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Mino Yang,Sangyoub Lee,Kim Yung Sik,Kook Joe Shin Korean Chemical Society 1989 Bulletin of the Korean Chemical Society Vol.10 No.6
A general perturbation series solution of the Smoluchowski equation is applied to investigate the rate of recombination and the remaining probability of a pair of particles in liquids. The radiative boundary condition is employed and the convergence of the perturbation series is analyzed in terms of a convergene factor in time domain. The upper bound to the error introduced by the n-th order perturbation scheme is also evaluated. The long time behaviors of the rate of recombination and the remaining probability are found to be expressed in closed forms if the perturbation series is convergent. A new and efficient method of purely numerical integration of the Smoluchowski equation is proposed and its results are compared with those obtained by the perturbation method. For the two cases where the interaction between the particles is given by (i) the Coulomb potential and (ii) the shielded Coulomb potential, the agreement between the two results is found to be excellent.
Effects of Light Intensity on the Steady-State Fluorescence Quenching Kinetics
Mino Yang,Sangyoub Lee,Kook Joe Shin,Kwang Yul Choo,Duckhwan Lee Korean Chemical Society 1991 Bulletin of the Korean Chemical Society Vol.12 No.4
Effects of light intensity on the steady-state fluorescence quenching kinetics are examined for general cases where the bimolecular quenching can occur via long-range energy transfer processes and the potential of mean force between the energy donor and acceptor molecules is not negligible. Approximate analytic expressions are derived for the steady-state quenching rate constant and for the ratio of the steady-state intensity of unquenched to quenched fluorescence. The analytic results are compared with the exact results obtained from numerical analysis and the results of conventional theories.
Mino Kang,Su Yeon Kim,안성수,Young Ran JU3 생화학분자생물학회 2013 Experimental and molecular medicine Vol.45 No.8
Cellular prion protein, a membrane protein, is expressed in all mammals. Prion protein is also found in human blood as an anchorless protein, and this protein form is one of the many potential sources of misfolded prion protein replication during transmission. Many studies have suggested that b-amyloid1–42 oligomer causes neurotoxicity associated with Alzheimer’s disease, which is mediated by the prion protein that acts as a receptor and regulates the hippocampal potentiation. The prevention of the binding of these proteins has been proposed as a possible preventative treatment for Alzheimer’s disease;therefore, a greater understanding of the binding hot-spots between the two molecules is necessary. In this study, the epitope mapping immunoassay was employed to characterize binding epitopes within the prion protein and complementary epitopes in b-amyloid. Residues 23–39 and 93–119 in the prion protein were involved in binding to b-amyloid1–40 and 1–42, and monomers of this protein interacted with prion protein residues 93–113 and 123–166. Furthermore, b-amyloid antibodies against the C-terminus detected bound b-amyloid1–42 at residues 23–40, 104–122 and 159–175. b-Amyloid epitopes necessary for the interaction with prion protein were not determined. In conclusion, charged clusters and hydrophobic regions of the prion protein were involved in binding to b-amyloid1–40 and 1–42. The 3D structure appears to be necessary for b-amyloid to interact with prion protein. In the future, these binding sites may be utilized for 3D structure modeling, as well as for the pharmaceutical intervention of Alzheimer’s disease.
A Nonlinear Theory for the Lotka-Volterra Model with an External lnput
Mino Yang,Sangyoub Lee,Seong Keun Kim,Kook Joe Shin,Moon Hee Ryu,Song Hi Lee,Dong J. Lee Korean Chemical Society 1992 Bulletin of the Korean Chemical Society Vol.13 No.5
A new perturbation theory called the star expansion method is used to obtain an approximate nonlinear solution of the Lotka-Volterra model under the influence of some kinds of external input. The effects of nonlinearity, amplitude and frequency of the external input on the chemical oscillations in the model are evaluated by taking specific values for the model parameters, and the results are discussed in detail.
