Forced swimming stress increases natatory activity of lead-exposed mice

Araujo Ulisses C.,Krahe Thomas E.,Ribeiro-Carvalho Anderson,Gomes Regina A. A.,Lotufo Bruna M.,Moreira Maria de Fátima R.,de Abreu-Villaça Yael,Manhães Alex C.,Filgueiras Cláudio C. 한국독성학회 2021 Toxicological Research Vol.37 No.1

Recent evidence points to the relationship between lead toxicity and the function of the hypothalamic-pituitary-adrenal axis, which suggests that lead exposure could influence how an individual cope with stress. Here we test this hypothesis by investigating the behavioral effects of lead exposure in mice during the forced swimming test (FST), a parading in which animals are exposed to a stressful situation and environment. Swiss mice received either 180 ppm or 540 ppm of lead acetate (Pb) in their ad-lib water supply for 60–90 days, starting at postnatal day 30. Control (Ctrl) mice drank tap water. At the end of the exposure period, mice were submitted to a 5-min session of FST or to an open-field session of the same duration. Data from naïve animals showed that corticosterone levels were higher for animals tested in the FST compared to animals tested in the open-field. Blood-lead levels (BLL) in Pb-exposed mice ranged from 14.3 to 106.9 μg/dL. No differences were observed in spontaneous locomotion between Ctrl and Pb-exposed groups in the open-field. However, in the FST, Pb-treated mice displayed higher swimming activity than Ctrl ones and this effect was observed even for animals with BLL higher than 20 μg/ dL. Furthermore, significant differences in brain glutathione levels, used as an indicator of led toxicity, were only observed for BLL higher than 40 μg/dL. Overall, these findings suggest that swimming activity in the FST is a good indicator of lead toxicity and confirm our prediction that lead toxicity influences behavioral responses associated to stress.

Field and Laboratory Investigation of Cold In-Place Recycling in Vietnam

Manh Tuan Nguyen,Ba Khanh Le,Manh Cuong Nguyen 한국도로학회 2018 한국도로학회 학술대회 발표논문 초록집 Vol.2018 No.05

In Vietnam, reclaimed asphalt pavement technology is considered as the key to reduce the cost of pavement construction, and decrease the industrial waste from flexible pavement rehabilitation. Ministry of Transportation has concentrated to develop RAP technology since 2008. As a result, there are three trademark of recycling technologies applied in Vietnam such as Wirtgen (Germany), Hall Brothers (U.S.), and Sakai (Japan). This paper is focused on asphalt pavement investigation of field and laboratory tests from Cold In-place recycling technology. The laboratory tests carried out on the material were conventional tests including Marshall stability, indirect tensile strength... Field data was collected using a Benkelman beam and core specimens for indirect tensile strength test.

Cytotoxic and apoptosis-inducing activities against human lung cancer cell lines of cassaine diterpenoids from the bark of <i>Erythrophleum fordii</i>

Ha, Manh Tuan,Tran, Manh Hung,Phuong, Thien Thuong,Kim, Jeong Ah,Woo, Mi Hee,Choi, Jae Sue,Lee, Suhyun,Lee, Jeong Hyung,Lee, Hyeong Kyu,Min, Byung Sun Elsevier 2017 Bioorganic & medicinal chemistry letters Vol.27 No.13

<P><B>Abstract</B></P> <P>A phytochemical investigation into the bark of <I>Erythrophleum fordii</I> yielded four new compounds, two new cassaine diterpenoids (erythrofordin T and U, <B>1</B> and <B>2</B>) and two new cassaine diterpenoid amines (erythroformine A and B, <B>6</B> and <B>7</B>), as well as nine known compounds. We report for the first time the isolation of erythrofordin V (<B>3</B>) from a natural source and that of the remaining eight known diterpenoids (<B>4</B>–<B>5</B>, <B>8</B>–<B>13</B>) from <I>E. fordii</I>. All structures were elucidated using spectroscopic analysis. Cytotoxic activity of the isolated compounds (<B>1</B>–<B>13</B>) was examined <I>in vitro</I> against three non-small cell lung cancer cell lines (A549, NCI-H1975, and NCI-H1229) using the MTT assay. Cassaine diterpene amines (<B>6</B>–<B>10</B>, <B>12</B>, <B>13</B>) exhibited potent cytotoxic activity against all three cell lines with IC<SUB>50</SUB> values between 0.4μM and 5.9μM. Erythroformine B (<B>7</B>) significantly induced apoptosis in all three cancer cells in a concentration-dependent manner.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

