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      • Underutilization of warfarin for prophylaxis in patients with atrial fibrillation or artial flutter in Korea

        ( Lyn Hyang Lee ),( Hyunah Kim ),( Nam Kyung Je ) 영남대학교 약품개발연구소 2016 영남대학교 약품개발연구소 연구업적집 Vol.26 No.-

        Objective: Anticoagulation therapy with warfarin is recommended for stroke prevention in patients with atrial fibrillation (AF) or atrial flutter (AFL) whose risks for stroke are high. However, previous studies suggest that warfarin is markedly underused. This study aims to investigate the incidence and risk factors of warfarin underutilization in patients with high risk of stroke in Korea. Methods: This was a cross-sectional study using the data of 2009 from National Patients Sample compiled by the Health Insurance Review and Assessment Service. Patients with high risk of thromboembolism were identified with congestive heart failure, hypertension, age≥75 years, diabetes, and prior stroke (CHADS2) score≥2. High-risk patients of bleeding were excluded using Anticoagulation and Risk Factors in Atrial Fibrillation (ATRIA) score >4. Warfarin and anti thrombotic therapy underutilization were defined and estimated in high-risk patients. Any demographic and clinical factors associated with warfarin and antithrombotic therapy underutilization were explored using a logistic regression model. Results: Of the national patient sample, 15,885 patients were identified with AF or AFL. Among them, a total of 8475 patients who had an admission history, CHADS2 ≥2, and ATRIA score ≤4 were included in the analysis. From the study sample, warfarin underutilization and anti thrombotic therapy underutilization were estimated to be 64.0% and 20.4%, respectively. Predictors of warfarin underutilization include female sex, age ≥80 years, lower CHADS2 score, and insurance type (Medical Aid program). Conclusions: A high portion of AF/AFL patients with CHADS2 score ≥2 were undertreated with warfarin. As ischemic stroke is one of the leading causes of death in Korea, a more aggressive approach to prevent stroke in patients with AF/AFL is required.

      • KCI등재

        Effects of Jamaican Bitter Yam (Dioscorea polygonoides) and Diosgenin on Blood and Fecal Cholesterol in Rats

        Marsha-Lyn McKoy,Peta-Gaye Thomas,Helen Asemota,Felix Omoruyi,Oswald Simon 한국식품영양과학회 2014 Journal of medicinal food Vol.17 No.11

        A sapogenin-rich preparation from Jamaican bitter yam (Dioscorea polygonoides) has been shown to reduce blood cholesterol concentrations in hypercholesterolemic rats and mice. Also, diosgenin supplementation has been reported to have antilipemic effects in several animal species. We investigated potential mechanisms of the lipid-lowering actions of bitter yam and also whether the actions were mediated by diosgenin. Sprague-Dawley rats were fed a hypercholesterolemic diet (4% cholesterol) alone or with 5% bitter yam or 1% diosgenin supplementation for 6 weeks. The control group was fed normal rat chow. The serum lipid profile, fecal cholesterol concentration, and serum lipase activity were assessed at the end of the period. The induction of hypercholesterolemia was inhibited by coadministration of 5% bitter yam or 1% diosgenin in the diet. Serum lipid profiles were similar in rats fed bitter yam or diosgenin. The fecal cholesterol concentration was significantly (P < .01) higher in rats fed diosgenin compared to the cholesterol group. However, there was no corresponding elevation in the group fed bitter yam. Administration of bitter yam or diosgenin supplement significantly increased (P < .01) the serum lipase activity compared to the normal control and cholesterol groups. The cholesterol-supplemented diet inhibited normal gain in body weight over the period. This action was potentiated by diosgenin. The effects of the respective supplements on body weight were not completely explained by food consumption. Supplementation of the diet with Jamaican bitter yam may be therapeutically beneficial in the management of hypercholesterolemia.

