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Qingli Meng,Kejun Wang,Xiallei Liu,Haishen Zhou,Li Xu,Zhaojun Wang,Meiying Fang 아세아·태평양축산학회 2017 Animal Bioscience Vol.30 No.4
Objective: The aim of this study is to identify genomic regions or genes controlling growth traits in pigs. Methods: Using a panel of 54,148 single nucleotide polymorphisms (SNPs), we performed a genome-wide Association (GWA) study in 562 pure Yorshire pigs with four growth traits: average daily gain from 30 kg to 100 kg or 115 kg, and days to 100 kg or 115 kg. Fixed and random model Circulating Probability Unification method was used to identify the associations between 54,148 SNPs and these four traits. SNP annotations were performed through the Sus scrofa data set from Ensembl. Bioinformatics analysis, including gene ontology analysis, pathway analysis and network analysis, was used to identify the candidate genes. Results: We detected 6 significant and 12 suggestive SNPs, and identified 9 candidate genes in close proximity to them (suppressor of glucose by autophagy [SOGA1], R-Spondin 2 [RSPO2], mitogen activated protein kinase kinase 6 [MAP2K6], phospholipase C beta 1 [PLCB1], rho GTPASE activating protein 24 [ARHGAP24], cytoplasmic polyadenylation element binding protein 4 [CPEB4], GLI family zinc finger 2 [GLI2], neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2 [NYAP2], and zinc finger protein multitype 2 [ZFPM2]). Gene ontology analysis and literature mining indicated that the candidate genes are involved in bone, muscle, fat, and lung development. Pathway analysis revealed that PLCB1 and MAP2K6 participate in the gonadotropin signaling pathway and suggests that these two genes contribute to growth at the onset of puberty. Conclusion: Our results provide new clues for understanding the genetic mechanisms underlying growth traits, and may help improve these traits in future breeding programs.
Qing-Quan Tan,Zong-Yao Sun,Ting Li,Qing-Hua Meng 제어·로봇·시스템학회 2017 International Journal of Control, Automation, and Vol.15 No.6
In this paper, we introduce a new method to solve the problem of output tracking control for a class ofgeneralized high-order uncertain nonlinear systems with disturbance. A key contribution of this paper is a resultrelating its serious uncertainties including unknown high-order terms, unknown nonlinear functions and the signalto be tracked. The main result is that the tracking error belongs to a prescribed small neighborhood of the origin infinite time. Design procedure is presented by improved adding a power integrator method.
Qing-Wei Meng,Qing-Yu Xu,Pan Deng,Kai-Yun Fu,Wen-Chao Guo,Guo-Qing Li 한국응용곤충학회 2018 Journal of Asia-Pacific Entomology Vol.21 No.2
Some insect growth disruptors (IGDs), such as pyriproxyfen and halofenozide, may be used to control Leptinotarsa decemlineata. However, their mechanism of action remains elusive. Methoprene-tolerant (Met) mediates juvenile hormone (JH) signal to control numerous essential physiological processes. In the present paper, we identified a Met gene (LdMet). LdMet protein was a typical basic helix-loop-helix/Per-Arnt-Sim (bHLHPAS) transcription factor with a bHLH domain, two PAS domains (PAS-A and PAS-B) and a region called PAS associated C terminal (PAC). Eight conserved amino acids critical for JH binding were located in PAS-B and PAC domains. The temporal expression pattern of LdMet was in accordance with the variation of circulating JH titers. Feeding of juvenoid methoprene or pyriproxyfen, or provide for JH dose-dependently stimulated the expression of LdMet. RNA interference-mediated knockdown of two JH degradation genes increased the transcription of LdMet, while silencing of a JH biosynthesis gene repressed the transcription. Conversely, ingestion of an ecdysteroid agonist halofenozide or 20-hydroxyecdysone (20E) reduced the mRNA levels of LdMet, in a dosedependent manner, whereas knockdown of either ecdysteroidogenesis or 20E signaling genes increased the mRNA accumulation. Providing that the expression of LdMet can be disturbed by methoprene, pyriproxyfen and halofenozide, LdMet may be a potential target of these IGDs in L. decemlineata larvae.
