중국어 번역에 나타난 한국어의 인과관계 표현에 대한 고찰 - ‘-어서’ ‘-니까’를 중심으로 -

LI XIAN 국제한국언어문화학회 2017 국제한국언어문화학회 학술대회 Vol.2017 No.06

Tanshinone IIA suppresses FcεRI-mediated mast cell signaling and anaphylaxis by activation of the Sirt1/LKB1/AMPK pathway

Li, Xian,Park, Soon Jin,Jin, Fansi,Deng, Yifeng,Yang, Ju Hye,Chang, Jae-Hoon,Kim, Dong-Young,Kim, Jung-Ae,Lee, Youn Ju,Murakami, Makoto,Son, Kun Ho,Chang, Hyeun Wook Pergamon Press 2018 Biochemical pharmacology Vol.152 No.-

<P><B>Abstract</B></P> <P>AMP-activated protein kinase (AMPK) and its upstream mediators liver kinase B1 (LKB1) and sirtuin 1 (Sirt1) are generally known as key regulators of metabolism. We have recently reported that the AMPK pathway negatively regulates mast cell activation and anaphylaxis. Tanshinone IIA (Tan IIA), an active component of <I>Salvia miltiorrhiza</I> extract that is currently used for the treatment of cardiovascular and cerebrovascular diseases, shows anti-diabetic activity and improves insulin resistance in <I>db/db</I> mice through activation of AMPK. The aim of this study was to evaluate the anti-allergic activity of Tan IIA <I>in vivo</I> and to investigate the underlying mechanism <I>in vitro</I> in the context of AMPK signaling. The anti-allergic effect of Tan IIA was evaluated using mouse bone marrow-derived mast cells (BMMCs) from <I>AMPKα2</I> <SUP>−/−</SUP> or <I>Sirt1</I> <SUP>−/−</SUP> mice, or BMMCs transfected with siRNAs specific for AMPKα2, LKB1, or Sirt1. <I>AMPKα2</I> <SUP>−/−</SUP> and <I>Sirt1</I> <SUP>−/−</SUP> mice were used to confirm the anti-allergic effect of Tan IIA in anaphylaxis <I>in vivo</I>. Tan IIA dose-dependently inhibited FcεRI-mediated degranulation and production of eicosanoids and cytokines in BMMCs. These inhibitory effects were diminished by siRNA-mediated knockdown or genetic deletion of AMPKα2 or Sirt1. Moreover, Tan IIA inhibited a mast cell-mediated local passive anaphylactic reaction in wild-type mice, but not in <I>AMPKα2</I> <SUP>−/−</SUP> or <I>Sirt1</I> <SUP>−/−</SUP> mice. In conclusion, Tan IIA suppresses FcεRI-mediated mast cell activation and anaphylaxis through activation of the inhibitory Sirt1-LKB1-AMPK pathway. Thus, Tan IIA may be useful as a new therapeutic agent for mast cell-mediated allergic diseases.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

Bolted end plate connections for steel reinforced concrete composite structures

Li, Xian,Wu, Yuntian,Mao, Weifeng,Xiao, Yan,Anderson, J.C.,Guo, Yurong Techno-Press 2006 Structural Engineering and Mechanics, An Int'l Jou Vol.24 No.3

In order to improve the constructability and meanwhile ensure excellent seismic behavior, several innovative composite connection details were conceived and studied by the authors. This paper reports experimental results and observations on seismic behavior of steel beam bolted to reinforced concrete column connections (bolted RCS or BRCS). The proposed composite connection details involve post tensioning the end plates of the steel beams to the reinforced concrete or precast concrete columns using high-strength steel rods. A rational design procedure was proposed to assure a ductile behavior of the composite structure. Strut-and-tie model analysis indicates that a bolted composite connection has a favorable stress transfer mechanism. The excellent capacity and behavior were then validated through five full-scale beam to column connection model tests.

Hybrid Fireworks Algorithm with Dynamic Coefficients and Improved Differential Evolution

( Lixian Li ),( Jaewan Lee ) 한국인터넷정보학회 2021 인터넷정보학회논문지 Vol.22 No.2

Fireworks Algorithm (FWA) is a new heuristic swarm intelligent algorithm inspired by the natural phenomenon of the fireworks explosion. Though it is an effective algorithm for solving optimization problems, FWA has a slow convergence rate and less information sharing between individuals. In this paper, we improve the FWA. Firstly, explosion operator and explosion amplitude are analyzed in detail. The coefficient of explosion amplitude and explosion operator change dynamically with iteration to balance the exploitation and exploration. The convergence performance of FWA is improved. Secondly, differential evolution and commensal learning (CDE) significantly increase the information sharing between individuals, and the diversity of fireworks is enhanced. Comprehensive experiment and comparison with CDE, FWA, and VACUFWA for the 13 benchmark functions show that the improved algorithm was highly competitive.

