백서 심근경색모델에서 시간경과와 경색의 크기에 따른 심자도의 변화

김미성(Mi Sung Kim),박영선(Young Sun Park),권순길(Sun Gil Kwon),지정훈(Jeong Hoon Ji),신종성(Jong Sung Shin),오광식(Kwang Sik Oh),양용모(Yong Mo Yang),연태진(Tae Jin Youn),김동운(Dong Woon Kim),조명찬(Myeong Chan Cho),이용호(Yong Ho 대한내과학회 2002 대한내과학회지 Vol.62 No.1

N/A Background: Magnetocardiogram (MCG), which records the changes of magnetic fields generated by the heart`s electrical activity, theoritically can provide unique data for clinical application. To date, MCG has been investigated only at a single time point after myocardial infarction (MI) with severe left ventricular dysfunction in rats. The purpose of the present study was to investigate sequential changes of MCG after MI and to evaluate effects of infarct size on MCG. Methods: Acute MI were induced by the permanent ligation of left coronary artery in 22 rats. Magnetic fields were recorded just above a rat with Nb Superconducting Quantum Interference Device (SQUID) gradiometer inside a magnetically shielded room. MCG was measured before and immediately after surgery and it was subsequently recorded at the time points of 1, 4 and 6 hours post operatively. MCG was also measured at 1, 3, 7 and 21 days after surgery. Results: Elevation of ST segment and appearance of pathological Q wave on the MCG were evident immediately after the ligation of coronary artery and persisted to 6 hours after MI. On MCG, ST segment was depressed and T wave was inverted from 1 day after MI. In rats with small-and moderate- sized MI (infarct size〈30%), ST depression returned to near the isoelectric level and Q wave disappeared from 7 days after MI. However, ST depression and Q wave were still present in rats with larger infarct (infarct size≥30%). Conclusion: Evolutional changes of MCG were well-recognized up to 21 days after MI. Furthermore, the infarct size can be expressed by the extent of Q wave and ST segment depression on MCG. Taken together, these data indicate that MCG is a helpful modality for the diagnosis, evaluation of infarct size and follow up after MI.(Korean J Med 62:42-48, 2002)

성악 전공 학생의 가칭 시 음성의 SPR(Singing Power Ratio)에 관한 연구

조성미,정옥란,이상욱 한국음성과학회 2004 음성과학 Vol.11 No.4

This study attempted to provide a spectrum analysis for quantitative evaluation of singing voice quality of singing students rather than the presence or absence of the singer's formant. The regression analysis was used to analyse the relationship between ringing quality, SPR, and SPP of singing voice of college student subjects majoring in music. This study measured singing power ratio (SPR) in 41 singing students. Digital audio recordings were made in sung vowels for acoustic analyses. Each sample was judged by 1 experienced singing teacher and 4 voice pathologists on one semantic bipolar 7-point scales (ringing-dull). The results showed that the SPR and SPP had significant correlations with ringing Quality. The SPR had a significant relationship with ringing quality on singing voice in singing students. The SPR can be an important quantitative measurement for evaluating singing voice quality.

