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자궁경부 상피내 병변 환자에서 LEETZ 원추절제술 후 HPV DNA Test 추적 검사의 임상적 의의
김미향,이태화,오영림,이천준,김원규 고신대학교 의과대학 2009 고신대학교 의과대학 학술지 Vol.24 No.2
Objective: This study was performed to investigate the clinical significance and timing of HPV test for follow up of patients after LEETZ treatment in CIN lesion Methods: From January 2005 to December 2008, 105 patients with CIN were treated with LLETZ at Kosin university gospel hospital, Busan, Korea. After LEETZ, HPV test and Pap smear were done after 3months. Every HPV typing was done by HPV DNA chip. Results: A total of 105 cases were enrolled in this study. There were 25 patients with CINⅠ, 38 with CINⅡ, 42 with CINⅢ. Mean age was 41.95 years (range, 23-71 years) at the time of LEETZ. Positive HPV DNA was found about 72.4% before LEETZ procedure and subtype 16 was the most common type (10.5%), follow by subtype 18 (6.6%) and subtype 58 (6.6%). During follow up after LEETZ, 65.6% had negative result after 3 month, 72.1% after 6 month, 73.9% after 9 month, 77.1% after 12 month, 79.2% after 15 month, 79.6% after 18 month, and 80.4% after 24 month. There were 2 cases of abnormal pap smear among persistent positive HPV DNA cases and no abnormal pap smear results in negative HPV DNA cases during follow up. Conclusion: Positive HPV DNA was found about 72.4% before LEETZ procedure and subtype 16 was the most common type (10.5%), follow by subtype 18 (6.6%) and subtype 58 (6.6%). We suggest that HPV DNA test is recommended per 6 Months, and close observation is recommended in persistent positive HPV DNA test cases.
송미숙,전기홍,송현종,김정은,박승구,신상건,이동훈,정성현,최연주,최완철,최민규,황재철,홍지만 아주대학교 1997 아주의학 Vol.2 No.2
This study was performed to identify risk factors for depression among the elderly in a rural area. A survey was done for the elderly living in Gosam-myenn, Ansung-kun during the period of July 28, 1997 and July 30, 1997. Demographic and sodoeconornic characteristics, and functional and health Status were assessed using a structured questionnaire, and the level of depression was measured by GDS score. The data obtained were analyzed by frequencies, percentage, t-test, ANOVA, and multiple regression, and the results were as follows: 1. The total sample consisted of 133 elderly. Of them, 47 elderly (35.4%) showed significant depressive Symptoms. 2. The GDS score was the highest for the group over 85 years of age (p < 0.05). Those living alone or widowed showed lower GDS score than those living with someone or married (p < 0.05). 3. The GDS score was the highest in the absolutely dependent group, followed by the partially dependent group, and the independent group (p < 0.01). The elderly who perceived their health Status as excellent showed the lowest GDS score. In contrast, those who had more than five chronic diseases showed the highest GDS score. 4. The elderly receiving financial and emotional support from their family or friends showed lower GDS score compared to those without any support. 5. The economically dependent group showed higher GDS score than that of independent group. 6. The elderly who involved in leisure activities showed lower GDS score than those without any involvement. 7. In terms of risk factors for depression, we found that perceived health Status, subjective economic Status, leisure activities, living arrangement and financial support were inversely associated with GDS score, whereas labor support was positively associated with GDS score. Based upon the above findings, this study suggests that these risk factors for depression in the elderly should be taken into consideration for a comprehensive mental health program for the elderly living in the rural area.
패혈증을 동반한 Clostridium perfringens에 의한 간농양 1례
배인규,조용균,홍성수,김승규,조윤행,정두련,김미나,우준희,배직현,류지소 대한화학요법학회 1999 대한화학요법학회지 Vol.17 No.3
저자들은 아직 국내에 보고된 적이 없는 C. perfringens에 관한 간농양과 이에 동반된 전격성 패혈증으로 증상 발현 후 24시간 이내에 사망하였던 증례를 경험하였기에 보고하는 바이다. Clostridial infection usually occurred in association with trauma, malignancy, or intra-abdominal disease. Liver abscess by Clostridium perfringens is very rare and has not been reported in Korea .We experienced a case of liver abscess by C. perfringens in a 70-year-old man who was presented with fever. He developed a progressive jaundice and sepsis. Abdominal CT scan showed about 7×7 ㎝ sized liver abscess and gas formation within abscess. We underwent percutaneous drainage of a hepatic abscess and empirical antimicrobial therapy. The patient died less than 24 hours after presentation. C. perfnngens was identified from blood and aspirate of liver abscess.
