이중구간중도절단된 생존자료의 생존함수 비교를 위한 검정: 한국인 암 예방연구 중 당뇨병에의 응용

지선하,남정모,김진흠,Jee, Sun-Ha,Nam, Chung-Mo,Kim, Jin-Heum 한국통계학회 2009 응용통계연구 Vol.22 No.3

이중구간중도절단된 자료의 생존함수를 비교하기 위한 두 검정법을 소개하고 한국인 암 예방연구 (Jee 등, 2005) 자료에 적용하여 당뇨병 잠복시간의 분포를 성별과 연령에 따라 비교하였다. Kim 등 (2006)의 검정법을 이중구간중도절단된 자료로 확장한 검정법은 위험집합의 크기에만 의존하는 가중값을 사용하기 때문에 대용량 자료의 분석에서 Sun (2006)의 검정법보다 계산 시간을 대폭 줄일 수 있으며, 이산형 생존자료뿐만 아니라 연속형 생존자료에도 적용가능한 장점이 있다. 당뇨병의 잠복시간이 성별에 따라 매우 유의하게 달랐으며 여자의 잠복시간이 남자보다 긴 것으로 나타났다. 4개 연령그룹 간 당뇨병의 잠복시간도 성별에 관계 없이 매우 유의하게 달랐으며 여자의 경우가 남자의 경우보다 그 차이가 훨씬 더 유의했다. 한편, 소표본 모의실험을 통해 제안한 검정법과 Sun (2006)의 검정법의 검정력을 비교하였으며 제안한 검정법의 검정력이 Sun (2006)의 검정법보다 더 좋은 것으로 나타났다. Two tests were introduced for comparing several survival functions with doubly interval-censored data and illustrated with data surveyed by Korean Cancer Prevention Study (Jee et al., 2005). The test which extended Kim et al. (2006)'s test to the doubly interval-censored data has an advantage over Sun (2006)'s test in terms of saving computation time because the proposed test only depends on the size of risk set, and also the proposed test is applicable to continuous failure time data as well as discrete failure time data unlike Sun's test. Comparing male with female groups on the incubation time of diabetes was highly different and the survival of female group was longer than that of male one. Regardless of gender, the difference in survival functions of four age groups was highly significant with p-value of less than 0.001. This trend was more remarkable for female group than for male one. Simulation results showed that the significance level of both tests was well controlled and the proposed test was better than Sun's test in terms of power.

진행성 비소세포폐암의 이차항암화학요법으로서 Docetaxel 단독요법의 성적

강현모,이정은,장필순,이연선,권선중,안진영,정성수,김주옥,김선영 충남대학교 암연구소 2006 암연구소 업적집 Vol.5 No.-

Background : The survival benefit associated with first-line chemotherapy in lung cancer has led to the need for second -line chemotherapy, for which Docetaxel (Taxotere^(?)) has proven efficacy in both settings. This study evaluated the safety and efficacy of docetaxel in patients with non-small cell lung cancer who had failed first-line platinum-based chemotherapy. Methods : Thirty one patients with non-small-cell lung cancer, who had failed first line platinum-based chemotherapy, between March 1999 and August 2003, were enrolled in this study. Patients received intravenous docetaxel, either 75 mg/㎡ or 100 mg/㎡, with routine premedication every three weeks. Results : Fourteen patients (45.2%) had a partial response. The median survival and progression- free survival times were 12.5 months (95% CI 7.3-17.6) and 3.0 months (95% CI 1.6-4.5), respectively. This study showed 2 factors gave different survival benefits; the age (< 60 years: 20.1 months vs. > 60 years: 6.6 months, p=0.0105) and the histological type (adenocarcinoma: 25.6 months vs. others: 7.9 months, p=0.0055). The predominant toxicity was neutropenia, which occurred as WHO grade 3 or 4 in 38.7 % of patients. One treatment related death was also reported. Non-hematological toxicity was minor and easily controlled. There were no significant statistical differences in the survival benefit and toxicity between the two doses. Conclusion : Docetaxel, as second-line monotherapy, was well tolerated and effective in patients with non-small-cell lung cancer who failed first line platinum -based chemotherapy. (Tuberc Respir DiS 2005: 58: 465-472)

진행성 비소세포폐암의 이차항암화학요법으로서 Docetaxel 단독요법의 성적

강현모,이정은,장필순,이연선,권선중,안진영,정성수,김주옥,김선영 충남대학교 암공동연구소 2006 암공동연구소 업적집 Vol.5 No.

