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Manivannan, R.,Samidurai, R.,Cao, Jinde,Alsaedi, Ahmed,Alsaadi, Fuad E. Elsevier 2018 Chaos, solitons, and fractals Vol.114 No.-
<P><B>Abstract</B></P> <P>This paper addresses an improved stability criterion for an interval time-delayed neural networks (NNs) including neutral delay and leakage delay. By proposing a suitable Lyapunov–Krasovskii functionals (LKFs) together with the Auxiliary function-based integral inequality (AFBII) and reciprocally convex approach (RCC) approach. The major purpose of this research is put forward to the consideration of inequality techniques together with a suitable LKFs, and mixed with the Leibniz–Newton formula within the structure of linear matrix inequalities (LMIs). It is amazing that, the leakage delay has a disrupting impact on the stability behaviour of such system and they cannot be neglected. Finally, numerical examples have been demonstrated to showing feasibility and applicability of the developed technique. In addition, the developed stability criteria tested for feasibility of the benchmark problem to explore the real-world application in the sense of discrete time-delay and leakage delay as a process variable in the system model.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Some new mathematical technique is adapted together with L-K functionals are estimated its derivative via delay-partitioning approach, which has not been considered yet in stability of model (1) with interval time-varying delays and leakage delays are introduced. </LI> <LI> Different from others in [12,15,16,18,21,22,27,33,44,47], several numerical examples are presented to illustrate the validity of the main results with a real-world simulation. This implies that the results of the present paper are essentially new. </LI> <LI> Additionally, Wirtinger double integral inequality (WDII) technique is taken into account to bound the time-derivative of triple integral Lyapunov–Krasovskii functionals (LKFs), which provide more tighter bounding technology to dealing with such LKFs, this technique has been never used in previous literature ****[12,15,16,18,21,22,27,33,44,47], which play an important role in reducing conservatism. ***** </LI> </UL> </P>
Analgesic activity of flavonoids isolated from Persicaria glabra (wild)
Manivannan Rajamanickam,Shopna Rajamohan 경희대학교 융합한의과학연구소 2020 Oriental Pharmacy and Experimental Medicine Vol.20 No.1
The present experimental study conducted to determine the four flavonoids (1–4) isolated from extracts of Persicaria glabra (Polygonaceae) and was tested for its potential central and peripheral analgesic activity. All animals were lowered on a hot plate (55 ± 0.5 °C), the observations were made before and after administration of respective drugs at 30, 60, and at the end of 90 min. In writhing method, acetic acid is administered intraperitoneal to the experimental animals to create pain sensation. The writhing movements were observed and counted for 30 min after acetic acid administration. The results showed that the compound quercetin (1) and its glycosides (3) at a dose of 100 and 200 mg/kg body weight significant analgesic activity (P < 0.05) in both central and peripheral models of analgesia used. The same doses, compounds 2 and 4 did not show any analgesic effects. Among them, quercetin (1) was the most potent in both models tested. Also due to structural difference of four compounds, a number of hydroxyl groups, substitution of –OCH3 and glycosylation, they will exhibit different analgesic responses. The P. glabra leaf extracts containing mixture of quercetin, isorhamnetin and their glycosides were effective in both the central and peripheral models of pain.
Manivannan, Shanmugam,Kang, Inhak,Kim, Kyuwon American Chemical Society 2016 Langmuir Vol.32 No.7
<P>Herein, we report a facile synthetic strategy for the in situ growth of Prussian blue nanostructures (PB NSs) at the amine-functionalized silicate sol-gel matrix (TPDT)-RGO composite via the electrostatic interaction. Subsequently, Pt nanostructures are electrodeposited onto the preformed ITO/TPDT-RGO-PB electrode to prepare the RGO/PB/Pt catalyst. The significance of the present method is that the PB NSs are in situ grown by interconnecting the RGO layers, leading to 3D cage-like porous nanostructure. The modified electrodes are characterized by FESEM, EDAX, XRD, XPS, and electrochemical techniques. The RGO/PB/Pt catalyst exhibits synergistic electrocatalytic activity and high stability toward methanol oxidation. The porous nature of the TPDT and PB and unique electron-transfer mediating behavior of PB integrated with RGO in the presence of Pt nanostructures facilitated synergistic electrocatalytic activity for methanol oxidation.</P>
Manivannan, Abinaya,Soundararajan, Prabhakaran,Muneer, Sowbiya,Ko, Chung Ho,Jeong, Byoung Ryong Hindawi Publishing Corporation 2016 BioMed research international Vol.2016 No.-
