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Kim, M.C.,Lee, J.S.,Kwon, Y.M.,O, E.,Lee, Y.J.,Choi, J.G.,Wang, B.Z.,Compans, R.W.,Kang, S.M. Elsevier/North-Holland 2013 Antiviral research Vol.99 No.3
The influenza M2 ectodomain (M2e) is poorly immunogenic and has some amino acid changes among isolates from different host species. We expressed a tandem repeat construct of heterologous M2e sequences (M2e5x) derived from human, swine, and avian origin influenza A viruses on virus-like particles (M2e5x VLPs) in a membrane-anchored form. Immunization of mice with M2e5x VLPs induced protective antibodies cross-reactive to antigenically different influenza A viruses and conferred cross protection. Anti-M2e antibodies induced by heterologous M2e5x VLPs showed a wider range of cross reactivity to influenza A viruses at higher levels than those by live virus infection, homologous M2e VLPs, or M2e monoclonal antibody 14C2. Fc receptors were found to be important for mediating protection by immune sera from M2e5x VLP vaccination. The present study provides evidence that heterologous recombinant M2e5x VLPs can be more effective in inducing protective M2e immunity than natural virus infection and further supports an approach for developing an effective universal influenza vaccine.
Minimum permanents on two faces of the polytope of doubly stochastic matrices
Pula, K.,Song, S.Z.,Wanless, I.M. North Holland [etc.] 2011 Linear algebra and its applications Vol.434 No.1
We consider the minimum permanents and minimising matrices on the faces of the polytope of doubly stochastic matrices whose nonzero entries coincide with those of, respectively,U<SUB>m,n</SUB>=I<SUB>n</SUB>J<SUB>n,m</SUB>J<SUB>m,n</SUB>0<SUB>m</SUB>andV<SUB>m,n</SUB>=I<SUB>n</SUB>J<SUB>n,m</SUB>J<SUB>m,n</SUB>J<SUB>m,m</SUB>. Here J<SUB>r,s</SUB> denotes the rxs matrix all of whose entries are 1, I<SUB>n</SUB> is the identity matrix of order n and 0<SUB>m</SUB> is the mxm zero matrix. We conjecture that V<SUB>m,n</SUB> is cohesive but not barycentric for 1<n<m+m and that it is not cohesive for n≥m+m. We prove that it is cohesive for 1<n<m+m and not cohesive for n≥2m and confirm the conjecture computationally for n<2m≤200. We also show that U<SUB>m,n</SUB> is barycentric.
EFFECTS OF ALTITUDE ON COMBUSTION CHARACTERISTIC DURING COLD START OF HEAVY-DUTY DIESEL ENGINE
Z. C. KAN,D. M. LOU,Z. Z. CAO,Z. Y. HU,S. LIU,Z. H. YANG 한국자동차공학회 2017 International journal of automotive technology Vol.18 No.2
Altitude has a significant effect on combustion of heavy-duty diesel engines, especially during cold start. An experimental study on a heavy-duty diesel engine operating at different altitudes was conducted. Tests were based on a direct injection (DI) turbocharged diesel engine with intake and exhaust pressure controlled by the plateau simulation test system to stimulate altitude conditions including 0 m, 1000 m, 2000 m, 3000 m and 4000 m. Results indicated that the compression and expansion resistance moment reduced and the speed increased during the cranking period. The peak pressure of several cycles was increased during the start-up period; however, the expansion pressure dropped more and the indicated mean effective pressure (IMEP) reduced as the altitude rose. While at an altitude of over 2000 m, the peak pressure fluctuated obviously during the start-up period. The higher the altitude was, the more the fluctuation amplitude and cycle number increased and combustion instability enhanced, which resulted the start-up period time increasing at high altitude. When the altitude rose, the cycle-to-cycle variation of the peak pressure and speed fluctuation increased during the idle, the ignition and CA50 were delayed and the combustion duration was shortened. The effect of altitude on combustion characteristics of the diesel engine was more significant during the start-up period than during its idle period.
