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Jain, Shweta,Ward, Jerrold M.,Shin, Dong-Mi,Wang, Hongsheng,Naghashfar, Zohreh,Kovalchuk, Alexander L.,Morse III, Herbert C. Elsevier 2017 The American journal of pathology Vol.187 No.9
<P>A number of mouse strains transgenic for B-cell receptors specific for nucleic acids or other auto antigens have been generated to understand how autoreactive B cells are regulated in normal and autoimmune mice. Previous studies of nonautoimmune C57BL/6 mice heterozygous for both the IgH and IgL knockins of the polyreactive autoantibody, 564, produced high Levels of autoantibodies in a largely Toll-like receptor 7 dependent manner. Herein, we describe studies of mice homozygous for the knockins that also expressed high levels of autoantibodies but, unlike the heterozygotes, exhibited a high incidence of mature B-cell Lymphomas and enhanced susceptibility to bacterial infections. Microarray analyses and serological studies suggested that lymphomagenesis might be related to chronic B-cell activation promoted by IL-21. Strikingly, mice treated continuously with antibiotic supplemented water did not develop Lymphomas or abscesses and exhibited less autoimmunity. This mouse model may help us understand the reasons for enhanced susceptibility to lymphoma development exhibited by humans with a variety of autoimmune diseases, such as Sjogren syndrome, systemic lupus erythematosus, and highly active rheumatoid arthritis.</P>
Kinesio Taping Associated with Acupuncture in the Treatment of the Paretic Upper Limb After Stroke
Moise´s S. Dall’Agnol,Fernanda Cechetti 사단법인약침학회 2018 Journal of Acupuncture & Meridian Studies Vol.11 No.2
The leading cause of disability in adults, leads to different consequences, such as hemiparesis and loss of function in the upper limb which can impair the performance of activities of daily living. Different techniques, such as like acupuncture and Kinesio Taping (KT), have been used to ameliorate this condition. However, there is no consensus on their concomitant effect on neurological patients. This study aimed to analyze the effects of acupuncture associated with KT on the upper limb of patients with chronic hemiparesis after stroke. In this clinical study, 16 subjects were divided into two intervention groups: acupuncture (ACP)—12 sessions of acupuncture—and acupuncture + Kinesio Taping (ACP-KT)—12 sessions of acupuncture plus KT. The Modified Ashworth Scale (spasticity), active goniometry [range of motion (ROM)], and the Wolf Motor Function Test (speed of movement) were used to assess the function of the affected upper limb. As a main result, both groups reduced spasticity in some studied musculature and increased ROM (p < 0.05), without intergroup difference. Moreover, there was no significant improvement concerning speed of movement in either group. Acupuncture was effective in reducing spasticity and increasing ROM of paretic upper limb after stroke, but did not contribute significantly to speed and quality of movement. KT did not show significant benefits concerning the analyzed variables.
EFFECTS OF PHOSPHORUS AND CALCIUM ON FEED INTAKE AND YIELD AND COMPOSITION OF MILK OF HOLSTEIN COWS
Morse, D.,Head, H.H.,Wilcox, C.J. Asian Australasian Association of Animal Productio 1994 Animal Bioscience Vol.7 No.2
Three concentrations of P (0.33, 0.43 and 0.54%) and two concentrations of Ca (0.60 and 0.97%) in ration dry matter were evaluated for effects on dry matter intake and on milk yield and composition using 24 Holstein cows. Cows were arranged in a $3{\times}2$ factorial experiment as an incomplete randomized block design with three 28-day periods. Each cow consumed at least one ration with each concentration of Ca. Dry matter intake, yield of 3.5% Fat Corrected Milk, and milk composition were not affected by concentration of P, but milk yield was greater when lowest concentration of P was fed (22.8 vs. 22.1 kg/day; p<0.07). Cows fed rations containing 0.60% Ca had greater milk (22.7 vs. 21.9 kg/day; p<0.02) and 3.5% Fat Corrected Milk yields (p<0.03) and slightly greater protein content than when fed 0.97% Ca. Dietary Ca:P ratios between 1.1:1 and 2.9:1 had no effect on dry matter intake, milk yield, or composition. Concentrations of P in plasma were within the normal range for all rations. Because cows had high dry matter intake, mean daily intakes of both P and Ca were greater than required for their level of milk yield.
A Model for Developing Urban Innovation Clusters
Morse, Sidney World Technopolis Association 2013 World Technopolis Review Vol.2 No.2
This paper seeks to build on previous work conducted by Porter, Devol, Florida, Bahrami and Evans, Wennberg and Lindqvist, and others contained in the literature, to construct a new way of looking at innovation cluster development. It seeks to describe the key elements contained in the research that serve as building blocks for innovation clustering, adding analysis dimensions that aim to further illuminate understanding of this process. It compares those building block characteristics to the innovation topography of U.S. urban centers, to shed light on a new framework through which urban innovation cluster formation can be considered. It identifies three building block analysis categories: 1) Technological Capability and Capacity (TCC); 2) Intellectual Propulsion Capacity (IPC); and 3) Structural Creative Inspiration (SCI). These three pillars form the architecture for creation of a Strategic Innovation Network (SIN), upon which clustering can be systematically analysed and built. The purpose of the SIN is to optimally organize and connect all available resources that include physical, financial, and human, such that innovation clustering is inspired, encouraged, nurtured, and ultimately constructed as fully functioning socio-economic organisms that provide both local and regional benefits. It is designed to aid both private enterprise and public policy leaders in their strategic planning considerations, and to enhance urban economic development opportunities.