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Rat의 복강에 삽입한 Filorouracil-Polyglycolic acid제형의 Fluorouracil용출에 관한 연구
노승무,정경수,오정연,김진향,양준묵,강대영,송규상,최정목,최선웅,이진호,조준식,민병무,김용백,김창식,박근성,김승영,김학용,인현빈 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1
A common form of relapse in adenocarcinoma of the stomach is intraperitioneal dissemination, in fact, among gastric adenocarcinoma patients who have undergone surgery intended to cure, approximately 50% of the patients develope initial recurrence in the peritoneal cavity regardless of the anatomic site of the primary tumor within the stomach. The efficacy of systemic postoperative chemotherapy to prevent peritoneal recurrence of gastrric adenocarcinoma is not satisfactory. There is still a great need for improved therapeutic strategies on the disseminated microscopic disease and small miliary nodules remaining on the peritoneal surface or lymphatics after operation. The authers have made fluorouracil-polyglycolic acid composite disks(Fu-PGA disks) with fluorouracil and biodegradable polymer: polyglycolic acid for more effective intraperitoneal chemotherapy. We inserted the Fu-PGA disk(s) in the peritoneal cavity of rat and pharmacokinetic study was performed to measure fluorouracil concentration in the peritoneal fluid, plasma, liver, kidney and heart tissue at 24 hour, 72 hour and 168 hour after insertion of Fu-PGA disk(s). Myelosuppressive action of this composite also was determined following its administration. The data of this study suggested that Fu-PGA composite will be a new device releasing drugs in a controlled manner and having targetability to peritoneum, and this device will be improving the efficacy of intraperitoneal chemotherapy for gastric adenocarcinoma.
TCE의 분해를 위한 광촉매 산화반응조의 운전인자 도출에 관한 연구
허준무,전승렬,김종수 한국환경농학회 2003 한국환경농학회지 Vol.22 No.2
광촉매 산화반응으로 인한 난분해성 유기오염물질의 분해효율을 증가시키기 위하여 산화반응의 매개체인 TiO_2 광촉매의 새로운 제조방법을 개발하였고, 이를 이용하여 TCE의 효과적인 분해를 위한 광촉매 산화반응조의 최적 운영인자를 도출하였다 TiO_2 광촉매는 해교제(Davan-C 0.24 wt%)와 결합제(PVA 0.16 wt%)를 첨가하여 슬립 캐스팅 방법으로 제조하였다. 촉매의 특성 변화에 따른 실험결과로 TCE 수용액의 분해효율이 가장 좋은 촉매의 상태는 TiO_2 코팅 횟수가 1회이고 TiO_2 슬립의 두께가 1mm인 촉매로 확인 되었다. 촉매 사용시간에 따른 비교에서는 사용시간이 250 시간인 촉매가 새로이 제작하여 사용한 촉매의 TCE 분해효율보다 20% 정도 감소되었다. 광촉매 산화반응조의 물리적 운영인자 도출을 위한 실험결과로 산소의 전처리와 재순환을 실시하면 그렇지 않은 경우보다 TCE 분해효율이 증가되었다. 촉매의 단위 표면적당 수용액의 부피비가 1.47㎖/㎠ 이하에서 높은 TCE분해효율을 보였으며 UV 광량의 조절시 광량이 225 W/㎠×100에서 75.8%의 최대 TCE 분해효율을 보였다. TCE의 초기 ?逾돋?조절했을 경우에는 농도가 2 ㎎/L 이하인 경우에 TCE의 분해효율이 높았다. 따라서 본 연구에서 제시한 방법으로 제조한 촉매를 이용하여 적절한 UV 광량과 상기한 운영조건하에 광촉매 산화반응조를 운영한다면 정수 및 폐수에 함유된 난분해성 유기성 오염물질을 제거하기 위한 공정으로 활용될 수 있을 것으로 기대된다. The objectives of this study are to manufacture an efficient TiO₂ photocatalyst and to delineate optimum operational parameters for TCE (trichloroethylene) degradation in a photocatalytic oxidative reactor. The TiO₂ photocatalyst, irradiated by 365 nm UV Light, is expected to increase degradation of TCE in solution by a series of photocatalytic oxidations in the reactor. A new membrane TiO₂ photocatalyst was eventually developed by coating a mixture of Davan-C(0.24 wt%) and PVA(0.16 wt%) on the surface of slips using the slip-casting method. Results show that increase in the number of coating of TiO₂ sol on surface of photcatalysts and in the surface thickness improved the endurance and photocatalysts, but these physical modifications caused significant decrease in the overall degradation efficiency of TCE. Pre-aeration or recirculation of the influents to the reactors containing TCE increased degradation efficiency of TCE. The optimum operational conditions for the surface area of photocatalysts and UV light intensity appeared to be 1.47 mL/㎠ and 225 W/㎠×100, respectively, in the reactor. Based on the overall experimental results, the photocatalytic oxidation of TCE with the new membrane TiO₂ photocatalyst is found to be very effective under the operational conditions delineated in this study.
