Can a low-cost exercise monitor provide useful heart rate monitoring for use in low-resource emergency departments?

Thomas A. O’Mara,Miguel Armengol de la Hoz,Oren J. Mechanic,Alon Dagan 대한응급의학회 2021 Clinical and Experimental Emergency Medicine Vol.8 No.3

Objective Our objective was to study the clinical monitoring capabilities of a low-cost fitness wristband while measuring patient satisfaction with a mobility permitting device in the emergency department. Methods Patients enrolled were on continuous three-lead telemetry monitoring in a high acuity zone of the emergency department. Patients were given a fitness band to wear while simultaneously monitored with standard three-lead monitor. A brief survey was conducted upon study end, and data was compared between wristband and three-lead telemetry. Median heart rate (HR) values were calculated, a Bland-Altman plot was generated, and sensitivity and specificity were calculated for comparison of the formal telemetry and the inexpensive wristband. Results Thirty-four patients with an average age of 61.5 years were enrolled. From June to October 2019, over 100 hours of data were collected. In comparison for comfort, participants scored 9.5 of 10, preferring wristband over telemetry. Using a correlation coefficient graph, we found a significant disparity of HR readings within a telemetry range of 40 to 140 beats/min. An R-value of 0.36 was detected. Using a Bland-Altman plot, we observed a significant difference in HR between the telemetry monitor and the wristband. The sensitivity and specificity of the wristband to detect bradycardia (HR <60 beats/min) were 76% and 86%, respectively, while the sensitivity and specificity of the wristband to detect tachycardia (HR >100 beats/min) were 92% and 51%, respectively. Conclusion Inexpensive fitness bands cannot be a suitable tool for monitoring patient’s HR because of inaccuracy in detecting bradycardia or tachycardia.

Static wind loads on rigid roof model with complex hyperbolic geometry

Juan S. Delnero,Julio Marañón Di Leo,Mariano A. Martinez 한국풍공학회 2021 Wind and Structures, An International Journal (WAS Vol.33 No.3

The use of tensioned structures, such as membranes, as solutions for roofing and other kinds of covers has become more and more frequent. Current regulations do not provide detailed information about the coefficients needed to develop efficient designs, regarding wind loads. A lot of simulations and tests have been performed on different geometries which are typically used in these kinds of designs. However, no precise and clear standard has been established, yet, in order to regulate efficiently this application. Current regulations consider only simple geometries, while the effects of the interference between multiple covers or between a cover and the near urban environment is completely absent. In this paper are presented the results obtained from testing a 1:75 scale complex geometry model in a boundary layer wind tunnel. More precisely a model of a parking lot for vans, roofed with a complex geometry tensioned membrane was tested in order to measure its pressure distribution. Due to the high complexity of the geometry and in order to obtain a better description of the effects of the wind it was decided to lead wind tunnel tests to validate and to verify the load conditions over the roof. Information about wind load distributions for simple geometries such as cones, hyperboloids, etc. alone can be easily found in current technical bibliography. However, when designs are based on more complex shapes, including arrays of simpler shapes, a profound lack of information is observed. Therefore, it is not possible to calculate the wind loads over the membrane which are needed to dimension the supporting structure.

Interfacial energies of carbon tetrabromide

U. Böyük,N. Maraşlı 한국물리학회 2009 Current Applied Physics Vol.9 No.3

The equilibrated grain boundary groove shapes for solid carbon tetrabromide (CTB) in equilibrium with its melt were directly observed by using a horizontal temperature gradient stage. From the observed grain boundary groove shapes, Gibbs–Thomson coefficient (Γ) and solid–liquid interfacial energy (σSL) and grain boundary energy (σgb) of CTB have been determined to be (7.88 ± 0.8) × 10-8 K m, (6.91 ± 1.04) × 10-3 J m-2 and (13.43 ± 2.28) × 10-3 J m-2, respectively. The ratio of thermal conductivity of equilibrated liquid phase to solid phase for CTB has also been measured to be 0.90 at its melting temperature. The value of σSL for CTB obtained in present work was compared with the values of σSL determined in the previous works for same material and it was seen that the present result is in good agreement with previous works. The equilibrated grain boundary groove shapes for solid carbon tetrabromide (CTB) in equilibrium with its melt were directly observed by using a horizontal temperature gradient stage. From the observed grain boundary groove shapes, Gibbs–Thomson coefficient (Γ) and solid–liquid interfacial energy (σSL) and grain boundary energy (σgb) of CTB have been determined to be (7.88 ± 0.8) × 10-8 K m, (6.91 ± 1.04) × 10-3 J m-2 and (13.43 ± 2.28) × 10-3 J m-2, respectively. The ratio of thermal conductivity of equilibrated liquid phase to solid phase for CTB has also been measured to be 0.90 at its melting temperature. The value of σSL for CTB obtained in present work was compared with the values of σSL determined in the previous works for same material and it was seen that the present result is in good agreement with previous works.

