Giant invasive mole presenting as a cause of abdominopelvic mass in a perimenopausal woman: An unusual presentation of a rare pathology

( Alpaslan Akyol ),( Memet Simsek ),( Ozlem Ucer ) 대한산부인과학회 2016 Obstetrics & Gynecology Science Vol.59 No.6

Invasive mole is a benign gestational trophoblastic disease that arises from the myometrial invasion of any gestational event via direct extension through tissue or vascular structures. Invasive mole (and other gestational trophoblastic diseases) may present with life-threatening complications including uterine perforation, excessive bleeding, acute hemoperitoneum, and abdominal pain. We report a case of invasive mole presenting as abdominal distention in a 51-year-old perimenopausal woman (gravida 12, para 12, abortion 0). The patient was admitted to the gynecology clinic with a giant uterine mass filling the pelvic and abdominal cavity. To our knowledge, this is the first case in the literature of a gestational trophoblastic neoplasia presenting with uterine mass of 28 weeks` gestational size in this age group. Interestingly, complications such as uterine rupture or invasion of the adjacent structures (such as parametrial tissues or blood vessels) had not developed in our patient despite the considerable enlargement of the uterus.

Influence of Dihydropyridine Calcium Antagonist Nitrendipine on Benzo(a)pyrene-induced Oxidative Stress

Göknur Aktay,Memet Hanifi Emre,Alaadin Polat 대한약학회 2011 Archives of Pharmacal Research Vol.34 No.7

The aim of this study was to investigate the influence of nitrendipine (NIT), a dihydropyridine derived calcium channel antagonist, on polycyclic aromatic hydrocarbon benzo(a)pyrene (BAP)-induced oxidative stress. Male Sprague Dawley rats (155-220 g) were divided into four groups: Control (corn oil, i.p.); BAP (200 mg/kg, i.p.), BAP + NIT (200 mg/kg, i.p. + 50 mg/kg, i.p.), and NIT (50 mg/kg, i.p.) groups. Twenty-four hours after the injection of BAP, the rats were sacrificed and blood samples, liver, lung, and brain tissues were removed to determine serum alanine transaminase (ALT), aspartate transferase (AST), and gamma-glutamyltransferase (GGT) activities and tissue thiobarbituric acid reactive substances (TBARS), glutathione (GSH), and superoxide dismutase (SOD) levels. BAP significantly elevated serum ALT and TBARS levels in all tissues. However, NIT pre-treatment protected against increasing TBARS levels in lung and brain tissues. In addition, NIT pre-treatment significantly increased SOD levels in lung and liver tissues, as well as GSH levels in the lungs, compared to the BAP group. Thus, in conclusion, further studies are required to confirm the protective effects of calcium channel blockers, especially in liver tissue.

Histologic Evidence of New Collagen Formulation Using Platelet Rich Plasma in Skin Rejuvenation: A Prospective Controlled Clinical Study

( Ozlem Karabudak Abuaf Hamza Yildiz ),( Huseyin Baloglu ),( Memet Ersan Bilgili ),( Hasan Aktug Simsek ),( Bilal Dogan ) 대한피부과학회 2016 Annals of Dermatology Vol.28 No.6

Background: Platelet-rich plasma (PRP) is an autologous concentration of human platelets contained in a small volume of plasma and has recently been shown to accelerate rejuvenate aging skin by various growth factors and cell adhesion molecules. Objective: This study was conducted to evaluate the efficacy and safety of intradermal injection of PRP in the human facial rejuvenation. Methods: This study was a prospective, single-center, single-dose, open-label, non-randomized controlled clinical study. PRP injected to the upper site of this right infra-auricular area and all face. Saline was injected to the left infra-auricular area. Histopathological ex-aminations were performed before PRP treatment, 28 days after the PRP, and saline (control) treatments. Results: Twenty women ranging in age from 40 to 49 years (mean age, 43.65±2.43 years) were enrolled in the study. The mean op-tical densities (MODs) of collagen in the pre-treatment, con-trol, and PRP-treated area were measured. They were 539±93.2, 787±134.15, 1,019±178, respectively. In the MOD of PRP, 89.05 percent improvement was found when MOD of PRP was compared with MOD of pre-treatment. The mean MOD of collagen fibers was clearly highest on the PRP side (p<0.001). The PRP-to-saline improvement ratio (89.05% to 46.01%) was 1.93:1. No serious side effects were detected. Conclusion: PRP increases dermal collagen levels not only by growth factors, but also by skin needling (the mesotherapy technique `point by point`). PRP application could be considered as an effective (even a single applica-tion) and safety procedure for facial skin rejuvenation. (Ann Dermatol 28(6) 718∼724, 2016)

Morphology and Mechanical Properties of Thermoplastic Polyurethane/Colemanite Composites

Ferhat ?en,Seyfullah Madakba?,Emre Ba?turk,Memet Vezir Kahraman 한국고분자학회 2017 폴리머 Vol.41 No.6

The aim of this study was to improve thermal stability, mechanical and surface properties of thermoplastic polyurethane (TPU) with the addition of colemanite. The TPU/colemanite composites having various ratios of TPU and colemanite were prepared. The chemical structure of the prepared composites was investigated by Fourier transform infrared spectroscopy (FTIR). Thermal properties of the samples were evaluated by thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC). Mechanical properties of the samples were characterized with stress-strain test. Hydrophobicity of the samples was determined by the contact angle measurements. Moreover, the surface morphology of the samples was investigated by a scanning electron microscopy - energy dispersive spectrometer mapping (SEMEDS). Finally, the obtained results prove that the prepared composites have good thermal, mechanical and surface properties and that they can be used in many applications such as the electronic devices, materials engineering and other emergent.

