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Pharmacokinetics and Biodistribution of Surface Modification Polymeric Nanoparticles
Mingxing Liu,Huifang Li,Guoan Luo,Qingfei Liu,Yiming Wang 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.4
The objective of this study is to investigate the pharmacokinetics and biodistribution of free breviscapine (BVP) and coated BVP-loaded poly (D, L-lactic acid) nanoparticles (BVP-PLANPs) in rats after i.v. administration. Coated BVP-PLA-NPs were prepared by the spontaneous emulsification solvent diffusion method and characterized. The BVP content in the NPs, the biological samples and in vitro release was measured by the high-performance liquid chromatography (HPLC). The mean sizes of coated BVP-PLA-NPs were 177 and 319 nm with a narrow distribution and smooth sphere shapes, entrapment efficiency of 86.9% and 93.1%, respectively. Drug release profiles in phosphate buffer and plasma exhibited a biphasic release phenomenon. After i.v. administration of free BVP and NPs suspensions in rats, area under plasma concentration-time curve and elimination t1/2 were increased 9.3-fold and 10.9-fold for 177 nm of NPs, and 4.4-fold and 17.1-fold for 319 nm of NPs compared with that of free BVP, respectively. NPs were mainly distributed in liver, spleen, heart and brain. In addition, NPs could penetrate blood brain barrier (BBB) and the particle size had some effect on pharmacokinetics and biodistribution. Coated BVP-PLA-NPs could effectively avoid the capture by the reticuloendothelial system and prolong the half-life of BVP. Moreover, these NPs could penetrate BBB and enhance the accumulation of BVP in brain.
Mingxing Wang,Daewan Kim,Simon Lee 한국디지털융합학회 2020 IJICTDC Vol.5 No.1
An ecological marketing strategy is a new marketing concept for sustainable development. The goal of ecological marketing is to build an ecological system with potential enterprises, enable members in the ecosystem to make profits, and achieve a win-win situation. This paper uses a single case (MI) study approach to aligning the concepts and guidelines prescribed by the technology-organization-environment framework. The qualitative research method of content analysis will be applied to analyze secondary sources such as MI corporate sustainability reports, journal articles, case study materials, trade publication articles, etc. Most of these materials are available on the website. By conducting the analysis through technological, organizational, and environmental aspects, the result answers the question that why the ecological marketing strategy could promote MI’s successful transformation and upgrading. After a comprehensive analysis, the other modern enterprises can learn more about ecological marketing strategy and realize ecological marketing can be concluded. Moreover, both the result and the analytic framework of Ecological marketing can also be a reference for modern enterprises to obtain their interests and establish a symbiotic ecological marketing system.
Presulfidation and activation mechanism of Mo/Al2O3 catalyst sulfided by ammonium thiosulfate
Mingxing Tang,Xuekuan Li,Hui Ge,Weibin Fan,Guofu Wang,Zhanjun Lyu 한국화학공학회 2014 Korean Journal of Chemical Engineering Vol.31 No.8
Mo/Al2O3 catalyst was presulfided with (NH4)2S2O3 to elucidate presulfidation and activation mechanism. Itis illustrated that the Mo oxide is firstly partially sulfided during presulfidation and then in situ reduced into MoS2−x inactivation, and finally sulfided to active state during hydrodesulfurization (HDS). A synergistic effect between the S2− andS6+ ions in (NH4)2S2O3 produces a positive influence on the HDS performance. The S2− ions contribute to the sulfidationof Mo ions, while the S6+ species interact with Al2O3 support, weakening the interaction of active species with support.
Mingxing Liu,Baowei Wu,Yue-E Wang,Lili Liu 제어·로봇·시스템학회 2023 International Journal of Control, Automation, and Vol.21 No.2
This paper is concerned with dynamic quantized output feedback and event-triggered guaranteed cost finite-time H∞ control for uncertain switched linear systems with exogenous disturbance. First, one mode-dependent periodic event-triggered strategy is designed, which means that each subsystem has its own event-triggered mechanism. Meanwhile, the periodic detection of the error greatly reduces the sampling number and avoids the appearance of Zeno behavior. Second, considering the state information of the system is difficult to obtain completely, dynamic quantized output feedback controllers based on logarithmic quantizer are used to stabilize the switched system. Besides, combine the multiple Lyapunov functionals and the average dwell time condition, the sufficient condition of finite-time boundedness with H∞ performance level is obtained for the uncertain switched system. Finally, the effectiveness of the proposed method is verified a practical example.
