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        Recent advances in enzyme immobilization techniques: Metal-organic frameworks as novel substrates

        Mehta, J.,Bhardwaj, N.,Bhardwaj, S.K.,Kim, K.H.,Deep, A. Elsevier Publishing Company 2016 Coordination chemistry reviews Vol.322 No.-

        <P>In the past few years, metal organic frameworks (MOFs) have drawn increasing research interest as bioimmobilization support materials. The unique properties of MOFs, including tunable porosity, desirable functionality, extremely high surface area, and chemical/thermal stability, have motivated a considerable interest in exploiting them as a potential matrix for enzyme immobilization. Improvements in the biocatalyst efficiency, promising recyclability, enhanced accessibility to active sites, and a high loading capacity are the main features of the novel MOF-enzyme supports. This review aims to cover the recent progress in the application of MOFs as enzyme immobilization supports. We discuss different approaches used in the development of MOF-enzyme biocatalytic supports, such as surface adsorption, diffusion, and in-situ encapsulation. The trends in current developments and the significance of each strategy are critically reviewed in this paper. (C) 2016 Elsevier B.V. All rights reserved.</P>

      • A micromachined electrochemical sensor for free chlorine monitoring in drinking water

        Mehta, A.,Shekhar, H.,Hyun, S.H.,Hong, S.,Cho, H.J. IWA Publishing 2006 Water Science & Technology Vol.53 No.4

        <P>In this work, we designed, fabricated and tested a disposable, flow-through amperometric sensor for free chlorine determination in water. The sensor is based on the principle of an electrochemical cell. The substrate, as well as the top microfluidic layer, is made up of a polymer material. The advantages include; (a) disposability from low cost; (b) stable operation range from three-electrode design; (c) fluidic interconnections that provide on line testing capabilities; and (d) transparent substrate which provides for future integration of on-chip optics. The sensor showed a good response and linearity in the chlorine concentration ranging from 0.3 to 1.6 ppm, which applies to common chlorination process for drinking water purification.</P>

      • SCISCIESCOPUS

        Graphene quantum dot modified screen printed immunosensor for the determination of parathion

        Mehta, J.,Bhardwaj, N.,Bhardwaj, S.K.,Tuteja, S.K.,Vinayak, P.,Paul, A.K.,Kim, K.H.,Deep, A. Academic Press 2017 Analytical biochemistry Vol.523 No.-

        <P>The widespread use of pesticides has immense effect on increased crop productions. However, they are also responsible for posing detrimental health hazards and/or for contaminating the environment with chemical residues. A routine and an on-field detection of pesticide residues in different food, water, and soil samples has become a need of the hour for which biosensors can offer a viable alternative. The present work reports a functionalized graphene quantum dot (GQD) based screen printed electro-chemical immunosensor for the detection of parathion. The application of GQDs has permitted the realization of a sensitive, robust, and reproducible sensor unlike those carried out earlier for the similar purposes. This immunosensor exhibited a dynamic linear response for parathion within the range of 0.01 -10(6) ng/L with a very low detection limit of 46 pg/L. According to the analysis of potential interferences, the proposed sensor was specifically detecting parathion even in the presence of its metabolite, paraoxon. The investigations of the proposed sensing approach with respect to stability, response reproducibility, and regeneration have fully supported its potential practical applicability. (C) 2017 Elsevier Inc. All rights reserved.</P>

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        The Role of Remittances in Financial Development: Evidence from Nonlinear ARDL and Asymmetric Causality

        MEHTA, Ahmed Muneeb,QAMRUZZAMAN, Md.,SERFRAZ, Ayesha,ALI, Asad Korea Distribution Science Association 2021 The Journal of Asian Finance, Economics and Busine Vol.8 No.3