세라믹튜브 및 패킹형 플라스틱 여재충전 혐기성 여상의 유가공 폐수 처리특성 및 반응조 내부거동
허준무,장봉기,서성철,박종안,이종화,배형석,김준현 순천향대학교 기초과학연구소 1997 순천향자연과학연구 논문집 Vol.3 No.2
This study was carried to develop of anaerobic reactor to be able to maximize the organic removal efficiency using laboratory-scale anaerobic filter. The ceramic tube and pall ring media were tested for the applicability as packing media of anaerobic filter for the treatment of a dairy waste. This study was conducted to determine the anaerobic treatability of a dairy waste, and investigate the effects of ceramic tube and pall ring media. Anaerobic filters were packed with packing volume of 65% of total working volume. When treating a dairy waste, the organic removal efficiency of anaerobic filter packed with pall rings was a little higher than that of anaerobic filter packed with ceramic tubes. This was because the reactor packed with ceramic tube had clogging problems and substrate transfer limitations. It seemed that the reactor packed with ceramic tubes had uneven packing due to structural characteristics. The COD removals of ceramic tube and pall ring anaerobic filters were greater than about 91% and 94%, respectively, at organic loading rate lower than 5kgCOD/㎥/d. The COD removals of both reactors decreased to 80% with organic loading rate of 10kgCOD/㎥/d. Biomass capture and solid-liquid-gas separation efficiency seemed to vary with the type of media.
柳茂烈,朴吉俊 東亞大學校附設스포츠科學硏究所 1992 스포츠科學硏究論文集 Vol.10 No.-
By measure and investigate the item of Physique and Physical Fitness of Juveniles' of Korea, Japan and China and as a result of Statisfical analysis came to conclusion as follows: 1) At the height and sitting height of Physique, these three Juveniles showed increasing Phenomenon by advancing in age, and Chinese juveniles showed predominant tendency than Korean and Japanese Juveniles, and school boys of Japan showed next standings and Korean school boys Showed the lowest tendency. on the other hand, school girls Showed predominant tendency in china and Japanese school girls Showed predominant tendency according to the younger age and Korean School girls showed Predominant tendency advancing in age. 2) At the Weight and the chest circumference, these three Countries' Juveniles showed increasing Phenomenon according to advancing in age. at Weight Japanese school boys showed Predominant tendency than Korean and Chinese, and Korean and Chinese school boys showed similar tendency. On the other hand, School girls in Japan there showed higher phenomenon according to the younger age, and Korean showed high tendency by advancing in age, and the group of 14∼15 years of chinese school girls showed some what low fendency. At chest circumference both, male and female Juveniles of Korean and Japan showed hight fendency at Japanese juveniles according to younger age, and advancing in age group, Korean showed higher numerical Value, and chinese showed low tendency at the weight and chest circumterence. 3) At the grasping power of the physical Fitness, these three countries' Juveniles showed gentle curve according to advancing their age at grasping power these three countries' Juveniles showed in creasing phenomenon mutually in tersect, Korean Juveniles showed low tendency. At the Trunk Flexion Korean, school boys showed higher tendency, and chinese school boys showed low tendency, and school girls in korea and Japan showed increasing phenomenon by mutually intersecting between them, but chinese showed the lowest fendency. 4) At the 50meter Dash, school boys showed the fendency of reducing record according to advance their age, and showed the other of Japan→China→and Korea, and the other hand, school girls showed horizontal curve of wtype according to advance their age, and Japan showed low tendency at whole age groups, and Korea and china showed high tendency of record. 5) At the Handball Throw, these three Countries' Juveniles showed increasing Phenomenon according to advancing in age, and Japan showed predominant phenomenon than Korea and China, but China showed entirely low curve shapes. 6) At the breathing Capacity of the lungs, the school boys showed shae of increasing curve according to advance their age, but on the other hand, Japan Showed predominant Phenomenon than Korea, and China, and Korea showed low tendency. At the school girls Japan and china showed in creasing phenomenon according to advance theirage, but Korea showed declining Phenomenon.