α-Amylase and Protein Tyrosine Phosphatase 1B Inhibitoryof Some Vietnamese Medicinal Plants Used to Treat Diabetes

Tran Manh Hung,Hoang Duc Manh,Pham Thi Hong Minh,윤의중,나민균,Won Keun Oh,민병선,배기환 한국생약학회 2007 Natural Product Sciences Vol.13 No.4

this study, the twenty-four ethyl acetate extracts of twenty-two medicinal plants, traditionally usedα-amylase and protein tyrosine phosphatase 1B (PTP1B)enzymes inhibitory activity in vitro. The results indicated that, twelve materials (50.0%) showed moderate tostrong inhibitory activity in α-amylase inhibitory activity with IC50 values ranging from 2.5 to 48.8g/mL;meanwhile, ten extracts (41.6%) could demonstrate PTP1B activity with IC50 values less than 30.5g/mL. Someplants presented interesting activities against both of α-amylase and PTP1B enzymes such as Catharanthusroseus, Carthamus tinctorius, Momordica charantia, Gynostemma pentaphyllum, Glycyrrhiza glabra, Smilaxglabra, Psidium guajava (leave), and Rehmannia glutinosa. The study may provide a proof, at least in a part, forthe ethno-medical use in diabetes disease of these plants. KeywordsVietnamese medicinal plants, diabetes, α-amylase, protein tyrosine phosphatase 1B

Adaptive Control for Uncertain Model of Omni-directional Mobile Robot Based on Radial Basis Function Neural Network

Duyen Ha Thi Kim,Tien Ngo Manh,Cuong Nguyen Manh,Nhan Duc Nguyen,Dung Pham Tien,Manh Tran Van,Minh Phan Xuan 제어·로봇·시스템학회 2021 International Journal of Control, Automation, and Vol.19 No.4

The paper proposes the method to deal with control problems of unmodeled components of the fourwheeled Omni-directional mobile robot. It is commonly challenging to design a model-based control scheme to achieve smooth movement in the tracking process due to the unknown elements in the mathematical model of the robot or external disturbances. Our main contribution focuses on designing an adaptive controller based on neural networks with online weight updating laws and Fuzzy logic to guarantee the high accuracy of the robot’s movement when the unknown factors adversely affect the robot control. At the initial step, a Dynamic Surface Control plays a role as a core of the controller for the robot system. Then, with the ability to estimate the appropriate value for uncertain nonlinear parts, a Radial Basis Function Neural Network is designed. Finally, a Fuzzy law is to utilize control parameters in each period to increase the adaptive behavior of the system. The stability and convergence of the system are proven by the Lyapunov’s stability theory. The simulation results illustrate the validity and the efficiency of the proposed control algorithm when the system is lack of robot model’s information.

Fungal Community Analyses of Endophytic Fungi from Two Oak Species, Quercus mongolica and Quercus serrata, in Korea

( Manh Ha Nguyen ),( Keum Chul Shin ),( Jong Kyu Lee ) 한국균학회 2021 Mycobiology Vol.49 No.4

