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Tze, Christina Ng Van,Fitzgerald, Henry,Qureshi, Akhtar,Tan, Huck Joo,Low, May Lee Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.7
The aim of this study was to assess the rate of uptake of a customised annual Colorectal Cancer Awareness, Screening and Treatment Project (CCASTP) using faecal immunohistochemical test (FIT) kits in low income communities in Malaysia. The immediate objectives were (1) to evaluate the level of adherence of CRC screening among low-income groups, (2) to assess the knowledge and awareness of the screened population and (3) to assess the accuracy of FIT kits. A total of 1,581 FIT kits were distributed between years 2010 to 2015 to healthy asymptomatic participants of the annual CCASTP organized by Empowered - the Cancer Advocacy Society of Malaysia. Data for socio-demographic characteristics, critical health and lifestyle information of the registered subjects were collected. Findings for use of the FIT kits were collected when they were returned for stool analyses. Those testingd positive were invited to undergo a colonoscopy examination. A total of 1,436 (90.8%) of the subjects retuned the FIT-kits, showing high compliance. Among the 129 subjects with positive FIT results, 92 (71.3%) underwent colonoscopy. Six cases (6.5%) of CRC were found. Based on the data collected, the level of awareness of stool examination and knowledge about CRC was poor amongst the participants. Gender, age group, ethnicity and risk factors (i.e. smoking, lack of exercise and low consumption of fresh fruits) were associated with positive FIT-kit results. In conclusion, CRC screening can be performed in the community with a single FIT-kit. Although CRC knowledge and awareness is poor in low-income communities, the average return rate of the FIT kits and rate of colonoscopy examination were 91.2% and 70.3%, respectively.
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Goodson III, William H.,Lowe, Leroy,Carpenter, David O.,Gilbertson, Michael,Manaf Ali, Abdul,Lopez de Cerain Salsamendi, Adela,Lasfar, Ahmed,Carnero, Amancio,Azqueta, Amaya,Amedei, Amedeo,Charles, Ame Oxford University Press 2015 Carcinogenesis Vol.36 No.suppl1
<P>Lifestyle factors are responsible for a considerable portion of cancer incidence worldwide, but credible estimates from the World Health Organization and the International Agency for Research on Cancer (IARC) suggest that the fraction of cancers attributable to toxic environmental exposures is between 7% and 19%. To explore the hypothesis that low-dose exposures to mixtures of chemicals in the environment may be combining to contribute to environmental carcinogenesis, we reviewed 11 hallmark phenotypes of cancer, multiple priority target sites for disruption in each area and prototypical chemical disruptors for all targets, this included dose-response characterizations, evidence of low-dose effects and cross-hallmark effects for all targets and chemicals. In total, 85 examples of chemicals were reviewed for actions on key pathways/mechanisms related to carcinogenesis. Only 15% (13/85) were found to have evidence of a dose-response threshold, whereas 59% (50/85) exerted low-dose effects. No dose-response information was found for the remaining 26% (22/85). Our analysis suggests that the cumulative effects of individual (non-carcinogenic) chemicals acting on different pathways, and a variety of related systems, organs, tissues and cells could plausibly conspire to produce carcinogenic synergies. Additional basic research on carcinogenesis and research focused on low-dose effects of chemical mixtures needs to be rigorously pursued before the merits of this hypothesis can be further advanced. However, the structure of the World Health Organization International Programme on Chemical Safety ‘Mode of Action’ framework should be revisited as it has inherent weaknesses that are not fully aligned with our current understanding of cancer biology.</P>
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( En X S Low ),( Maimouna N K Al Mandhari ),( Charles C Herndon ),( Evelyn X L Loo ),( Elizabeth H Tham ),( Kewin T H Siah ) 대한소화기기능성질환·운동학회(구 대한소화관운동학회) 2020 Journal of Neurogastroenterology and Motility (JNM Vol.26 No.4
