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Molecular Characterization of FLT3 Mutations in Acute Leukemia Patients
Ishfaq, Mariam,Malik, Arif,Faiz, Mariam,Sheikh, Ishfaq Ahmad,Asif, Muhammad,Khan, Muhammad Nasrullah,Qureshi, Muhammad Saeed,Zahid, Sara,Manan, Abdul,Arooj, Mahwish,Qazi, Mahmood Husain,Chaudhary, Ade Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.9
Fms-like tyrosine kinase 3 (FLT3) performs a vital role in the pathogenesis of hematopoietic malignancies. Therefore in recent times, the focus of several studies was on use of FLT3 as a prognostic marker. The present study investigated the molecular characterization and incidence of FLT3 mutations in acute leukemia patients in Pakistan. A total of 55 patients were studied, of which 25 were suffering from acute lymphoblastic leukemia (ALL) and 30 were suffering from acute myeloid leukemia (AML). The polymerase chain reaction demonstrated FLT3/ITD mutations in 1 (4%) of 25 ALL patients, a male with the L2 subtype. In AML cases the rate was 4 (13.3%) of 30, three males and one female. The AML-M4 subtype was found in three and the AML M2 subtype in the other. In the AML cases, a statistically significant (p=0.009) relationship was found between WBC (109/L) and FLT3/ITD positivity. However, no significant relationship was found with other clinical parameters (p>0.05). In acute myeloid leukemia (AML) $FLT3/ITD^+$ mutation was more prevalent in elderly patients 31-40 age groups, 21-30 and 51-60 age groups respectively. In acute lymphoblastic leukemia (ALL) statistically no significant relationship was found between clinical features and FLT3/ITD positivity (p>0.05). However, in acute lymphoblastic leukemia (ALL) $FLT3/ITD^+$ mutation was more commonly found in age groups of 21-30.
Mariam S. Arain,Tasneem G. Kazi,Hassan I. Afridi,Muhammad Bilal,Jamshed Ali,Abdul Haseeb 한국공업화학회 2018 Journal of Industrial and Engineering Chemistry Vol.62 No.-
It is reported in literature that zinc (Zn2+) has antidepressant activity. In present study Zn2+ was analyzed in blood serum of male patients having various psychiatric disorders (schizophrenia, depression, bipolar). As it is usually present in trace levels. Hence a novel, environmental friendly, dual-cloud point extraction (d-CPE) method was developed for the enrichment of its trace levels in acid digested serum samples. In the first step of d-CPE, Zn2+ was complexed with 1-(2-pyridylazo)-2-naphthol (PAN), and the complex was entrapped in a nonionic surfactant (Triton X-114). After achieving cloud point by heating, the mixture was separated into two layers i.e. aqueous and surfactant-rich by centrifugation. In second step of d-CPE, the analyte complex in the surfactant-rich phase was treated wih acid to extract back the metal analytes in acidic aqueous phase, the mixture was again heated upto cloud point and the whole procedure was repeated. This time the aqueous phase, having the metals, was taken and subjected to FAAS using conventional nebulization. The accuracy of the developed methodologies (conventional and d-CPE), were verified by their application to certified reference material of serum (CRM). Reliability of the method was checked by relative standard deviation (%RSD), which was found to be <5%. The limit of detection and limit of quantification were calculated for the proposed method as 1.09 μg/L, and 3.63 respectively and enhancement factor was found to be 40. The developed procedure was successfully applied to the serum samples of patients (male) having different psychiatric disorders and non-psychiatric control subjects for the determination of Zn2+.
Comedia sin titulo de Garcia Lorca: ensayo dramatizado para una didactica inconclusa
( Mariam Budia ) 고려대학교 스페인·라틴아메리카연구소 2010 스페인라틴아메리카연구 Vol.3 No.-
Este articulo supone el analisis de Comedia sin titulo -una de las piezas inacabadas de Federico Garcia Lorca-, obra en la que observamos lenguajes ideologicos con los que el autor expresa su vision de la vida tanto dentro como fuera de la escena. El dramaturgo, en este auto alegorico de la revolucion, comparte sus didascalias con los lectores/espectadores mediante un ensayo dramatico: Lorca(maestro) comunica a su audiencia(discipulos) una didactica pronunciada, principalmente, a traves de las palabras de AUTOR. Comedia sin titulo articula las instrucciones para la comprension de la nueva verdad; asimismo, con este alegato liturgico, creemos que Lorca investiga sobre las nuevas tendencias escenicas y manifiesta su deseo de renovacion social.
Mariam S. Mansouri,안부현,Hamda Al Shibli,Hamad Al Yassi,Tawaddod Saif Alkindi,이지성,김영근,류종은,Daniel S. Choi 한국물리학회 2018 Current Applied Physics Vol.18 No.11
We present a novel process to fabricate three-dimensional (3D) metallic patterns from 3D printed polymeric structures utilizing different hygroscopic swelling behavior of two different polymeric materials. 3D patterns are printed with two different polymers as cube shape. The surface of the 3D printed polymeric structures is plated with nickel by an electroless plating method. The nickel patterns on the surface of the 3D printed cube shape structure are formed by removing sacrificial layers using the difference in the rate of hygroscopic swelling between two printing polymer materials. The hygroscopic behavior on the interfaced structure was modeled with COMSOL Multiphysics. The surface and electrical properties of the fabricated three-dimensional patterns were analyzed and characterized.
