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Mervat M. El-Eshmawy,Enas M. Elkhamisy,Eman Elsayed,Shaheer Kamal 대한당뇨병학회 2017 Diabetes and Metabolism Journal Vol.41 No.3
Background: Low circulating prolactin hormone was associated with increased risk for type 2 diabetes mellitus. An inverse association of serum prolactin with cardiac remodeling was also previously suggested. Thus, the first question arises whether low serum prolactin is associated with adverse cardiac remodeling in subjects with prediabetes and if so what the impact of gender is? Second, could serum prolactin be considered a predictor of cardiac morbidity in those subjects? This study was conducted to assess prolactin level variations in relation to echocardiographic indices of cardiac remodeling among adult men and women with prediabetes. Methods: This cross sectional study enrolled 80 subjects with prediabetic; 40 men and 40 women. Anthropometric measurements, plasma glucose, lipid profile, homeostasis model assessment of insulin resistance, white blood cells count, prolactin and echocardiography were assessed. Results: Prolactin was significantly lower in men than in women with prediabetes. Left ventricular mass (LVM) was significantly higher in men than in women with prediabetes. The proportion of left ventricular hypertrophy (LVH) in men with prediabetes was 45% compared with 22.5% in women (P=0.03). We also found inverse independent associations of serum prolactin with LVM and LVH in men, but not in women. Conclusion: In prediabetes, physiologically low serum prolactin is an independent predictor of increased LVM and LVH in adult men, but not in women. Prolactin may be a potential diagnostic biomarker for cardiac remodeling in adult men with prediabetes.
( Mervat Morsy Abbas Ahmed El-gendy ),( Hind A. A. Al-zahrani ),( Ahmed Mohamed Ahmed El-bondkly ) 한국균학회 2016 Mycobiology Vol.44 No.3
In the screening of marine mangrove derived fungi for lovastatin productivity, endophytic Aspergillus luchuensis MERV10 exhibited the highest lovastatin productivity (9.5 mg/gds) in solid state fermentation (SSF) using rice bran. Aspergillus luchuensis MERV10 was used as the parental strain in which to induce genetic variabilities after application of different mixtures as well as doses of mutagens followed by three successive rounds of genome shuffling. Four potent mutants, UN6, UN28, NE11, and NE23, with lovastatin productivity equal to 2.0-, 2.11-, 1.95-, and 2.11-fold higher than the parental strain, respectively, were applied for three rounds of genome shuffling as the initial mutants. Four hereditarily stable recombinants (F3/3, F3/7, F3/9, and F3/13) were obtained with lovastatin productivity equal to 50.8, 57.0, 49.7, and 51.0 mg/gds, respectively. Recombinant strain F3/7 yielded 57.0 mg/gds of lovastatin, which is 6-fold and 2.85-fold higher, respectively, than the initial parental strain and the highest mutants UN28 and NE23. It was therefore selected for the optimization of lovastatin production through improvement of SSF parameters. Lovastatin productivity was increased 32-fold through strain improvement methods, including mutations and three successive rounds of genome shuffling followed by optimizing SSF factors.
Mervat Mahrous,Walid Al Morsy,Ahmed Al-Hujaily,Sameerah AL-Sulimani 한국유방암학회 2012 Journal of breast cancer Vol.15 No.2
Metastasis to the breast from extra-mammary tumors is rare with only a few sporadic cases reported. We present a 58-yearold female patient diagnosed with renal cell carcinoma. Five years ago she had a radical nephrectomy and was free of disease, then discovered solitary breast mass following self-examination. The patient presented to the breast clinic for evaluation whereupon the breast mass was identified on physical and radiological examinations. Fine needle aspiration was diagnostic of metastatic renal cell carcinoma and subsequent imaging studies demonstrated multiple pulmonary deposits and recurrent renal mass in the tumor bed of the diseased site. In a multidisciplinary clinic, the patient was elected for excision biopsy followed by systemic tyrosine kinase inhibitor therapy. Six months later she had brain metastasis and received whole brain irradiation followed by palliative therapy. We are presenting this rare case with the aim of increasing awareness of breast secondaries.