이규완,이충휘,조상현,박정미 한국전문물리치료학회 2001 한국전문물리치료학회지 Vol.8 No.1
The purposes of this study were to investigate the therapeutic effects of an early exercise program after mastectomy and to provide the early exercise program protocol for patients who had undergone mastectomy. The subjects were seventy women who were diagnosed with breast cancer. They were randomly assigned either to a experimental group (n=35) that received early postoperative exercise program or to a control group (n=35) that received only education by nurses. Data were obtained for each patient from goniometric measurements of shoulder flexion, abduction, external rotation, 10 elements of functional performance, and subjective pain evaluation using visual analogue scale (VAS). All variables were measured preoperatively, three days postoperatively, and one month postoperatively. Data were compared by groups using independent t-test and Mann-Whitey U test for parametric or non-parametric data, respectively. There were no significant differences between the groups for all variables preoperatively and at three days postoperatively. But there were significant differences at one month postoperatively. The experimental group showed a statisti-cally significant increases in shoulder flexion, abduction, and external rotation and in the pain VAS at one month Postoperatively (p〈,05). Also, at one month prostoperatively, the experimental group had less difficulty with three elements of functional performance-doing up a 'back' zippered article of clothing, reaching the ipsilateral scaula, and contralateral scapula with the fingers on the operated side- than the control group (p〈.05). The results of this study suggest that after mastectomy, the early exercise program conducted by a well-trained physical therapist can make a significant contribution to the return of more normal shoulder function and activities of daily living and to an increased quality of life.
마비성구어장애인의 조음향상을 위한 철자판 시·청각적 중재 적용 사례연구
박미진,최양규 대구대학교 특수교육재활과학연구소 2008 再活科學硏究 Vol.26 No.2
신경학적인 손상이나 질환으로 생길 수 있는 의사소통 장애 가운데 가장 많은 비중을 차지하고 있는 것이 마비성 구어장애(dysarthria)이다. 본 연구는 철자판을 이용한 시·청각적 중재가 마비성 구어장애인의 조음향상에 어떠한 영향을 주는지를 알아보는 데 그 의의를 둔다. 연구 대상자는 평균연령 56세로 경직형, 이완형, 실조형의 마비성 구어장애인 3명을 대상으로 하였다. 대상자 선별 평가도구로 구강안면 기능 평가, 자음 정확도 평가, 문장 발화 속도 평가, 교호 운동속도 평가를 실시하였다. 중재 프로그램은 총 5단계로 핵심어휘 확인하기, 핵심어휘 철자 조합하기, 핵심 어휘 따라 말하기, 읽기, 말하기 단계로 구성하였다. 각 단계마다 하위 단계로 구성되어 있으며 각각의 브렌치 단계가 있다. 실험 철자는 기초선, 중재, 유지 단계로 대상자 간 중다 기초선 설계를 사용하였으며 각 단계마다 대상자의 교호 운동속도(SMR), 단어 명료도 점수, 문장 명료도 점수를 평가하였다. 이 연구의 결과는 철자판을 이용한 시·청각적 중재가 마비성 구어장애인의 교호 운동속도를 빨라지게 하였으며 단어 명료도와 문장 명료도를 향상시켰다. The purpose of this study is to examine how the Visual and Auditory Treatment Program of the spelling board effects the Dysarthric Speech, particulary in Sequential Motion Rate, Word Intelligibility and Sentence Intelligibility. For this purpose, ataxic dysarthric subject, spastic dysarthric subject and flaccid dysarthric subject, were selected in the four screening tests. The program consisted of 5 steps. The first step was check out the target vocabulary. The second step was to a combination of spelling. The third step was repeating to the vocabulary. The forth step was reading to the target vocabulary. The fifth step was saying to the target vocabulary. Each step was consisted sub-steps. The program was performed using subjects that consisted of three stages; baseline stage, treatment stage and maintenance stage. The results was as follows; The first, Visual and Auditory Treatment Program of the spelling board was effective in developing Sequential Motion Rate in the Dysarthric subjects. The second, Visual and Auditory Treatment Program of the spelling board increased the word intelligibility of the Dysarthric subjects. The third, Visual and Auditory Treatment Program of the spelling board increased the sentence intelligibility of the Dysarthric subjects. 신경학적인 손상이나 질환으로 생길 수 있는 의사소통 장애 가운데 가장 많은 비중을 차지하고 있는 것이 마비성 구어장애(dysarthria)이다. 본 연구는 철자판을 이용한 시·청각적 중재가 마비성 구어장애인의 조음향상에 어떠한 영향을 주는지를 알아보는 데 그 의의를 둔다. 연구 대상자는 평균연령 56세로 경직형, 이완형, 실조형의 마비성 구어장애인 3명을 대상으로 하였다. 대상자 선별 평가도구로 구강안면 기능 평가, 자음 정확도 평가, 문장 발화 속도 평가, 교호 운동속도 평가를 실시하였다. 중재 프로그램은 총 5단계로 핵심어휘 확인하기, 핵심어휘 철자 조합하기, 핵심 어휘 따라 말하기, 읽기, 말하기 단계로 구성하였다. 각 단계마다 하위 단계로 구성되어 있으며 각각의 브렌치 단계가 있다. 실험 철자는 기초선, 중재, 유지 단계로 대상자 간 중다 기초선 설계를 사용하였으며 각 단계마다 대상자의 교호 운동속도(SMR), 단어 명료도 점수, 문장 명료도 점수를 평가하였다. 