Background/Aims Adverse early life experiences are associated with the development of stroke, cancer, diabetes, and chronic respiratory and ischemic heart diseases. These negative experiences may also play a role in the development of irritable bowel syndrome (IBS)--a functional gastrointestinal disease. This review discusses the research to date on the parental, perinatal, and childhood risk and protective factors associated with the development of IBS. Methods A literature search was completed for studies published between 1966 and 2018 that investigated premorbid factors occurring during the perinatal and childhood periods as well as parental factors that were associated with the development of IBS. Results Twenty-seven studies fulfilled the review criteria. Risk factors that appeared in more than one study included: (1) parental IBS, substance abuse, parental punishment, and rejection as parental risk factors; (2) low birth weight as a perinatal risk factor; and (3) crowded living conditions in low-income families, childhood anxiety, depression, or child abuse as childhood risk factors. Protective factors for IBS were emotional warmth from the parents and being born to an older mother. Conclusions More effort is needed to identify what fetal and maternal factors are associated with low birth weight and IBS. A well-executed prospective birth cohort with a collection of bio-samples and functional data will provide a better understanding of how adversity and the interplay between genetics, epigenetics, and numerous risk factors affect the development of IBS. (J Neurogastroenterol Motil 2020;26:437-446)
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( Jaime Aherrera ),( Lowe Chiong ),( Paul Reganit ),( Felix Punzalan ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: Patients with documented acute coronary syndromes (ACS) exhibit a wide spectrum of early risk of death. An elevated neutrophil count predicts a worse outcome in ACS. In contrast, a low lymphocyte count is related to high risks of adverse outcomes. The neutrophil-lymphocyte ratio (NLR), therefore, integrates for two WBC subtypes with opposite actions in terms of vascular infl ammation. Objectives: Among patients diagnosed with ACS, we aim to determine if an elevated NLR taken within 24 hours of admission is associated with higher rates of adverse outcomes. Methods: A prospective cohort of adult patients admitted with a diagnosis of ACS was conducted. The participants were stratifi ed into two: low to intermediate NLR (NLR < 6.5) and high NLR (NLR > 6.50). Primary outcome was in-hospital mortality. Secondary outcomes include development or worsening of congestive heart failure (CHF) and the development of cardiogenic shock, re-infarction, renal failure, pneumonia, and arrhythmias. Results: 117 patients with a mean age of 60 +/- 13 were included. Diagnosis on admission was unstable angina (28%), NSTEMI (40%), and STEMI (37%). Analysis of data showed that the odds of in-hospital deaths among those with a high NLR is 5.71 times higher compared to those with low-intermediate NLR [OR 5.71 (1.53-21.23, p 0.009)]. Using linear regression, the NLR of patients who were non-survivors was computed at 9.91, while the NLR of those who survived was 5.47. A high NLR was also predictive of the development or worsening of CHF, shock, re-infarction, arrhythmias, and development of any adverse outcome. Conclusion: Among patients with ACS, an elevated NLR (>6.5) taken within 24 hours of presentation is a useful marker to predict in-hospital mortality, development or worsening or CHF, and development of shock, re-infarction, and arrhythmias.
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Predictive value of post-operative drain amylase levels for post-operative pancreatic fistula
Tang Ee Ling Serene,Shelat Vishalkumar G,Junnarkar Sameer Padmakumar,Huey Cheong Wei Terence,Low Jee Keem,Wang Bei,Woon Wei Liang Winston 한국간담췌외과학회 2018 Annals of hepato-biliary-pancreatic surgery Vol.22 No.4
Backgrounds/Aims: Traditionally, surgically placed pancreatic drains are removed, at the discretion of the operating surgeon. Moving towards enhanced recovery after surgery (ERAS), we looked for predictors for early drain removal. The purpose of this paper was to establish which postoperative days’ (POD) drain amylase is most predictive against post-operative pancreatic fistula (POPF). Methods: We conducted a retrospective study of 196 patients who underwent pancreatic resection at our institute from January 2006 to October 2013. Drain amylase levels were routinely measured. The International Study Group of Pancreatic Fistula (ISGPF) definition of POPF, and clinical severity grading were used. Results: 5.1% (10 of 196) patients developed ISGPF Grades B and C POPF. Negative predictive value of developing significant POPF, if drain amylase values were low on PODs 1 and 3 was 98.7% (95% CI: 0.93-1.00). This translated to confidence in removing surgically placed pancreatic drains, at POD 1 and 3 when drain amylase values are low. Conclusions: Patients with low drain amylase values on POD 1 and 3, are unlikely to develop POPF and may have pancreatic drains removed earlier.