( Mervat Morsy Abbas Ahmed El-gendy ),( Naziha M. Hassanein ),( Hussein Abd El-hay Ibrahim ),( Doaa H. Abd El-baky ) 한국균학회 2017 Mycobiology Vol.45 No.2
The ability of dead cells of endophytic Drechslera hawaiiensis of Morus alba L. grown in heavy metals habitats for bioremoval of cadmium (Cd<sup>2+</sup>), copper (Cu<sup>2+</sup>), and lead (Pb<sup>2+</sup>) in aqueous solution was evaluated under different conditions. Whereas the highest extent of Cd<sup>2+</sup> and Cu<sup>2+</sup> removal and uptake occurred at pH 8 as well as Pb<sup>2+</sup> occurred at neutral pH (6-7) after equilibrium time 10 min. Initial concentration 30 mg/L of Cd<sup>+2</sup> for 10 min contact time and 50 to 90 mg/L of Pb<sup>2+</sup> and Cu<sup>2+</sup> supported the highest biosorption after optimal contact time of 30 min achieved with biomass dose equal to 5 mg of dried died biomass of D. hawaiiensis. The maximum removal of Cd<sup>2+</sup>, Cu<sup>2+</sup>, and Pb<sup>2</sup> equal to 100%, 100%, and 99.6% with uptake capacity estimated to be 0.28, 2.33, and 9.63 mg/g from real industrial wastewater, respectively were achieved within 3 hr contact time at pH 7.0, 7.0, and 6.0, respectively by using the dead biomass of D. hawaiiensis compared to 94.7%, 98%, and 99.26% removal with uptake equal to 0.264, 2.3, and 9.58 mg/g of Cd<sup>2+</sup>, Cu<sup>2+</sup>, and Pb<sup>2+</sup>, respectively with the living cells of the strain under the same conditions. The biosorbent was analyzed by Fourier Transformer Infrared Spectroscopy (FT-IR) analysis to identify the various functional groups contributing in the sorption process. From FT-IR spectra analysis, hydroxyl and amides were the major functional groups contributed in biosorption process. It was concluded that endophytic D. hawaiiensis biomass can be used potentially as biosorbent for removing Cd<sup>2+</sup>, Cu<sup>2+</sup>, and Pb<sup>2+</sup> in aqueous solutions.
Mervat M. El-Eshmawy,Hala A. Abd El-Hafez,Walaa Othman El Shabrawy,Ibrahim A. Abdel Aal 대한당뇨병학회 2013 Diabetes and Metabolism Journal Vol.37 No.6
Background: Recent evidence has suggested an association between subclinical hypothyroidism (SCH) and microalbuminuria in patients with type 2 diabetes. However, whether SCH is related to microalbuminuria among subjects with prediabetes has not been studied. Thus, we evaluated the association between SCH and microalbuminuria in a cohort of prediabetic Egyptian adults. Methods: A total of 147 prediabetic subjects and 150 healthy controls matched for age and sex were enrolled in this study. Anthropometric measurements, plasma glucose, lipid profile, homeostasis model assessment of insulin resistance (HOMA-IR),thyroid stimulating hormone (TSH), free thyroxine, triiodothyronine levels, and urinary albumin-creatinine ratio (UACR) were assessed. Results: The prevalence of SCH and microalbuminuria in the prediabetic subjects was higher than that in the healthy controls (16.3% vs. 4%, P<0.001; and 12.9% vs. 5.3%, P=0.02, respectively). Prediabetic subjects with SCH were characterized by significantly higher HOMA-IR, TSH levels, UACR, and prevalence of microalbuminuria than those with euthyroidism. TSH level was associated with total cholesterol (P=0.05), fasting insulin (P=0.01), HOMA-IR (P=0.01), and UACR (P=0.005). UACR was associated with waist circumference (P=0.01), fasting insulin (P=0.05), and HOMA-IR (P=0.02). With multiple logistic regression analysis, SCH was associated with microalbuminuria independent of confounding variables (β=2.59; P=0.01). Conclusion: Our findings suggest that prediabetic subjects with SCH demonstrate higher prevalence of microalbuminuria than their non-SCH counterparts. SCH is also independently associated with microalbuminuria in prediabetic subjects. Screening and treatment for SCH may be warranted in those patients.
