Transcriptional activation of hypoxia-inducible factor-1α by HDAC4 and HDAC5 involves differential recruitment of p300 and FIH-1

Seo, Hee-Won,Kim, Eun-Jin,Na, Hyelin,Lee, Mi-Ock Elsevier 2009 FEBS letters Vol.583 No.1

<P><B>Abstract</B></P><P>The interplay between hypoxia-inducible factor-1α (HIF-1α) and histone deacetylase (HDACs) have been well studied; however, the mechanism of cross-talk is unclear. Here, we investigated the roles of HDAC4 and HDAC5 in the regulation of HIF-1α function and its associated mechanisms. HDAC4 and HDAC5 enhanced transactivation by HIF-1α without stabilizing HIF-1α. HDAC4 and HDAC5 physically associated with HIF-1α through the inhibitory domain (ID) that is the binding site for factor inhibiting HIF-1 (FIH-1). In the presence of these HDACs, binding of HIF-1α to FIH-1 decreased, whereas binding to p300 increased. These results indicate that HDAC4 and HDAC5 increase the transactivation function of HIF-1α by promoting dissociation of HIF-1α from FIH-1 and association with p300.</P><P><B>Structured summary:</B></P><P>MINT-6802187:</P><P><I>HIF1 alpha</I> (uniprotkb:Q16665) <I>physically interacts</I> (MI:0218) with <I>FIH1</I> (uniprotkb:Q9NWT6) by <I>anti bait coimmunoprecipitation</I> (MI:0006)</P><P>MINT-6802058:</P><P><I>HIF1 alpha</I> (uniprotkb:Q16665) <I>physically interacts</I> (MI:0218) with <I>HDAC4</I> (uniprotkb:P56524) by <I>pull down</I> (MI:0096)</P><P>MINT-6802021:</P><P><I>HIF1 alpha</I> (uniprotkb:Q61221) <I>physically interacts</I> (MI:0218) with <I>HDAC4</I> (uniprotkb:P56524) by <I>anti bait coimmunoprecipitation</I> (MI:0006)</P><P>MINT-6802036:</P><P><I>HIF1 alpha</I> (uniprotkb:Q61221) <I>physically interacts</I> (MI:0218) with <I>HDAC5</I> (uniprotkb:Q9UQL6) by <I>anti bait coimmunoprecipitation</I> (MI:0006)</P><P>MINT-6802102:</P><P><I>HIF1 alpha</I> (uniprotkb:Q16665) <I>physically interacts</I> (MI:0218) with <I>HDAC5</I> (uniprotkb:Q9UQL6) by <I>pull down</I> (MI:0096)</P><P>MINT-6802121, MINT-6802156:</P><P><I>P300</I> (uniprotkb:Q09472) <I>physically interacts</I> (MI:0218) with <I>HIF1 alpha</I> (uniprotkb:Q16665) by <I>anti bait coimmunoprecipitation</I> (MI:0006)</P>

춘천교대 신입생의 대학생활 실태조사

심미옥 춘천교육대학교 학생생활연구소 1993 學生生活硏究 Vol.18 No.-

인지발달론적 교육 입장에서의 사회-도덕성 발달을 위한 교수모형

문미옥 서원대학교 교육연구소 1987 敎育發展 Vol.6 No.1

The purpose of this study is to suggest the instructional models for young children's Socio-moral development as a cognitive developmentalist's(Piaget and Kohlberg) view. In this study, the models consist of two strategies such as socio- moral discussion and democra tization of classroom. First, socio -moral discussion model consists of two or three phases, those are as follows: 1.presentation socio-moral dilemma which is planned by teacher hypothetically. 2.discussion about the dilemma. 3.role playing (rediscussion). Second. democratization of classroom model consists of three phases, those are as follows: 1.private discussion about the moral problem in classroom such as fighting between children. 2.public discussion about the moral problem which are popular in every children. 3.discussion about the prosocial behavior such as cooperation. sharing‥‥‥.

중도·중복장애 학생의 성공적인 통합교육을 위한 교육적 지원에 대한 질적 연구 : 초등학교 통합학급 교사, 특수학급 교사 및 특수학교 초등교사의 인식을 중심으로