        This study's impetus is to explore fresh evidence to answer the question, i.e., whether remittances asymmetrically influence financial development in Bangladesh from 1975 to 2019. The study employs several tests, i.e., nonlinear unit root test, Autoregressive Distributed Lagged (ARDL), NARDL, and asymmetric causality test for establishing the pattern of association. Nonlinear unit root tests confirm that variables follow a nonlinear system of being stationary after the first difference. nonlinearity among variables is investigated by performing the BDS test and nonlinear OLS. Directional causality is investigated through both linear and nonlinear effects of remittance inflows by following the non-granger casualty test. The test statistics of Fpass and tBDM showed the Long-run cointegration in the empirical model and positive effect running from remittances inflow to financial development both in the long-run and short-run. Furthermore, the results of a standard Wald test divulge the presence of long-run and short-run asymmetry. Asymmetry causality test established unidirectional causality due to positive and negative shocks in remittances inflows to Bank-based financial development and feedback hypothesis hold for explaining causality between positive and negative shocks in remittance inflows and Stock-based financial development.

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        The Effect of Technology and Open Innovation on Women-Owned Small and Medium Enterprises in Pakistan

        MEHTA, Ahmed Muneeb,ALI, Asad,SALEEM, Hina,QAMRUZZAMAN, Md.,KHALID, Rimsha Korea Distribution Science Association 2021 The Journal of Asian Finance, Economics and Busine Vol.8 No.3

        Technological adaption and innovative activities foster small and medium enterprises (SMEs) growth, especially women-owned SMEs in Pakistan, However, the impact of technological adaption and innovative activities on SMEs growth in the context of Pakistan has been examined by very researchers. This study aims to identify the effect of technology and open innovation policies on the growth of women-owned SMEs and the present trends and management challenges for successful full implementation of open innovation. The study considered a sample of 693 women enterprises located in different cities in Pakistan. Open innovation is measured through eight innovative practices, reflecting the exploration and exploitation of technology in SMEs. Study findings revealed that women enterprises were involved in several open innovation policies during the last five years. Moreover, the study indicated no significant differences between manufacturing and service SMEs regarding open innovation practices; however, women enterprises are more impressively engaged in open innovation practices. Findings also reveal that women-owned SMEs follow open innovation, mainly for market-related intentions, to compete with competitors and meet customers' demands. Thus, it is suggested that government policy relating to thriving SMEs owned by women should be innovation-oriented. The study contributes to the theoretical and practical implications. Further, the study is helpful for SMEs, researchers, practitioners, and decision-makers.

      • Evaluation of Diagnostic Accuracy of Magnetic Resonance Imaging in Posterior Ligamentum Complex Injury of Thoracolumbar Spine

        Mehta Gaurav,Shetty Utsav Chandrashekar,Meena Dharamraj,Tiwari Ashok Kumar,Nama Kishan Gopal,Aseri Dharmendra 대한척추외과학회 2021 Asian Spine Journal Vol.15 No.3

        Study Design: Prospective diagnostic imaging study. Purpose: The stability of the thoracic and lumbar spine depends significantly on the posterior ligamentum complex (PLC). Therefore, it is essential to diagnose PLC injuries accurately before deciding on a treatment plan for thoracolumbar injury patients. However, the efficacy of magnetic resonance imaging (MRI) in diagnosing PLC remains undetermined. Overview of Literature: MRI has become the ultimate tool in diagnosing spine injury cases, as previous literature suggests that it has very high sensitivity and specificity. But this is still controversial and as many surgeons rely on just MRI for selecting the patient for surgery, it becomes important to know the diagnostic accuracy of it. Methods: Patients who sustained injuries from T1 to L3 and required posterior surgery were prospectively studied. The treating surgeon and musculoskeletal radiologist participating in the study reviewed preoperative MRI images to characterize the level(s) of injury and the integrity of the six components of the PLC. These were classified as intact, incompletely disrupted, or disrupted. During the surgical procedure, the surgeon also classified each component of the PLC, and the radiologist’s and surgeon’s findings were compared. Results: Out of 66 patients, 46 were males (69.7%) and 20 were females (30.3%), and the average age was 34.12 years. According to the kappa score, there was a moderate level of agreement between the radiologist’s interpretation and the intraoperative findings for all PLC components except for the thoracolumbar fascia and ligamentum flavum for which there was a slight agreement. The sensitivity for the intact PLC components ranged from 100% (supraspinous ligament) to 66.67% (ligamentum flavum). The specificity ranged from 100% (interspinous ligament) to 52% (thoracolumbar fascia). The Spearman’s rank correlation ranged from 0.061 for the thoracolumbar fascia to 0.918 for the interspinous ligament, and the percentage agreement ranged from 81.82% (interspinous ligament to 36.36% (thoracolumbar fascia). Conclusions: The sensitivity and specificity of MRI for diagnosing injury of the PLC in this study were lower than those previously reported in the literature. The integrity of the PLC as determined by MRI should not be used in isolation to determine treatment.