Study of leaching of a 2M-Zirconolite (Ca0,83Ce0,17ZrTi1,66Al0.34O7) in acidic and basic media
R. Souag,N. Kamel,M. Hammadi,Z. Kamel,D. Moudir,F. Aouchiche,Y. Mouheb,S. Kamariz 한양대학교 세라믹연구소 2015 Journal of Ceramic Processing Research Vol.16 No.1
Zirconolite is a mineral intended for actinides elements confinement and is known for its good chemical durability. In this work, 2M-zirconolite, with the chemical formula: Ca0,83Ce0,17ZrTi1,66Al0.34O7 have been synthesized at 1400 o C by the metallurgical route at a laboratory scale. This stoechiometry corresponds to a CeO2 loading of 8.61 m.%. Ce is employed as an actinide surrogate. The effect of both pH and temperature on the chemical durability of this mineral has been studied. Phase identification and micrography observations have been done by X-ray diffraction, scanning electronic microscopy, and Fourrier transform infra-red spectroscopy. The end-product has a monophasic structure of 2M-zirconolite. Its density is about 4.013 g/cm3 , and its relative density is of 96 %TD. It has a microhardeness of 370 MPa. The Ce behavior in leaching media of extreme pH values: acidic medium (pH = 2) and basic medium (pH = 12), at 23 o C and 70 o C, shows that the Ce dissolution speeds are faster at 70 o C compared with those obtained at 23 o C. The 2M-zirconolite matrice presently studied appears to have a good chemical durability.
M.Z.A. Rafiquee,Masoom R. Siddiqui,H.N. Haque,M. Shamsul Ola,Hamad A. Al-Lohedan,Z.A. ALOthman,Saikh M. Wabaidur 한국공업화학회 2016 Journal of Industrial and Engineering Chemistry Vol.34 No.-
Reduction of molecular oxygen by 2-mercaptoethanol in the presence of cobalt(II)histidine is described. Cobalt(II)histidine complex forms dinuclear 2:1 (Co:O2) complex with molecular oxygen (m-dioxyte-trakis(histidinato)dicobalt(II)). The molecular oxygen did not directly react with 2-mercaptoethanol, but,reacted in the form of an adduct with cobalt(II)histidine complex. During the course of the reaction themolecular oxygen is reduced to hydroxide ion while the cobalt(II)histidine complex was oxidized tocobalt(III)histidine while 2-mercaptoethanol is reduced into 2,20-dithiodiethanol. The decrease inabsorbance for the dioxygen complex was monitored spectrophotometrically and was observed that thevalues of rate constant increased with the increase in [2-mercaptoethanol]. The values of kobs also increasedwith increasing [NaOH]. Thus, from the results of these studies, mechanism of the reaction has beenproposed. In addition, the values of various equilibrium constants and rate constants were also determinedusing nonlinear least square techniques.
Chaudhry, M.Z.,Tahir, M.J.,Rafique, M. Asian Australasian Association of Animal Productio 1994 Animal Bioscience Vol.7 No.3
Six heifers each of $F_1$, $F_2$, $F_3$, $F_4$ H. Friesian $\times$ Sahjwal halfbreds and pure Sahiwal with overall average initial age and live weight of $315.6{\pm}134.8 days$ and $143.8{\pm}48.5kg$, respectively were used for this study. The under trial animals were fed according to N.R.C. (1978). The overall average age at maturity, first conception and first calving was $563.8{\pm}116.8$, $675.8{\pm}135.6$ and $956.8{\pm}149.8days$ with live weights as $302.2{\pm}58.6$, $342.6{\pm}41.5$ and $433.9{\pm}38.1kg$, respectively. The overall 305 days and total milk yield for 1st lactation was $2,729.0{\pm}669.3$ and $2,992.7{\pm}377.5litre$ while the FCM (at 4%) was $2,934.2{\pm}410.8litre$. The lactation length was $336.6{\pm}69.6days$. The fat and solids not fat contents were $4.5{\pm}0.2$ and $8.2{\pm}0.3percent$, respectively. The milk production in Sahiwal cows was significantly lower than crossbred cows. The services per conception were $2.5{\pm}1.3$. The overall per head per day consumption of DM, TCP and ME was $10.9{\pm}1.2kg$, $1,399{\pm}199gm$ and $22.6{\pm}2.4 M.Cal.$, respectively. The overall milk producing efficiency for the production of one litre of FCM was $1.12{\pm}0.15kg$ of DM, $142.2{\pm}17.76gm$ of TCP and $2.31{\pm}0.27M.Cal.$ of energy while the feeding cost was Rs. $1.46{\pm}0.22$ per litre of FCM produced. The feeding cost per litre FCM was significantly higher in Sahiwal and $F_2$ than in other genetic groups.