이미경,박경옥,한경근 국립특수교육원 2009 특수교육연구 Vol.16 No.2

본 연구는 초등학교에 근무하는 통합학급 교사, 특수학급 교사 및 특수학교 초등교사 15명을 대상으로 중도·중복장애 학생들의 성공적인 통합교육을 위해 교육적 효과가 좋을 것으로 기대되는 학생의 수준, 통합교육을 방해하는 요인, 그리고 교육적 지원에 관해 인식을 개별면담을 통해 알아보았다. 연구결과, 중도·중복장애의 통합 및 통합 가능한 학생의 수준에 대해서는 중도·중복장애의 통합교육의 효과성에 대한 논란만큼 교사들마다 인식의 차이를 보였으며, 중도·중복장애 학생의 통합교육에 대한 방해요인으로는 1) 장애학생의 문제행동, 2) 장애학생에 대한 인식 부족, 3) 체계적인 교육 및 행정적 전문성의 부족, 4) 심리적 어려움을 해결할 창구의 부족, 5) 장애학생에 대한 교육적, 의료적, 치료적, 심리적인 전문지식의 부족 등으로 나타났다. 중도·중복장애 학생을 위한 교육적 지원으로는 1) 중도·중복장애 학생에게 맞는 개별 처방적인 교육과정 편성의 운영의 내실화, 2) 개별화 교육의 강화 및 교사간 협력, 3) 통합학급 교사와 특수교사의 전문성 강화 등을 꼽고 있었다. 연구 결과를 바탕으로 중도·중복장애 학생들이 성공적인 통합교육으로 교육성 성취를 높일 수 있는 방안에 대한 논의를 하였다.

교직의 여성화와 교육대학교 입학정원의 성별 할당제에 관한 연구

심미옥,라병소,백정자 춘천교육대학교 학생생활연구소 1997 學生生活硏究 Vol.21 No.-

취업한 기혼여성의 자녀보육서비스 개선을 위한 제언

채옥희,정은미 한국가정과학회 2004 한국가정과학회지 Vol.7 No.2

The purpose of this study is to examine the foreign and korean child care service, and to provide the political proposal for employ of working wives and enhancement of home welfare. The political proposals for working wives are as follows ; Now societal recognition that all children are the responsibility of our society is needed to provide the good quality child care service. Our society should support the child care service to be provided a variety of service by child care staff, and should promote the administration and direction in child care center and service. Most of all, societal support, administration and direction should be the same in home-based care and center-based care.

교과 성취와 성역할 사회화

심미옥 춘천교육대학교 초등교육연구소 2002 敎育硏究 Vol.19 No.-

초등 교사의 갈등 요인과 이직 요인의 분석

심미옥 춘천교육대학교 초등교육연구소 2001 敎育硏究 Vol.18 No.-

무지카 픽타의 이론적 제 규명

김미옥 민족음악학회 2003 음악과 민족 Vol.25 No.-

This study deals with the subject of musica ficta together with diverse theoretical clarifications made by early theorists and recent scholars, since it has been one of the most puzzling topics in the twentieth century in relation to the examination of Medieval and Renaissance music, and since clarifications of some problems are necessary. Musica ficta, originally a by-product of the hexachord which was designed for monophonic plainsong, began to be taken for granted in polyphonic music for a number of melodic and harmonic reasons from the 13th century. Influenced by this change, early theorists became attentive to clarify its functions theoretically. And in some cases, they even went too far to reconcile with other independent theories, especially the church modes. In result, diverse interpretations on the use of musica ficta came out and in turn they caused much of the recent debate on the same subject. Diverse theoretical clarifications on the use of it in early and recent times can be summarized in 3 ways as follows: 1) Explanations on the function of musica ficta made by early theorists which are easily understandable: correction of dim,/aug. intervals, best contrapunctal progressions in the cadence, leading tone, transposition of melody, and so on. 2) contentions on the function of musica ficta suggested by recent scholars, due to the lack of theoretical explanations in early treatises: mutation of the hexachords, cases when accidentals do not mean the alteration of notes, rhetorical means, partial signatures, etc. 3) Interpretations made by early theorists which also caused the recent debate, due to their diverse views or joining with other independent theories: the role of accidental signatures, relationship between the church modes and the hexachord, rejection of the concept of the church modes in polyphony with musica ficta. In spite of the heated debate, scholars generally agree on that almost all the functions of musica ficta came from the importance of linear structure, and that, from the 15th century, the "modern Meaning" of accidentals(alteration of individual pitches, rhetorical means) began to take precedence over other traditional one, in accordance with the growing felling for the simultaneous control of sonority. These agreements can be supported by new theoretical suggestions made around that time(an octave scale with new syllables or with twelve modern chromatic steps, appearances of A^#, newly coined terms for musica ficta, etc.) and stylistic changes in music itself(the change in the pattern of partial signatures, and decline on the use of itself).

Alkylhalide가 Mouse의 LDH isozyme 분포에 미치는 영향 : Cellulose Acetate Electrophoresis Method

권미경,김영옥,박은주,이동화,이명미,이문희,이양자 曉星女子大學校 藥學大學 學生會 1988 曉星藥誌 Vol.4 No.-

The effect of Carbontetrachloride administration on Lactatedehydrogenase isozyme patterns were analyzed by cellulose acetate electrophoresis for the brain, heart, kidney, lung, liver and mouse muscle. Each other tissue was found to have a characteristic distribution of these isozymes. At normal condition, aerobic tissue such as brain, heart, kidney, and lung were found to have all five isozymes from LDH_1 to LDH_5, while anaerobic tissues such as liver and muscle were found to have superiorly LDH_5 The toxicity of Carbontetrachloride administration was most prominence in the liver, and lung toxicity was occured also.