Signatures of coherent vibrational energy transfer in IR and Raman line shapes for liquid water
Yang, Mino,Skinner, J. L. Royal Society of Chemistry 2010 Physical chemistry chemical physics Vol.12 No.4
<P>We calculate theoretical IR and Raman line shapes for the OH stretch region of liquid water, using mixed quantum/classical and electronic-structure/molecular-dynamics methods. Our approach improves upon the time-averaging approximation used earlier for the same problem, and our results are in excellent agreement with experiment. Previous analysis of theoretical results for this problem considered the extent of delocalization (over local OH stretch excitations) of the instantaneous vibrational eigenstates. In this work we present a complementary analysis in the time-domain, by decomposing the appropriate response functions into diagonal and off-diagonal contributions (in the local mode basis). Our analysis indicates that all vibrational spectra show signatures of coherent vibrational energy transfer. This is manifest in different (IR, isotropic and depolarized Raman) experiments to different extents, because of the competition between coherent energy transfer and rotational disorder.</P> <P>Graphic Abstract</P><P>Time-domain analysis of theoretical line shapes calculated by mixed quantum/classical and electronic-structure/molecular-dynamics methods reveals coherent vibrational energy transfer. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=b918314k'> </P>
Spatial Distribution of Dislocations in Relation to a Substructure in High-Quality GaN Film
Yang, Mino,Kim, Chong-Don,Kim, Hee-Goo,Yang, Cheol-Woong Cambridge University Press 2013 Microscopy and microanalysis Vol.19 No.5
<B>Abstract</B><P>The dislocation distribution of high-quality single-crystal gallium nitride (GaN) films grown by the hybrid vapor phase epitaxy was analyzed. This study examined the domain structure of GaN from the dislocation distribution on the macroscale by optical microscopy. The surface structure of GaN consisted of domains with microcolumns as the substructure. The inner domains contained a lower density of dislocations but a large number of these dislocations were observed along the domain boundaries. The existence of a domain boundary structure doubly increased the total dislocation density.</P>
Involvement of Immune Responses in the Efficacy of Cord Blood Cell Therapy for Cerebral Palsy
Kang, Mino,Min, Kyunghoon,Jang, Joonyoung,Kim, Seung Chan,Kang, Myung Seo,Jang, Su Jin,Lee, Ji Young,Kim, Sang Heum,Kim, Moon Kyu,An, SeongSoo A.,Kim, MinYoung Mary Ann Liebert 2015 STEM CELLS AND DEVELOPMENT Vol.24 No.19
<P>This study evaluated the efficacy of umbilical cord blood (UCB) cell for patients with cerebral palsy (CP) in a randomized, placebo-controlled, double-blind trial and also assessed factors and mechanisms related to the efficacy. Thirty-six children (ages 6 months to 20 years old) with CP were enrolled and treated with UCB or a placebo. Muscle strength and gross motor function were evaluated at baseline and 1, 3, and 6 months after treatment. Along with function measurements, each subject underwent (18)F-fluorodeoxyglucose positron emission tomography at baseline and 2 weeks after treatment. Cytokine and receptor levels were quantitated in serial blood samples. The UCB group showed greater improvements in muscle strength than the controls at 1 (0.94 vs. -0.35, respectively) and 3 months (2.71 vs. 0.65) after treatment (Ps<0.05). The UCB group also showed greater improvements in gross motor performance than the control group at 6 months (8.54 vs. 2.60) after treatment (P<0.01). Additionally, positron emission tomography scans revealed decreased periventricular inflammation in patients administered UCB, compared with those treated with a placebo. Correlating with enhanced gross motor function, elevations in plasma pentraxin 3 and interleukin-8 levels were observed for up to 12 days after treatment in the UCB group. Meanwhile, increases in blood cells expressing Toll-like receptor 4 were noted at 1 day after treatment in the UCB group, and they were correlated with increased muscle strength at 3 months post-treatment. In this trial, treatment with UCB alone improved motor outcomes and induced systemic immune reactions and anti-inflammatory changes in the brain. Generally, motor outcomes were positively correlated with the number of UCB cells administered: a higher number of cells resulted in better outcomes. Nevertheless, future trials are needed to confirm the long-term efficacy of UCB therapy, as the follow-up duration of the present trial was short.</P>
Chaotic Motion of a Magnetic Domain Structure under an Alternating Field
Michinobu Mino,Yousuke Yamamoto 한국물리학회 2013 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.63 No.3
Magnetic domains in a garnet thin film under alternating magnetic fields up to 2000 Hz havebeen investigated at room temperature. Domain structures and motions have been observed. Whenthe field frequency is low, the magnetization changes periodically, and the domain pattern has alabyrinth structure. When the amplitude and the driving frequency of the field are increased,irregular oscillations of the magnetization appear, and chaotic motions of the domain are observed. In this region, domain structures have a disk-like shape. These disks grow from some crystal defects,and a growing point shows a branch-like form.