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Mohiuddin, Mohammed Khaliq,Chava, Srinivas,Upendrum, Pavani,Latha, Madhavi,Zubeda, Syeda,Kumar, Ajith,Ahuja, Yog Raj,Hasan, Qurratulain,Mohan, Vasavi Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.7
Background: Evaluation of Human papilloma virus (HPV) and its association with promoter methylation of candidate genes, p53 and Aurora A in esophageal cancer. Materials and Methods: One hundred forty-one esophageal tissue samples from different pathologies were evaluated for HPV infection by PCR, while the promoter methylation status of p53 and Aurora A was assessed by methylation-specific restriction based PCR assay. Statistical analyses were performed with MedCalc and MDR software. Results: Based on endoscopy and histopathology, samples were categorized: cancers (n=56), precancers (n=7), esophagitis (n=19) and normals (n=59). HPV infection was found to be less common in cancers (19.6%), whereas its prevalence was relatively high in precancers (71.4%), esophagitis (57.8%) and normals (45.7%). p53 promoter methylation did not show any significant difference between cancer and normal tissues, whereas Aurora A promoter methylation demonstrated significant association with disease (p=0.00016, OR:5.6452, 95%CI:2.18 to 14.6) when compared to normals. Aurora A methylation and HPV infection was found in a higher percentages of precancer (66.6%), esophagitis (54.5%) and normal (45.2%) when compared to cancers (14.2%). Conclusions: Aurora A promoter methylation is significantly associated with esophageal cancer, but the effect of HPV infection on this epigenetic alteration is not significant. However MDR analysis showed that the hypostatic effect of HPV was nullified when the cases had Aurora methylation and tobacco exposure. Further HPV sub-typing may give an insight into its reduced prevalence in esophageal cancer verses normal tissue. However, with the present data it is difficult to assign any significant role to HPV in the etiopathology of esophageal cancer.
Mohiuddin, M.,Sexton, J.,Missous, M. The Institute of Electronics and Information Engin 2013 Journal of semiconductor technology and science Vol.13 No.5
This paper investigates the two dominant but intertwined current blocking mechanisms of Switching and Kirk Effect in pure ternary InAlAs/InGaAs/InAlAs Double Heterojunction Bipolar Transistors (DHBTs). Molecular Beam Epitaxy (MBE) grown, lattice-matched samples have been investigated giving substantial experimental results and theoretical reasoning to explain the interplay between these two effects as the current density is increased up to and beyond the theoretical Kirk Effect limit for devices of emitter areas varying from $20{\times}20{\mu}m^2$ to $1{\times}5{\mu}m^2$. Pure ternary InAlAs/InGaAs/InAlAs DHBTs are ideally suited for such investigations because, unless corrective measures are taken, these devices suffer from appreciable current blocking effect due to their large conduction band discontinuity of 0.5 eV and thus facilitating the observation of the two different physical phenomena. This enhanced understanding of the interplay between the Kirk and Switching effect makes the DHBT device design and optimization process more effective and efficient.
Mohiuddin, Md,Akther, Asma,Jo, Eun Byul,Kim, Hyun Chan,Kim, Jaehwan Professional Engineering Publishing Ltd 2016 Proceedings of the Institution of Mechanical Engin Vol. No.
<P>The present study investigates a film actuator made with dielectric cellulose acetate films separated by narrow spacers as a means of electrostatic actuation for potential haptic application. Fabrication process for the actuator is explained along with experiments conducted over a wide frequency range of actuation frequency. A valid finite element simulation of the actuator is made on the quarter section of the actuator by using full 3D finite elements. Vibration characteristics such as fundamental natural frequency, mode shape and output velocity in the frequency range for haptic feeling generation are obtained from the finite element analysis and compared with the experimental results. Experimental results demonstrate that the finite element model is practical and effective enough in predicting the vibration characteristics of the actuator for haptic application. The film actuator shows many promising properties like high transparency, wide range of actuation frequency and high vibration velocity for instance.</P>
Mohiuddin, Mohammed Khaliq,Chowdavaram, Suman,Bogadi, Varun,Prabhakar, Boddu,Rao, Kondadasula Pandu Ranga,Devi, Suneetha,Mohan, Vasavi Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.14
Purpose: To understand the epidemiology of different upper gastrointestinal (UGI) tract related abnormalities through endoscopic data analysis. Materials and Methods: A retrospective study of three years from January 2009 to December 2011 was conducted with data from endoscopic surveillance of upper GI tract problems, collected from the Gastroenterology Unit, Osmania General Hospital, Hyderabad. MS excel and Medcalc software (comparison of proportions) were used for data analysis. Results: A total of 10,029 (6,468 in males and 3,561 in females) endoscopies were performed during this three-year period. The male to female ratio was 1.8:1. Overall, ~30% of endoscopies evaluated showed patients with acid peptic disorders, 13.6% with vascular-related abnormalities, 10.6% showed structural abnormalities, followed by 6.3% with malignancies. Burden of malignancies was mostly observed in the older age group (60-69 years). Esophageal cancer cases decreased (p=0.0001) whereas stomach cancers increased over this period (p=0.0345). We also observed an increased incidence of acid peptic disease (APD) (p=0.0036) and gastroesophageal reflux disease (GERD) (p=0.0002) cases during this period. Conclusions: Endoscopic diagnosis is useful for early detection of UGI anomalies and helpful for physicians to manage and treat varied kinds of UGI disorders. Analysis of data revealed changing trends in the incidence of various pathologies of the UGI tract. Functional dyspepsia and GERD definitely reduce the quality of life of the individual. The role of our diverse dietary habits and lifestyle associated with these problems have not yet been established, though there have been reports on the effect of coffee, spicy food, wheat-based diet, screening of UGI pathologies along with collection of complete personal and medical history details, can h elp in correlating the patients' condition with various aspects of lifestyle and diet.
Transparent and Flexible Haptic Actuator based on Cellulose Acetate Stacked Membranes
Md Mohiuddin,Hyun-U Ko,김현찬,김재환,김상연 한국정밀공학회 2015 International Journal of Precision Engineering and Vol.16 No.7
The tactile sensation is the human interact with machines in the form of felt sensations in the hand or other parts of body skin. This paper presents a film type actuator for haptic feedback devices, based on electrostatic actuation of plasticized cellulose acetate stacked membranes actuator, which is fabricated and evaluated for suitability of haptic feedback devices. The stacked membranes actuator shows many promising properties such as high transparency, lightweight, wide range of actuation frequency and high vibration acceleration for instance. The actuator structure shows intense vibration acceleration due to several layers of stacked membranes associated with the intensified electrostatic attraction force between chargeable cellulose acetate membranes. Experiment for measuring vibrational acceleration was conducted over a wide frequency range and actuation voltage to prove actuator’s great potential application as tactile actuator of haptic feedback devices. In addition, the operating principle, fabrication method and performance measurements are explained in details.