Mariam Charfeddine,Donia Bouaziz,Safa Charfeddine,Asma Hammami,Oumèma Nouri Ellouz,Radhia Gargouri Bouzid 한국식물생명공학회 2015 Plant biotechnology reports Vol.9 No.2
Plant growth and productivity are greatly affected by environmental stresses such as dehydration, high salinity, low temperature and pathogen infection. Plant adaptation to these environmental stresses is controlled by cascades of molecular networks. The dehydration-responsive element-binding (DREB) transcription factors play an important role in the response of plants to environmental stresses by controlling the expression of many stress-related genes. They specifically interact with C-repeat/DRE (A/ GCCGAC) sequences present in the promoter regions of target genes. One of the DREB1 cDNA was previously cloned and overexpressed in transgenic potato plants. These transgenic plants displayed an improved tolerance to high salinity and drought stresses. The StDREB1 factor belongs to A-4 group that seem to be involved in biotic stress response. This report investigates the effect of Fusarium solani infection on the StDREB1 transgenic lines. Since a number of pathogenesis-related (PR) proteins are considered as DREB1 target genes, the expression of PR2, PR9 and PR3 genes were tested under biotic stress conditions. The β-1,3-glucanase (PR2) was specifically induced upon infection, whereas the chitinase and the peroxydase were expressed constitutively. The data also show that high levels of DREB1 transcripts accumulated rapidly when wild-type and transgenic plants were infected by F. solani. DREB1 transgenic potato plants accumulated higher levels of pathogenesis-related gene transcripts, such as PR2. These results showed that StDREB1 plays an important role in response to fungal attack in potato.
Mariame Houhou,Khalid Amrani Joutei,Chaimae Rais,Said Louahlia 한국작물학회 2018 Journal of crop science and biotechnology Vol.21 No.3
The reduction in atmospheric inputs of SO42- as a result of stricter regulations of sulfur emission and the depletion in sulfur reserves following the intensification of agricultural production has caused a serious decrease in soil S-concentration. This would markedly affect growth and quality of numerous economically important plants. Foeniculum vulgare or fennel is one of the most cultivated aromatic and medicinal plants, mostly used for their powerful therapeutic effects. Being one of the cultivated species, Foeniculum vulgare could be affected by environmental disturbances like sulfur deficiency. In this work, the poor sulfur supply had a serious impact on the therapeutic quality of fennel seed extracts. At the application of sulfur deficiency, total phenolic compounds of fennel seeds extract decreased by 30% and their total antioxidant activity decreased by 21%. Sulfur starvation also reduced the antibacterial activity of fennel seeds against Staphylococcus aureus, Enterococcus faecalis, and Pseudomonas aeruginosa by increasing the MIC of seed extracts.
Dietary intakes of adolescents from food insecure households
Mariam Nakitto,Kana Asano,Injoo Choi,Jihyun Yoon 한국영양학회 2017 Nutrition Research and Practice Vol.11 No.6
BACKGROUND/OBJECTIVES: This study aimed at evaluating the dietary intakes of Korean adolescents affected by food insecurity, in comparison with those who were food secure. SUBJECTS/METHODS: The study used one day 24-hour dietary recall data from the 6th Korea National Health and Nutrition Examination Survey. The study subjects consisted of 1,453 adolescents of whom 695 were middle school-aged and 758 were high school-aged. Food security status was assessed using the 18-item questionnaire. Nutrient intake was evaluated in terms of nutrient density, insufficient intake, and excessive intake for selected nutrients, in addition to meeting the appropriate range for total energy intake and energy intakes from carbohydrate, sugar, protein, fat, and saturated fatty acids. Food intake was evaluated in terms of food group servings and dietary diversity score (DDS). RESULTS: The percentages of food insecurity were 11.1% for middle school-aged adolescents and 16.8% for high school-aged adolescents. Food insecure middle school-aged adolescents had higher intake of carbohydrate (P = 0.006) but lower intake of fat (P = 0.010) and saturated fatty acids (P = 0.005) than their food secure counterparts although the intake of both groups was in the recommended ranges. Nutrient intake among high school-aged adolescents was generally similar regardless of food security status. Both food secure and insecure adolescents showed insufficient intake of vitamin A, vitamin C, and calcium, and excessive sodium intake. They additionally had low prevalence of meeting appropriate intake ranges for energy, carbohydrate, and sugar. Food intake in terms of food group servings and DDS was also similar regardless of food security status among both age groups, with low intakes of foods from fruit and dairy groups. CONCLUSIONS: Except for a few nutrients among the middle school-aged adolescents, dietary intakes among Korean adolescents did not differ by food security status in this study.