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      • KCI등재

        Influence of synthetic polymers on the mechanical properties of hardened b-calcium sulfate hemihydrate plasters

        Ping-ping Zhou,Hua-chun Wu,Yong-Mei Xia 한국공업화학회 2016 Journal of Industrial and Engineering Chemistry Vol.33 No.-

        Polymers have been used to modulate mechanical strengths and water absorption of construction ormodeling materials as like gypsum. To understand the structure–performance relationship of polymersin hydration and properties of gypsum plaster, several designed carboxyl polyether sulfonates wereinvestigated with comparison of some commercial polymers. It is found that bending strength of thehardened b-hemihydrate plaster is inversely proportional to number of carboxyl groups in the polymerthat retards hydration. The mechanical strengths enhancement is coincident with acceleration of initialhydration, while decrease of mechanical strengths happened with retard of the hydration.

      • KCI등재후보

        Use of Clozapine for the Treatment of Schizophrenia: Findings of the 2006 Research on the China Psychotropic Prescription Studies

        Tian-Mei Si,Yun-shu Zhang,Liang Shu,Ke-Qing Li,Xie-He Liu,Qi-Yi Mei,Gao-Hua Wang,Pei-Shen Bai,Li-Ping Ji,Xian-Sheng Cheng,Cui Ma,Jian-Guo Shi,Hong-Yan Zhang,Hong Ma,Xin Yu 대한정신약물학회 2012 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.10 No.2

        Objective: Clozapine is one of the most commonly used antipsychotic drugs in China. To date, few studies have investigated the patterns the prescription of clozapine nationwide. The present study examined these patterns in China in 2006 and identified the demographic and clinical characteristics associated with the use of clozapine. Methods: Using a standardized protocol and data collection procedure, we surveyed 5,898 patients with schizophrenia in 10provinces with differing levels of economic development. Results: Overall, clozapine had been prescribed for 31.9% (n=1,883) of the patients; however we found considerable variation among the 10 provinces. The frequency of clozapine use was highest in Sichuan (39.3%) and lowest in Beijing (17.3%). The mean daily dose of clozapine was 210.36±128.72 mg/day, and 25.1% of the patients were treated with clozapine in combination with other antipsychotics. Compared with the group not receiving clozapine, clozapine-user had been treated for longer durations and had experienced a greater number of relapses and hospitalizations. Furthermore, those in the clozapine-user had lower family incomes, were less able to seek psychiatric services, and more likely to be male and have a positive family history of schizophrenia. A multiple logistic regression analysis revealed that age, sex, professional help-seeking behaviors, duration of illness, economic status, educational level, and clinical manifestations were associated with the use of clozapine. Conclusion: Clozapine use is common in China. However, use of the antipsychotic varies among provinces, and demographic and clinical factors play important roles in the prescription of clozapine.

      • KCI등재후보

        Factors that Influence the Presciption of Antipsychotics for Patients with Schizophrenia in China

        Tian-Mei Si,Liang Shu,Ke-Qing Li,Xie-He Liu,Qi-Yi Mei,Gao-Hua Wang,Pei-Shen Bai,Li-Ping Ji,Xian-Sheng Chen,Cui Ma,Jian-Guo Shi,Hong-Yan Zhang,Hong Ma,Xin Yu 대한정신약물학회 2011 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.9 No.3

        Objective: To investigate the patterns of antipsychotic use in China and to analyze the factors that influence antipsychotic prescriptions. Methods: A standardized survey was conducted from May 20 to 24 2002 in five different regions of China with varying economic levels. The patterns of antipsychotic medication use were analyzed in a sample of 4,779 patients with schizophrenia. The survey gathered information on demographic characteristics, clinical profiles, and antipsychotic medications prescribed. Multiple logistic regression was used to analyze factors related to patterns of antipsychotic medication use. Results: A plurality of patients with schizophrenia was treated with clozapine (39%); this was followed by risperidone, sulpride,chlorpromazine, perphenazine, and haloperidol. More than 56.3% of patients were treated with only one atypical antipsychotic. The mean daily dose of chlorpromazine was 365±253 mg (mean±standard deviation), and 6.5% of patients were treated with depot injections of typical antipsychotic medications. A total of 73.7% (n=3,523) of patients with schizophrenia received monotherapy,24.8% (n=1,183) received two antipsychotics, 1.1% (n=52) received three antipsychotics, and one received four different antipsychotics. Patients often simultaneously received other classes of medications including anticholinergic agents, benzodiazepines,β-blockers, antidepressants, and mood stabilizers. Economic status and clinical symptoms were the main factors that contributed to the patterns of antipsychotic prescription. Conclusion: The present study suggests that atypical antipsychotic medications, especially clozapine, are the primary psychiatric treatments of choice in the management of schizophrenia in China. Moreover, the economic status and clinical profile of the patient are the major factors affecting the prescription of antipsychotic medication.