      • Effect of geometrical parameters of reentry capsule over flowfield at high speed flow

        Mehta, R.C. Techno-Press 2017 Advances in aircraft and spacecraft science Vol.4 No.4

        The main purpose of the paper is to analyze effect of geometrical parameters of the reentry capsules such as radius of the spherical cap, shoulder radius, back shell inclination angle and overall length on the flow field characteristics. The numerical simulation with viscous flow past ARD (Atmospheric Reentry Demonstrator), Soyuz (Russian) and OREX (Orbital Reentry EXperimental) reentry capsules for freestream Mach numbers range of 2.0-5.0 is carried out by solving time-dependent, axisymmetric, compressible laminar Navier-Stokes equations. These reentry capsules appear as bell, head light and saucer in shape. The flow field features around the reentry capsules such as bow shock wave, sonic line, expansion fan and recirculating flow region are well captured by the present numerical simulations. A low pressure is observed immediately downstream of the base region of the capsule which can be attributed to fill-up in the growing space between the shock wave and the reentry module. The back shell angle and the radius of the shoulder over the capsule are having a significant effect on the wall pressure distribution. The effects of geometrical parameters of the reentry capsules will useful input for the calculation of ballistic coefficient of the reentry module.

      • KCI등재후보

        Isolated oculomotor nerve palsy secondary to non-aneurysmal subarachnoid hemorrhage

        Mehta Shyle,Bathini Abhijith,Dubey Anwesha,Barpujari Awinita,Kassem Ahmad,Sulaiman Mohanad,Binning Mandy 대한뇌혈관외과학회 2022 Journal of Cerebrovascular and Endovascular Neuros Vol.24 No.3

        We present a case series of two patients who developed unilateral cranial nerve III (CNIII) palsy following non-aneurysmal SAH (NASAH). Subarachnoid hemorrhage (SAH) can present with various signs and symptoms. Early diagnosis is paramount to determine treatment course. Thus, clinicians must be aware of the variable clinical presentations of this condition. Two patients were admitted to a single institution for SAH. Patient 1, 52-year-old male, presented with headache, left eye ptosis, and painless diplopia. A non-contrast head computed tomography (CT) demonstrated a SAH within the left sylvian fissure and blood surrounding the mesencephalon and falx. Patient 2, 70-year-old male, presented with mild headache, acute onset of blurry vision, and right eye ptosis. A non-contrast head CT demonstrated a diffuse SAH predominantly in the Sylvian and suprasellar cisterns. Patients were admitted to the neuro intensive care unit and underwent diagnostic angiograms to identify possible aneurysms. Magnetic resonance imaging and angiograms for both patients were negative. Patients were managed with best medical therapy and followed up in the outpatient setting. Unilateral CNIII palsy in the setting of NASAH was identified in both patients. Diagnostic angiograms were negative for aneurysms; therefore, SAH were determined to be spontaneous. We propose that unilateral CNIII palsy is a possible sign of NASAH.

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