( Qing Meng ),( Hyoung-chun Kim ),( Seikwan Oh ),( Yong-moon Lee ),( Zhenzhen Hu ),( Ki-wan Oh ) 한국응용약물학회 2018 Biomolecules & Therapeutics(구 응용약물학회지) Vol.26 No.5
Cocaine- and amphetamine-regulated transcript (CART) peptide is a widely distributed neurotransmitter expressed in the central nervous systems. Previously, several reports demonstrated that nucleus accumbal-injected CART peptide positively modulated behavioral sensitization induced by psychostimulants and regulated the mesocorticolimbic dopaminergic pathway. It is confirmed that CART peptide exerted inhibitory effect on psychostimulant-enhanced dopamine receptors signaling, Ca<sup>2+</sup>/calmodulin-dependent kinase signaling and crucial transcription factors expression. Besides modulation of dopamine receptors-related pathways, CART peptide also exhibited elaborated interactions with other neurotransmitter receptors, such as glutamate receptors and γ-aminobutyric acid receptors, which further account for attribution of CART peptide to inhibition of psychostimulant-potentiated locomotor activity. Recently, CART peptide has been shown to have anxiolytic functions on the aversive mood and uncontrolled drug-seeking behaviors following drug withdrawal. Moreover, microinjection of CART peptide has been shown to have an antidepressant effect, which suggests its potential utility in the mood regulation and avoidance of depression-like behaviors. In this review, we discuss CART pathways in neural circuits and their interactions with neurotransmitters associated with psychostimu-lant- induced depression.
Qing Bo Meng,양고수,이연식 한국공업화학회 2014 Journal of Industrial and Engineering Chemistry Vol.20 No.4
Optipore V503, a commercial hypercrosslinked hydrophobic polymer adsorbent, was sulfonated to become hydrophilic to allow more efficient microwave-assisted desorption of adsorbed nonpolar volatile organic compounds (VOCs) such as benzene under humidified conditions. Compared to Optipore V503, the hydrophilic adsorbents showed reduced adsorption capacities towards benzene, but significantly improved microwave-assisted desorption efficiencies under a semi-continuous 600 W microwave irradiation process. The increased desorption efficiency was mainly attributed to adsorbed water, which indirectly allowed heating of the polymer adsorbents to higher temperatures upon irradiation by microwaves.
Meng, Qing,Kim, Hyoung-Chun,Oh, Seikwan,Lee, Yong-Moon,Hu, Zhenzhen,Oh, Ki-Wan The Korean Society of Applied Pharmacology 2018 Biomolecules & Therapeutics(구 응용약물학회지) Vol.26 No.5
Cocaine- and amphetamine-regulated transcript (CART) peptide is a widely distributed neurotransmitter expressed in the central nervous systems. Previously, several reports demonstrated that nucleus accumbal-injected CART peptide positively modulated behavioral sensitization induced by psychostimulants and regulated the mesocorticolimbic dopaminergic pathway. It is confirmed that CART peptide exerted inhibitory effect on psychostimulant-enhanced dopamine receptors signaling, $Ca^{2+}$/calmodulin-dependent kinase signaling and crucial transcription factors expression. Besides modulation of dopamine receptors-related pathways, CART peptide also exhibited elaborated interactions with other neurotransmitter receptors, such as glutamate receptors and ${\gamma}$-aminobutyric acid receptors, which further account for attribution of CART peptide to inhibition of psychostimulant-potentiated locomotor activity. Recently, CART peptide has been shown to have anxiolytic functions on the aversive mood and uncontrolled drug-seeking behaviors following drug withdrawal. Moreover, microinjection of CART peptide has been shown to have an antidepressant effect, which suggests its potential utility in the mood regulation and avoidance of depression-like behaviors. In this review, we discuss CART pathways in neural circuits and their interactions with neurotransmitters associated with psychostimulant-induced depression.
Qing-Hua Meng,Zong-Yao Sun,Yushan Li 제어·로봇·시스템학회 2018 International Journal of Control, Automation, and Vol.16 No.4
A smooth control method may do not obtain a desired convergence. On the other hand, a no-continuous method may cause a close-loop system to chatter. In order to avoid the aforementioned disadvantages, a non-smooth finite-time control method is proposed and applied on an active four-wheel-steering electric vehicle driven by four in-wheel motors to improve the safety and manoeuvrability in this paper. Based on an ideal electric vehicle steering tracking model, a non-smooth finite-time convergence controller is constructed for controlling the four wheels’ steering angles of an electric vehicle. The front wheel cornering stiffness, rear wheel cornering stiffness and external disturbance of a practical car are regarded as bounded uncertain parameters according to practical conditions. An A-class car model in the Carsim software is utilized to simulate the designed controller. The simulation results show that the controller based on finite-time convergence can track the ideal vehicle steering model better to obtain zero sideslip angle and expected yaw rate even when there exist perturbation of cornering stiffness and disturbance of lateral wind. It means the control system of the electric vehicle is robust with uncertainty. The simulation results also show that the non-smooth finite-time control method is better than the slide mode control method for the active four-wheel-steering system of the electric vehicle.