건강한 청년의 단시간 공해노출과 일회성 운동이 폐기능과 생리반응에 미치는 영향

김민주(Min-Joo Kim),이대택(Dae-Taek Lee),송국섭(Gook-Sup Song),방승기(Seung-Ki Pang) 한국생활환경학회 2015 한국생활환경학회지 Vol.22 No.1

This study examined whether an acute exercise during a short-term exposure to a polluted environment affected pulmonary function and physiological responses in healthy young adults. Thirteen men (mean = 22.4 yrs) were randomly exposed to a polluted air (PA) or to clean air (CA) in a chamber. During the exposure, they rested for 30 min followed by a bench stepping exercise (40 cm height, 120 bpm) for 10 min. And they recovered from the exercise for 15 min in the chamber. The pulmonary function, heart rate, blood lactate, and blood pressure were measured during the exposure. At the end of 30 min resting, peak expiratory flow rate (PEFR) was higher in PA than CA. Immediately after the exercise, forced expiratory volume at 1 sec (FEV1) was higher in PA than CA. At 15th min of recovery, forced vital capacity, FEV1, and PEFR were significantly higher in PA than CA. No differences in cardiovascular and blood lactate responses were noticed. The results suggest that an acute intensive physical work out with breathing of volatile organic compounds induced changes of pulmonary function but not physiological adjustments.

활성탄과 제올라이트 13X 충진탑을 사용한 TSA 공정에서 조업조건이 벤젠의 흡착 및 탈착에 미치는 영향

정민영 ( Min-young Jung ),서성섭 ( Sung-sup Suh ) 한국공업화학회 2018 공업화학 Vol.29 No.5

본 연구는 VOC 제거 기술인 TSA 공정에서 제올라이트 13X와 활성탄이 채워진 두 종류의 탑을 사용하여 원료농도, 질소 유량, 수증기 유량, 탑 온도 등 조업조건의 영향을 분석하였다. 본 연구의 TSA 사이클은 흡착단계, 수증기 탈착단계, 건조 및 냉각단계로 구성되었다. 2% 벤젠 농도에서 제올라이트 13X와 활성탄의 사이클 당 전체 흡착량은 각각 4.44 g과 3.65 g으로 활성탄보다 충전밀도가 큰 제올라이트 13X가 더 많은 양의 벤젠을 흡착할 수 있었다. 수증기 탈착의 결과에서 수증기 유량을 증가시키고 탑의 외부 가열로 온도를 높이면 탈착시간이 짧아지고 배출되는 벤젠의 농도가 높아지는 것으로 나타났다. 2% 벤젠 농도에서 수증기 유량을 75 g/hr로 증가시키면 탈착시간이 1 hr에서 최대 33 min까지 단축되어 상대적으로 건조 및 냉각단계의 시간이 늘어나 수증기 제거와 탑 냉각을 충분히 진행할 수 있었다. 탑 온도를 높이면 탈착량이 증가하나 150 ℃ 이상에서는 에너지소비는 증가하는 반면 탈착량은 거의 일정했다. 연속 사이클 조업에서 재생단계 완료 시 잔존하게 되는 벤젠의 비율이 늘어나면 흡착제 working capacity 감소의 원인이 될 수 있다. 제올라이트 13X를 이용해 연속 사이클 공정실험을 수행한 결과 탑 내부에 잔존하는 벤젠의 비율이 4번째 사이클 이후 일정한 값으로 유지되었다. The effects of operating conditions such as benzene concentration, nitrogen flow rate, steam flow rate, and bed temperature on TSA process were experimentally investigated as a potential VOC removal technology using two kinds of beds packed with activated carbon and zeolite 13X. The TSA cycle studied was composed of the adsorption step, steam desorption step, and drying and cooling step. At 2% benzene concentration, the total adsorption amounts of zeolite 13X and activated carbon were 4.44 g and 3.65 g, respectively. Since the zeolite 13X has a larger packing density than that of the activated carbon, the larger benzene amount could be adsorbed in a single cycle. Increasing the water vapor flow rate to 75 g/hr at 2% benzene concentration reduced the desorption time from 1 hr to a maximum of 33 min. If the desorption time is shortened, the drying and cooling step period can be relatively increased. Accordingly, the steam removal and bed cooling could be sufficiently performed. The desorption amounts increased with the increase of the bed temperature. However, the energy consumption increased while the desorption amount was almost constant above 150 ℃. In the continuous cycle process, when the amount of remained benzene at the completion of the regeneration step increased, it might cause a decrease in the working capacity of the adsorbent. The continuous cycle process experiment for zeolite 13X showed that the amount of remained benzene at the end of regeneration step maintained a constant value after the fourth cycle.