Kinetics Model of Bainitic Transformation With Stress
Mingxing Zhou,Guang Xu,Haijiang Hu,Qing Yuan,Junyu Tian 대한금속·재료학회 2018 METALS AND MATERIALS International Vol.24 No.1
Thermal simulations were conducted on a Gleeble 3800 simulator. The main purpose is to investigate the effects ofstress on the kinetics of bainitic transformation in a Fe-C-Mn-Si advanced high strength bainitic steel. Previousstudies on modeling the kinetics of stress affected bainitic transformation only considered the stress below theyield strength of prior austenite. In the present study, the stress above the yield strength of prior austenite is takeninto account. A new kinetics model of bainitic transformation dependent on the stress (including the stresses belowand above the yield strength of prior austenite) and the transformation temperature is proposed. The new modelpresents a good agreement with experimental results. In addition, it is found that the acceleration degree of stresson bainitic transformation increases with the stress whether its magnitude is below or above the yield strength ofaustenite, but the increasing rate gradually slows down when the stress is above the yield strength of austenite.
Combined Effect of the Prior Deformation and Applied Stress on the Bainite Transformation
Mingxing Zhou,Guang Xu,Li Wang,Haijiang Hu 대한금속·재료학회 2016 METALS AND MATERIALS International Vol.22 No.6
There has been a continued interest over the past years in the effects of external stress or prior deformation onthe bainite transformation. In this study, the combined effect of prior deformation and stress on the bainitetransformation was investigated and the interaction between the effects of prior deformation and stress wasdiscussed in detail. The results show that although single deformation and single stress promote the bainitetransformation, their combination cannot promote the bainite transformation to a much larger degree. In addition, atthe early stage of transformation, the promotion effects of prior deformation and stress on the amount of the bainitetransformation are enhanced by each other. However, at the latter stage, the deformation weakens the promotioneffect of the stress. Moreover, prior deformation at a low temperature accelerates the kinetics of the bainite transformationwith stress, but it decreases the amount of the bainite transformation even if the deformation is small.
Mingxing Luo,Jiru Zhang,Xiaoxuan Liu,Cai Wu 대한토목학회 2023 KSCE Journal of Civil Engineering Vol.27 No.8
Studies show that the shear strength of angular-shaped calcareous sand is mainly affected by dilatancy, interparticle locking, and particle breakage. In the present study, a series of consolidated-drained triaxial compression tests on calcareous sands are carried out to investigate the strength impacts of dilatancy, interparticle locking, and particle breakage. It is found that as the stress level increases, the friction angle difference reflecting the effect of the particle breakage increases. In contrast, the friction angle difference reflecting the interparticle locking and dilatancy effect decreases gradually. Moreover, the critical stress ratio of the high-angled calcareous sands decreases, which may be attributed to particle breakage. The obtained results demonstrate that when the stress level exceeds a certain value, the critical stress ratio remains constant. Then the correlation between the particle breakage, interparticle locking, and dilatancy effects in the shear strength is studied. Finally, based on the performed analysis on energy dissipation in calcareous sands, a dilatancy model is proposed that covers the particle breakage effect. The performed analyses demonstrate that the proposed model can accurately explain the experimental data.
Preparation of CdSe QDs-carbohydrate Conjugation and its Application for HepG2 Cells Labeling
Mingxing Jiang,Yan Chen,Guiqing Kai,Ruijun Wang,Huali Cui,Meili Hu 대한화학회 2012 Bulletin of the Korean Chemical Society Vol.33 No.2
In present study, CdSe quantum dots (QDs) were prepared with a novel but simple, effective and exercisable method. Nine different types of carbohydrate molecules were used to modify CdSe QDs. D-mannose (Man)-coated quantum dots were prepared for labeling human hepatoma (HepG2) cells, because of the high expression of mannose receptor (MR) on HepG2 cells. The uptake characteristics of CdSe QDs-Man were investigated in HepG2 cells. The absorption rate result of MTT assay in 48 h suggested the extremely low cytotoxicity of CdSe QDs-Man. The presence of quantum dots was confirmed with fluorescence microscopy. These results were encouraging regarding the application of QDs molecules for early detection of HepG2 cells.