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      • 남녀 대학생의 성역할 모델과 취업 및 결혼관

        김현주,이동원,김모란 이화여자대학교 한국문화연구원 1995 韓國文化硏究院 論叢 Vol.66 No.1-3

        This study examines the differences in the expectations of employment and marriage among Korean university students. We focus on the gender differences among students. The data were collected through self-reported questionnaires in 1994. The sample size is 894 cases. Because the sexual division of labor is still a prominent pattern in Korea, we expect that the ideals and preparations, in the male-oriented employment area and in the female-oriented marriage area would show differences among female and male students. We found no difference in the employment area but significant differences in the marriage area. Rather, sex role models were found having significant implications in the male-female differences. Major findings related to marriage show that the gender effects are overlapping with the sex role model effects. However, the differences in employment area which do not show the gender difference depends on the sex role model. The results show that most university students eager to and prepare well to have a job. Although most students expect to marry, and increasing proportion of female students decide not to marry. Major reasons of the negative perspective for marriage seem to be related to the perception that the present marriage system is unfavorably constructed for women. Even if many of university students show the sign on egalitarian perspectives, the pace of changes toward egalitarianism among male students lags far behind that of among women. Based on these findings we can see many students try to maximize their interests. They would like to enjoy the stability of the preexisting sexual division of labor as well as the fruit of egalitarian division of labor.

      • KCI등재

        수복용복합레진의 표면처리방법에 따른 표면중합률 및 변색정도의 변화와 그 상관관계에 대한 연구

        박성호,김모란,노병덕,안현정 대한치과보존학회 2000 Restorative Dentistry & Endodontics Vol.25 No.3

        The purpose of the present study was first, to evaluate the relationship between composite surface conversion and surface discoloration, second. to know if there was difference in surface discoloration between celluloid-strip-finished composite surface and polished surface. In addition, the discoloration of composite surface was also evaluated with visual inspection or digital camera with high resolution monitor. Z-100 Tetric Ceram. Spectrum. and Aelitiril were used. The composite surfaces were celluloid-strip finished (group1) , polished (group 2) . celluloid- strip finished under nitrogen gas purging (group 3) or only light cured without finishing or polishing under nitrogen gas purging (group 4) . The microhardness of each samples were also measured in each group, The samples of each group were also divided into 4 subgroup whether they were immediately placed in disclosing solution (0.2% Erythrosin, pH 7.0) (subgroup1 ) . l day after light curing(subgroup 2 ) .3day after light rulings (subgroup3) or 7 day after light curing(subgroup4). The computer controlled spectrophotometer was used to determine CIELAB coordinates (L*, a * , b*) The amounts of color difference were compared. The results were as follows: 1.There was no difference in discoloration between celluloid strip finished composite surface and polished surface 2.The samples discolored more when they were placed in disclosing solution immediately after polymerization than other groups. 3.When the samples were light cured under nitrogen gas purging and without polishing process. they discolored more than other groups even through they showed higher microhardness. 4.With visual inspection or digital camera. only a limited information was available in detecting composite surface discolation

      • KCI등재

        Screening and production of dsRNA molecules for protecting Cucumis sativus against Cucumber mosaic virus through foliar application

        Mo Qin,Lv Beibei,Sun Yu,Wu Xiao,Song Lili,Cai Run,Tang Xueming 한국식물생명공학회 2022 Plant biotechnology reports Vol.16 No.4

        Cucumber mosaic virus (CMV), which is one of the most prevalent plant viruses, harms many crops around the word. Although CMV causes severe economic losses to agriculture, successful prevention and treatment strategies are lacking. RNA interference (RNAi) is a promising strategy for the control of CMV because of its impressive specificity and sustain- ability. Here, a bacterial expression approach was conducted to produce hairpin RNA, and the best expression conditions to produce a high yield of dsRNA were explored. The highest expression of dsRNA in Escherichia coli HT115 was achieved at 37 °C using 2 mM IPTG and 17 h post-induction. For resistance analysis, six dsRNA molecules were constructed for CMV 1a, 2a, 3a and coat protein (CP). In cucumber (Cucumis sativus), foliar application of dsRNA preparations derived from CMV-1a and CMV-2a proteins conferred efficient protection against CMV. Our findings confirm that the exogenous application of dsRNA with a bacterial prokaryotic expression system could be a powerful biotechnological tool to protect plants against virus infections.