Sludge Solubilization using Microwave Irradiation in the Presence of Fe Powder

Yi, Min-Joo,Choi, Hyun-Kyung,Han, Ihn-Sup Korean Society of Soil and Groundwater Environment 2010 지하수토양환경 Vol.15 No.2

In this study, microwave irradiation, which is reflected by metals, was used to reduce the amount of sewage sludge, and the results were used to verify solubilization efficiency and determine optimum operation conditions. Biogas production and methane content of the gas under optimized conditions were measured with the biochemical methane potential (BMP) test. The sludge was taken from a thickened sludge tank at J sewage treatment plant (JSTP) in Seoul, Korea. For the experiments, 50 mL of sludge was filled in vessels and the vessels were irradiated with the power of 500, 600, 700, and 800W for 2~5 min. In addition, Fe powder was added by 0.01, 0.05, and 0.1 g to compare the efficiency with and without Fe powder. The results confirmed that solubilization efficiency was higher in the presence of Fe powder. The optimum conditions of 0.01 g addition of Fe powder with 800W irradiation for 5 min, yielded nearly 22.95% higher solubilization efficiency than without Fe powder. The BMP tests were carried out using sludge obtained from the experiments carried out under the optimum conditions. As a result, sludge subjected by 800W with 0.01 g of Fe powder for 5 min displayed the highest level of gas production and methane content. Through this study, it could be confirmed that solubilization efficiency increased by addition of Fe powder.

Dopant-Activation and Damage-Recovery of Ion-Shower-Doped Poly-Si through $PH_3/H_2$ after Furnace Annealing

Kim, Dong-Min,Kim, Dae-Sup,Ro, Jae-Sang,Choi, Kyu-Hwan,Lee, Ki-Yong The Korean Infomation Display Society 2004 Journal of information display Vol.5 No.1

Ion shower doping with a main ion source of $P_2H_x$ using a source gas mixture of $PH_3/H_2$ was conducted on excimer-laser- annealed (ELA) poly-Si. The crystallinity of the as-implanted samples was measured using a UV-transmittance. The measured value of as-implanted damage was found to correlate well with the one calculated through/obtained from TRIM-code simulation. The sheet resistance was found to decrease as the acceleration voltage increased from 1 kV to 15 kV at a doping time of 1 min. However, it increases as the acceleration voltage increases under severe doping conditions. Uncured damage after furnace annealing is responsible for the rise in sheet resistance.

Rotor 증후군

심찬섭(Chan Sup Sim),이성원(Sung Won Lee),손무영(Moo Young Sohn),김진숙(Jean Sook Kim),한명동(Myung Dong Han),백정민(Cheong Min Paik) 대한소화기학회 1981 대한소화기학회지 Vol.13 No.2

Rotor syndrame is a familial disorder characterized by chronic, nonhemolytic, and predominantly conjugated hyperbilirubinemia with normal liver tissue without any pigment deposit in the liver cells. A 36-year-old Korean female was admitted due to intermittent jaundice, indigestion and general malaise. Physical examination revealed icteric sclera, but no hepatomegaly. Laboratory findings showed increased serum bilirubin with direct reacting bilirubin predominating and prolonged BSP retention (32% in 45 min.) Oral cholecystography revealed well-visualization but intravenous cholangiography did not reveal the gall bladder and the duct, Percutaneous needle biopsy specimen of liver showed no special abnormalities. Urinary total coproporphyrin excreation was increased. A brief review of the pertinent literature was made.