동시를 통한 총체적 언어교육이 아동의 다중지능 발달에 미치는 효과

이성은,황영미 한국초등국어교육학회 2003 한국초등국어교육 Vol.22 No.-

본 연구는 아동의 다중지능 발달을 위해 '동시를 통한 총체적 언어교육 모형' 정립하여 이를 실제 적용한 후, 동시를 통한 총체적 언어교육이 아동의 다중지능 발달에 미치는 효과를 검증하는데 목적이 있다. 선행 연구를 기초로 듣기, 말하기, 읽기, 쓰기, 문학, 관련교과 활동 영역으로 구성된 '동시를 통한 총체적 언어교육 모형' 정립하고 Gardner의 다중지능을 4 지능 측면으로 IQ적 측면, EQ적 측면, SQ적 측면, NQ적 측면에서의 효과를 검증하였다. 초등학교 2학년 아동을 대상으로 다중지능 발달에 관한 Shearer의 다중지능 발달 척도에 관한 사전 검사 실시 후, 총 8주동안 동시를 통한 총체적 언어교육을 실시하였다. 그 결과, IQ적 지능의 하위 MI 영역인 언어적 지능 발달에는 매우 효과적이었으나 논리-수학적인 지능의 경우 효과가 나타나지 않았으며, EQ적 지능의 하위 MI 영역인 음악적 지능, 신체-운동적 지능 발달에 모두 효과적이었다. 또한 SQ적 지능의 하위 MI 영역인 대인관계 지능, 개인이해 지능 발달에 효과적이었으며, NQ적 측면의 지능 발달에는 효과가 나타나지 않았다. 따라서 효과가 나타나지 않은 부분의 보완과 다중지능을 향상시킬 수 있는 총체적 언어교육에 대한 후속 연구를 위해 교사들이 고려할 사항들을 제언하였다 . The purpose of this study was to observe the effects of whole language education, through children's poetry on the multiple intelligence. To do this study has been established by being constituted by the related listening, speaking, reading writing, literature and related subject matters. Also, the 8 intelligences of Gardener have been distinguished in to the following categories: IQ, EQ, SQ, and NQ. The objects of this study were second graders. The model of whole language education through children's poetry had been used in a language classroom after investigating Shearer's position on the criteria of multiple intelligence development of second graders. The developed model had been executed in the language classroom during 8 weeks from March to May. As a result, it was shown to be effective for the development of language intelligence (which is a sub MI area of IQ) and also for the development of musical, physical intelligence (which is a sub MI area of IQ) but not effective for the development of logical-mathematical intelligence. Also, it was effective for interpersonal relationship and understanding intelligence (which is a sub MI area of SQ), but was not effective for the development of NQ. Therefore, a suggestion for further investigation of ways to supplement the non effective aspects of this model taking into consideration teachers will be stated. Finally, for whole language education activities, the role of the teacher is pivotal. This investigation deals with the need for Whole language and the related strategies for practicing it. Thus, this investigation is meant to be of concrete and substantial help for teachers in practice who want to apply whole language education to their activities.

실용음악 전공 학생들의 발성치료 전후 성대 및 음성 특성 비교

황연신,심미란,김철준,최용석,김상연,최찬호,선동일,Hwang, Yeon Shin,Shim, Mi Ran,Kim, Chul Jun,Choi, Yong Suk,Kim, Sang Yeon,Choi, Chan Ho,Sun, Dong Il 대한후두음성언어의학회 2016 대한후두음성언어의학회지 Vol.27 No.2

Background and Objectives : Many students major in applied music singing have various difficulties in phonation when they sing or perform. But the studies about this cause are lack. The purpose of this study is whether singing voice therapy based on vocal music is effective or not to applied music singing students that have difficulties in phonation. Materials and Methods : Singing voice therapy program had been done to 8 students major in applied music singing during 7 weeks. We did laryngeal stroboscope, perceptual, acoustic and aerodynamic examination before and after singing voice therapy to this students. And we studied post examination results have differences or improvements compared to pre examination results. Results : Four male students don't have effective improvement after singing voice therapy but they shows slight improvement in aerodynamic examination values compared to pre examination values. Four female students shows improvement in aerodynamic examination values and pitch range increasing. Above all, one student's vocal nodules disappeared after singing voice therapy. Conclusion : Singing voice therapy based on music singing is very effective to the students major in applied music singing. Above all, their curriculum in applied music singing should include phonation training based on music singing before training perform and technic practices.

정밀주조 다이캐스팅을 이용한 자동차 레귤레이터 하우징 성형해석에 관한 연구

성백섭,김미애,차용훈,김정대,김덕중,이연신 한국공작기계학회 2006 한국공작기계학회 추계학술대회논문집 Vol.2006 No.-

The casting defects that are caused by molten metal were cold shut formation, entrapment of air, gas, and inclusion. But the control of casting defects has been based on the experience of the foundry engineers. In this thesis, the computer simulation analyzed the flow of molten metal. The quantitative analyses which proposed the effective mold design was executed Flow patterns of 0.1-0.16m/s molten metal in 15mm thin plate casting were investigated in order to optimize die-casting process. As increasing ingate velocity in thin plate casting, cold shot was decreased. The parameters of runner shape that affected on the optimized conditions that was calculated with simple equation were investigated. These die casting process control techniques of automobile regulator housing parts have achieved good agreement with the experimental data of tensile strength, hardness test, and material structure photographies satisfactory results.