Background : The survival benefit associated with first-line chemotherapy in lung cancer has led to the need for second -line chemotherapy, for which Docetaxel (Taxotere^(?)) has proven efficacy in both settings. This study evaluated the safety and efficacy of docetaxel in patients with non-small cell lung cancer who had failed first-line platinum-based chemotherapy. Methods : Thirty one patients with non-small-cell lung cancer, who had failed first line platinum-based chemotherapy, between March 1999 and August 2003, were enrolled in this study. Patients received intravenous docetaxel, either 75 mg/㎡ or 100 mg/㎡, with routine premedication every three weeks. Results : Fourteen patients (45.2%) had a partial response. The median survival and progression- free survival times were 12.5 months (95% CI 7.3-17.6) and 3.0 months (95% CI 1.6-4.5), respectively. This study showed 2 factors gave different survival benefits; the age (< 60 years: 20.1 months vs. > 60 years: 6.6 months, p=0.0105) and the histological type (adenocarcinoma: 25.6 months vs. others: 7.9 months, p=0.0055). The predominant toxicity was neutropenia, which occurred as WHO grade 3 or 4 in 38.7 % of patients. One treatment related death was also reported. Non-hematological toxicity was minor and easily controlled. There were no significant statistical differences in the survival benefit and toxicity between the two doses. Conclusion : Docetaxel, as second-line monotherapy, was well tolerated and effective in patients with non-small-cell lung cancer who failed first line platinum -based chemotherapy. (Tuberc Respir DiS 2005: 58: 465-472) 연구배경 : 일차항암화학요법 후에 생존의 이득을 얻었음에도 불구하고 비소세포폐암 환자들의 대다수가 결국은 재발하거나 진행성 병변을 보인다. 이에 저자들은 기존의 여러 연구에서 보고 된 구제요법으로서 docetaxel의 항암효과와 비교적 적은 독성의 결과를 바탕으로,platinum을 근거로 한 항암화학요법을 시행 밖았으나 개발되거나 진행된 비소세포폐암 환자들을 대상으로 docetaxel 단독요법의 치료효과와 부작용에 대하여 알아보고자 하였다. 방법 : 조직학적으로 비소세포폐암으로 진단을 받고 platinum을 근거로 한 항암화학요법을 받았으나 재발 또는 진행성 병변을 보인 31명의 환자들을 대상으로 docetaxel 75 mg/m² 또는 100 mg/m²을 3주마다 정주하였다. 임상기록을 통한 후향적인 방법으로 분석하였다. 결과 : 1) 재발 또는 진행성 병변을 보인 31명중 남녀 비는 24:7이고 중앙연령은 60세였다. 2) 반응평가로 완전 관해는 없었고 부분관해는 14명(45.2%), 불변이 10명(32.3%), 진행이 7명(22.6%)으로 전체적인 반응율은 45.2%이었다. 3)중앙생존기간은 12.5개월(95% 신뢰구간: 7.3개월 17.6개월) 이었고, 1년 생존율은 52%였다. 무진행생존기간의 중앙값은 3.0개월(95%신뢰구간: 1.6개월 -4.5개월)이며, 반응군에서의 중앙반응지속피간은 3.7개월(95% 신뢰구간: 3.0개월 - 4.4개월)이었다. 4) 60세 미만인 경우(20.1 months vs 6.6 months. p=0,0105), 조직학적 아형이 선암일 경우(25.6 months vs 7.9 months, 0=0.0055) 통계적으로 유의한 생존기간의 증가가 있었다. 5) 부작용으로 3도 이상의 백혈구 감소증은 12명(38.7%),호중구 감소증에 동반된 발열은 6명(19.3%),감염이 동반된 호중구 감소증은 4명(12.9%)에서 발생했다. 치료와 관련되어 1명이 사망하였다. 6) Docetaxel 용량에 따른 생존기간의 차이나 독성의 차이는 없었다. 결론 : Platinum을 근거로 하는 항암화학요법으로 치료받은 후 재발 또는 진행성 병변을 보이는 비소세포폐암환자들에게 docetaxel을 투여하는 것은 비교적 안전하고 효과적인 항암치료법으로 사료된다.