Acharya, S.,Adamová,, D.,Adolfsson, J.,Aggarwal, M.M.,Aglieri Rinella, G.,Agnello, M.,Agrawal, N.,Ahammed, Z.,Ahn, S.U.,Aiola, S.,Akindinov, A.,Al-Turany, M.,Alam, S.N.,Albuquerque, D.S.D.,Aleks North-Holland Pub. Co 2018 Physics letters. Section B Vol.780 No.-
<P><B>Abstract</B></P> <P>The production of <SUP> Z 0 </SUP> bosons at large rapidities in Pb–Pb collisions at <SUB> s NN </SUB> = 5.02 TeV is reported. <SUP> Z 0 </SUP> candidates are reconstructed in the dimuon decay channel ( <SUP> Z 0 </SUP> → <SUP> μ + </SUP> <SUP> μ − </SUP> ), based on muons selected with pseudo-rapidity − 4.0 < η < − 2.5 and <SUB> p T </SUB> > 20 GeV/ c . The invariant yield and the nuclear modification factor, <SUB> R AA </SUB> , are presented as a function of rapidity and collision centrality. The value of <SUB> R AA </SUB> for the 0–20% central Pb–Pb collisions is 0.67 ± 0.11 (stat.) ± 0.03 (syst.) ± 0.06 (corr. syst.) , exhibiting a deviation of 2.6<I>σ</I> from unity. The results are well-described by calculations that include nuclear modifications of the parton distribution functions, while the predictions using vacuum PDFs deviate from data by 2.3<I>σ</I> in the 0–90% centrality class and by 3<I>σ</I> in the 0–20% central collisions.</P>
Assem, Magda M,Osman, Ahmed,Kandeel, Eman Z,Elshimy, Reham AA,Nassar, Hanan R,Ali, Radwa E Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.10
Background: In the last decade, it has become clear that change of gene expression may alter the hematopoietic cell quiescent state and consequently play a major role in leukemogenesis. WT1 is known to be a player in acute myeloid leukemia (AML) and FOXP3 has a crucial role in regulating the immune response. Objectives: To evaluate the impact of overexpression of WT1and FOXP3 genes on clinical course in adult and pediatric AML patients in Egypt. Patients and methods: Bone marrow and peripheral blood samples were obtained from 97 de novo non M3 AML patients (63 adult and 34 pediatric). Real-time quantitative PCR was used to detect overexpression WT1 and FOXP3 genes. Patient follow up ranged from 0.2 to 39.0 months with a median of 5 months. Results: In the pediatric group; WT1 was significantly expressed with a high total leukocyte count median 50X109/L (p=0.018). In the adult group, WT1 had an adverse impact on complete remission induction, disease-free survival and overall survival (p=0.02, p=0.035, p=0.019 respectively). FOXP3 overexpression was associated with FAB subtypes AML M0 +M1 vs. M2, M4+M5 (p =0.039) and the presence of hepatomegaly (p=0.005). Conclusions: WT1 and FOXP3 overexpression has an adverse impact on clinical presentation, treatment response and survival of pediatric and adult Egyptian AML patients.
Makary, Meena M.,Eun, Seulgi,Soliman, Ramy S.,Mohamed, Abdalla Z.,Lee, Jeungchan,Park, Kyungmo Wolters Kluwer Health | Lippincott Williams Wilkin 2017 NEUROREPORT - Vol.28 No.12
<P>Controversy exists regarding the involvement of the primary motor cortex (M1) during motor imagery (MI) and also regarding the differential somatotopic representation of motor execution (ME) and mental simulation of movement, that is, MI within M1. Although some research reported clear M1 involvement during MI without overt motor output, others did not. However, possible somatotopic representation between execution and imagery has not been clearly investigated to date. The aim of the present study was to aid in the resolution of this controversy by investigating the possible involvement of M1 during MI, and the differential, within M1, somatotopic representation between execution and imagery by quantitatively assessing different location markers such as activation peak and center of mass as well as intensity differences between the two tasks in case of with and without the overlap between the two representations. Forty-one healthy volunteers participated in two functional MRI runs of mouth-stretching ME and MI tasks. Our findings suggest the clear involvement of M1 (BA 4) during MI with lower signal intensity compared with ME, and further showed distinct centers for each representation along the y-axis (anteroposterior plane), with MI showing more involvement of the anterior sector of M1 (BA 4a), whereas ME recruited more of the posterior sector (BA 4p). These results parallel the pioneering findings of a functional distinction between BA 4a and BA 4p, where BA 4a is more involved in the cognitive aspects of MI, whereas BA 4p is more related to executive function, promoting the idea of distinctive somatotopic mapping between execution and imagery within M1 sectors.</P>