93r evaluation functions for the evaluation element of function and caner.

초등학교 망 구축과 활용에 관한 연구

설문규 진주교육대학교 2000 論文集 Vol.42 No.-

Recently, Information Communication Technology has been developed rapidly throughout the world. therefore. Especially, every country in the world is doing its best to build information infrastructure and select more systematic computer education to successfully prepare for the 21st century's Information age. In our country, the 7th curriculum is also placing more stock in computer education to further student's ability to properly cope with information age, and is try to attain the 2000 nation computer education project as soon as possible. The school LAN will install in our all schools to 2002 by the Education Ministry. In this thesis, I have embarked on literary research and the same time survey. I have studied the points to be considered of design layout network, necessity, application, case study of construction, in elementary school. All the computer is basically connected to be utilized by anybody at any time and at any place with school-LAN.

혈관평활근세포에서 산화에너지대사 억제에 의한 아밀로이드전구단백질 대사의 변화

한문구,최웅,김헌식,안희열,한설희 대한치매학회 2002 Dementia and Neurocognitive Disorders Vol.1 No.1

Background: A reduction in the activity of cytochrome c oxidase(COX) has been recently identified in mitochondria from platelets and postmortem brain tissue of AD patients Sodium azide (NaN₃). a COX inhibitor, is an effective chemical agent producing energy shortage and oxidative stress both in vitro and in vivo system Furthermore it has been suggested that vascular compromise could be either directly involved AD pathogenesis or indirectly associated with triggering pathogenetic events leading to AD This study was performed to investigate amyloid precursor protein (APP) metabolism by inhibition of mitochondrial energy metabolism in cultured vascular smooth muslce cells (VSMCs) Materials and Methods: VSMCs isolated from the aorta of seven weeks old Spraque-Dawley rat were treated with NaN₃in a low concentration (100-500μM) or in a high concentration (1-100mM) Cellular proliferation and viability were determined by MTS (3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenly)-2H-tetrazolium) assay Cellular APP was detected with N-terminal specific antibody 22C11. Celldeath was determined by observation of morphology and terminal deoxynucleotidyl transferase-mediated dUTP-fluorescein nick end labeling stain (TUNEL) We used ginkgo biloba extract(EGb761) and melatonin as anti-oxidants to investigate the mechanism of latered APP metabolism Results: The viability of VSMCs was increased after treatment with 1 mM and 10mM NaN₃(p<0.05) unitl 3 hr and then dimnished Many TUNEL positive cells were found in 10mM and 100mM treatment group. but were not apoptotic in nature 22C11 immunoreactivity was not changed at 3 hr, 6hr, 12hr Anti-oxidants reduced cellular proliferation (p<0.05). but did not block TUNEL positivities and did not influence the 22C11 immunoreactivity In a low concentration NaN₃ treatment group the viability of VSMCs was increased concentration dependently(p<0.05) Immunoblot with 22C11 showed the concentration dependent decrease at 145 kDa, 125 kDa. and high molecular weight range (>160kDa) TUNEL staining showed DNA fragmentations and condensations of nuclear chromatin suggesting apoptosis After treatment with anti-oxidants, the cellular proliferation was more decreased (p<0.05), and TUNEL positive cell deaths were blocked Immunoreactivities of 125 kDa (immature APP). 145 kDa (mature APP). and higher molecular weight bands were recovered below 400μM of NaN₃ Immunoreactivity of 145 kDa was recovered in 100 μM NaN₃ treated group Conclusions: The presumed mechanism of low concentration COX inhibitor is the overproduction of reactive oxygen species resulting from a depression of the mitochondiral electron transport chain. whereas potential consequence of high concentration COX inhibitor might be related to decreassion of ATP synthesis and bioenergetic impairment Reactive oxygen radicals in response to low concentration COX inhibitor alter the processing of APP in VSMCs This investigation demonstrated analtered APP metabolism as a peripheral marker of AD Therefore VSMCs treated with low concentration COX inhibitor could be concsidered as a novel in vitro model of AD.

공용 컴포넌트 참조 모델을 이용한 경매 컴포넌트의 설계 및 구현

강문설 광주대학교 산업기술연구소 2002 産業技術硏究 Vol.16 No.-

본 논문에서는 공용 컨포넌트에 대한 영역 분류와 어플리케이션 개발에 필요한 소프트웨어 아키텍처를 제공하기 위한 참조 모델을 제안하고, 공용 컴포넌트 참조 모델을 이용한 경매 컴포넌트의 프로토타입을 설계하고 구현하였다. 참조 모델은 분산 객체 컴퓨팅 환경에서 고려되었으며, 비즈니스 로직은 공통 개체 컴포넌트, 공통 프로세스 컴포넌트, 공통 영역 컴포넌트, 특정 영역 컴포넌트에 의해서 처리되도록 하였다. In this paper, we propose a reference model for software architecture that is need to develop an application, domain classification of common components. Also we design and implementation an auction components using common component reference model. We intend to develop reference model using framework for distributed object computing environment, business logics intend to manage common entity component, common process component, common domain component, and specific domain component.