Alpha-Amylase Immobilization on Epoxy Containing Thiol-Ene Photocurable Materials

( Cakmakci ),( Emrah ),( Ozkan Danis ),( Serap Demir ),( Yusuf Mulazim ),( Memet Vezir Kahraman ) 한국미생물 · 생명공학회 2013 Journal of microbiology and biotechnology Vol.23 No.2

Thiol-ene polymerization is a versatile tool for several applications. Here we report the preparation of epoxide groups containing thiol-ene photocurable polymeric support and the covalent immobilization of α-amylase onto these polymeric materials. The morphology of the polymeric support was characterized by scanning electron microscopy (SEM), and energy dispersive spectroscopy (EDS) coupled with SEM was used to explore the chemical composition. The polymeric support and the immobilization of the enzyme were characterized by FTIR analysis. SEM-EDS and FTIR results showed that the enzyme was successfully covalently attached to the polymeric support. The immobilization efficiency and enzyme activity of α-amylase were examined at various pH (5.0-8.0) and temperature (30-80oC) values. The storage stability and reusability of immobilized α-amylase were investigated. The immobilization yield was 276 ± 1.6 mg per gram of polymeric support. Enzyme assays demonstrated that the immobilized enzyme exhibited better thermostability than the free one. The storage stability and reusability were improved by the immobilization on this enzyme support. Free enzyme lost its activity completely within 15 days. On the other hand, the immobilized enzyme retained 86.7% of its activity after 30 days. These results confirm that α-amylase was successfully immobilized and gained a more stable character compared with the free one.

Omalizumab as a Succesfull Therapy in Normocomplementemic Urticarial Vasculitis: A Series of Four Patients and Review of the Literature

( Ece Nur Degirmentepe ),( Kubra Kızıltac ),( Pırıl Etikan ),( Ralfi Singer ),( Bachar Memet ),( Emek Kocaturk ) 대한피부과학회 2019 Annals of Dermatology Vol.31 No.3

Urticarial vasculitis is an eruption characterized by inflamed itchy or painful red papules or plaques that resemble urticaria but last longer than 24 hours and heal with residual pigmentation or purpura. Histopathologically, urticarial vasculitis presents as leukocytoclastic vasculitis with perivascular infiltrate and fibrin deposits. The treatment options are oral antihistamines, oral corticosteroids, dapsone, colchicine and hydroxychloroquine. We report four cases with normocomplementemic urticarial vasculitis who were treated with omalizumab and a brief review of the literature on the use of omalizumab in normocomplementemic urticarial vasculitis. (Ann Dermatol 31(3) 335∼338, 2019)

Selective molecularly imprinted polymer for the analysis of chlorpyrifos in water samples

Oya Aydın Urucu,Aslı Beyler Çi gil,Hatice Birtane,Ece Kök Yetimo glu,Memet Vezir Kahraman 한국공업화학회 2020 Journal of Industrial and Engineering Chemistry Vol.87 No.-

In this paper, a new molecularly imprinted solid-phase extraction (MISPE) method was described for thedetermination of the chlorpyrifos in water samples. A thiol-ene based UV-cured polymer was preparedby mixing glyoxal bis (-diallyl acetal), pentaerythritol tetrakis (3-mercaptopropionate), polyethyleneglycol diacrylate (PEGDA), and photoinitiator. Chlorpyrifos was added to the prepared polymer as atemplate analyte, and its analysis was performed by gas chromatography with mass detection (GC–MS). The influence of some analytical parameters was studied. We found that the use of the molecularlyimprinted polymer (MIP) UV-cured disc provides an easy, selective, and available solution for removingchlorpyrifos from water samples.

Could the Neutrophil to Lymphocyte Ratio be a Poor Prognostic Factor for Non Small Cell Lung Cancers?

Kacan, Turgut,Babacan, Nalan Akgul,Seker, Metin,Yucel, Birsen,Bahceci, Aykut,Eren, Ayfer Ay,Eren, Memet Fuat,Kilickap, Saadettin Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.5

Background: Although many prognostic factors have been identified for lung cancers, new ones are needed to determine the course of the disease. Recently, a high neutrophil to lymphocyte ratio (NLR) prior to surgery or treatment has been shown to be an indicator of prognosis for cancer. The aim of this study was to investigate the value of NLR as a prognostic factor and the correlation between NLR and other probable clinical prognostic factors in non small cell lung cancer patients prior to treatment. Materials and Methods: Data of patients who were diagnosed with non-small cell lung cancer in our institution were retrospectively reviewed. Demographic and clinicopathologic characteristics were recorded. NLR was calculated before the application of any treatment. Results: A total of 299 patients, 270 (90%) males and 29 (10%) females, were included in the study. Age (p<0.001) stage (p<0.001), Eastern Cooperative Oncology Group performance status (p<0.001), weight loss (p<0.001), anemia (p<0.001), histopatology (p<0.001), NLR ${\geq}3$ (p=0.048), NLR ${\geq}4$ (p=0.025) and NLR ${\geq}5$ (p=0.018) were found to be the prognostic factors. Age, anemia, Eastern Cooperative Oncology Group performance status, the stage, NLR (${\geq}5$) were an independent prognostic factors. There was a positive correlation between NLR and the Eastern Cooperative Oncology Group performance status (0.23, p=0.001), the C reactive protein levels (r=0.36, p<0.001). Conclusions: Prior to treatment high NLR was found as an independent poor prognosis factor. Besides, NLR correlated with Eastern Cooperative Oncology Group performance status and the C reactive protein levels.