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Development of new inner diaphragms for a H-beam and composite box column joint
Mahbub Khan,Brian Uy,Jin W Kim 국제구조공학회 2022 Steel and Composite Structures, An International J Vol.42 No.3
This paper presents an experimental and a numerical investigation of a H-beam – composite box column joint fabricated with two new inner diaphragms and a continuous inner diaphragm. The main objective of the current research project is to investigate the structural performance of the newly developed inner diaphragms under a cyclic loading protocol. Hysteretic behaviour of the composite joints is analysed to investigate the structural performance of the new and continuous inner diaphragms. This paper compares the result of the finite element (FE) models with the new and continuous inner diaphragms against their counterpart experimental results. To produce a design criterion for the newly developed inner diaphragms, yielding or failure area of the inner diaphragms under tensile stress is analysed from the FE results.
Mahbub Hasan,Jong-Gu Choi,Hafeza Akter,Sang-Suk Lee 한국자기학회 2022 Journal of Magnetics Vol.27 No.4
The suppression of cytokine storm in severe coronavirus disease 2019 (COVID-19) patients can be treated with monoclonal antibody therapy against CD3 for T cell receptor inhibition. An optimized liquid phase as a CD3 antibody-magnetic nanoparticle (Ab-MNP) conjugate can inhibit the overactivation of T cells. We aim to analyze the distribution of Fe in the spleen after acute administration of silica-conjugated amine magnetite (Fe3O4) nanoparticles (35 nm) delivered by intravenous injection. The Fe element distribution and concentration levels in spleen tissue were analyzed using energy dispersive spectroscopy (EDS) and inductively coupled plasmamass spectrometry (ICP-MS). The experimental result is a difference in the concentration of Fe elements, which was 1.89×103 mg/kg in the spleen of a control mouse not administered with MNPs, whereas increases significantly to 1.93×103 mg/kg in that of a mouse administered with MNPs. Further, time kinetic analysis of biochemical and immunological parameters is required to confirm its suitability in bio-administration.
Timber-FRP composite beam subjected to negative bending
Mahbube Subhani,Anastasia Globa,Jules Moloney 국제구조공학회 2020 Structural Engineering and Mechanics, An Int'l Jou Vol.73 No.3
In the previous studies, the authors proposed the use of laminated veneer lumber – carbon fiber reinforced polymer (LVL-CFRP) composite beams for structural application. Bond strength of the LVL-to-CFRP interface and flexural strengthening schemes to increase the bending capacity subjected to positive and negative moment were discussed in the previous works. In this article, theoretical models are proposed to predict the moment capacity when the LVL-CFRP beams are subjected to negative moment. Two common failure modes – CFRP fracture and debonding of CFRP are considered. The non-linear model proposed for positive moment is modified for negative moment to determine the section moment capacity. For the debonding based failure, previously developed bond strength model for CFRP-to-LVL interface is implemented. The theoretical models are validated against the experimental results and then use to determine the moment-rotation behaviour and rotational rigidity to compare the efficacy of various strengthening techniques. It is found that combined use of bi- and uni-directional CFRP U-wrap at the joint performs well in terms of both moment capacity and rotational rigidity.
Strengthening of steel-concrete composite beams with composite slab
Mahbube Subhani,Muhammad Ikramul Kabir,Riyadh Al-Ameri 국제구조공학회 2020 Steel and Composite Structures, An International J Vol.34 No.1
Steel-concrete composite beam with profiled steel sheet has gained its popularity in the last two decades. Due to the ageing of these structures, retrofitting in terms of flexural strength is necessary to ensure that the aged structures can carry the increased traffic load throughout their design life. The steel ribs, which presented in the profiled steel deck, limit the use of shear connectors. This leads to a poor degree of composite action between the concrete slab and steel beam compared to the solid slab situation. As a result, the shear connectors that connects the slab and beam will be subjected to higher shear stress which may also require strengthening to increase the load carrying capacity of an existing composite structure. While most of the available studies focus on the strengthening of longitudinal shear and flexural strength separately, the present work investigates the effect of both flexural and longitudinal shear strengthening of steel-concrete composite beam with composite slab in terms of failure modes, ultimate load carrying capacity, ductility, end-slip, strain profile and interface differential strain. The flexural strengthening was conducted using carbon fibre reinforced polymer (CFRP) or steel plate on the soffit of the steel I-beam, while longitudinal shear capacity was enhanced using post-installed high strength bolts. Moreover, a combination of both the longitudinal shear and flexural strengthening techniques was also implemented (hybrid strengthening). It is concluded that hybrid strengthening improved the ultimate load carrying capacity and reduce slip and interface differential strain that lead to improved composite action. However, hybrid strengthening resulted in brittle failure mode that decreased ductility of the beam.