      • KCI등재

        The Effect of Transformation on the Virulence of Streptococcus pneumoniae

        Xue-Mei Zhang,Yi-Bing Yin,Dan Zhu,Bao-De Chen,Jin-Yong Luo,Yi-Ping Deng,Ming-Fang Liu,Shu-Hui Chen,Jiang-Ping Meng,Kai Lan,Yuan-Shuai Huang,Ge-Fei Kang 한국미생물학회 2005 The journal of microbiology Vol.43 No.4

        Although pneumococcus is one of the most frequently encountered opportunistic pathogen in the world, the mechanisms responsible for its infectiveness have not yet been fully understood. In this paper, we have attempted to characterize the effects of pneumococcal transformation on the pathogenesis of the organism. We constructed three transformation-deficient pneumococcal strains, which were designated as Nos. 1d, 2d, and 22d. The construction of these altered strains was achieved via the insertion of the inactivated gene, comE, to strains 1, 2 and 22. We then conducted a comparison between the virulence of the transformation-deficient strains and that of the wild-type strains, via an evaluation of the ability of each strain to adhere to endothelial cells, and also assessed psaA mRNA expression, and the survival of hosts after bacterial challenge. Compared to what was observed with the wild-type strains, our results indicated that the ability of all of the transformation-deficient strains to adhere to the ECV304 cells had been significantly reduced (p < 0.05), the expression of psaA mRNA was reduced significantly (p < 0.05) in strains 2d and 22d, and the median survival time of mice infected with strains 1d and 2d was increased significantly after intraperitoneal bacterial challenge (p < 0.05). The results of our study also clearly indicated that transformation exerts significant effects on the virulence characteristics of S. pneumoniae, although the degree to which this effect is noted appears to depend primarily on the genetic background of the bacteria.

      • SCIESCOPUSKCI등재

        The Effect of Transformation on the Virulence of Streptococcus pneumoniae

        Zhang Xue-Mei,Yin Yi-Bing,Zhu Dan,Chen Bao-De,Luo Jin-Yong,Deng Vi-Ping,Liu Ming-Fang,Chen Shu-Hui,Meng Jiang-Ping,Lan Kai,Huang Yuan-Shuai,Kang Ge-Fei The Microbiological Society of Korea 2005 The journal of microbiology Vol.43 No.4

        Although pneumococcus is one of the most frequently encountered opportunistic pathogen in the world, the mechanisms responsible for its infectiveness have not yet been fully understood. In this paper, we have attempted to characterize the effects of pneumococcal transformation on the pathogenesis of the organism. We constructed three transformation-deficient pneumococcal strains, which were designated as Nos. 1d, 2d, and 22d. The construction of these altered strains was achieved via the insertion of the inactivated gene, comE, to strains 1, 2 and 22. We then conducted a comparison between the virulence of the transformation-deficient strains and that of the wild-type strains, via an evaluation of the ability of each strain to adhere to endothelial cells, and also assessed psaA mRNA expression, and the survival of hosts after bacterial challenge. Compared to what was observed with the wild-type strains, our results indicated that the ability of all of the transformation-deficient strains to adhere to the ECV304 cells had been significantly reduced (p < 0.05), the expression of psaA mRNA was reduced significantly (p < 0.05) in strains 2d and 22d, and the median survival time of mice infected with strains Id and 2d was increased significantly after intraperitoneal bacterial challenge (p < 0.05). The results of our study also clearly indicated that transformation exerts significant effects on the virulence characteristics of S. pneumoniae, although the degree to which this effect is noted appears to depend primarily on the genetic background of the bacteria.