      • SCISCIESCOPUS
      • KCI등재

        Double-culture Method Enhances the in Vitro Inhibition of Atopy-inducing Factors by Lactococcus lactis

        Yu Ran Jo(조유란),Sang Mo Kang(강상모),Hyun Pyo Kim(김현표) 한국생명과학회 2015 생명과학회지 Vol.25 No.7

        유산균이 활성화된 비만세포에서 발현하는 IL-4와 IL-13을 조절할 수 있는지를 분석하였고, GATA-1, GATA-2, NF-AT1, NF-AT2, NF-κB p65 전사인자의 활성을 억제하는지를 실험적으로 규명하였다. 이전 연구에서 T cell에서 CD4+/CD25+/foxp3+ 증가를 실험하여 항아토피 기능성이 있는 유산균을 탐색하였고, Staphylococcus aureus에 대한 항균력을 증가시키는 유산균의 이중배양법을 확인하였다. 여기서는 RBL-2H3 비만세포를 이용하여 이 배양법으로 배양한 유산균이 아토피 피부염의 원인이 되는 allergy 염증반응에서 얼마나 억제능을 갖는지 알아보았다. 그 결과 Lc. lactis culture with medium containing Lb. plantarum supernatants > Lc. lactis > Lc. lactis culture broth with medium containing Lb. plantarum culture broth > Lb. plantarum의 순으로 나타났다. 이 cell 수준(level of mast cells)에서의 순서는 이전 연구의 level of microorganisms (anti-S. aureus)에서의 아토피 유발인자 억제능 순서와 같다. 따라서 세포수준에서도 Lb. plantarum 배양상층액을 첨가한 배지에 Lc. lactis 배양한 경우가 활성화된 비만세포의 allergy 반응으로의 분화 및 활성을 가장 잘 억제하고 관련 유전자 발현을 선택적으로 조절하는 anti-allergy 효과를 나타낸다고 사료된다. We analyzed whether lactic acid bacteria could control the expression of IL-4 and IL-13 in activated mast cells and whether these bacteria could inhibit the activity of transcription factors such as GATA-1, GATA-2, NF-AT1, NF-AT2, and NF-κB p65. We previously described a technique for identification of lactic acid bacteria with anti-atopy functionality by confirming increased expression of CD4+/CD25+/foxp3+ in T cells. We also confirmed that a double-culture method increased the antibacterial activity of these lactic acid bacteria against Staphylococcus aureus (S. aureus). In the present study, we characterized the effect of lactic acid bacteria cultured by this double-culture method on inhibition of allergic inflammatory reactions of RBL-2H3 mast cells, a cellular model of atopic dermatitis. The strongest anti-allergic effects of the lactic acid bacteria were seen in the following order: Lactococcus lactis broth cultured with medium containing Lactobacillus plantarum culture supernatant > Lc. lactis > Lc. lactis broth cultured with medium containing Lb. plantarum culture supernatant > Lb. plantarum. Thus, Lc. lactis cultured in medium containing Lb. plantarum culture supernatant had the strongest inhibitory effect on the differentiation of mast cells during allergic reactions, which may be mediated through the selective regulation of expression of relevant genes.

      • KCI등재

        Case Report : Carvenous lymphangioma of the vulva

        ( Kyung Ran Yoon ),( A Jin Mo ),( Sung Ho Park ),( Yeon Sik Na ),( Sung Taek Park ) 대한산부인과학회 2015 Obstetrics & Gynecology Science Vol.58 No.1

        Lymphangioma is a rare proliferation of the lymphatic system which is classified as either lymphangioma circumscription or carvenous lymphangioma. The involvement of the vulva is very rare and only a small number of case reports have been made on carvenous lymphangioma of the vulva. We herein report a case of 20-year-old unmarried girl presented with gradually expanding and painless tumor of the left labium majus. The mass was removed surgically and pathology confirmed as carvenous lymphangioma, with no recurrences to date.