Variations of microhardness with solidification parameters and electrical resistivity with temperature for Al–Cu–Ag eutectic alloy

U. Böyük,N. Maraşlı,E. Çadırlı,H. Kaya,K. Keşlioğlu 한국물리학회 2012 Current Applied Physics Vol.12 No.1

AleCueAg eutectic alloy was directionally solidified upwards with different growth rates (1.83e 498.25 mm/s) at a constant temperature gradient (8.79 K/mm) and with different temperature gradients (3.99e8.79 K/mm) at a constant growth rate (8.30 mm/s) by using a Bridgman type directional solidification apparatus. The dependence of microhardness (HV) on the growth rate (V), temperature gradient (G) and microstructure parameter (l) were found to be HV ¼ k1 V0.10, HV ¼ k2 G0.13 and HV ¼ k3 l 0.22, respectively. The electrical resistivity of the AleCueAg eutectic cast alloy increases linearly with the temperature in the range of 300e780 K. The enthalpy of fusion and specific heat change during melting for same alloy were also determined to be 223.8 J/g, and 0.433 J/g K, respectively by a differential scanning calorimeter from heating curve during the transformation from eutectic solid to eutectic liquid.

Determination of solid–liquid interfacial energy for a solid Sn in equilibrium with a Sn―Ag―Zn eutectic liquid

S. Engin,U. Böyük,N. Maraşlı 한국물리학회 2011 Current Applied Physics Vol.11 No.4

The equilibrated grain boundary groove shapes for a solid Sn in equilibrium with a Sn―Ag―Zn eutectic liquid were observed in a linear temperature gradient by using a Bridgman type directional solidification apparatus. The Gibbs―Thomson coefficient, solideliquid interfacial energy and grain boundary energy for a solid Sn in equilibrium with a Sn―Ag―Zn eutectic liquid were determined to be (8.21 ± 0.7) × 10^-8 Km,(116.2 ± 15.1) × 10^-3 Jm^-2 and (228.1 ± 34.2) × 10^-3 Jm^-2, respectively from observed grain boundary groove shapes. A comparison of present results with the previous experimental and theoretical results for similar solids in equilibrium with the different liquid was also made.

Experimental Determination of Interfacial Energies for Solid Sn in Equilibrium with Sn-Mg-Zn Liquid

Yemliha Altıntas,Esra Öztürk,Sezen Aksöz,Kâzım Keşlioğlu,Necmettin Maraşlı 대한금속·재료학회 2015 METALS AND MATERIALS International Vol.21 No.2

The equilibrated grain boundary groove shapes of solid Sn in equilibrium with Sn-Mg-Zn liquid were observedfrom a quenched sample by using a radial heat flow apparatus. The Gibbs-Thomson coefficient, solid-liquidinterfacial energy and grain boundary energy of solid Sn were determined from the observed grain boundarygroove shapes. The thermal conductivity of the eutectic solid phase for Sn-8.12 at% Mg-4.97 at% Zn alloy and thethermal conductivity ratio of the liquid phase to the solid phase for Sn-8.12 at% Mg-4.97 at% Zn alloy at eutectictemperature were also measured with a radial heat flow apparatus and a Bridgman-type growth apparatus,respectively. The Gibbs-Thomson coefficient, solid-liquid interfacial energy and grain boundary energy of solidSn in equilibrium with Sn-Mg-Zn liquid were determined to be (8.3 ± 0.6)×10-8 Km, (118.5 ± 14.2)×10-3 Jm-2and (225.1 ± 29.3)×10-3 J m-2 respectively from observed grain boundary groove shapes. A comparison ofpresent results for solid Sn in the Sn-8.12 at% Mg-4.97 at% Zn alloy with the results obtained in previous worksfor similar solid Sn in equilibrium with different binary or ternary liquid was made.

