Weekly versus 3-weekly paclitaxel in combination with carboplatin in advanced ovarian cancer: which is the optimal adjuvant chemotherapy regimen?

Matilda X. Lee,David SP Tan 대한부인종양학회 2018 Journal of Gynecologic Oncology Vol.29 No.6

The 3-weekly regimen of carboplatin and paclitaxel is the backbone of first line adjuvant chemotherapy for advanced ovarian cancer. The landmark Japanese Gynaecologic Oncology Group (JGOG) 3016 study demonstrated significant improvements in progression-free survival and overall survival with dose dense weekly administration of paclitaxel in combination with 3-weekly carboplatin. However, efforts to replicate these benefits have failed in subsequent phase III trials. Weekly paclitaxel is purported to have enhanced antitumor activity, with stronger anti-angiogenic effects, and yet is better tolerated. In this review, we explore the rationale for dose dense weekly paclitaxel, and compare the relevant trials as well as quality of life considerations. Possible reasons for the difference in outcomes between the JGOG 3016 and other studies are reviewed, with a focus on how the addition of bevacizumab, the variations between histological and molecular subtypes of epithelial ovarian cancers, and ethnic pharmacogenetic differences may potentially affect the efficacy of dose dense paclitaxel.

Museums and the Intangible Heritage : the Case Study of the Afrikaans Language Museum

Matilda Burden 국립민속박물관 2007 International Journal of Intangible Heritage Vol.2 No.-

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A Trend Analysis on Chile ICT Policy in Education Informatization: Focused on Reports from APEC eLearning Training Program (2006 – 2014)

Kim YoungHwan,Matilda A. Kruse APEC국제교육협력원 2014 Asia-Pacific Cybereducation Journal Vol.10 No.2

The purpose of this study is to discuss and analyze the trends in ICT in education informatization and the need for more scholarly research and dialogue done between Korea and Chile due to their similar ideals in furthering ICT in education in their respective economies. In result of this, 29 individual and team reports submitted by Chilean trainees in the APEC eLearning Trainee Program from 2006-2014 were analyzed. From this study, the results based on the reports were as follows. 1) The need for high quality teacher training programs created by the government and motivating the teachers to participate in these programs. 2) Implementation of more cooperation and collaboration between teacher-student, teacher-expert, and publicprivate partnership programs. 3) Improving students’ aptitude in utilizing ICT, especially in education. 4) Due to the majority of the trainees’ coming from the teaching profession, more research is needed to be done by other stakeholders involved in education informatization, such as government officials, learners, and professors, in order to enhance the totality of this study.

Need Assessments for Designing APEC Edutainment Exchange Program (AEEP) in Sakha

Maria Maximova,Kim Sang-mi,Matilda A. Kruse,Kim Young-hwan,Vasily Maximov 부산대학교 교육연구소 2014 교육혁신연구 Vol.24 No.2

본 연구는 러시아 사하공화국과 한국 간 APEC 에듀테인먼트 교류 프로그램(이하 AEEP) 개발을 위 해 사하공화국 현지 교사와 교육전문가들을 대상으로 프로그램에 관한 요구와 기타 관련된 사항들의 실태를 분석하고자 하는 것이다. 이를 위해 본 연구에서는 문헌연구를 기반으로 현지 조사와 함께 설 문조사와 인터뷰를 실시하였다. 현지 조사는 한-사하 AEEP를 주관할 대학교와 AEEP 참가자들의 고등 학교 그리고 캠프장과 다양한 체험학습대상지들을 방문하였고, 담당 교사들 및 교수들을 대상으로 교 육 현황과 프로그램에 관한 요구 조사를 실시하였다. 그에 따른 주요 결과는 다음과 같다. 첫째, 러시 아 극동 지구에 위치한 사하는 문화와 역사, 환경 및 기후의 측면에서 독특하고 다양한 교육 자원들 을 보유하고 있다. 그리고 이를 활용한 청소년 대상의 국제교육협력활동에 높은 요구를 보이고 있었 다. 둘째, AEEP를 통해 대규모 국제교류활동을 실시하기 위해서는 참여자들의 한-러 간 언어 장벽, 이에 따른 통역 지원, 참여 경비, 현지 교민 및 관련 기관과의 연계 등과 같은 점을 고려해야 한다. 셋째, 사하공화국은 한국에 대해 긍정적인 이미지를 가지고 있으나, 우리나라 학생들에게는 지리적으 로 뿐만 아니라 음식과 대화 방식 등 다소 낯설고 독특한 문화를 가지고 있어서 문화의 차이에 대해 충분한 사전 교육이 필요한 것으로 나타났다. 따라서 이후 후속연구에서는 상기와 같은 점을 고려하 여, 사하공화국의 풍부한 자연 환경을 안전하고 매력적으로 활용하고, 다양한 측면에서의 체제적 지 원을 포함하는 AEEP 개발 연구가 필요할 것이다. The purpose of this study is to assess the need for APEC Edutainment Exchange Program(AEEP) and current status of educational environment of Sakha in Russia in order to design AEEP with Korea. To this end, based on literature review, this study conducted a field research in Sakha visiting universities, schools, camp sites and various sits for experiential learning for students and did a survey and interviews targeting the local teaches and education experts. The results are as follows. First, having high demand for international educational cooperation activities for students, Sakha, located in the far east of Russia, has attractive and divergent educational resources in the aspect of culture, history, and natural environments. Second, it needs to consider participation costs, matters of interpretation due to language barriers between Korea and Russia, and involvement and support from local Korean residents and related institutions. Third, there should be enough attention and orientation to Korean students so that they can understand and respect the cultural difference of speaking attitude and food in Sakha. These results could provide preliminary data to develop Sakha-Korea AEEP utilizing divergent cultural resources and rich natural environments of Sakha with systemic support for participants.