Simulated Moving Bed를 이용한 Bupivacaine 키랄분리 : (1) Preparative Chromatography를 이용한 기본조건 결정 (1) Optical Separation Conditions for Preparative Chromatography

윤지연,이중기,서성섭,최민호,박태진 한국화학공학회 2003 Korean Chemical Engineering Research(HWAHAK KONGHA Vol.41 No.6

Racemate Bupivacaine의 키랄분리를 위한 크로마토그래피의 최적분리조건을 조사하였다. Kromasii^(�) 키랄고정상에서 최적이동상조성 성분은 n-hexane/2-propanol/acetic acid/triethylamine, 99/1/0.3/0.05(vol.%)이였다. 이동상 조성성분인 2-propanol의 부피비가 증가할수록 체류시간과 분리도가 동시에 감소되었다. 이동상 성분 중에서 미량으로 존재하는 triethylamine이 증가할수록 피크의 sharpness가 증가하고 체류시간 역시 감소하였다. 또한, acetic acid가 없으면, 크로마토그래피 광학분할이 불가능하였으며 부피 0.3%에서 분리도가 가장 높음을 확인할 수 있었다. 한편, 키랄의약품의 대량분리방법중의 하나인 SMB(simulated moving bed)크로마토그래피 시스템(직경 1.0cm×10cm×8개 칼럼으로 구성)의 최적분리조건을 전산모사에 의해 구하였으며, 이를 실험으로 확인하였다. 그 결과 switching time 15분, feed의 유량 0.1 ml/min, desorbent 0.86 ml/min, raffinate 0.3 ml/min, extract 0.66 ml/min, recycle 1.0 ml/min일 때 100% 순도의 R-form과 S-form을 얻을 수 있었으며, 실험치와 전산모사치간의 오차는 ??2%이내였다. The chiral separation of racemate Bupivacaine was carried out to find the optimum condition for chromatographic system. The optimum species and composition for mobile phase were n-hexane/2-propanol/acetic acid/triethylamine, 99/1/0.3/0.05(vol.%) in case Kromasil� chiral stationary phase was employed. The retention time and resolution decreased with the increase in the ratio of 2-propanol in the mobile phase. The sharpness of peak and retention time decreased, as the content of triethylamine increased. Without the existence of acetic acid, the chromatographic separation didn't occur, and the resolution was the highest at the acetic acid volume ratio of 0.3%. The optimum condition of SMB (simulated moving bed) was determined by simulation and its results was compared with exprimental data from lab-scale SMB (10 mm 1D×8 ea). Rased on the SMB simulation and experimental results, 100% purity of R and S Bupivacaine were obtained and the error between the calculated and experimental value was within ±2%.

Suppressive effects of three diketopiperzines from marine-derived bacteria on TGFBIp-mediated septic responese in human endothelial cells and mice

( Byeongjin Jung ),( Sae Kwang Ku ),( Ming Gao ),( Kyung Min Kim ),( Min Su Han ),( Hyukjae Choi ),( Jong Sup Bae ) 영남대학교 약품개발연구소 2016 영남대학교 약품개발연구소 연구업적집 Vol.26 No.-

Diketopiperazine is a naturally occurring cyclic dipeptide found from diverse living organisma. The com-pounds in this structure class have been known with a broad spectrum of bioactivities including anti-inflamma-tory activities. Transforming growth factor β-induced protein (TGFBIp) is an extracellular matrix protein whose expression in several cell types is greatly increased by TGB- β. TGFBIp is released by human umbilical vein endothelica cells and functions as a mediator of experi-mental sepsis. Here, three (1-3) of diketopiperazines were isolated from two strains of marine-derived bacteria and we hypothesized that 1-3 could reduce TGFBIp-mediated severe inflammatory responses in human endothelial cells and mice. Here, we investigated the anti-septic effects and underlying mechanisms of 1-3 effectively inhibited lipopolysac-charide-induced release of TGFBIp and suppressed TGFBIp-mediated septic responses. In addition, 1-3 sup-pressed cecal ligation and puncture (CLP)-induced sepsis lethality and pulmonary injury. In conclusion, 1-3 sup-pressed TGFBIp-mediated and CLP-induced septic response. Therefore, 1-3 could be a potential therapeutic agent for treatment of various severe vascular inflamma-tory diseases inhibition of the TGFBIp signaling pathway.

