메니에르병의 진단기준

Jose A. Lopez-Escamez,John Careyb,Won-Ho Chung,Joel A. Goebeld,Måns Magnusson,Marco Mandalà,David E. Newman-Tokerg,Michael Strupp,Mamoru Suzuki,Franco Trabalzini,Alexandre Bisdorff 대한평형의학회 2015 Research in Vestibular Science Vol.14 No.3

This paper presents diagnostic criteria for Ménierè’s disease jointly formulated by the Classification Committee of the Bárány Society, The Japan Society for Equilibrium Research, the European Academy of Otology and Neurotology, the Equilibrium Committee of the American Academy of Otolaryngology-Head and Neck Surgery, and the Korean Balance Society. The classification includes two categories: definite Ménière's disease and probable Menière's disease. The diagnosis of definite Ménière's disease is based on clinical criteria and requires the observation of an episodic vertigo syndrome associated with low- to me-dium-frequency sensorineural hearing loss and fluctuating aural symptoms (hearing, tinnitus and/or fullness) in the affected ear. Duration of vertigo episodes is limited to a period between 20 minutes and 12 hours. Probable Ménierè's disease is a broader concept defined by episodic vestibular symptoms (vertigo or dizziness) associated with fluctuating aural symptoms occurring in a period from 20 minutes to 24 hours. Res Vestib Sci 2015;14(3):67-74

Enhanced Photocatalytic Reduction And Selective Adsorption Of Gold Ions From Electronic Waste Solutions Onto Metal-Free Photocatalysts

Sandip Mandal(Mandal Sandip),Yunho Lee(이윤호),Seongbeom Jeon(전성범) 대한환경공학회 2021 대한환경공학회 학술발표논문집 Vol.2021 No.11

VALUE DISTRIBUTIONS OF L-FUNCTIONS CONCERNING POLYNOMIAL SHARING

Mandal, Nintu Korean Mathematical Society 2021 대한수학회논문집 Vol.36 No.4

We mainly study the value distributions of L-functions in the extended selberg class. Concerning weighted sharing, we prove an uniqueness theorem when certain differential monomial of a meromorphic function share a polynomial with certain differential monomial of an L-function which improve and generalize some recent results due to Liu, Li and Yi [11], Hao and Chen [3] and Mandal and Datta [12].

Purification and Characterization of a Deoxyriboendonuclease from Mycobacterium smegmatis

Mandal, Prajna,Chakraborty, Phulghuri,Sau, Subrata,Mandal, Nitai Chandra Korean Society for Biochemistry and Molecular Biol 2006 Journal of biochemistry and molecular biology Vol.39 No.2

A deoxyriboendonuclease has been purified to near homogeneity from a fast growing mycobacterium species, M. smegmatis and characterized to some extent. The size of enzyme is about 43 kDa as determined by a denaturing gel analysis. It shows optimum activity at $32^{\circ}C$ in Tris-HCl buffer (pH 7.2) containing 2.5 mM of $MgCl_2$. Both EDTA and $K^+$ but not $Na^+$ inhibit its activity. Evidences show that the enzyme is not a restriction endonuclease but catalyzes the endonucleolytic cleavage of both the double- as well as the single-strand DNA non-specifically. It has been shown that the cleavage by this enzyme generates DNA fragments carrying phosphate groups at 5' ends and hydroxyl group at the 3' ends, respectively. Analysis reveals that no endonuclease having size and property identical to our deoxyriboendonuclease had been purified from M. smegmatis before. The property of our enzymes closely matches with the deoxyriboendonucleases purified from diverse sources including bacteria.

Landslide susceptibility mapping using modified information value model in the Lish river basin of Darjiling Himalaya

Biplab Mandal,Sujit Mandal 대한공간정보학회 2017 Spatial Information Research Vol.25 No.2

The spatial distribution of mountain slope instability deals with the potential zones for landslides occurrences. In the present study, information value model was modified to make the modified information value model using RS & GIS to assess landslide susceptibility of the Lish river basin of Eastern Darjeeling Himalaya. Eleven important causative factors of slope instability like slope, aspect, curvature, lithology, geomorphology, soil, NDVI, drainage density, relative relief, LULC, elevation were considered and corresponding thematic data layers were generated in Arc GIS (10.1) environments. 87 very small to large various types landslide locations were identified with the help GPS through extensive field survey and incorporating Google earth image (2015). The entire thematic data layers were extracted from ASTER GDEM, Topographical maps (78 B/9; 1: 50,000), LANDSAT 8 OLI satellite image, Google earth image (2015) etc. All the thematic data layers were integrated on GIS environment to generate the landslide susceptibility map of the study area. The Lish river basin was classified into six landslide susceptibility zones i.e. very low, low, moderate, moderately high, high and very high considering the ranges of landslide susceptibility index. Finally, an accuracy assessment was done in Arc GIS by ground truth verification of 54 training sites having landslides from Google earth image (2015) for each landslide susceptibility class and compared with probability model which demonstrates the overall accuracy of the present study is 87.04% and Kappa coefficient is 84.41%.

A Note on How and Why Growth and Unemployment Go Hand in Hand in Developing Economies

Biswajit Mandal,Arindam Mandal 한국국제경제학회 2015 International Economic Journal Vol.29 No.4

This paper develops a simple model to explain the phenomenon of persistent unemployment, even in an economy experiencing high output growth. In the model, unemployment grows at a rate identical with the growth rate of input factors and sectors. The result is primarily triggered by a pre-fixed minimum wage for unskilled workers. To corroborate our claim, we have empirically tested our model hypothesis using data for 12 developing countries and found empirical results consistent with the theory. To mitigate or reduce unemployment, history becomes crucial in deciding on the desired rate of growth in different sectors.