여대생의 건강증진 생활양식 관련요인

성미혜 韓國學校保健學會 2004 韓國學校保健學會誌 Vol.17 No.2

Purpose : This study was undertaken in order to examine the relationships of control, perceived health status, self-efficacy, social support, and demographic characteristics for a health promoting lifestyle in college women, and to determine the factors affecting a health promoting lifestyle of women in the early stage of adulthood. Method : There were 161 students from one university in K city. The instruments used for this study were a survey of general characteristics, a health promoting lifestyle (47 items), control (8 items), perceived health status (6 items), self-efficacy (17 items), and social support (18 items). The data analysis was done by use of mean, percentage, t-test, ANOVA, Pearson Correlation coefficients and stepwise regression with the SPSS Win (Version 10.0) program. Results : The results of this study are as follows : 1) The average item score for the health promoting lifestyle was low at 2.39. In the sub-categories, the highest degree of performance was interpersonal support (2.97), and the lowest degree was health responsibility (1.76). 2) In the relationship between social demographics and a health promoting lifestyle, there were significant differences in age, disease experience, and the family's disease experience. 3) Social support revealed only significant correlations with a health promoting lifestyle. 4) Social support was the highest factor that predicted a health promoting lifestyle in college women (15%). Social support, age and disease experience accounted for 20% in a health promoting lifestyle of college women.

Extension of Lance Life by Change of Height of Lances in the Smelting Furnace of Mitsubishi Process

Sung‑Mi Lim,Soo‑Sang Park,Kyung‑Woo Yi 대한금속·재료학회 2021 METALS AND MATERIALS International Vol.27 No.10

A Mitsubishi process, which pertains to continuous Cu production, involves a smelting furnace, cleaning furnace, and convertingfurnace connected in series. One of the main issues pertaining to the smelting furnace is the frequent interruption ofoperations required to allow the inspection and replacement of lances, because lances are frequently fractured. The presentstudy was aimed at modifying the operating conditions of the smelting furnace to suppress lance fractures. A numericalmodel was developed to simulate the transport phenomena in the furnace, including multi-phase behaviors. The simulationresults showed that the lances were exposed to a severely erosive atmosphere with high temperatures. Further calculationindicated that raising the positions of the lances could lower the temperature of the lances, and reducing the occurrence ofsplashed melt, which contains erosive sulfides. The smelting furnace was operated under the conditions of the raised lanceheight and attentively monitored for several months. It was confirmed that by implementing such a change of the lanceheights, the occurrence of lance failures has been considerably reduced without notably affecting the reaction ability of thesmelting furnace.

결직장 종양에서의 p53 단백웨 면역조직화학적 과발현 -Immunohistochemical study of p53 protein expression in colorectal tumors-

이미숙,서재홍,임성철 대한병리학회 1996 Journal of Pathology and Translational Medicine Vol.30 No.7