유한요소법을 이용한 수직형 롤러 분쇄기용 테이블 라이너의 내구 해석에 관한 연구

최형모,이경영,조석수,이선봉 三陟大學校 産業科學技術硏究所 2002 産業科學技術硏究論文集 Vol.7 No.1

Vertical roller mill, which perform the grinding and parting blending of raw material, is the one of the important machine to produce ordinary portland cement. The table liner belonged to the vertical roller is mill the one of the main parts influencing its grinding efficiency. The life of table liner is estimatede to 4×107cycles in the design stage, but at the field, when its operating time reaches to 4×106 ~ 8×106 cycles, the fracture of table liner being to be found. The fracture of table liner commences from the outside edge of grinding path contacting with the grinding roller. Its maintenance normally take 30% of the total maintenance costs of the roller mill. Therefore, this study shows the clarification of the reasons occuring the fatal destruction of the table liner by fatigue fracture analysis utilizing fracture mechanics and by FEM using ANSYS 5.6.

정상교합과 부정교합에서의 상·하악골과 제 1 대구치 위치에 관한 비교연구

윤병모,안병근,이건주,김선해,박영주,한호진 대한치과교정학회 1993 대한치과교정학회지 Vol.23 No.4

There has been so much controversies about the position of upper and lower jaws, and their first permanent molars in normal occlusion and Angle's class ⅠㆍⅡㆍⅢ malocclusions. So, the purpose of this study is to compare the position of upper and lower jaws, and their first molars in normal occlusion and Angle's class ⅠㆍⅡㆍⅢ malocclusions by lateral cephalometric analysis. The sample consisted of one hundred and twenty girls(thirty in each group) who had completed growth. The findings of this study were as follows : 1. In class Ⅰ malocclusion, both maxilla and mandible were slightly posterior position than normal occlusion, but they showed harmonious relationship. 2. In class Ⅱ malocclusion, the mandible was greatly retruded, and the maxilla was also slightly retruded to the cranial base as compared with normal occlusion. 3. In class Ⅲ malocclusion, the maxilla was significantly retruded to the cranial base, but no significant difference was found in mandibular position as compared with normal occlusion. 4. The maxillary first molar was located at posterior position in class Ⅱ malocclusion, and anterior position in class Ⅲ malocclusion to the cranium, so that the rotation of mandible was influenced by that. 5. The mandibular first molar showed constant relationship to the mandible in all four group, but different position to the cranial base in direct proportion to the mandibular position. 6. On the treatment planning of class Ⅲ malocclusion, it seems to be better to promote the mandibular horizontal growth by ingibiting the verbical growth of masillary molar area, and on the treatment planning of class Ⅲ malocclusion, it seems to be better to promote the antero-inferior growth of maxilla and to promote the mandibular vertical growth by inducing the vertical growth of maxillary molar area.

신규 생리활성물질 개발을 위해 분리한 방선균주의 특성

이모래,김오정,최은화,정동선 서울여자대학교 자연과학연구소 2004 자연과학연구논문집 Vol.16 No.-

Actinomycetes were isolated from soil at Kangdong area in Seoul to screen bioactive metabolites. One of strains having antibacterial activity was selected and characterized. The isolated strain was identified as Streptomyces sp. on the basis of its cultural, morphological and physiological properties. This strain produced antibacterial substances in culture broth after 7days cultivation, and its productivity continued to increase for 14 days. The metabolites exhibited potent antibacterial activities to various bacterial strains including multidrug-resistant strain of Staphylococcus aureus.

