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( Ming Yi Zhao ),( Ming Hua Yang ),( Liang Chun Yang ),( Yan Yu ),( Min Xie ),( Shan Zhu ),( Rui Kang ),( Dao Lin Tang ),( Zhi Gang Jiang ),( Wu Zhou Yuan ),( Xiu Shan Wu ),( Li Zhi Cao ) 생화학분자생물학회(구 한국생화학분자생물학회) 2011 BMB Reports Vol.44 No.9
HMGB1 is associated with human cancers and is an activator of autophagy which mediates chemotherapy resistance. We here show that the mRNA levels of HMGB1 are high in leukemia cells and it is involved in the progression of childhood chronic myeloid leukemia (CML). HMGB1 decreases the sensitivity of human myeloid leukemia cells K562 to anti-cancer drug induced death through up-regulating the autophagy pathway, which is confirmed by the observation with an increase in fusion of autophagosomes and autophagolysosomes. When overexpressing HMGB1, both mRNA levels of Beclin-1, VSP34 and UVRAG which are key genes involved in mammalian autophagy and protein levels of p-Bcl-2 and LC3-II are increased. Luciferase assays document that over-expression of HMGB1 increases the transcriptional activity of JNK and ERK, which may be silenced by siRNA. The results suggest that HMGB1 regulates JNK and ERK required for autophagy, which provides a potential drug target for therapeutic interventions in childhood CML. [BMB reports 2011; 44(9): 601-606]
Thermal and mechanical properties of poly(latic acid) reinforced with silanized basalt scales
Shan-Shan Yao,Ming-Zhan Gao,Zhao-Yang Feng,Fan-Long Jin,박수진 한국화학공학회 2022 Korean Journal of Chemical Engineering Vol.39 No.7
Biodegradable poly(lactic acid) (PLA)-based composites were prepared using PLA and basalt scale (BS) viaa solution-blending method. BS surfaces were treated using a silane coupling agent, and their surface properties werecharacterized by high-resolution scanning electron microscopy, energy-dispersive X-ray spectrometry, and X-ray photoelectronspectrometry. Moreover, the influence of BS content on the thermal properties, flexural properties, impactstrength, and morphology of the PLA/silane-coupling-agent-treated BS (KH-BS) composites was analyzed. The thermalstability of the composites significantly increased due to the addition of KH-BS. Impact strength tests showed thatthe impact strength of the PLA/KH-BS composite with 4 wt% KH-BS was 3.14 kJ/m2, which is 51% higher than that ofpristine PLA (2.07 kJ/m2). The analysis of the fracture surfaces of the composites after the impact strength tests revealeda rough morphology with numerous river-like micro-cracks. The study results demonstrate that the addition of KH-BSsignificantly improves the thermal stability and impact strength of PLA/KH-BS composites.
A New Stilbene Glucoside from the Roots of Polygonum multiflorum Thunb.
Ming-Lu Xu,Ming Shan Zheng,Yeon-Kyong Lee,문동철,Chong-Soon Lee,우미희,정병선,Eung Seok Lee,장영동,장현욱,이승호,손종근 대한약학회 2006 Archives of Pharmacal Research Vol.29 No.11
One new stilbene glucoside (6), along with five known compounds (1-5), were isolated from the roots of Polygonum multiflorum Thumb., and their chemical structures established based on physicochemical and spectroscopic data. Of the compounds, compound 3 showed DNA topoisomerase I and II inhibitory activities.
Protective Constituents against Sepsis in Mice from the Root Barks of Ulmus davidiana var. japonica
Ming Shan Zheng,Jong Keun Son,Gao Li,Ying Li,서창섭,Yeun-Kyung Lee,Jun-Sub Jung,송동근,Hong-Beom Bae,Sang-Hyun Kwak,Hyun-Wook Chang,김재룡 대한약학회 2011 Archives of Pharmacal Research Vol.34 No.9
In the course of isolating preventive agents against sepsis based on the in vivo assay model, eleven known compounds, (-)-catechin (1), catechin-7-O-β-apiofuranoside (2), catechin-7-O-α-Lrhamnopyranoside (3), catechin-3-O-α-L-rhamnopyranoside (4), catechin-7-O-β-D-glucopyranoside (5), butyl (+)-5'-methoxyisolariciresinol-9'-O-β-D-xylopyranoside (6), lyoniside (7), nudiposide (8), α-nigerose (9), butyl α-D-fructofuranoside (10), and procyanidin B3 (11) were isolated from the root barks of Ulmus davidiana var. japonica. Compounds 2, 6, and 8 significantly protected against sepsis in a mouse model with survival rates of mice exposed to 10 mg/kg of LPS/D-GalN ranged from 80%-100%. Among them, 8 exhibited the most potent protective effect and decreased the plasma levels of TNF-α, IL-10 and ALT activity.