항-CD3 단일클론 항체와 접합된 아민-덱스트란 자성나노입자의 생리식염수 내 자기저항 특성
HASAN MAHBUB,최종구,신명우,이상석 한국물리학회 2023 새물리 Vol.73 No.9
COVID-19의 사이토카인 폭풍의 원인이 되는 T 세포 과잉 활성화를 억제하는 면역치료용 항체인 항-CD3e mAb(145-2C11)를 자성나노입자(MNPs)의 표면에 접합하여 자기적 특성을 조사하였다. MNPs와 CD3 항체의 접합에 필요한 가교제로 글루타르알데하이드를 이용하였다. TEM-EDS 스펙트럼 분석에서 존재하는 원소의 무게 순서는 C > O > Fe > P > Cl > N > S 이었으며, 2단자 구리 전극 수조에서 측정한 MNPs-mAb 접합체가 포함된 PBS 용액의 자기저항 곡선으로부터 자기저항값, 자기저항비, 용액 보자력은 각각 18 MΩ, −22.2%, 300 Oe으로 대칭 피크를 나타내었다. 이러한 결과는 항체가 접합된 MNPs가 외부 자기장에 의하여 원하는 표적으로 조절 및 유도될 수 있음을 보여주는 것으로 사료된다. Anti-CD3e mAb (145-2C11), which is an immunotherapeutic antibody that inhibits the overactivation of T cells and the cause of the cytokine storm in COVID-19, was conjugated to the surface of magnetic nanoparticles (MNPs), and its magnetic properties were investigated. Glutaraldehyde was used as a cross-linking agent to conjugate MNPs and CD3 antibody (MNP-mAb). In the transmission electron microscopy–energy dispersive spectroscopy spectrum analysis, the order of the weights of the elements present was C > O > Fe > P > Cl > N > S. From the magnetoresistance curve of the phosphate-buffered saline solution containing the MNP-mAb conjugate measured in a two-terminal copper electrode bath, the magnetoresistance value, ratio, and solution coercivity were 18 MΩ, −22.2%, and 300 Oe, respectively, with symmetrical peaks. These results reveal that the antibody-conjugated MNPs can be regulated and induced to the desired target using an external magnetic field.
Synthesis and Characterization of Methyltriethoxysilyl-Mediated Mesoporous Silicalites
Mohammad Mahbub Rabbani,오원태,Dae-Geun Nam 한국전기전자재료학회 2011 Transactions on Electrical and Electronic Material Vol.12 No.3
A series of mesoporous silicalites was synthesized using different compositions of tetraethylorthosilicate and methyltriethoxysilane (MTES) as the silica source. Cetyltrimethylammonium bromide was used as the organic template. Their detailed pore structures were investigated by transmission electron microscopy, X-ray diffraction, and N2 adsorption method. The thermal properties of these silicalites were studied by thermogravimetric analysis. The increased amount of MTES destroyed mesoporous channels and reduced pore sizes from 3.4 nm to 2.8 nm in calcined silicalites. The calcined silicalite transformed completely into an amorphous state at 30% MTES loading. Methyl pending groups of MTES hindered the structural ordering of ≡Si-O- frameworks, resulting in an amorphous structure. This was caused by the insufficient formation of supramolecular assembly with the organic template. No capillary condensation step was found in MS 7/3 silicalite. The other capillary condensation steps shifted toward the lower relative pressure with increasing MTES content, indicating the reduction of pore sizes.