이 연구의 결과는 철자판을 이용한 시·청각적 중재가 마비성 구어장애인의 교호 운동속도를 빨라지게 하였으며 단어 명료도와 문장 명료도를 향상시켰다. The purpose of this study is to examine how the Visual and Auditory Treatment Program of the spelling board effects the Dysarthric Speech, particulary in Sequential Motion Rate, Word Intelligibility and Sentence Intelligibility. For this purpose, ataxic dysarthric subject, spastic dysarthric subject and flaccid dysarthric subject, were selected in the four screening tests. The program consisted of 5 steps. The first step was check out the target vocabulary. The second step was to a combination of spelling. The third step was repeating to the vocabulary. The forth step was reading to the target vocabulary. The fifth step was saying to the target vocabulary. Each step was consisted sub-steps. The program was performed using subjects that consisted of three stages; baseline stage, treatment stage and maintenance stage. The results was as follows; The first, Visual and Auditory Treatment Program of the spelling board was effective in developing Sequential Motion Rate in the Dysarthric subjects. The second, Visual and Auditory Treatment Program of the spelling board increased the word intelligibility of the Dysarthric subjects. The third, Visual and Auditory Treatment Program of the spelling board increased the sentence intelligibility of the Dysarthric subjects.
난분해성 유기물질 제거를 위한 오존/촉매 공정의 비교에 관한 연구
이규환,이유미,이동석 강원대학교 산업기술연구소 2006 産業技術硏究 Vol.26 No.A
Ozone alone and catalytic ozone processes were introduced for treatment of humic acid, which is representative refractory organic compound. The treatment efficiencies of humic acid in each process were analyzed in pH variation, DOC removal, and UV_(254) decrease. Mn loaded GAC catalyst was prepared by loading potassium permanganate onto the granular activated carbon surface. BCM-GAC and BCM-Silica gel catalyst were prepared by BCM. UV_(254) decrease in all processes was comparatively high with efficiency over 87%. DOC removal in ozone/GAC process was the highest with 78%, and removal rates for other processes followed the order ozone/BCM-GAC(62%) > ozone/BCM-silica gel(45%) > ozone/silica gel(43%) > ozone/Mn Loaded GAC(42%) > ozone alone(37%).
반몰입형 가상현실 시스템을 이용한 게임 및 시지각 훈련 컨텐츠 개발
박동규,천미향,한경임 국립7개대학공동논문집간행위원회 2003 공업기술연구 Vol.3 No.-
A Fully immersive virtual reality system requires much cost and heavy equipments, therefore still far away from general-purpose equipment. Our system requires only CCD camera and beam projector system for implementing half-immersive virtual reality system. We acquire user's action from CCD camera and show interactive moving picture in 2-dimensional screen space. We implemented some kinds of digital contents on our system, which can be used in interactive computer game and for developing person's sense of eyesight and perception.
대장균에서 대량 생산한 B형 간염바이러스 X 단백질의 발현 특성
정미경,민성식,이희구,오은숙,이혜경,이태규,임종순,박순희 大韓免疫學會 1996 大韓免疫學會誌 Vol.18 No.4
The X protein of human hepatitis B virus (HBx) consists of 154 amino acids and transactivates various cellular and viral promoters and enhancers. This protein has been also implicated in virus-mediated oncogenesis of hepatocytes. However, there are still controversial reports on its mechanism related to its oncogenicity. To elucidate the presence of any correlation between immune responses against HBx protein and hepatitis pathogenicity, convenient sources for recombinant HBx protein and anti-HBx antibodies are necessary. Three recombinant vectors were constructed to express the X open reading frame (ORF) of hepatitis B virus in E. coli. Recombinant E. coli transformed with one of these plasmid, pET- AX plasmid, which containd X ORF deleted in N-terminus, did not produce HBx protein. However, when X ORF containing 154 amino acids was cloned in pET, the HBx protein was produced. A GST fusion protein containing 146 amino acids encoded by ORF X was also successfully expressed. This protein was produced in large quantities of more than-60% of total proteins However, nonfused HBx protein was produced in small quantities. As both proteins were produced in inclusion bodies, HBx recombinant GST-fusion protein was further proccessed for purification. GST-X fusion protein was solubilized by sarkosyl. The solublized protein was purified by affinity to glutathione sepharose bead. The purified HBx protein was fairly good immunogen eliciting good humoral immune responses in mice. We produced polyclonal antibodies against HBx recombinant proteins and confirmed the specificity of the antibodies.