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Goh, Lynette,Phua, Kong Boo,Low, Yee,Chiang, Li Wei,Yong, Chen,Chiou, Fang Kuan The Korean Society of Pediatric Gastroenterology 2021 Pediatric gastroenterology, hepatology & nutrition Vol.24 No.4
Purpose: There is no consensus regarding adjuvant therapies following Kasai portoenterostomy (KP) for biliary atresia (BA). This study aimed to analyze the effect of extended perioperative intravenous antibiotics (PI-Abx) and adjuvant corticosteroid on cholangitis and jaundice clearance rates in the 3 years post-KP in children with BA. Methods: Data of patients who underwent KP between 1999-2018 at a single center were retrospectively analyzed. Group A (1999-2010) received PI-Abx for 5 days, Group B (2010-2012) received PI-Abx for 5 days plus low-dose prednisolone (2 mg/kg), and Group C (2012-2017) received PI-Abx for 14 days plus high-dose prednisolone (5 mg/kg). Results: Fifty-four patients were included with groups A, B, and C comprising 25, 9, and 20 patients, respectively. The number of episodes of cholangitis was 1.0, 1.6, and 1.3 per patient (p=NS) within the first year and 1.8, 2.3, and 1.7 (p=NS) over 3 years in Groups A, B, and C, respectively. The jaundice clearance rate at 6 months was 52%, 78%, and 50% (p=NS), and the 3-year native liver survival (NLS) rate was 76%, 100%, and 80% (p=NS) in Groups A, B, and C, respectively. A near-significant association was observed between the incidence of cholangitis within the first year and decompensated liver cirrhosis/death at 3 years post KP (p=0.09). Persistence of jaundice at 6 months was significantly associated with decompensated cirrhosis/death at 3 years (p<0.001). Conclusion: The extended duration of PI-Abx and adjuvant corticosteroids was not associated with improved rates of cholangitis, jaundice clearance, or NLS in patients with BA.
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Zi Jia Low,Jia Chyi Wong,Kuan Hoon Ngoi,Chin Hua Chia,김현중,김홍철,이문호 한국고분자학회 2021 Macromolecular Research Vol.29 No.3
In this study, we reports the first quantification details of the pencil hardness, eraser abrasion resistance and steel wool abrasion resistance of optically-transparent and biaxially-oriented poly(ethylene terephthalate) (PET) films in various thicknesses before and after hard coating (HC) and/or optically clear adhesive (OCA) coating. Surprisingly, the PET base films were determined to exhibit unrealistically very low hardness and abrasion resistances although their stress-strain behavior followed a ductile and tough plastic nature as a high performance engineering plastic: the pencil hardness was only ≤9B even at a low loading force, 0.100 kgf, and the onset loading force to cause scratches was far below 0.013 kgf in both eraser and steel wool abrasions. These collectively confirmed that, without surface protections, PET base films are not suitable for any advanced applications. Such the low hardness and poor abrasion resistances could be improved substantially by only thin HC coating of di(trimethylolpropane) tetraacrylate (HC-a, an ultraviolet curable acrylic resin). In addition, the OCA coating based on an acrylic copolymer adhesive provided adhesion function to the PET films, showing excellent adhesion strength onto chemically-toughened glass. However, the OCA layer causes cushioning effect because of its easy plastic deformation nature, making negative impact on the hardness and abrasion resistance performances of the PET film. Thus, the OCA coating should be thinned until retaining good adhesion to adherends. Overall, PET films coated with HC and/or OCA are suitable for advanced applications in various fields including smart phones, foldable phones, and flexible display devices.
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International Evidence on the Link between Quality of Governance and Stock Market Performance
SOO-WAH LOW,SI-ROEI KEW,LAIN-TZE TEE 연세대학교 동서문제연구원 2011 Global economic review Vol.40 No.3
This paper examines the link between country-level governance and global stock market returns. We find a negative relation between governance quality and equity return. Countries with low governance scores, on average, have higher equity returns than those with high governance scores after controlling for global risk factors known to influence international equity returns. This implies that investors associate low governance quality with increased risk and thus demand higher risk premium. We find that the quality of governance as measured by Political Stability and Absence of Violence is key governance dimension affecting international equity returns, suggesting that heightened investor concerns over political risks have profound impact on equity markets. Interestingly, we find no evidence that variation in equity returns is affected by the governance indicator representing Voice and Accountability. The findings of this study provide important policy implications.
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