      • KCI등재

        서울 오피스 거래 특성에 관한 실증연구

        인채권(Lyn, Chai-Kwon),여홍구(Yuh, Hong-Koo) 한국지역개발학회 2013 韓國地域開發學會誌 Vol.25 No.4

        This study aims to investigate the effect of Sale and Leaseback(SLB) agreements on price differentials between SLB and non-SLB transactions. Under SLB agreements, corporations simultaneously sign the lease agreements for properties being sold.. Previous studies found that Firms agree to SLB for various reasons, such as taxation, accounting, and finance; finance was the largest driving force of all. Studies have also depicted a positive correlation of the SLB announcements to the stock market, such news producing positive returns to the shareholders. Not much studies, however, have been conducted on the impact of SLB on transaction prices. Using a set of data on SLB transactions, this study examines the price impact on commercial property transactions in Seoul"s office market. Out of 656 transactions overall, we have selected 551 for sufficient analysis. Among them, 74 cases were SLB transactions, representing 13.4% of the sample. Multi-variate regression results reveal that transactions structured as SLB occured at lower prices than non-SLB transactions when all other conditions were equal. Specifically, the correlation coefficient of SLB dummy variable was -0.13, indicating that SLB transactions occurred at a discounted price of 12.2%. Further studies are required to better understand the determinants of price differentials in SLB transactions.

      • KCI등재

        권근 『周易淺見錄』의 군신공치론연구 - 安民을 위한 조화로운 상태의 추구 -

        홍린 ( Lyn Hong ) 한국공자학회 2024 공자학 Vol.52 No.-

        권근은 같은 시기 활동한 정도전과 비교하여 군권과 서열질서를 옹호했다는 평가와, 상대적으로 온건하지만 경연 및 간관 제도 등 군권에 대한 견제장치를 설치했다는 평가를 모두 받고 있다. 본고는 『주역천견록』에 대한 분석을 통해 그가 국정운영 주도권의 소재를 확정하기보다는 군신관계의 다양한 상황에 따른 유연한 지침을 내리고 있다고 평가한다. 우선 유약한 군주의 경우 강명한 신하들의 도움을 받아야 하지만 신하에게 과도한 주도권을 내주어서는 안 되고, 강명한 신하들 역시 유약한 군주라고 해서 넘보아서는 안 된다고 보았다. 특히 강명한 군주가 재위할 시 군주를 범하려는 시도는 도덕적 오명과 일신상 불행을 초래한다고 경고했다. 그러나 다른 한편으로는 군주가 신하를 높여야 하며 신하는 두려움과 조급함을 참고 자신과 뜻이 맞지 않는 군주를 거부하는 주체적인 태도를 가져야 한다고 역설했다. 그리고 이러한 군신조화는 안민이라는 유가의 정치적 이상을 추구할때에만 정당화됨을 강조했다. 권근의 군신공치론의 특징은 군주-신하 간 권리의 배분 문제를 논한 것이 아니라 상황에 따라 유연하게 조화를 이루어서 공동의 목표인 안민을 달성할 것을 주문한다는 것이다. In comparison to the contemporary Jung Do-jeon, Kwon Geun's evaluations diverge, oscillating between advocating royal authority and hierarchical order, and relatively advocating restraint measures within the royal authority, such as Remonstration’s System(臺諫) and King’s education(經筵). This paper analyzes his work, 'Zhouyi Qianjianlu(周易淺見錄)', to argue that instead of definitively determining the locus of political leadership, Kwon Geun provides flexible guidance based on various circumstances within the monarch-officials relationship. Firstly, in the case of a vulnerable monarch, assistance from prominent officials is deemed necessary; however, yielding excessive leadership authority to officials is cautioned against. Even for distinguished officials, overlooking a vulnerable ruler is not advisable. Particularly, during the reign of a prominent monarch, attempts to transgress against the monarchs are warned to lead to moral condemnation and personal misfortune. However, on the other hand, monarchs must elevate their officials, and officials, while harboring fear and urgency, should maintain a proactive attitude in rejecting monarchs with whom they disagree. In this context, Kwon Geun emphasized that monarchs and officials must pursue the political ideal of 'peace and security for the people(安民)' together rather than colliding. The distinctive feature of Kwon Geun's monarch-officials relationship theory lies not in the discussion of the distribution of rights between monarchs and officials, but in asserting that they should flexibly harmonize in different situations to achieve the common goal of 'peace and security for the people'.

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