한무영,김준규,박상철 대한건축학회 2003 대한건축학회논문집 Vol.19 No.11
Greening roof is gaining much interest as means for reduction of heat island effect and prevention of urban flooding. However, the effect of Greening roof on the quantity and quality of runoff has not been addressed simultaneously. In this study, the characteristics of rainfall runoff is investigated by a set of pilot plants with different depths of soil in order to investigate the effect of greening roof on the runoff characteristics and runoff water quality. Greening roof had reduction of rainfall runoff about 23~95 % at the 10 cm of depth of soil and about 24~100% at the 20 cm of depth of soil. Also, greening roof could decrease runoff of rainfall about 84~91 % of total quantity of rainfall during experimental period. However, greening roof gives much impact to the water quality. Filtrate of greening roof has been neutralized (pH 7~7.5) from acidic (pH 4~5). However, electro conductivity and turbidity of greening roof slightly increased. Overall, the greening roof has a good potential to reduce and delay the runoff peak flow. The quality of runoff from greening roof is good enough to be used for non drinking purpose.
권혁무,김정택,최준호 한국품질경영학회 2000 품질혁신 Vol.1 No.1
본 사례는 국내 APT 건설 현장에서 수행된 식스시그마 프로젝트에 대한 것으로 페콘크리트 발생 저감 및 잔량발생에 영향을 미치는 주요 인자들을 파악하고 개선안을 도출하는 과정을 보였다. 프로젝트는 식스시그마의 방법론을 따라 정의, 측정, 분석, 개선, 관리의 절차에 따라 주요 변수를 규명하고 개선안을 찾아내는 식으로 진행되었다. 분석결과 페콘크리트 발생을 줄이기 위해서는 첫째, 거푸집 시공 및 타설 프로세스를 개선하고 둘째, 압송관 및 펌프카 내 잔여 레미콘을 최소한으로 감소시키며 셋째, 최종적으로 남은 레미콘을 재활용할 수 있도록 하는 세가지로 요약되었다.
안무업,황성오,임경수,강성준 대한응급의학회 1993 대한응급의학회지 Vol.4 No.2
Disaster is a any community or regional events that disrupts community functions and activities and cause concern for the lives, health, and property of the citizens of that community. Successful management of disaster requires adequate planning and practice drills. Emergency medical service must play an important role in disaster management because any disaster produces various types of patients who need emergent care. We tried to analyse korean disaster planning in review of three recent disasters including aircraft crash, ship submergence, and road traffic accident. The result of disaster survey shows that there are many defects in Korean disaster plan at the stage of notification, propagation, rescue, stabilization and withdrwal and emergency medical service system is not being involved in disaster management because korean disaster plan is a civil-defence model. We conclude that current korean disaster plan is inadequate for management of disaster and it should be reinforced.