Bivariate statistical index for landslide susceptibility mapping in the Rorachu river basin of eastern Sikkim Himalaya, India

Sujit Mandal,Kanu Mandal 대한공간정보학회 2018 Spatial Information Research Vol.26 No.1

The main goal of the study is to prepare a landslide susceptibility map under Geographical Information System (GIS) environment using statistical index model to identify and demarcate the areas of future landslide occurrence. Firstly, landslide locations were identified with the help of previous reports, satellite images and intensive field study. For the preparation of landslide inventory, 80 landslide locations were identified and randomly separated to create training and validation datasets. Fifty landslides (62.5%) were used as training dataset and remaining 30 landslides (37.5%) were used for validating the model. Twelve landslide conditioning factors, including morphometric factors (slope angle, slope aspect, curvature, relative relief and drainage density) and non-morphometric factors (bedrock geology, soil, distance from drainage, distance from lineament, distance from road, Normalized Difference Vegetation Index (NDVI) and land use/land cover), were used to generate landslide susceptibility map of Rorachu river basin. Finally, the accuracy of the model was assessed by area under curve of Receiver Operating Characteristics (ROC) curve and landslide density method. The statistics of ROC curve showed that, the landslide susceptibility map using statistical index model has an accuracy of 91% which indicates a very good predictive capacity of the model. The result reveals that, landslide density of the Rorachu river basin is increasing with landslide susceptibility classes.

Neuroprotective effect of ibuprofen by intranasal application of mucoadhesive nanoemulsion in MPTP induced Parkinson model

Surjyanarayan Mandal,Snigdha Das Mandal,Krishna Chuttani,Krutika K. Sawant,Bharat Bhushan Subudhi 한국약제학회 2016 Journal of Pharmaceutical Investigation Vol.46 No.1

This study was to investigate the neuroprotective effect of Ibuprofen by intranasal route against inflammationmediated by dopaminergic neurodegeneration in 1-methyl- 4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mice model of Parkinson’s disease (PD). Ibuprofen loaded sodium hyaluronate based mucoadhesive nanoemulsion (MNEI) was developed by using response surface methodology (RSM) and was characterized. Male C57BL/6 mice were first treated with four intraperitoneal injections of MPTP (20 mg/kg of body weight) at 2 h intervals followed by Ibuprofen for 2 consecutive weeks at 2.86 mg/kg of body weight per day. Optimal MNEI containing 3 % Labrafil M 1944 CS as oil phase, 36 %of Accenon CC and Transcutol P at 3:1 ratio and 0.5 % sodium hyaluronate was stable, non-ciliotoxic with 46.3 ± 2.28 nm as average globule size PdI value and TEM result showed the narrow size distribution of MNEI. The result showed that all three independent variables had a significant effect (p\0.05) on the responses. In-vivo results revealed significant reduction of MPTP-mediated dopamine depletion after nasal administration of Ibuprofen through MNEI. MPTP intoxication significantly decreased striatal DA content to 29.92 % which was elevated to 58.21 % after Ibuprofen treatment using MNEI. Significant improvement in motor performance and gross behavioural activity of the mice was observed through the findings of rota-rod and open field test findings. Findings of the investigation revealed that Ibuprofen through developed MNEI was shown to protect neurons against MPTP-induced injury in the striatum and could be a promising approach to treat PD.

Purification and Characterization of a Deoxyriboendonuclease from Mycobacterium smegmatis

Prajna Mandal,Phulghuri Chakraborty,Subrata Sau,Nitai Chandra Mandal 한국생활환경학회 2006 BMB Reports Vol.39 No.2

Brain targeting efficiency of Curcumin loaded mucoadhesive microemulsion through intranasal route

Snigdha Das Mandal,Surjyanarayan Mandal,Jayvadan Patel 한국약제학회 2016 Journal of Pharmaceutical Investigation Vol.46 No.2

This study was aimed at designing mucoadhesive microemulsion gel to enhance the brain uptake of curcumin through intranasal route. Suitable oil, surfactant and cosurfactant for the development of microemulsion were selected based on maximum curcumin solubility, drug excipients compatibility through FTIR study and non-toxicity to sheep nasal mucosa. Curcumin loaded mucoadhesive microemulsion (CMME) was developed by incorporating polycarbophil as mucoadhesive polymer into Capmul MCM based optimal microemulsion (CME) and was subjected to characterization, stability, mucoadhesion and naso-ciliotoxicity study. Brain uptake of Curcumin via nasal route was studied by performing biodistribution study in Swiss albino rats. CME was found to be transparent, stable and non ciliotoxic with 57.66 nm ± 3.46, -16.28 mV ± 4.11 and 98.08 % ± 1.01 as average globule size, zeta potential and drug content respectively. PdI and TEM study depicted the narrow size distribution of CME. Following single intranasal administration of CMME and CME at dose of 2.86 mg/kg, Maximum Curcumin uptake in the olfactory bulb was more than 11 fold (51.1 ± 2.8) than that of intravenous injection of Curcumin solution (4.4 ± 1.1). AUC ratio of brain tissues to that in plasma obtained after nasal administration of CMME were significantly higher than those after intravenous administration of Curcumin solution. Findings of the present study revealed that optimal CMME and intranasal route may be considered to be promising and an alternative approach for brain targeting of Curcumin.