잿빛만가닥버섯(Lyophyllum decastes)의 ITS 영역염기서열 및 RAPD에 의한 계통학적 유연관계 분석

우성미 외 한국버섯학회 2009 한국버섯학회지 Vol.7 No.3

인공재배된 만가닥버섯(Hypsizygus mamoreus)과 잿빛만가닥버섯(Lyophyllum decastes)을 ITS I·IV 부위의 염기서열에 의해 종속간 유연관계 및 RAPD 다형성을 분석하였다. ITS I·IV영역부위 종속간 유연관계에서 Group1(SPA 100, 101, 102)은 만가닥버섯 에 속하였으며, Group2(11균주) 잿빛만가닥버섯 의 대조 분리군 11균주는 동일한 종으로 동정되었다. ITS결과 14개 균주 시 4개 그룹으로 분류되었으며, Cluster I과 Cluster II는 58%의 유사도를 Cluster III과 Cluster IV는 41%의 유사성을 보였다. 또한 인공재배한 잿빛만가닥버섯의 종 다양성을 분석하기위해 RAPD를 수행한 결과 가장 수량이 양호하며 우량계통인 SPA 202는 잿빛만가닥버섯인 Lyophyllum decastes SPA 203과 그룹화 되었으며 75%의 유사성을 보여주었고, Lyophyllum decastes 공시균주인 SPA 103과 SPA 104의 유사성은 65%로 나타났다. Phylogenetic relationships of Hypsizygus mamoreus and Lyophyllum decastes artificial cultivated using ITS sequences and RAPD polymorphism have been analyzed. Based on ITS region sequences of 14 strains, we could divide into 2 group as group1 to Hypsizygus mamoreus and the control isolated group2 to Lyophyllum decastes were identified as the same species. Restrict analysis of rDNA ITS region which was amplified by PCR, 14 collected strains could be classified into 4 clusters. There was approximately 58% genetic similarity between cluster I (SPA 100, 101, 102) and cluster II (SPA 200, 208 and SPA 201, 202), 41% between cluster III (SPA 104, 103, 203) and cluster IV (SPA 204, 206, 207, 205) by BLAST analysis. RAPD polymorphisms were used to analyze the species diversity of artificially cultivated Lyophyllum decastes SPA 202. As a result, similarity between SPA 202 and SPA 203 was 75%, at the same time, similarity between SPA 202 and Pleurotus eryngii SPA 103 and SPA 104 was 65%.

Myocardial Protection by Recombinant Soluble P-selectin Glycoprotein Ligand-1 Suppression of Neutrophil and Platelet Interaction Following Ischemia and Reperfusion

Sang Soo Ham,Yoon Young Jang,Jin Ho Song,Hyang Mi Lee,Kwang Joon Kim,Jun Sik Hong,Yong Kyoo Shin 대한생리학회-대한약리학회 2000 The Korean Journal of Physiology & Pharmacology Vol.4 No.6

<P> Polymorphonuclear leukocytes (PMNs) play an important role in myocardial ischemia/reperfusion (MI/R) injury. Moreover, platelets are also important blood cells that can aggravate myocardial ischemic injury. This study was designed to test the effects of PMNs and platelets separately and together in provoking cardiac dysfunction in isolated perfused rat hearts following ischemia and reperfusion. Additional control rat hearts were perfused with 75⁓10<SUP>6</SUP> PMNs, with 75⁓10<SUP>6</SUP> platelets, or with 75⁓10<SUP>6</SUP> PMNs⁢75⁓10<SUP>6</SUP> platelets over a five minute perfusion followed by a 75 min observation period. No significant reduction in coronary flow (CF), left ventricular developed pressure (LVDP), or the first derivative of LVDP (dP/dt max) was observed at the end of the observation period in any non-ischemic group. Similarly, global ischemia (I) for 20 min followed by 45 minutes of reperfusion (R) produced no sustained effects on the final recovery of any of these parameters in any group of hearts perfused in the absence of blood cells. However, I/R hearts perfused with either PMNs or platelets alone exhibited decreases in these variables of 5∼10% (p<0.05 from control). Furthermore, I/R hearts perfused with both PMNs and platelets exhibited decreases of 50 to 60% in all measurements of cardiac function (p<0.01). These dual cell perfused I/R hearts also exhibited marked increases in cardiac myeloperoxidase (MPO) activity indicating a significant PMN infiltration, and enhanced P-selectin expression on the coronary microvascular endothelium. All cardiaodynamic effects as well as PMN accumulation and P-selectin expression were markedly attenuated by a recombinant soluble PSGL-1 which inhibits selectin mediated cell adhesion. These results provide evidence that platelets and PMNs act synergistically in provoking post-reperfusion cardiac dysfunction, and that this may be largely due to cell to cell interactions mediated by P-selectin. These results also demonstrate that a recombinant soluble PSGL-1 reduces myocardial reperfusion injury by platelet and PMNs interaction.