<P>Silicon- (Si-) induced salinity stress resistance was demonstrated at physiological and proteomic levels in<I> Capsicum annuum</I> for the first time. Seedlings of<I> C. annuum</I> were hydroponically treated with NaCl (50 mM) with or without Si (1.8 mM) for 15 days. The results illustrated that saline conditions significantly reduced plant growth and biomass and photosynthetic parameters and increased the electrolyte leakage potential, lipid peroxidation, and hydrogen peroxide level. However, supplementation of Si allowed the plants to recover from salinity stress by improving their physiology and photosynthesis. During salinity stress, Si prevented oxidative damage by increasing the activities of antioxidant enzymes. Furthermore, Si supplementation recovered the nutrient imbalance that had occurred during salinity stress. Additionally, proteomic analysis by two-dimensional gel electrophoresis (2DE) followed by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS) revealed that Si treatment upregulated the accumulation of proteins involved in several metabolic processes, particularly those associated with nucleotide binding and transferase activity. Moreover, Si modulated the expression of vital proteins involved in ubiquitin-mediated nucleosome pathway and carbohydrate metabolism. Overall, the results illustrate that Si application induced resistance against salinity stress in<I> C. annuum</I> by regulating the physiology, antioxidant metabolism, and protein expression.</P>
Transportation Problem for Interval Valued Trapezoidal Intuitionistic Fuzzy Numbers
Manivannan Annamalai,J. Jansi Rani,S. Dhanasekar 한국지능시스템학회 2022 INTERNATIONAL JOURNAL of FUZZY LOGIC and INTELLIGE Vol.22 No.2
The aim of the decision-makers in the transportation industry is to maximize profit by minimizing the transportation cost. The transportation structure is the center of economic activity inthe business logistics system. However, transportation costs may vary owing to various unpredictable factors. In this study, cost of the transporting unit is considered as an interval valuedtrapezoidal intuitionistic fuzzy number to deal with these uncertainties. The transportationproblem with interval-valued trapezoidal intuitionistic fuzzy cost is discussed here, and thecosts are ordered by score and score expected functions. As a special case, the interval-valuedtrapezoidal intuitionistic cost is not converted into crisp numbers to solve the transportationproblem and derive the initial basic feasible (IBF) solution through interval-valued intuitionistic costs. Furthermore, the optimality of the derived initial basic feasible solution is checkedusing the modified distribution (MODI) method. The effectiveness and validation of thedeveloped approach were illustrated using numerical examples.
Manivannan Ramamurthi,이종신,양승한,김영석 한국정밀공학회 2013 International Journal of Precision Engineering and Vol.14 No.10
The element based cohesive zone model (ECZM) is used widely for examining the delamination or decohesion of the interface surface in adhesively-bonded materials using finite element models (FEM). In this study, a surface based cohesive model available in commercial finite element analysis (FEA) code was used in place of the EZCM because of the similarities with both models when the interface thickness is zero and the advantages of fewer input parameters, easy modeling and reduced computational time. A mode I fracture study with the 90° peel test and simulation were performed in polymer-coated steel. The results were compared with the ECZM. The surface based cohesive model predicted delamination well and the results were closer to those obtained by the ECZM. The cohesive model requires fine meshing in the FEM to predict delamination closely. The same simulations were carried out using coarse meshes to evaluate the feasibility of using it in coarse meshes. The results showed that coarse mesh simulations can also predict delamination with accuracy close to those performed with fine meshes.
Manivannan, Abinaya,Kim, Jin-Hee,Yang, Eun-Young,Ahn, Yul-Kyun,Lee, Eun-Su,Choi, Sena,Kim, Do-Sun Hindawi 2018 BioMed research international Vol.2018 No.-
<P>Pepper is an economically important horticultural plant that has been widely used for its pungency and spicy taste in worldwide cuisines. Therefore, the domestication of pepper has been carried out since antiquity. Owing to meet the growing demand for pepper with high quality, organoleptic property, nutraceutical contents, and disease tolerance, genomics assisted breeding techniques can be incorporated to develop novel pepper varieties with desired traits. The application of next-generation sequencing (NGS) approaches has reformed the plant breeding technology especially in the area of molecular marker assisted breeding. The availability of genomic information aids in the deeper understanding of several molecular mechanisms behind the vital physiological processes. In addition, the NGS methods facilitate the genome-wide discovery of DNA based markers linked to key genes involved in important biological phenomenon. Among the molecular markers, single nucleotide polymorphism (SNP) indulges various benefits in comparison with other existing DNA based markers. The present review concentrates on the impact of NGS approaches in the discovery of useful SNP markers associated with pungency and disease resistance in pepper. The information provided in the current endeavor can be utilized for the betterment of pepper breeding in future.</P>