C -11 및 F - 18 표지 콜린의 합성과 체내동태에 관한 연구

전권수,유국현,김상욱,임상무,홍성운,서용섭,양승대,안순혁,허민구 대한핵의학회 2001 핵의학 분자영상 Vol.35 No.3

Objectives: Recently, [methyl-(11)^C]-(β-Hydroxyethyl)trimethylammonium ([(11)^C]choline) has been discovered to be a very effective tracer in imaging various human tumors using positron emission tomography. Because of the short half-life of C-11, it is very difficult to use in a routine imaging procedure and needs a frequent synthesis of [(11)^]choline. This can be supplemented by the substitution of [(11)^Ccholine with [methyS-18]fluorocholine. Here, we would like to report cell uptake and biodistribution of [(11)^Ccholine and [(18)^F]fluorocholine as a basic study. Methods [(11)^C]Choline was prepared by the treatment of [(11)^C]CHzI with N,N-dimethylaminoethanol and [18F]fluorocholine was synthesized from reaction of CHzBr[18F]F with N,N-dimethylaminoethanol. The radiochemical purity was checked by high performance liquid chromatography (HPLC). The biodistribution of [(11)^C]choline and [(18)^F]fluorocholine was determined in balb/c mouse at 5 min, 20 min, 40 min and 80 min. The cell uptake wa measured using glioma (9L) and colon adeocarcinoma (SW620). Results: The radiochemical purity was more than 98% after purification. In the liver, uptake did not change over time the uptake was 20/ID/g for [C]choline and 13%ID/g for [(18)^F]fluorocholine. In the kidney, radioactivity decreased over tirne the uptake was 15%1D/g for [(11)^Ccholine and 20%ID/g for [(18)^F]fluorocholine, 80 min post-injection. The cell uptake of [(11)^Ccholine was 4.93% for glioma (9L) and 18.69F for colon adenocarcinoma (SW620). For [(18)^F]fluorocholine, 1.77% for glioma (9L) and 2.77% for colon adenocarcinoma (SW620). Conclusion: [(11)^CCholine and [(18)^F]fluorocholine showed a different cell uptake tendency, depending on cancer cell line. (Korean J Nucl Med 200135:185-191)

Monocrotaline으로 유발한 백시의 폐동맥고혈압에서 TGF-β와 PDGF의 발현

조민선,조상호,양우익,한운섭 대한병리학회 1999 Journal of Pathology and Translational Medicine Vol.33 No.8

한국판 IOWA 코너스 평정 척도의 개발

신민섭,류명은,김붕년,황준원,조수철 大韓神經精神醫學會 2005 신경정신의학 Vol.44 No.1

Objectives : This study was conducted to develop the Korean version of the I0WA Conners rating scale (K-IOWA), and to examine its reliability and validity. Methods : The subjects were 41 normal children and 40 ADHD children between the ages of 5 and 12. All of the teachers administered the K-IOWA and the abbreviated Conners' rating scale to calculate the internal consistency coefficient of the K-I0WA and to examine its validity. Results : The reliability coefficient of the K-IOWA (Cronbach's α) was .913. The range of correlation coefficients between K-IOWA scores and the Abbreviated Conners Rating Scale scores were from .81 to .93. The mean score of the ADHD group on the K-IOWA was significantly higher than that of the normal group. The result of factor analysis showed that the K-IOWA was composed of 2 factors (Inattention/Overactive and Oppositional/Defiant). Conclusion : These results suggest that the K-IOWA rating scale is a very reliable and valid test and it would be useful in diagnostic evaluation and the treatment effect for ADHD children.