Chemical Constituents of Melandrium firmum Rohrbach and Their Anti-Inflammatory Activity
Ming Shan Zheng,Do Hoon Kim,Nam Kyung Hwang,Tae Chul Moon,Jong Keun Son,장현욱 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.3
In our ongoing search for anti-inflammatory agents originating from Korean medicinal plants, we found that the hexane and BuOH fractions of the MeOH extract from the whole plants of Melandrium firmum Rohrbach inhibited 5-lipoxygenase (5-LOX) activity. By activity-guided fractionation, eleven compounds, α-spinaterol (1), ursolic acid (2), ergosterol peroxide (3), α- spinaterol glucoside (4), 2-methoxy-9-β-D-ribofuranosyl purine (5), aristeromycin (6), ecdysteron (7), polypodoaurein (8), (-)-bornesitol (9), mannitol (10) and cytisoside (11) were isolated from the hexane and BuOH fractions using column chromatography. Compounds 2, 5, 6, 8, 9, 10 and 11 were isolated for the first time from this plant. Compounds 1, 3, 4 and 7 inhibited 5- LOX activity with IC50 values of 21.04 µM, 42.30 µM, 32.82 µM, and 17.18 µM, respectively.
Chemical Constituents of Melandrium firmum Rohrbach and Their Anti-Inflammatory Activity
Zheng, Ming Shan,Hwang, Nam-Kyung,Kim, Do-Hoon,Moon, Tae-Chul,Son, Jong-Keun,Chag, Hyeun-Wook 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.3
In our ongoing search for anti-inflammatory agents originating from Korean medicinal plants, we found that the hexane and BuOH fractions of the MeOH extract from the whole plants of Melandrium firmum Rohrbach inhibited 5-lipoxygenase (5-LOX) activity. By activity-guided fractionation, eleven compounds, ${\alpha}-spinaterol$ (1), ursolic acid (2), ergosterol peroxide (3), ${\alpha}-spinaterol$ glucoside (4), 2-methoxy-9-${\beta}$-D-ribofuranosyl purine (5), aristeromycin (6), ecdysteron (7), polypodoaurein (8), (-)-bornesitol (9), mannitol (10) and cytisoside (11) were isolated from the hexane and BuOH fractions using column chromatography. Compounds 2, 5, 6, 8, 9, 10 and 11 were isolated for the first time from this plant. Compounds 1, 3, 4 and 7 inhibited 5-LOX activity with $IC_{50}$ values of 21.04 ${\mu}M$, 42.30 ${\mu}M$, 32.82 ${\mu}M$, and 17.18 ${\mu}M$, respectively.
Zheng, Ming-Shan,Lee, Yeun-Kyung,Li, Ying,HwangBo, Kyoung,Lee, Chong-Soon,Kim, Jae-Ryong,Lee, Sunny Kyung-Seon,Chang, Hyun-Wook,Son, Jong-Keun 대한약학회 2010 Archives of Pharmacal Research Vol.33 No.9
Twenty five compounds including ten triterpenes (1-3, 5-11), six flavonoids (12-15, 24, 25), five lignans (17, 18, 21-23), two butenyl clohexnone glycosides (19-20), one fructofuranoside (16) and one fatty acid (4) were isolated from the roots of Ulmus davidiana var. japonica. The structures of those compounds were identified by comparing their physicochemical and spectral data with those of published in literatures. All the compounds were evaluated for DNA topoisomerase inhibitory activities and cytotoxicities. Among the purified compounds, 4 and 19 showed more potent inhibitory acitivities ($IC_{50}$: 39 and 19 ${\mu}M$, respectively) than camptothecin, as the positive control ($IC_{50}$: 46 ${\mu}M$) against topoisomerase I. Compounds, 4, 10, 12, 19, 24 and 25 showed strong inhibitory activities toward DNA topoisomerase II ($IC_{50}$: 0.1, 0.52, 0.47, 0.42, 0.17 ${\mu}M$ and 17 nM, respectively), which were more potent than that of etoposide as positive control ($IC_{50}$: 20 ${\mu}M$). In A549 cell line, 5 and 6 showed cytotoxicities ($IC_{50}$: 4 ${\mu}M$ and 3 ${\mu}M$, respectively, with $IC_{50}$ of camptothecin as positive control: 10.3 ${\mu}M$). In the HepG2 cell line, 3, 5 and 7 showed cytotoxicity ($IC_{50}$: 4, 3 and 4 ${\mu}M$, respectively, with $IC_{50}$ of camptothecin: 0.3 ${\mu}M$). Compounds 6, 12 and 23 showed cytotoxicities in the HT-29 cell line ($IC_{50}$: 19, 19 and 15 ${\mu}M$, respectively, with $IC_{50}$ of camptothecin: 2 ${\mu}M$).
연구논문(硏究論文)(재록(再錄)) : 의약화학 ; 하수오로부터 신규 Stilbene Glucoside의 분리 및 구조결정
허명록 ( Ming Lu Xu ),정명선 ( Ming Shan Zheng ),이연경 ( Yeon Kyong Lee ),문동철 ( Dong Cheol Moon ),이종순 ( Chong Soon Lee ),우미희 ( Mi Hee Woo ),장영동 ( Yurng Dong Jahng ),장현욱 ( Hyeun Wook Chang ),이승호 ( Seung Ho Lee 영남대학교 약품개발연구소 2007 영남대학교 약품개발연구소 연구업적집 Vol.17 No.-