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Germán Chamorro-Cevallos,Leticia Garduño-Siciliano,Elizdath Martínez-Galero,Angélica Mojica-Villegas,Nicole Pages,Gabriela Gutiérrez-Salmeán 한국식품영양과학회 2014 Journal of medicinal food Vol.17 No.5
Benzo[alpha]pyrene (B[a]P) was used to test the possible antimutagenic effects of Arthrospira (Spirulina) maxima (SP) on male and female mice. SP was orally administered at 0, 200, 400, or 800 mg/kg of body weight to animals of both sexes for 2 weeks before starting the B[a]P (intraperitoneal injection) at 125 mg/kg of body weight for 5 consecutive days. For the male dominant lethal test, each male was caged with two untreated females per week for 3 weeks. For the female dominant lethal test, each female was caged for 1 week with one untreated male. All the females were evaluated 13–15 days after mating for incidence of pregnancy, total corpora lutea, total implants and pre- and postimplant losses. SP protected from B[a]P-induced pre- and postimplant losses in the male dominant lethal test, and from B[a]P-induced postimplantation losses in treated females. Moreover, SP treatment significantly reduced the detrimental effect of B[a]P on the quality of mouse semen. Our results illustrate the protective effects of SP in relation to B[a]P-induced genetic damage to germ cells. We conclude that SP, owing mainly to the presence of phycocyanin, could be of potential clinical interest in cancer treatment or prevention of relapse.