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        A Rerouting-Controlled ISL Handover Protocol For LEO Satellite Networks

        ( Wei Dong ),( Junfeng Wang ),( Minhuan Huang ),( Jian Tang ),( Hongxia Zhou ) 한국인터넷정보학회 2012 KSII Transactions on Internet and Information Syst Vol.6 No.10

        In this paper, a rerouting-controlled ISL (Inter-Satellite link) handover protocol for LEO satellite networks (RCIHP) is proposed. Through topological dynamics and periodic characterization of LEO satellite constellation, the protocol firstly derives the ISL related information such as the moments of ISL handovers and the intervals during which ISLs are closed and cannot be used to forward packet. The information, combined with satellite link load status, is then been utilized during packet forwarding process. The protocol makes a forwarding decision on a per packet basis and only routes packets to living and non-congested satellite links. Thus RCIHP avoids periodic rerouting that occurs in traditional routing protocols and makes it totally unnecessary. Simulation studies show that RCIHP has a good performance in terms of packet dropped possibility and end-to-end delay.

      • KCI등재후보

        ATCS: An Adaptive TCP Coding Scheme for Satellite IP Networks

        ( Wei Dong ),( Junfeng Wang ),( Minhuan Huang ),( Jian Tang ),( Hongxia Zhou ) 한국인터넷정보학회 2011 KSII Transactions on Internet and Information Syst Vol.5 No.5

        In this paper we propose ATCS, a practical TCP protocol coding scheme based on network coding for satellite IP networks. The proposal is specially designed to enhance TCP performance over satellite networks. In our scheme, the source introduces a degree of redundancy and transmits a random linear combination of TCP packets. Since the redundant packets are utilized to mask packet loss over satellite links, the degree of redundancy is determined by the link error rates. Through a simple and effective method, ATCS estimates link error rates in real time and then dynamically adjusts the redundant factor. Consequently, ATCS is adaptable to a wide range of link error rates by coding TCP segments with a flexible redundancy factor. Furthermore, the scheme is compatible with traditional TCP variants. Simulation results indicate that the proposal improves TCP performance considerably.

      • KCI등재

        A Novel Method for Survivability Test Based on End Nodes in Large Scale Network

        ( Ming Liang ),( Zhao Gang ),( Wang Dongxia ),( Huang Minhuan ),( Li Xiang ),( Miao Qing ),( Xu Fei ) 한국인터넷정보학회 2015 KSII Transactions on Internet and Information Syst Vol.9 No.2

        Survivability is a necessary property of network system in disturbed environment. Recovery ability is a key actor of survivability. This paper concludes network survivability into a novel composite metric, i.e. Network Recovery Degree (NRD). In order to measure this metric in quantity, a concept of Source-Destination Pair (SD Pair), is created to abstract end-to-end activity based on end nodes in network, and the quality of SD Pair is also used to describe network performance, such as connectivity, quality of service, link degree, and so on. After that, a Survivability Test method in large scale Network based on SD pairs, called STNSD, is provided. How to select SD Pairs effectively in large scale network is also provided. We set up simulation environment to validate the test method in a severe destroy scenario and evaluate the method scalability in different large scale network scenarios. Experiment and analysis shows that the metric NRD correctly reflects the effort of different survivability strategy, and the proposed test method STNSD has good scalability and can be used to test and evaluate quantitative survivability in large scale network.

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        MiR-339 attenuates LPS-induced intestinal epithelial cells inflammatory responses and apoptosis by targeting TLR4

        Meiying Xie,Lina Zhang,Luoye Li,Minhuan Fan,Lianjie Hou 한국유전학회 2020 Genes & Genomics Vol.42 No.9

        Background Intestinal epithelial cells are important for defending against pathogen infection. LPS is an endotoxin that is highly antigenic and cytotoxic produced by bacteria. LPS disrupts the intestine epithelium integrity and induced the intestinal epithelial cell infammation and apoptosis. Our previous study has predicted the function of exosome miRNAs through bioinformatics analysis, and we found that miR-339 had a potential function in cell infammation response. To our knowledge, no published paper has demonstrated the miR-339 function in protecting the intestine epithelium against bacterial infection. Objective The objective of this study is to evaluate the miR-339 function in regulating intestinal epithelial cells to defend against bacterial infection through biological experiments and bioinformatics analyses. Methods Through the miR-339 transfection experiment and TLR4 interfering experiment, we evaluated the function of miR339 and TLR4 in the process of infammatory responses and apoptosis. Through Bioinformatics analyses and dual-luciferase reporter experiment, we identifed the target gene of miR-339. Results miR-339 attenuates LPS-induced intestinal epithelial cells infammatory responses through the TLR4/NF-κB signaling pathway and inhibited LPS-induced apoptosis through the P53 signaling pathway. TLR4 is the target gene of miR-339. TLR4 reduced LPS-induced proinfammatory responses and apoptosis. Conclusions In conclusion, miR-339 protected the intestine epithelial cells from LPS-induced cell infammation and apoptosis through targeting TLR4. This study expanded our understanding of how miRNAs and genes work collaboratively in regulating intestinal epithelial cells to defend against bacterial infection.

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