RELEVANCE OF HPV INTEGRATION TO CARCINOGENESIS

Lorincz, Attila 가톨릭중앙의료원 가톨릭암센터 1994 암심포지움 Vol.- No.1

As early as the 1980s it was recognized that HPV DNA detectable in cervical cancer cell lines was always integrated into the human genome. Small studies on clinical cancer biopsies proved that integration was not an artifact of cell culture and also demonstrated that HPV DNA occurs in the episomal state in condylomas. These results fostered the hypthesis that HPV integration is an important and consistant aspect of cancer promotion by oncogenic HPV types. Integration of HPV DNA generally resulted in distruption of the E1 or E2 genes with preservation and overexpression of the E6 and E7 oncoproteins. Experiments on cell lines confirmed the improtance of continued expression of E6/E7 when it was demonstrated that a repression of synthesis of the E7 product caused a dramatic decrease or termination of cell growth. Recent work has shown that integrated HPV DNA is detectable in approximately 70% of cervical cancers but that only episomal HPV genomes are detectable in 20 to 25% of cancers and in virtually 100% of condylomas and intraepithelial lesions. Furthermore, in cancers at other body sites (e.g., Buschke-Lowenstein cancers), he resident HPV genomes are usually episomal. Thus, the earlier simplistic model of HPV integration requires modification.

HYBRID CAPTURE??: A NEW TECHNOLOGY FOR HPV DETECTION

Lorincz, Attila 가톨릭중앙의료원 가톨릭암센터 1994 암심포지움 Vol.- No.1

Hybrid Capture is a rapid and sensitive chemiluminescence-based test for detecting human papillomavirus(HPV) DNA in clinical specimens. The assay utilizes the high specificity of RNA probes to detect the DNAs of 16 common anogenital HPV types and to distinguish between oncogenic(types 16,18,31,33,35,39,45,51,52,56 and 58) and non-oncogenic(types 6,11,42,43 and 44) HPVs. The test has a simple format similar to an immunoassay and provides quantitative results in approximatel 4 hours. With minimal training, a laboratory technologist can use Hybrid Capture to analyze over 100 clinical specimens in one day. The new test has shown good accuracy, precision and reproducibility in several multicenter trials involving cervical specimens from over 500 women. Hybrid Capture has demonstrated clinical utility in the management of women with equivocal results on Pap smear. In one study of 216 women, positivity for HPV DNA was associated with a greatly increased likelihood(OR=23, 3-176) of high-grade cervical intraepithelial neoplasia(CIN). A second study of over 400 women with equivocal or low-grade Pap smears has confirmed these results. A cohort of women with no current or past history of cervical intracpithelial lesions has been followed for a median of 3.5 years. Initially, 600 were HPV DNA positive and 7,600 were HPV DNA negative. The relative risk of developing CIN in the HPV-positive women was over 20, with an absolute risk for CIN of over 25%. Of 98 women positive for HPV 16 DNA, approximately 40% developed CIN during followup. The period of highest risk for CIN was within the first two years. By 4 years, the risk for CIN had decreased over 15-fold to almost control levels.

Heuristic Algorithms for Optimization of Energy Consumption in Wireless Access Networks

( Josip Lorincz ),( Antonio Capone ),( Dinko Begusic ) 한국인터넷정보학회 2011 KSII Transactions on Internet and Information Syst Vol.5 No.4

Energy consumption of wireless access networks is in permanent increase, which necessitates development of more energy-efficient network management approaches. Such management schemes must result with adaptation of network energy consumption in accordance with daily variations in user activity. In this paper, we consider possible energy savings of wireless local area networks (WLANs) through development of a few integer linear programming (ILP) models. Effectiveness of ILP models providing energy-efficient management of network resources have been tested on several WLAN instances of different sizes. To cope with the problem of high computational time characteristic for some ILP models, we further develop several heuristic algorithms that are based on greedy methods and local search. Although heuristics obtains somewhat higher results of energy consumption in comparison with the ones of corresponding ILP models, heuristic algorithms ensures minimization of network energy consumption in an amount of time that is acceptable for practical implementations. This confirms that network management algorithms will play a significant role in practical realization of future energy-efficient network management systems.