Need Assessments for Designing APEC Edutainment Exchange Program (AEEP) in Sakha

Vasily Maximov,Kim Young-hwan,Matilda A. Kruse,Maria Maximova,Kim Sang-mi 부산대학교 교육발전연구소 2014 교육혁신연구 Vol.24 No.2

The purpose of this study is to assess the need for APEC Edutainment Exchange Program(AEEP) and current status of educational environment of Sakha in Russia in order to design AEEP with Korea. To this end, based on literature review, this study conducted a field research in Sakha visiting universities, schools, camp sites and various sits for experiential learning for students and did a survey and interviews targeting the local teaches and education experts. The results are as follows. First, having high demand for international educational cooperation activities for students, Sakha, located in the far east of Russia, has attractive and divergent educational resources in the aspect of culture, history, and natural environments. Second, it needs to consider participation costs, matters of interpretation due to language barriers between Korea and Russia, and involvement and support from local Korean residents and related institutions. Third, there should be enough attention and orientation to Korean students so that they can understand and respect the cultural difference of speaking attitude and food in Sakha. These results could provide preliminary data to develop Sakha-Korea AEEP utilizing divergent cultural resources and rich natural environments of Sakha with systemic support for participants.

3R-Refinement principles: elevating rodent well-being and research quality

Puneet Rinwa,Marie Eriksson,Ian Cotgreave,Matilda Bäckberg 한국실험동물학회 2024 Laboratory Animal Research Vol.40 No.1

This review article delves into the details of the 3R-Refinement principles as a vital framework for ethically sound rodent research laboratory. It highlights the core objective of the refinement protocol, namely, to enhance the well-being of laboratory animals while simultaneously improving the scientific validity of research outcomes. Through an exploration of key components of the refinement principles, the article outlines how these ethics should be implemented at various stages of animal experiments. It emphasizes the significance of enriched housing environments that reduce stress and encourage natural behaviors, non-restraint methods in handling and training, refined dosing and sampling techniques that prioritize animal comfort, the critical role of optimal pain management and the importance of regular animal welfare assessment in maintaining the rodents well-being. Additionally, the advantages of collaboration with animal care and ethics committees are also mentioned. The other half of the article explains the extensive benefits of the 3R-Refinement protocol such as heightened animal welfare, enhanced research quality, reduced variability, and positive feedback from researchers and animal care staff. Furthermore, it addresses avenues for promoting the adoption of the protocol, such as disseminating best practices, conducting training programs, and engaging with regulatory bodies. Overall, this article highlights the significance of 3R-Refinement protocol in aligning scientific advancement with ethical considerations along with shaping a more compassionate and responsible future for animal research.

Neuroimaging Findings in Racemose Neurocysticercosis: Case Description and Literature Review

Nikoletta Kollia,Aikaterini Theodorou,Paschalis Zervas,Lina Palaiodimou,Matilda Papathanasiou,Panagiotis Toulas,Maria Theodorakopoulou,Georgios Dimopoulos,Drosos Karageorgopoulos,Elisabeth Andreadou,A 대한신경초음파학회 2021 대한신경초음파학회지 (JNN) Vol.13 No.2

Neurocysticercosis (NCC), the most common central nervous system (CNS) parasitic infection among the immunocompetent population can imitate every clinical feature of brain-diseases accurately, drawing attention away from the real culprit and delaying the proper treatment. There are two types of NCC, the parenchymal and the extraparenchymal form. The extraparenchymal NCC include the ventricular cysticercosis, the subarachnoid cysts including giant cysts or racemose cysticercosis with chronic meningitis, the spinal (intra- or extramedullary) cysticercosis and the ophthalmic cysticercosis. It is estimated that about 30% of epilepsy cases in endemic countries are due to NCC and especially the racemose NCC is more aggressive and associated with higher mortality rates. There is a significant heterogeneity in clinical phenotypes, regarding the racemose NCC, which depends on the parasite load and evolutionary stage in association with its location in CNS and the host’s immune response. Crucial for the management of the racemose NCC is the early recognition of the symptoms and the swift initiation of antiparasitic therapy with anti-inflammatory agents in combination with the shunt-insertion in cases of obstructive hydrocephalus. In view of the former considerations we conducted a narrative literature review on racemose NCC and described the diagnostic challenges of a relevant case that we had evaluated in our Department of Neurology.