한랭작업 근로자들의 건강위해에 관한 연구

박호추,정설미,문덕환,이종태,김대환,김정호,최재일,황용식,이용희,이채언 大韓産業醫學會 1999 대한직업환경의학회지 Vol.11 No.1

In order to evaluate the status of cold exposure and its health hazards of workers at cold storage workplaces and to provide basic data for effective health care, the author measured core temperature and also observed clinical symptoms and signs, past and present history, and general health examination data on 99 cold exposed workers for exposure group and 96 non-exposed workers for control group working at 2 food refrigerating companies in Pusan area from January 6, 1998 to February 24, 1998. The results were as follows: 1. There was statistically significant difference in water intake between the exposure and control group and increased urine volume, urine frequency in exposure group without statistically significant difference. 2. Past and present illness in exposure group were hypertension (18.2%), hepatopathy (8.1%), gastro-intestinal disease(7.1%), arthritis (4.0%), intervertebral disc herniation(4.0%), and so on, and hypertension, arthritis was statistically significant difference compared to control group. 3. Symptoms in exposure group were fatigue(89.9%), headache (64.6%). drowsy(63.6%), neck stiffness(59.6%), excessive food intake(59.6%). general weakness(58.6%), hunger(58.6%), numbness(54.5%), and so on, and there was statistically significant difference between the exposure and control group except fatigue, drowsy. 4. As results of clinical test abnormality rate of the systolic, diastolic blood pressure and electrocardiogram were significantly higher in exposed group than control. 5. Core temperature in exposure group was statistically significantly lower than control group and the highest statistically significant inverse correlation with the working hours and working frequency of daily mean cold storage. As above results, the author suggested that the further studies should be conducted to evaluate the health status of workers about chronic health effects in cold workplaces and to establish effective health care methods for them.

The Effect of Secretory Factors of Adipose-Derived Stem Cells on Human Keratinocytes

Moon, Kyoung Mi,Park, Ye-Hyoung,Lee, Jae Seol,Chae, Yong-Byung,Kim, Moon-Moo,Kim, Dong-Soo,Kim, Byung-Woo,Nam, Soo-Wan,Lee, Jong-Hwan Molecular Diversity Preservation International (MD 2012 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Vol.13 No.1

<P>The beneficial effects of adipose-derived stem cell conditioned medium (ADSC-CM) on skin regeneration have been reported. Although the mechanism of how ADSC-CM promotes skin regeneration is unclear, ADSC-CM contained various growth factors and it is an excellent raw material for skin treatment. ADSC-CM produced in a hypoxia condition of ADSC—in other words, Advanced Adipose-Derived Stem cell Protein Extract (AAPE)—has great merits for skin regeneration. In this study, human primary keratinocytes (HKs), which play fundamental roles in skin tissue, was used to examine how AAPE affects HK. HK proliferation was significantly higher in the experimental group (1.22 μg/mL) than in the control group. DNA gene chip demonstrated that AAPE in keratinocytes (<I>p</I> < 0.05) notably affected expression of 290 identified transcripts, which were associated with cell proliferation, cycle and migration. More keratinocyte wound healing and migration was shown in the experimental group (1.22 μg/mL). AAPE treatment significantly stimulated stress fiber formation, which was linked to the RhoA-ROCK pathway. We identified 48 protein spots in 2-D gel analysis and selected proteins were divided into 64% collagen components and 30% non-collagen components as shown by the MALDI-TOF analysis. Antibody array results contained growth factor/cytokine such as HGF, FGF-1, G-CSF, GM-CSF, IL-6, VEGF, and TGF-β3 differing from that shown by 2-D analysis. Conclusion: AAPE activates HK proliferation and migration. These results highlight the potential of the topical application of AAPE in the treatment of skin regeneration.</P>

Differences in perceived parental stress between parents with very low birth weight infants and nurses in neonatal intensive care units, South Korea

Moon, Seol-Hee,Park, Ho-Ran,Kim, Dong Yeon Korean Academy of Child Health Nursing 2021 Child Health Nursing Research Vol.27 No.3