Part 5. Economic Cooperation Between Korea And Hungary : Potential Areas of Cooperation between Korean and Hungarian Economies -Chapter 19

( Peter Lorincze ) 연세대학교 동서문제연구원 1990 East and West Studies Series Vol.10 No.-

A General Dry Density Law for Sands

Emoke Imre,Janos Lorincz,Q. Phong Trang,Stephen Fityus,Jozsef Pusztai,Gabor Telekes,Tom Schanz 대한토목학회 2009 KSCE Journal of Civil Engineering Vol.13 No.4

The direct interpolation of a transfer function needs exponentially many data in terms of the number of the fractions in the grading curve. The suggested transfer function construction method - based on a double approximation technique, the grading entropy concept and at most quadratic many data in terms of the fraction number – is tested on the example of the dry density of sands here using some previously measured data. In the first approximation step a “preliminary transfer function” is interpolated in the nonnormalized grading entropy diagram on the basis of some “optimal” soil data. In the second approximation step the preliminary transfer function is extended to the space of the possible grading curves with the constant function. The so determined transfer function is tested against an independent “non-optimal” data set, measured on some soil series with basically continuous (i.e., not gap-graded) grading curves. The aim of this paper is to present the main results of the study supporting the goodness of the method and the predictability of the dry density transfer function. The direct interpolation of a transfer function needs exponentially many data in terms of the number of the fractions in the grading curve. The suggested transfer function construction method - based on a double approximation technique, the grading entropy concept and at most quadratic many data in terms of the fraction number – is tested on the example of the dry density of sands here using some previously measured data. In the first approximation step a “preliminary transfer function” is interpolated in the nonnormalized grading entropy diagram on the basis of some “optimal” soil data. In the second approximation step the preliminary transfer function is extended to the space of the possible grading curves with the constant function. The so determined transfer function is tested against an independent “non-optimal” data set, measured on some soil series with basically continuous (i.e., not gap-graded) grading curves. The aim of this paper is to present the main results of the study supporting the goodness of the method and the predictability of the dry density transfer function.

Dynamic allocation of power delivery paths in consolidated data centers based on adaptive UPS switching

AL-Hazemi, Fawaz,Peng, Yuyang,Youn, Chan-Hyun,Lorincz, Josip,Li, Chao,Song, Guo,Boutaba, Raouf Elsevier 2018 COMPUTER NETWORKS - Vol.144 No.-

<P><B>Abstract</B></P> <P>Although technique known as server consolidation approach in a data center can reduce the overall power consumption, the Power Usage Effectiveness (PUE) of the data center will still be negatively affected with presence of distributed Uninterruptible Power Supplies (UPSs). The impact on the PUE arises from the fact that all UPS modules are kept running to maintain power availability for only a few active servers during off-peak periods. To address this problem, in this paper technique for reducing power consumption in a data center by consolidating the UPSs used during off peak periods is proposed. The proposed technique achieves power savings by leveraging a micro Automatic Transfer Switch (micro-ATS) at the server end. The novelty of this work lies in developed adaptive algorithm that continuously looks for opportunities to reduce the number of UPSs by offloading under-loaded UPSs to a neighboring UPS whenever that neighboring UPS can handle the extra load. In various simulated scenarios involving corporate data centers, our approach demonstrates the ability to save more power and achieve lower PUE degradation compared with state-of-the-art approaches such as server consolidation. Specifically, the proposed approach achieves a savings of approximately 20% to 40% in a data center’s power consumption, depending on the data center’s off-peak periods, which can be accomplished using only 80% of the UPS modules in the data center.</P>