Comparison of digital and traditional skin wound closure assessment methods in mice

Coco X. Huang,Elisha Siwan,Sarah L. Fox,Matilda Longfield,Stephen M. Twigg,Danqing Min 한국실험동물학회 2023 Laboratory Animal Research Vol.39 No.4

Background: Chronic skin wounds are a common complication of many diseases such as diabetes. Various traditional methods for assessing skin wound closure are used in animal studies, including wound tracing, calliper measurements and histological analysis. However, these methods have poorly defined wound closure or practical limitations. Digital image analysis of wounds is an increasingly popular, accessible alternative, but it is unclear whether digital assessment is consistent with traditional methods. This study aimed to optimise and compare digital wound closure assessment with traditional methods, using a diabetic mouse model. Diabetes was induced in male C57BL/6J mice by high-fat diet feeding combined with low dose (65 mg/kg of body weight) streptozotocin injections. Mice fed normal chow were included as controls. After 18 weeks, four circular full-thickness dorsal skin wounds of 4 mm diameter were created per mouse. The wounds were photographed and measured by callipers. Wound closure rate (WCR) was digitally assessed by two reporters using two methods: wound outline (WCR-O) and re-epithelialisation (WCR-E). Wounded skin tissues were collected at 10-days post-wounding and wound width was measured from haematoxylin and eosin-stained skin tissue. Results: Between reporters, WCR-O was more consistent than WCR-E, and WCR-O correlated with calliper measurements. Histological analysis supported digital assessments, especially WCR-E, when wounds were histologically closed. Conclusions: WCR-O could replace calliper measurements to measure skin wound closure, but WCR-E assessment requires further refinement. Small animal studies of skin wound healing can greatly benefit from standardised definitions of wound closure and more consistent digital assessment protocols.

Multiple roles of phosphoinositide-specific phospholipase C isozymes (Mini Reviews)

Pann Ghill Suh,Jae Il Park,Lucia Manzoli,Lucio Cocco,Joanna C. Peak,Matilda Katan,Kiyoko Fukami,Tohru Kataoka,Sang Uk Yun,Sung Ho Ryu 한국생화학분자생물학회 2008 BMB Reports Vol.41 No.6

Non-invasive estimation of relative pressure in turbulent flow using virtual work-energy

Marlevi, David,Ha, Hojin,Dillon-Murphy, Desmond,Fernandes, Joao F.,Fovargue, Daniel,Colarieti-Tosti, Massimiliano,Larsson, Matilda,Lamata, Pablo,Figueroa, C. Alberto,Ebbers, Tino,Nordsletten, David A. Elsevier 2020 Medical image analysis Vol.60 No.-

<P><B>Abstract</B></P> <P>Vascular pressure differences are established risk markers for a number of cardiovascular diseases. Relative pressures are, however, often driven by turbulence-induced flow fluctuations, where conventional non-invasive methods may yield inaccurate results. Recently, we proposed a novel method for non-turbulent flows, <I>ν</I>WERP, utilizing the concept of virtual work-energy to accurately probe relative pressure through complex branching vasculature. Here, we present an extension of this approach for turbulent flows: <I>ν</I>WERP-t. We present a theoretical method derivation based on flow covariance, quantifying the impact of flow fluctuations on relative pressure. <I>ν</I>WERP-t is tested on a set of <I>in-vitro</I> stenotic flow phantoms with data acquired by 4D flow MRI with six-directional flow encoding, as well as on a patient-specific <I>in-silico</I> model of an acute aortic dissection. Over all tests <I>ν</I>WERP-t shows improved accuracy over alternative energy-based approaches, with excellent recovery of estimated relative pressures. In particular, the use of a guaranteed divergence-free virtual field improves accuracy in cases where turbulent flows skew the apparent divergence of the acquired field. With the original <I>ν</I>WERP allowing for assessment of relative pressure into previously inaccessible vasculatures, the extended <I>ν</I>WERP-t further enlarges the method's clinical scope, underlining its potential as a novel tool for assessing relative pressure <I>in-vivo</I>.</P> <P><B>Highlights</B></P> <P> <UL> <LI> vWERP-t uses virtual work-energy to accurately assess turbulent relative pressure. </LI> <LI> In-vitro, vWERP-t shows 1:1 agreement with invasive measurements of relative pressure. </LI> <LI> In transient flow, vWERP-t shows significant improvement compared to other approaches. </LI> <LI> vWERP-t guarantees divergence free flow even in turbulent fields, improving accuracy. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>