Fungal endophytes have been recorded in various plant species with a richness of diversity, and their presence plays an essential role in host plant protection against biotic and abiotic stresses. This study applied the Illumina MiSeq sequencing platform based on the amplification of fungal ribosomal ITS2 region to analyze fungal endophytic communities of two oak species (Quercus mongolica and Q. serrata) with different oak wilt disease susceptibilities in Korea. The results showed a total of 230,768 sequencing reads were obtained and clustered at a 97% similarity threshold into 709 operational taxonomic units (OTUs). The OTUs of Q. serrata were higher than that of Q. mongolica with the number of 617 OTUs and 512 OTUs, respectively. Shannon index also showed that Q. serrata had a significantly higher level of fungal diversity than Q. mongolica. Total of OTUs were assigned into 5 fungal phyla, 17 classes, 60 orders, 133 families, 195 genera, and 280 species. Ascomycota was the dominant phylum with 75.11% relative abundance, followed by Basidiomycota with 5.28%. Leptosillia, Aureobasidium and Acanthostigma were the most abundant genera detected in Q. serrata with the average relative abundance of 2.85, 2.76, and 2.19%, respectively. On the other hand, Peltaster, Cladosporium and Monochaetia were the most common genera detected in Q. mongolica with the average relative abundance of 4.83, 3.03, and 2.87%, respectively. Our results indicated that fungal endophytic communities were significantly different between two oak species and these differences could influence responses of host trees to oak wilt disease caused by Raffaelea quercus-mongolicae.

The Impact of Vietnam’s New Rural Development Program on Rural Household Income: Cross-sectional Evidence Covering Communes That Hosted Korea’s Saemaul Undong Program

Manh Hung Do,비엣 흥 응웬(Viet Hung Nguyen),투하 응웬 티(Thu Ha Nguyen Thi),한 호앙 티(Hanh Hoang Thi),프엉 투 응웬 티(Phuong Thu Nguyen Thi) 영남대학교 박정희새마을연구원 2018 새마을학연구 Vol.3 No.2

베트남의 1986년도 정치경제 개혁, 즉 도어머이(Doi Moi)는 베트남의 경제를 개방적 사회주의경제로 전환시켰으며, 이를 계기로 베트남 경제는 획기적으로 근대화되었다. 그러나 이 과정에서 급속한 도시화는 도농 간 불균형을 가져왔으며, 이 도농 간 격차를 줄이기 위해 베트남 정부는 2006년에 새농촌개발(NRD) 프로그램을 도입하기에 이르렀다. 이 프로그램은 농촌 지역의 사회기반시설의 확충과 생활환경의 개선, 생산 활동의 종합적 발전, 소득증대, 농민들의 육체적ㆍ정신적 건강 증진 등을 목표로 하고 있었다. 이 논문의 주된 목적은 NRD 프로그램의 시행이 NRD의 궁극적 목적 중 하나인 농가소득 증대에 미치는 영향에 대한 과학적 증거를 제시하는 데 있다. 또한 이와 더불어 새마을운동의 시범사업을 실시한 지역과 그렇지 않은 지역 간에 소득 증대에서 차이가 있는가를 다중회귀분석을 통해 밝혀보고자 한다. 분석 결과는 NRD의 시행이 상당히 긍정적 결과를 가져왔으며 코민 수준에서 농가소득 증대와 생활환경의 개선에 중요한 영향을 미쳤다는 것을 보여주었다. 또한 도로 건설, 전기 도입, 주민 역량 강화, 제도의 발전 등이 농가소득 증대에 큰 영향을 미쳤음을 확인했다. 회귀분석의 결과는 또한 새마을 사업을 시행하고 있는 코뮌들이 그렇지 않은 코뮌에 비해 연소득이 1200만 동(미화530달러) 더 많다(또는 41.8% 더 높다)는 것을 보여주었다. The economic and political reform of Vietnam in 1986 (the Doi Moi) has transformed its economy positively and significantly into an open socialist-oriented market economy. This caused a dramatic change of Vietnam’s economy towards modernization. However, the urbanization process created an unbalanced development between the urban and rural regions. To solve the gaps between these regions, the government of Vietnam firstly introduced the New Rural Development (NRD) program in 2006 to encourage and mobilize a revolutionary and campaign to improve local infrastructure, living condition, comprehensive development of related-production activities in rural regions, as well as increase income, and improve physical and mental health of people living in rural communities. One of the main purposes of this research paper is aimed at providing a scientific evidence for justifying whether the NRD implementation could have an impact on rural households’ income, one of the ultimate goals of the NRD, and examining the difference of incomes between Saemaul Undong (SU)-piloted provinces with the other provinces by employing a multiple regression model. The analysis results show that the NRD implementation has shown positive results and significant impacts on increasing rural households’ income and improving living conditions at the communal levels. Criteria such as road development, access to electricity, capacity building, and institutional development have significantly influenced on the households’ income. The regression model also indicates that the communes currently implementing SU pilots have a better annual income of 12 million VND (~US$ 530) or 41.8% higher than the other communes.