국어의미론 연구와 외국 이론의 수용

염선모 대구대학교 인문과학연구소 1990 人文科學硏究 Vol.8 No.-

한의진단명과 진단요건의 표준화 연구 III : 3차년도 연구결과 보고

최선미,양기상,최승훈,박경모,박종현,심범상,김성우,노석선,이인선,정진홍,이진용,김달래,임형호,김윤범,박성식,송태원,김종우,이승기,최윤정,신순식 한국한의학연구원 1997 한국한의학연구원논문집 Vol.3 No.1

The diagnostic requirements were suggested and explained regarding the systems of differentiation of symptoms and signs in the third year study of standardization and unification of the terms and conditions used for diagnosis in oriental medicine. The systems were as follows : - analyzing and differentiating of epidemic febrile disease - analyzing and differentiating in accordance with the Sasang constitution medicine based on four-type recognition - differentiation of disease according to pathological changes of Chong and Ren channels - standards for diagnosis of women's disease - standards for diagnosis of children's disease - standards for diagnosis of motor and sensor disturbance (-muscle. born, joint, etc.) - standards for diagnosis of neuropsychiatric disease - standards for diagnosis of five sense organ disease - standards for diagnosis of external disease The indivisual diagnosis pattern was arranged by the diagnostic requirements in the following order : another name, notion of diagnosis pattern, index of differentiation of symptoms and signs, the main point of diagnosis, analysis of diagnosis pattern, discrimination of diagnosis pattern, prognosis, a way of curing a disease, prescription, herbs in common use, disease appearing the diagnosis pattern, documents. The standards for diagnosis of each disease was arranged by the diagnostic requirements in the following order : another name, notion of disease, the main point of diagnosis, analyzing and differentiating of disease, analysis of disease, discrimination of disease, prognosis, a way of curing and prescription of disease, disease in western medicine appearing the disease in oriental medicine, documents.

瀉靑丸과 그 構成藥物群의 항산화 효과

權寧模,朴宣東 대한본초학회 2002 大韓本草學會誌 Vol.17 No.2

Objectives : Exposure to oxidant molecules can generate reactive oxigen species(ROS; for example, H2O2, O2-, OH · ). These free radicals can alter DNA, proteins and membrane phospholipids. ROS are responsible for many diseases including cancer, neurodegerative diseases and cardiovascular diseases. Thus, to prevent against celluar damages associated with oxidative stress, antioxidants is important and many research about natioxidants are being conducted over the world. Methods : This study was performed to research the antioxidant activities of Sachunghwan(瀉靑丸) and its component groups in vitro. The experimental group was divided into 4 groups: Sachunghwan(SC), Samultang group(SC-1), Chungyul group(SC-2) and Haepyo group(SC-3). Results: 1. All experimental groups had significant antioxidant activity in linoleic acid system on concentration in comparison with control group. 2. In DPPH radical scavenging experiment and inhibitory effect experiment on superoxide generation in xanthine-xanthine oxidase system showed that all experimental groups had a dose-dependent effect. SC and SC-2 have more effect than SC-1 and SC-3. 3. Inhibitory effect experiment on superoxide generation induced by xanthine-xanthine oxidase system showed that all experimental groups had a dose-dependent effect. SC and SC-2 have more effect than SC-1 and SC-3. 4. In the inhibitory effect experiment on lipid peroxidation reaction in H2O2-Fe2+system showed that all experimental groups had a dose-dependent effect. SC-1 and SC-3 have more effect than SC and SC-2. 5. In the experiment on Nitrate scavenging activity showed that all experimental groups had a dose-dependent effect. SC and SC-2 have more effect than SC-1 and SC-3. Conclusion: Sachunghwan(SC) has an antioxidant activity and its antioxidant activity is likely to be associated with Chungyul group(SC-2).

고정식 교정장치에 의한 균혈증의 발생가능성에 관한 연구

임순모,안병근,김선해,박영주,한호진,이윤상 대한치과교정학회 1993 대한치과교정학회지 Vol.23 No.4

The purpose of this study was to investigate a possibility of chronic or intermittent bacteremia in patients undergoing orthodontic treatment with fixed orthodontic appliance. Orthodontic patients who had been injured by orthodontic appliances and/or suffered from gingivitis were selected. They had not taken any antibiotics for 1 month. The number of subjects were 21 including 7 males and 14 females. Blood samples of the subjects were cultured and, IgG, IgA and IgM levels in the serum were quantified. The author found following results. 1. No bacterial growth was found in 7-day culture of all the samples. 2. The immunoglobulin levels in serum were confined in normal range. 3. This study could not deny the possibility of transient bacteremia episode undergoing orthodontic treatment.