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Skin Safety Evaluation of Pectinase Lyase-modified Red Ginseng (GS-E3D) in Human Patch Test
Mi Kyung Pyo(표미경),Gyeong Hee Lee(이경희),Jin Seong Kim(김진성),Yun Ho Jo(조윤호),You Jin Lee(이유진),Dayu Jung(정다유),Dae Seok Yoo(유대석),Won Yong Kim(김원용),Seon Woo Cha(차선우),Ki Young Park(박기용),Ki Moo Lee(이기무) 한국약용작물학회 2018 한국약용작물학회 학술대회논문집 Vol.2018 No.2
Evaluation of Acute oral and Dermal Toxicity of Pectinase Lyase-modified Red Ginseng (GS-E3D)
Mi Kyung Pyo(표미경),Gyeong Hee Lee(이경희),Jin Seong Kim(김진성),Yun Ho Jo(조윤호),You Jin Lee(이유진),Dayu Jung(정다유),Dae Seok Yoo(유대석),Won Yong Kim(김원용),Seon Woo Cha(차선우),Ki Young Park(박기용),Ki Moo Lee(이기무) 한국약용작물학회 2018 한국약용작물학회 학술대회논문집 Vol.2018 No.2
Safety of Pectinase Lyase-modified Red Ginseng (GS-E3D) on Acute and Genetic Toxicity
Mi Kyung Pyo(표미경),Ji Sun Lee(이지선),You Jin Lee(이유진),Yun Ho Jo(조윤호),Dayu Jung(정다유),Won Yong Kim(김원용),Jin Seong Kim(김진성),Dae Seok Yoo(유대석),Sang Won Cho(조상원),Seon Woo Cha(차선우) 한국약용작물학회 2019 한국약용작물학회 학술대회논문집 Vol.2019 No.2
홍삼가수분해추출물의 db/db 마우스에서 신장 손상 예방효과
김찬식 ( Chan-sik Kim ),조규형 ( Kyuhyung Jo ),표미경 ( Mi Kyung Pyo ),김진숙 ( Jin Sook Kim ),김정현 ( Junghyun Kim ) 대한본초학회 2018 大韓本草學會誌 Vol.33 No.4
Objectives : Diabetic nephropathy is one of the most significant chronic complications of diabetes. Advanced glycation end products (AGEs) have been implicated in the development of diabetic nephropathy. GS-E3D is an enzymatic modified red ginseng extract by pectin lyase and has an increased concentration of the ginsenoside Rd compared to an unmodified red ginseng extract. In this study, we evaluated the preventive effects of GS-E3D on renal dysfunction in the type 2 diabetic db/db mice. Methods : GS-E3D (100 or 250 ㎎/㎏ body weight per day) was given to db/db mice through oral gavage for 6 weeks. Body weight and blood glucose levels were examined. At the end of the experiment, albuminuria was measured. The renal tissues were collected for histological examination, and immunohistochemical staining was used to detect renal accumulation of AGEs and podocyte loss Results : In the db/db mice, severe hyperglycemia developed, and albuminuria was significantly increased. Diabetes induced markedly morphological alterations to the renal glomerular cells. AGE accumulations and podocyte loss were detected in renal glomeruli. No difference in blood glucose levels was noted between GS-E3D-treated and vehicletreated diabetic db/db mice. However, GS-E3D treatment significantly reduced albuminuria and AGE accumulations in diabetic mice. Moreover, the loss of podocytes was restored by GS-E3D treatment. Conclusions : GS-E3D might be beneficial for the treatment of diabetic nephropathy. The ability of GS-E3D on to attenuate albuminuria and podocyte dysfunction in the db/db mice may be mediated by the inhibition of AGE accumulation.