Purpose: This descriptive study compared the perceived parental stress levels between parents with very low birth weight infants (VLBWIs) and nurses in the neonatal intensive care unit (NICU). Methods: In total, 83 parents of VLBWIs and 78 NICU nurses were enrolled. Data were collected with the Parental Stress Scale (PSS) and analyzed using the t-test and analysis of variance in SAS version 9.4. Results: The average PSS score was 3.31 among parents and 3.45 among nurses. The stress score was significantly higher among nurses with children (t=2.46, p=.016) and senior nurses (t=2.12, p=.037). There was a significant difference in the stress score according to parents' education (t=3.29, p=.002) and occupation (F=3.14, p=.049) in the sights and sounds subscale. Mothers had significantly higher stress scores than fathers in the parental role alterations subscale (t=2.32, p=.023). Parental stress scores were higher than those perceived by nurses in the infant's appearance and behaviors subscale for breathing patterns (t=2.95, p=.004), followed by jerky/ restless behavior (t=2.70, p=.008). Conclusion: Nurses should provide explanations to parents of VLBWIs in order to reduce parental stress about the appearances and behavior of VLBWIs. This is more important than aspect of the NICU environment and education about parental roles.

Effect of plasma membrane monoamine transporter genetic variants on pharmacokinetics of metformin in humans

Seol Ju Moon,Jaeseong Oh,SeungHwan Lee,Yewon Choi,Kyung-Sang Yu,Jae-Yong Chung 대한임상약리학회 2018 Translational and Clinical Pharmacology Vol.26 No.2

Metformin, an oral hypoglycemic agent belonging to biguanide class, is widely used to treat type 2diabetes mellitus, and several drug transporters such as organic cation transporters (OCTs), multidrugand toxin extrusion transporter (MATE), and plasma membrane monoamine transporter(PMAT) are thought to affect its disposition. We evaluated the role of PMAT genetic variations onthe pharmacokinetic characteristics of metformin in a Korean population. In this retrospectivestudy, 91 healthy subjects from four different metformin pharmacokinetic studies were analyzed;in each study, the subjects were administered two oral doses of metformin at intervals of 12 hoursand dose-normalized pharmacokinetic parameters were compared between the subjects’ genotypes. Subjects who had more than one allele of c.883-144A>G single nucleotide polymorphism (SNP)in PMAT gene (rs3889348) showed increased renal clearance of metformin compared to wild-typesubjects (814.79 ± 391.73 vs. 619.90 ± 195.43 mL/min, p=0.003), whereas no differences in metforminexposure were observed between the PMAT variant subjects and wild-type subjects. Similarly,subjects with variant rs316019 SNP in OCT2 showed decreased renal clearance of metformin comparedto wild-type subjects (586.01 ± 160.54 vs. 699.13 ± 291.40 mL/min, p=0.048). Other SNPs inPMAT and MATE1/2-K genes did not significantly affect metformin pharmacokinetics. In conclusion,the genetic variation of c.883-144A>G SNP in PMAT significantly affects the renal clearance ofmetformin in healthy Korean male subjects.

Sub-acute toxicity study in female ICR mice following repetitive intramuscular injection of cervical cancer vaccines

Seol-Hee Moon,Du-Yeol Kim,Jung-Min Lee,Hee-Won Park,Hye-Yeong Lee,Yong-Hoon Lee,Jaesung Lee,Jiwon Jung,Min-Ju Kim,Kyoung-Baek Choi,Yu-Kyoung Oh,Young-Bong Kim,Sujeong Kim,Seung Min Oh 환경독성보건학회 2014 환경독성보건학회지 Vol.29 No.-

Objectives : The sub-acute toxic effects following repetitive intramuscular injection of two cervical cancer vaccines newly developed against human papillomaviruse (HPV)16/58/18 and HPV16 were investigated in female ICR (CrljOri: CD1) mice, and the no-observedadverse-effect-level (NOAEL) of the cervical cancer vaccines was estimated. Methods : Female ICR mice (n=15 in each group) were exposed to a 1:1 mixture of two cervical cancer vaccines by repetitive intramuscular injection (once a week, 5 times) for 5 weeks. Mortality, body weight, organ weight, hematological/biochemical parameters, and histopathological effects were examined at different concentrations (0, 1×10<SUP>8</SUP>, 5×10<SUP>8</SUP>, and 2.5×10<SUP>9</SUP> copies/animal) of the cervical cancer vaccines. Results : The cervical cancer vaccines did not show toxic responses for body weight, absolute/relative organ weight, hematological/biochemical parameters, or histopathological parameters. Conclusions Female ICR mice exposed to vaccines for cervical cancer did not show any toxic response. We suggest that a NOAEL of the vaccine following repetitive intramuscular injection for 5 weeks is >2.5×10<SUP>9</SUP> copies/animal.