      • Experiences of Family of Patient with Newly Diagnosed Advanced Terminal Stage Hepatocellular Cancer

        Shih, Whei-Mei Jean,Hsiao, Ping-Ju,Chen, Min-Li,Lin, Mei-Hsiang Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.8

        Background: Hepatocellular carcinoma (HCC) is the most common primary liver cancer and the third leading cause of cancer-related death worldwide due to its generally poor prognosis. Caregiver burden for liver cancer cases is higher than with other cancer and needs especial attention. Methods: To explore the experiences of families of patients with newly diagnosed advanced terminal stage hepatocellular cancer by interview. Results: Nine participants were recruited in this study. Content analysis of the interviews revealed four themes: blaming oneself, disrupting the pace of life, searching all possible regimens, and not letting go. Conclusions: This study provides new insight into the needs and support of family members especially when they are facing loved ones with newly diagnosed advanced terminal stage HCC. These results will inform future supportive care service development and intervention research aimed at providing assistance in reducing unmet supportive care needs and psychological distress of these family members.

      • SCIESCOPUSKCI등재

        Adaptive coordinated control strategy for multi-terminal flexible DC transmission systems with deviation control

        Mei, Mingwan,Wang, Ping,Che, Yanbo,Xing, Chao The Korean Institute of Power Electronics 2021 JOURNAL OF POWER ELECTRONICS Vol.21 No.4

        Due to the advantages of multiple power supply points and multiple power receiving points, the multi-terminal direct current (MTDC) technology has gradually become the main trend in the future development of DC power grids. The coordinated control of a MTDC system is one of the key technologies to realize the stable operation of power systems. Droop control is an effective coordinated control method to maintain the power and voltage balance of a DC transmission system. However, improper selection of the droop coefficient leads to an imbalance of the power and voltage distribution. An improved coordinated control strategy based on an adaptive droop coefficient is proposed to realize a faster dynamic response and a more reasonable power distribution, which is applicable to all of the topologies of MTDC systems. The power and voltage deviation controls are added to prevent the output power and voltage from exceeding the range that a converter can bear. In addition, a lagging link is added in the current loop to compensate for the delay caused by the current loop and to improve the response speed of the system. Taking the MMC topology as an example, the dynamic characteristics of the proposed control strategy are analyzed, and a four-terminal MTDC simulation model based on the MATLAB/Simulink simulation platform has been established to verify the superiority of the proposed strategy under different disturbances.

      • KCI등재후보
      • SCIESCOPUSKCI등재

        Hybrid DC circuit breaker with fault current suppression capability

        Mei, Mingwan,Wang, Ping,Che, Yanbo,Ishaq, Muhammad,Xing, Chao The Korean Institute of Power Electronics 2021 JOURNAL OF POWER ELECTRONICS Vol.21 No.10

        Due to the rapid development of DC transmission, research on DC side fault protection has also made significant progress. The bipolar short-circuit fault is one of the most severe types of DC side faults. It can cause a current surge, which affects the safe operation of a system. Therefore, this paper proposes a new type of hybrid DC circuit breaker (DCCB) to realize the rapid suppression of bipolar short-circuit current. The new DCCB consists of three parts: a nominal current branch (NCB), an energy absorption branch (EAB), and a freewheeling branch (FB). Different control strategies can be adopted to achieve line protection functions for different types of faults. For transient faults, the absorption and suppression of the fault current are achieved mainly through the EAB and FB. The DCCB ensures that the amplitude of the current delivered by the DC line is maintained in a safe operating area of the transmission line. The EAB is disconnected after a short-term of operation for permanent faults to achieve complete isolation between the converter side and the fault side. The parameter design of the DCCB is carried out to provide a reference for the practical application of this research. Finally, the effectiveness of the proposed DCCB protection strategy is verified by simulations, and the function of the DCCB is further verified by experiments.

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