Ferromagnetism in Zn_1–<i>x</i>Mn_<i>x</i>O Nanoparticles Prepared by Ball Milling

Manh, T. V.,Phan, T. L.,Lee, B. W.,Liu, Chunli,Ho, T. A.,Thanh, T. D.,Vuong, N. M.,Yu, S. C. IEEE 2015 IEEE transactions on magnetics Vol.51 No.11

<P>Previous studies pointed out that ferromagnetism in Mn-doped ZnO was related to exchange interactions between Mn ions mediated by lattice defects. This means that it is possible to modify a Mn-doped ZnO paramagnet to a ferromagnet by creating lattice defects in it. The present work starts from a paramagnetic Zn0.98Mn0.02O sample prepared by solid-state reaction and then creates more defects upon mechanical milling. By changing the milling time (t(m)) from 0.5 to 20 h, we produced nanocrystalline (NC) samples with average crystallite sizes (d) ranging from 30 to 157 nm. The d decrease generated lattice strain and defects. This broadens and blurs the lines of Raman scattering and electron spin resonance (ESR) spectra. Interestingly, magnetization studies versus magnetic field revealed the samples with d <= 150 nm exhibiting room-temperature ferromagnetic (FM) order. The FM order became largest as d = 72 nm, corresponding to a saturation magnetization of M-s approximate to 0.006 emu/g. Apart from this d value, M-s would be gradually decreased. X-ray absorption fine structure (XAFS) spectra revealed a coexistence of Mn2+ and Mn3+ ions in the samples. Their concentration ratio was slightly changed with decreasing d, due to the slight shift of the absorption edge. With the features of Fourier-transformed XAFS and ESR spectra, we believe that ferromagnetism in the NC samples is related to oxygen vacancies residing on the surface of nanoparticles. Local lattice distortions can lead to zinc interstitials for the samples d < 72 nm, which decreases M-s.</P>

Magnetocaloric Manganites

Manh-Huong Phan,Seong-Cho Yu 한국자기학회 2007 한국자기학회 학술연구발표회 논문개요집 Vol.- No.-

Determinants Influencing the Conversion of Financial Statements: The Case of Multinational Firms in Vietnam

Manh Dung TRAN,Thi Tuyet Mai NGO,To Uyen PHAN,Duc Tai DO,Thi Thuy Hang PHAM 한국유통과학회 2020 The Journal of Asian Finance, Economics and Busine Vol.7 No.3

The research aims to investigate the impact levels of determinants on the conversion of financial statements from Vietnamese accounting standards (VAS) to International financial reporting standards (IFRS) in the multinational firms in Vietnam. The method of data collection was done through the survey and subjects are accountants in Multinational Firms doing business in Hanoi and ten neighboring provinces. After checking the information on the votes, there are 170 questionnaires with full information for data entry and analysis. We use Cronbach‟s Alpha, EFA analysis and run regression model to investigate the impact levels of each independent variable on dependent variable of the conversion of VAS financial statements to IFRS. The results show that five determinants including Economic, Politics, Law, Culture, and Conditions for implementation have positive relationships with the conversion of VAS financial statements to IFRS. In particular, Economic determinant is the most strongest. Based on the findings, some recommendations are given for improving the conversion of VAS financial statements to IFRS of multinational firms doing business in the context of Vietnam. The results are considered a useful reference for firms when making financial statements to transparently change the financial statement information and improve the quality of financial statement information.