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Ding Sheng-Long,Zhang Tai-Wei,Zhang Qi-Chen,Ding Wang,Li Ze-Fang,Han Guan-Jie,Bai Jin-Song,Li Xi-Lei,Dong Jian,Wang Hui-Ren,Jiang Li-Bo 생화학분자생물학회 2021 Experimental and molecular medicine Vol.53 No.-
Night shift workers with disordered rhythmic mechanical loading are more prone to intervertebral disc degeneration (IDD). Our results showed that circadian rhythm (CR) was dampened in degenerated and aged NP cells. Long-term environmental CR disruption promoted IDD in rats. Excessive mechanical strain disrupted the CR and inhibited the expression of core clock proteins. The inhibitory effect of mechanical loading on the expression of extracellular matrix genes could be reversed by BMAL1 overexpression in NP cells. The Rho/ROCK pathway was demonstrated to mediate the effect of mechanical stimulation on CR. Prolonged mechanical loading for 12 months affected intrinsic CR genes and induced IDD in a model of upright posture in a normal environment. Unexpectedly, mechanical loading further accelerated the IDD in an Light-Dark (LD) cycle-disrupted environment. These results indicated that intrinsic CR disruption might be a mechanism involved in overloading-induced IDD and a potential drug target for night shift workers.
An Jen Chiang,Min-Yu Chen,Chia-Sui Weng,Hao Lin,Chien-Hsing Lu,Peng-Hui Wang,Yu-Fang Huang,Ying-Cheng Chiang,Mu-Hsien Yu,Chih-Long Chang 대한부인종양학회 2017 Journal of Gynecologic Oncology Vol.28 No.5
Objective: The malignant transformation (MT) of ovarian mature cystic teratoma (MCT)to squamous cell carcinoma (SCC) is very rare. This study analyzed cases from multiplemedical centers in Taiwan to investigate the clinicopathologic characteristics, treatment, andprognostic factors of this disease and reviewed related literature. Methods: Pathological reports of 16,001 patients with primary ovarian cancer who weretreated at Taiwan medical centers from 1990 to 2011 were reviewed. In total, 52 patients withMT of MCT to SCC were identified. Results: Among all ovarian MCTs, the incidence of MT to SCC is 0.2%. The median age ofpatients was 52 years (range, 29–89 years), and the mean tumor size was 10.5 cm (range, 1–40cm). We analyzed the patients in our study and those in the literature and determined thatearly identification and complete surgical resection of the tumor are essential for long-termsurvival. In addition, adjuvant chemotherapy or concurrent chemoradiotherapy can be usedto treat this malignancy. Old age, large tumor size (≥15.0 cm), and solid components in MCTsare suitable indicators predicting the risk of MT of MCT to SCC. Conclusion: Similar to general epithelial ovarian cancers, the early detection of MT of MCTto SCC is critical to long-term survival. Therefore, older patients with a large tumor or those with a tumor containing a solid component in a clinically diagnosed MCT should beevaluated to exclude potential MT to SCC.
( Jing Wang ),( Wei Chen ),( Fang Wang ),( Dong Wu ),( Jia Ming Qian ),( Jun Ren Kang ),( Hai Long Li ),( En Ling Ma ) 한국임상영양학회 2015 Clinical Nutrition Research Vol.4 No.2
Mitochondrial neurogastrointestinal encephalopathy (MNGIE) is characterized by significant gastrointestinal dysmotility. Early and long-term nutritional therapy is highly recommended. We report a case of MNGIE in a patient who was undergoing longterm nutrition therapy. The patient was diagnosed with a serious symptom of fatty liver and hyperlipidemia complications, along with homozygous mutation of the thymidine phosphorylase (TYMP) gene (c.217G > A). To our knowledge, this is the first report of such a case. Herein, we describe preventive measures for the aforementioned complications and mitochondrial disease-specific nutritional therapy.