The Role of Mitochondrial Dynamic Dysfunction in Age-Associated Type 2 Diabetes

Vezza Teresa,Díaz-Pozo Pedro,Canet Francisco,de Marañón Aranzazu M.,Abad-Jiménez Zaida,García-Gargallo Celia,Roldan Ildefonso,Solá Eva,Bañuls Celia,López-Domènech Sandra,Rocha Milagros,Víctor Víctor M 대한남성과학회 2022 The World Journal of Men's Health Vol.40 No.3

Mitochondrial dynamics, such as fusion and fission, play a critical role in maintaining cellular metabolic homeostasis. The molecular mechanisms underlying these processes include fusion proteins (Mitofusin 1 [MFN1], Mitofusin 2 [MFN2], and optic atrophy 1 [OPA1]) and fission mediators (mitochondrial fission 1 [FIS1] and dynamin-related protein 1 [DRP1]), which interact with each other to ensure mitochondrial quality control. Interestingly, defects in these proteins can lead to the loss of mitochondrial DNA (mtDNA) integrity, impairment of mitochondrial function, a severe alteration of mitochondrial morphology, and eventually cell death. Emerging evidence has revealed a causal relationship between dysregulation of mitochondria dynamics and age-associated type 2 diabetes, a metabolic disease whose rates have reached an alarming epidemic-like level with the majority of cases (59%) recorded in men aged 65 and over. In this sense, fragmentation of mitochondrial networks is often associated with defects in cellular energy production and increased apoptosis, leading, in turn, to excessive reactive oxygen species release, mitochondrial dysfunction, and metabolic alterations, which can ultimately contribute to β-cell dysfunction and insulin resistance. The present review discusses the processes of mitochondrial fusion and fission and their dysfunction in type 2 diabetes, with special attention given to the therapeutic potential of targeting mitochondrial dynamics in this complex metabolic disorder.

In Vivo Genotoxicity and Oxidative Stress Evaluation of an Ethanolic Extract from Piquiá (Caryocar villosum) Pulp

Mara Ribeiro Almeida,Alexandre Ferro Aissa,Tarsila Daysy Ursula Hermogenes Gomes,Joana D’Arc Castania Darin,Renan Campos Chiste,Adriana Zerlotti Mercadante,Lusaˆnia Maria Greggi Antunes,Maria Lourdes 한국식품영양과학회 2013 Journal of medicinal food Vol.16 No.3

In this study, the ethanolic extract obtained from piquiá pulp was assessed for genotoxicity and oxidative stress by employing the micronucleus test in bone marrow and peripheral blood cells in addition to comet, thiobarbituric-acid–reactive substances (TBARS), and reduced glutathione assays in the liver, kidney, and heart. Additionally, phytochemical analyses were performed to identify and quantify the chemical constituents of the piquiá extract. Wistar rats were treated by gavage with an ethanolic extract from piquiá pulp (75 mg/kg body weight) for 14 days, and 24 h prior to euthanasia, they received an injection of saline or doxorubicin (15 mg/kg body weight, intraperoneally). The results demonstrated that piquiá extract at the tested dose was genotoxic but not mutagenic, and it increased the TBARS levels in the heart. Further studies are required to fully elucidate how the properties of ethanolic extract of piquiá pulp can affect human health.

A Glimpse to the Resident Life in a HBP Team

( Mara Mardare ),( Alina Puscasu ),( Victor Burloiu ),( Andrei Vacarasu ),( Irina Bondoc ),( Andrada Spanu ),( Razvan Iosifescu ),( Marius Zamfir ),( Niculae Iordache ),( Octav Ginghina ),( Radu Ghena 대한간학회 2021 춘·추계 학술대회 (KASL) Vol.2021 No.1

Capacity of a transmission tower under downburst wind loading

Mara, T.G.,Hong, H.P.,Lee, C.S.,Ho, T.C.E. Techno-Press 2016 Wind and Structures, An International Journal (WAS Vol.22 No.1

The wind velocity profile over the height of a structure in high intensity wind (HIW) events, such as downbursts, differs from that associated with atmospheric boundary layer (ABL) winds. Current design codes for lattice transmission structures contain only limited advice on the treatment of HIW effects, and structural design is carried out using wind load profiles and response factors derived for ABL winds. The present study assesses the load-deformation curve (capacity curve) of a transmission tower under modeled downburst wind loading, and compares it with that obtained for an ABL wind loading profile. The analysis considers nonlinear inelastic response under simulated downburst wind fields. The capacity curve is represented using the relationship between the base shear and the maximum tip displacement. The results indicate that the capacity curve remains relatively consistent between different downburst scenarios and an ABL loading profile. The use of the capacity curve avoids the difficulty associated with defining a reference wind speed and corresponding wind profile that are adequate and applicable for downburst and ABL winds, thereby allowing a direct comparison of response under synoptic and downburst events. Uncertainty propagation analysis is carried out to evaluate the tower capacity by considering the uncertainty in material properties and geometric variables. The results indicated the coefficient of variation of the tower capacity is small compared to those associated with extreme wind speeds.