Ziziphus spina-christi based bio-synthesis of Ag nanoparticles
Mervat F. Zayed,Wael H. Eisa,Yasser K. Abdel-Moneam,Salah M. El-kousy,Ahmed Atia 한국공업화학회 2015 Journal of Industrial and Engineering Chemistry Vol.23 No.-
The bio-production of silver nanoparticles (Ag NPs) using Ziziphus spina-christi extract was studied as a novel, rapid, low-cost and eco-friendly route. The impact of experimental factors, such as the extract quantity, precursor concentration and pH on the size and size distribution of Ag NPs, was studied with the aid of UV–vis spectrophotometer and transmission electron microscope (TEM). The FTIR analysis was carried out to identify the functional groups in Ag NPs. The as-synthesized Ag NPs was used as a catalyst for the reduction of 4-nitrophenol (4-NP) to 4-aminophenol (4-AP) in the presence of NaBH4.
Mohamed, Mervate Mohamed,Alsaiari, Raiedhah,Al-Qadri, Fatima A.,Shedaiwa, Iman Mohammad,Alsaiari, Mabkhoot,Musa, Esraa Mohamed,Alkorbi, Faeza,Alkorbi, Ali S. The Corrosion Science Society of Korea 2022 Corrosion Science and Technology Vol.21 No.5
Cyclic Voltammetry and weight loss measurements were used to investigate corrosion prevention of tin in a 0.5M citric acid solution containing Anthocyanins extracted from grapes at various concentrations and temperatures. Results showed that the investigated chemicals, Anthocyanins extracted from grapes, performed well as tin corrosion inhibitors in 0.5M citric acid. Increasing the concentration of Anthocyanins increased their corrosion inhibition efficiencies. When the temperature dropped, their inhibition efficiencies, increased indicating that higher temperature tin dissolution predominated the adsorption of Anthocyanins at the surface of tin metal. When inhibitor concentrations were increased, their inhibition efficiencies were also increased. These results revealed that corrosion of tin metal was inhibited by a mixed type of adsorption on the metal surface. The adsorption isotherm of Langmuir governed the adsorption of Anthocyanins. Thermodynamic parameters such as the enthalpy of adsorption, the entropy of adsorption, and Gibbs free energy and kinetic parameters such as activation energy, enthalpy of activation, and entropy of activation were computed and discussed in this study.
Ahmed Sallam,Mervat Hashad,El-Sayed Hamed,Mohamed I. Hassan 한국작물학회 2015 Journal of crop science and biotechnology Vol.18 No.5
The frequency, duration, and severity of heat and drought stresses singly or in combination can be aggravated by climate change. Under these stresses, the stored carbohydrates in stems play an important role in grain filling in wheat (Triticum aestivum L.) post-anthesis. This study examines the genetic variation of stem characters in wheat and their role in supporting grain weight under favorable and drought, combined drought, and heat conditions. Field experiments were conducted with seven spring wheat genotypes along with their F1 and F2 progenies. Stem diameter (SD), stem density (SDN), and stem weight (SW) were measured in 21 F1 (half-diallel analysis) and 12 F2 (3 x 4 North Carolina Design II) crosses. Among stem characters, SD was significantly correlated with thousand kernel weight (TKW) and grain yield per spike (GYPS) in all environments in F1 and F2. All characters showed high heritability estimates. For stem characters, the highest heritability was found for SD in both generations. High positive phenotypic and genotypic correlations were found between stem characters and both TKW and GYPS. The correlation between reductions due to stress (%) in stem characters and reduction due to stress in TKW and GYPS confirmed the strong relationships between stem characters and yield attributes in the stressed environments. We conclude that stem characters, especially SD, may play an important role in sustaining grain filling under such conditions. This is possibly due to a greater stem capacity for assimilates storage post-anthesis and subsequent remobilization to the grains.