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Self-association of bee propolis: effects on pharmaceutical applications
Jiri Trousil,Martin Hruby,Jiri Panek,Jana Matějková,Jan Kucka,Petr Stepanek 한국약제학회 2014 Journal of Pharmaceutical Investigation Vol.44 No.1
Propolis is a resinous product collected byhoneybees from various plant sources; it is widely used intraditional medicine and has been reported to have a broadspectrum of pharmacological effects (i.e., antibacterial,antifungal, antiviral and anti-inflammatory effects). Themost commonly used propolis formulations are gargles, inwhich propolis tinctures are diluted with water. The dilutionprocess is accompanied by nanoprecipitation, and thepropolis droplets are dispersed in the prepared gargle. Inthe present study, we investigated the dependence of theproperties of propolis nanodispersions on the method ofpreparation. The particle size was found to be approximately150 nm and was observed to decrease withincreasing dilution as the zeta potential of the particlesbecame more negative, which stabilized the dispersion. The dispersion dissolved upon alkalization and reprecipitatedduring acidification. The addition of salt destabilizedthe dispersion. The uptake of propolis from the dispersionwas modeled using 1-octanol and was found to be rapidand only slightly dependent on the nanoparticle size. Propolis susceptibility tests showed that the most effectivedispersion of propolis was tenfold-diluted EEP (P-80-10and JP-80-10). The disc diffusion method was used toevaluate the antibacterial activity of chosen dispersions ofpropolis against Staphylococcus aureus, Escherichia coliand Candida albicans. Propolis samples with differentlocations of origin exhibited different effects against thestrain of C. albicans.