Difference of Risk-relievers between High Risk and Low Risk in Online Purchasing
Fang, Hua-Long,Kwon, Sun-Dong,Bae, Kee-Su Korea Data Strategy Society 2014 Journal of information technology applications & m Vol.21 No.3
The Online business model for purchasing agent service is getting more popular. However, consumers perceive more risk when buying products from foreign online purchasing agents (FOPA) than from common online sellers (COS). This study focuses on finding out how consumers manage risk when they perceive risk and what different risk-reliever strategies they use when buying from high-risk FOPA and low-risk COS. This study has proved the following two. First, when consumers perceive risk at online purchasing, they tend to select risk-reliever strategies, such as the use of communication media, online assurance mark, seller's record, and secure payment to mitigate risk. With the application of those risk-reliever strategies, they built trust with the seller. Second, risk-perception of FOPA influences usage of communication media and check of online assurance mark more strongly than that of COS. On the contrary, risk-perception of COS influences the check of seller record more strongly than that of FOPA. This study helps to explain why FOPA is proliferating, despite its inherent high risk due to the fact that buyers and sellers are separated in time and space and that buyers and sellers have different social and cultural backgrounds. This study also helps managers of E-commerce to relieve consumer's risk-perception and to build trust.
Difference of Risk-relievers between High Risk and Low Risk in Online Purchasing
Hua-Long Fang,Sun-Dong Kwon,Kee-Su Bae 한국데이타베이스학회 2014 Journal of information technology applications & m Vol.21 No.3
The Online business model for purchasing agent service is getting more popular. However, consumers perceive more risk when buying products from foreign online purchasing agents (FOPA) than from common online sellers (COS). This study focuses on finding out how consumers manage risk when they perceive risk and what different risk-reliever strategies they use when buying from high-risk FOPA and low-risk COS. This study has proved the following two. First, when consumers perceive risk at online purchasing, they tend to select risk-reliever strategies, such as the use of communication media, online assurance mark, seller’s record, and secure payment to mitigate risk. With the application of those risk-reliever strategies, they built trust with the seller. Second, risk-perception of FOPA influences usage of communication media and check of online assurance mark more strongly than that of COS. On the contrary, risk-perception of COS influences the check of seller record more strongly than that of FOPA. This study helps to explain why FOPA is proliferating, despite its inherent high risk due to the fact that buyers and sellers are separated in time and space and that buyers and sellers have different social and cultural backgrounds. This study also helps managers of E-commerce to relieve consumer’s risk-perception and to build trust.
INTERGALACTIC MEDIUM IN THE ACDM UNIVERSE FROM COSMOLOGICAL SIMULATIONS
FENG LONG-LONG,HE PING,FANG LIZHI,SHU CHI-WANG,ZHANG MENG-PING The Korean Astronomical Society 2005 Journal of The Korean Astronomical Society Vol.38 No.2
The temperature (T) and entropy (S) fields of baryonic gas, or intergalactic medium (IGM), in the ACDM cosmology are analyzed using simulation samples produced by a hybrid cosmological hydrodynamic/N-body code based on the weighted essentially non-oscillatory scheme. We demonstrate that, in the nonlinear regime, the dynamical similarity between the IGM and dark matter will be broken in the presence of strong shocks in the IGM. The heating and entropy production by the shocks breaks the IGM into multiple phases. The multiphase and non-Gaussianity of the IGM field would be helpful to account for the high-temperature and high-entropy gas observed in groups and clusters with low-temperature IGM observed by Ly$\alpha$ forest lines and the intermittency observed by the spikes of quasi-stellar object's absorption spectrum.
최명익 심리소설의 리얼리즘적 특성 연구- 단편소설 “비오는 길”을 중심으로
방용남(Fang, Long-Nan) 한국문화융합학회 2018 문화와 융합 Vol.40 No.5
20세기 30년대의 한국 심리소설을 몰밀어서 서양의 문학사조나 유파를 근거로 모더니즘으로 규정하는 것은 서사학적인 측면에서는 여러 가지 문제점들이 제기된다. 이런 규정은 리얼리즘에 대한 오독에서 기인한 것일 수도 하고, 작가의 창작동기, 창작주장 및 작품의 의미담론에 대해 문학텍스트에 대한 본체론적인 분석을 간과한데서 기인한 것일 수도 있다. 그 논의의 중심에 작가 최명익이 서 있다. 그만큼 그와 그의 작품에 대한 새로운 평가는 20세기 30년대 한국 심리소설 또는 심리주의소설에 대한 재조명과 함께 문학사의 정리 작업이 될 것이다. It arise a number of problems from an epic point of view that is defined modernism putting together Korean psychological novels of the 20th century 30’s based on Western trend of literary or clique. These rules can be attributed to a misreading on realism, and may be due to the writer’s failure to make a analysis of ontology of literary text about his creative motives, creative arguments, and the meaning of his work. The writer is at the center of the discussion. Thus, a new assessment of him and his works will be a cleanup operation of the history of literature, along with a reinvestigation of Korean psychological or psychological novels in the 20th century 30’s