배추 시스테인 단백질 분해 효소 억제 유전자 BCPI-1의 발현과 종자 발아 및 유묘 생장과의 연관성
홍준기,이은영,김정률,양경애,최영주,정우식,김호일,윤대진,이상열,조무제,임체오 Plant molecular biology and biotechnology research 2003 Plant molecular biology and biotechnology research Vol.2003 No.-
Phytocystatins are protein inhibitors of cysteine proteinases of the papain family that have been identified in both monocot and dicot plants. A cDNA encoding a phytocystatin, BCPI-1 (Brassica Cysteine Proteinase Inhibitor-1) has been isolated from Chinese cabbage (Brassica campestris L. ssp. pekinensis) flower buds. Here, we tested whether BCPI-1 transcription is regulated by hormones, and could be involved in regulating cysteine proteinases during and after germination. BCPI-1 was sensitive to exogenous GA_(3) and ABA, which are important factors controlling seed germination, suggesting that the expression of BCPI-1 is hormonally regulated. We introduced a recombinant plasmid containing the full-length BCPI-1 cDNA under the control of cauliflower mosaic virus 35S promoter into rice embryogenic calli using the particle delivery method, and regenerated a number of transgenic rice plants. Constitutively over-expressed BCPI-1 caused changes in overall plant growth and development, including reduced germination and seedling growth. These data support the role of the BCPI-1 in the regulation of endogenous proteinases during both seed germination and subsequent seedling development. Phylocystatins은 papain계열의 cysteine 단백질 분해 효소 활성을 특이적으로 억제하는 억제자로 다양한 식물 종으로부터 분리되었다. 본고에서는, 배추 화아 cDNA library로부터 분리된 phytocystatin인 BCPI-1(Brassica Cysteine Proteinase Inhibitor-1)의 생체 내 기능에 대해 연구하였다. 먼저, BCPI-1 전사체는 발아 조절에 중요한 영향을 미치는 GA₃와 ABA에 의해 예민하게 증가, 혹은 감소되는 반응을 보임으로써, BCPI-1이 식물 호르몬의 영향을 받으며, 특히 발아나 유묘의 생장 조절에 관련이 있음을 알 수 있었다. Particle bombardment 방법을 통하여 BCPI-1을 벼의 배 형성 세포 내에 도입, 재분화 시켜 형질 전환 벼를 생성하였다. CaMV 35S promoter의 조절에 의해 지속적인 BCPI-1 발현을 보이는 형질 전환 벼의 경우, 발아와 유묘 생장이 현저히 지연되었다. 위의 결과들을 바탕으로, BCPI-1이 식물체 내에서 생성되는 cysteine 계열의 단밸질 분해 효소 활성을 조절하여 종자의 발아와 유묘의 생장에 영향을 미치는 것으로 추측한다.
차봉준,조재기,이무진 東亞大學校 附設 스포츠科學硏究所 1997 스포츠科學硏究論文集 Vol.15 No.-
This study aims at examining the factors of professional consciousness and working conditions of coaches which is an urgent question of Pusan athletics, and giving the basic data for the improvement of thier positions and working conditions, when international sports games such as the Asian Games in 2002, the East Asian Games in '97. The World Cup in 2002 of joint auspices of Korea and Japan are invited and it is filled with a great deal of interest of sports than ever before and Pusan in riging as an international sports city. The subjects of examination were limited to 138 coaches who worked at elementary school, middle school, high school in Pusan. The way of analysis of data was intersection analysis and significance also was proved using Χ2 and signicance level was 0.05. The reliance coefficient of questionnaire was 0.6819 relatively high culculating CronBacha alpha value. The results of this study are as follows ; in the first place, in the professional conciousness, the motivation to have chosen choach job was "have aptitude for" which was highest. All answered positively to the questions ; Do you think choach job is the task of life? Do you have your firm view of teaching in coach job. Do you think coach job should be suited to your character and aptitude. Can you find your life worth living as choach? Do you have self-esteem as a choach"; and the professional consciousness of choaches was very high. but the question to players that do you want to be a choach was answered negatively. Second, in the working conditions, the teaching time of a day was positive but compensation system such as salary, stability of job, and private time, vacation or day off, was negative and it was proved that choach job don't gain public acceptance. But the relationship with director were all positive. In the items that should be developed for working conditions, the most answers were "gurantee of job in his life". The mediums that should impreve these problems prositvely were "school", "Education Board", "athletics association" in order. In the reasion of being content with choach job, the most answers were "for finding his life worth living as a choach" but in the reason of being discontent with choach job, the most answers were "no guaranting of status and the unstability of job". The salary that choach receives now was "athletics association", "school", and "parents of students" and "Education Board" in order. As the result above, in the factor of professional consciousness answers were greatly high and positive, but in the factor of working conditions there still remained problems of status guarantee, salary, compensation system, and thhe unstability of job.