      • Experience with Ledipasvir/Sofosbuvir-Based Treatment for the Treatment of HCV Genotype 1a in Korea

        ( Chan Ran You ),( Sang Wook Choi ),( Sun Hong Yoo ),( Jung Hyun Kwon ),( Soon Woo Nam ),( Se Hyun Cho ),( Joon-Yeol Han ),( Do Seon Song ),( U Im Chang ),( Jin Mo Yang ),( Sung Won Lee ),( Hae Lim Le 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1

        Aims: In this multicenter retrospective cohort study, we aimed to evaluate the effectiveness of IFN-free direct acting anti-viral agents (DAA) for patients with HCV genotype 1a in a real life setting in Korea. Methods: We analyzed clinical data of all consecutive DAA-treated patients for chronic HCV genotype 1a infection from eight clinical centers in Korea. Between May 2016 to April 2017, 35 patients were included in this study. The primary efficacy endpoint was end of treatment response (ETOR) and sustained virological response 12 weeks (SVR12). Adverse events (AEs) and laboratory data were also collected for analysis. Results: A total of 35 patients with genotype 1a HCV infection, 8 patients (22.9%) had compensated liver cirrhosis and 14 patients (40%) were treatment-experienced. Ledipasvir/sofosbuvir (LDV/SOF) with ribavirin were administered to six of seven treatment-experienced patients with cirrhosis. Thirteen patients were over 65 years old (37.1%) and female patients were dominant (65.7%, 23/35 patients). The Child-Pugh scores of all patients were 5 or 6. The rate of SVR12 was 94.7% (18/19 patients) and the rate of ETOR was 96.6% (28/29 patients). SVR12 and ETOR were obtained in all patients completed treatment for 12 weeks. Five of 33 patients (15.2%) had detectable HCV RNA at week 4 of therapy, but all of them achieved SVR12. LDV/SOF without ribavirin was tolerated well. The dose of ribavirin was reduced in two patients because they complained fatigue and general weakness after the treatment of LDV/SOF with ribavirin. Conclusions: In patients with HCV genotype 1a infection, LDV/SOF based regimen was very effective and well tolerated.

      • KCI등재

        Evaluation of the Neurological Safety of Epidural Milnacipran in Rats

        ( Seung Mo Lim ),( Mee Ran Shin ),( Kyung Ho Kang ),( Hyun Kang ),( Francis Sahngun Nahm ),( Baek Hui Kim ),( Hwa Yong Shin ),( Young Jin Lim ),( Sang Chul Lee ) 대한통증학회 2012 The Korean Journal of Pain Vol.25 No.4

        Background: Milnacipran is a balanced serotonin norepinephrine reuptake inhibitor with minimal side effects and broad safety margin. It acts primarily on the descending inhibitory pain pathway in brain and spinal cord. In many animal studies, intrathecal administration of milnacipran is effective in neuropathic pain management. However, there is no study for the neurological safety of milnacipran when it is administered neuraxially. This study examined the neurotoxicity of epidural milnacipran by observing behavioral and sensory-motor changes with histopathological examinations of spinal cords in rats. Methods: Sixty rats were divided into 3 groups, with each group receiving epidural administration of either 0.3 ml (3 mg) of milnacipran (group M, n = 20), 0.3 ml of 40% alcohol (group A, n = 20), or 0.3 ml of normal saline (group S, n = 20). Results: There were no abnormal changes in the behavioral, sensory-motor, or histopathological findings in all rats of groups M and S over a 3-week observation period, whereas all rats in group A had abnormal changes. Conclusions: Based on these findings, the direct epidural administration of milnacipran in rats did not present any evidence of neurotoxicity in behavioral, sensory-motor and histopathological evaluations.

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