ANTECEDENTS OF SUBJECTIVE KNOWLEDGE DEVELOPMENT AND IMPACTS ON FIRST TIME BUYING AND RE-PURCHASING PREFERENCE HETEROGENEITY : EVIDENCE IN THE CHINESE CAR MARKET

Lixian Qian,Didier Soopramanien 글로벌지식마케팅경영학회 2014 Global Marketing Conference Vol.2014 No.2

Subjective knowledge (SK thereafter) is defined as what consumers think they know, or their perceived level of knowledge (Brucks, 1985). SK influences what consumers search for, the effort that they put into searching, and the purchasing decision and choice of brands they finally make (Hadar, Sood, & Fox, 2013; Moorman, Diehl, Brinberg, & Kidwell, 2004). The existing literature on consumer knowledge development mainly argues that SK development is associated with consumers’ product related experience, such as product ownership and experience from usage (Alba & Hutchinson, 2000; Park, Mothersbaugh, & Feick, 1994). This study contributes to the literature as follows. We consider a broad market segmentation where the market consists of product owners and non-owners, The literature suggests that these two groups of consumers should have different levels of perceived knowledge due to their different product-specific experience (Park et al., 1994). Our research specifically contends that it is important to distinguish, within the group of non-owners, between those who intend to buy and those who do not intend to buy the product. Thus, this study examines how previous ownership and intention to buy, which is the goal motivation, influence the SK levels of consumers, which in turn impacts on consumers’ heterogeneous preferences for different attributes within a product category. It is contended that the motivation to learn about a product category of non-car owners who have strong intentions to buy influences what this group learns compared to those non-owners who do not intend to buy. More specifically, the research proposes to uncover how learning influences how different groups of consumers perceive their subjective knowledge and how this relationship in turn shapes their preferences, especially when we compare owners and non-owners who have strong intentions of buying a product. Therefore, we develop following research hypotheses: H1: The SK level is positively associated with the product ownership experience. H2: The SK level is positively associated with purchase intention. H3: The relationship between purchase intention and SK level is moderated by the ownership of the product. H4: Preference heterogeneity for different types of brand attributes of the product between owners and non-owners is moderated by the SK level. The empirical context that illustrates the importance of this research is the Chinese car market where the majority of consumers are first time buyers. Our research shows that the SK level is positively associated with both car ownership and purchase intention. Furthermore, the segmentation analysis finds that purchase intention has a significant effect only on non-car owners’ SK level, while the effect on car owners’ SK level is insignificant. An interesting finding is that SK development, in turn, influences consumer’s preferences for different types of brand attributes of a product. We demonstrate the role of SK in forming consumer preference heterogeneity by comparing preferences for a tangible and a non-tangible brand attribute respectively across different consumer segments. We further show how this preference heterogeneity across two consumer segments (car owners versus non-car owners) depends on their SK level. The results of this study can be generalized beyond the specific context of the empirical study of the Chinese car market when marketers are considering new products launch or launching products where the majority of consumers may be unfamiliar with the product.

Soil Property Affect Arsenic Uptake in Garland Chrysanthemum (c. Coronarium) Fertilized with Chicken Manure Bearing Roxarsone and its Metabolites

Lixian Yao,Lianxi Huang,Zhaohuan He,Changmin Zhou,Guoliang Li 한국토양비료학회 2014 한국토양비료학회 학술발표회 초록집 Vol.2014 No.6

Creating Signs in the Dissemination of Digital Avatars as Brand Spokespersons - A Case Study of the Virtual Spokesperson of Florasis, a Chinese Makeup Brand

Lixian Yin,Won-Ho Choi 한국콘텐츠학회 2022 한국콘텐츠학회 ICCC 논문집 Vol.2022 No.12

The Variable Amplitude Coefficient Fireworks Algorithm with Uniform Local Search Operator

Lixian Li,이재완 한국인터넷정보학회 2020 인터넷정보학회논문지 Vol.21 No.3

Fireworks Algorithm (FWA) is a relatively novel swarm-based metaheuristic algorithm for global optimization. To solve the low-efficient local searching problem and convergence of the FWA, this paper presents a Variable Amplitude Coefficient Fireworks Algorithm with Uniform Local Search Operator (namely VACUFWA). Firstly, the explosive amplitude is used to adjust improving the convergence speed dynamically . Secondly, Uniform Local Search (ULS) enhances exploitation capability of the FWA. Finally, the ULS and Variable Amplitude Coefficient operator are used in the VACUFWA. The comprehensive experiment carried out on 13 benchmark functions. Its results indicate that the performance of VACUFWA is significantly improved compared with the FWA, Differential Evolution, and Particle Swarm Optimization.

ANTECEDENTS OF SUBJECTIVE KNOWLEDGE DEVELOPMENT AND IMPACTS ON FIRST TIME BUYING AND RE-PURCHASING PREFERENCE HETEROGENEITY: EVIDENCE IN THE CHINESE CAR MARKET

Lixian Qian,Didier Soopramanien 글로벌지식마케팅경영학회 2014 Global Marketing Conference Vol.2014 No.7

Subjective knowledge (SK thereafter) is defined as what consumers think they know, or their perceived level of knowledge (Brucks, 1985). SK influences what consumers search for, the effort that they put into searching, and the purchasing decision and choice of brands they finally make (Hadar, Sood, & Fox, 2013; Moorman, Diehl, Brinberg, & Kidwell, 2004). The existing literature on consumer knowledge development mainly argues that SK development is associated with consumers’ product related experience, such as product ownership and experience from usage (Alba & Hutchinson, 2000; Park, Mothersbaugh, & Feick, 1994). This study contributes to the literature as follows. We consider a broad market segmentation where the market consists of product owners and non-owners, The literature suggests that these two groups of consumers should have different levels of perceived knowledge due to their different product-specific experience (Park et al., 1994). Our research specifically contends that it is important to distinguish, within the group of non-owners, between those who intend to buy and those who do not intend to buy the product. Thus, this study examines how previous ownership and intention to buy, which is the goal motivation, influence the SK levels of consumers, which in turn impacts on consumers’ heterogeneous preferences for different attributes within a product category. It is contended that the motivation to learn about a product category of non-car owners who have strong intentions to buy influences what this group learns compared to those non-owners who do not intend to buy. More specifically, the research proposes to uncover how learning influences how different groups of consumers perceive their subjective knowledge and how this relationship in turn shapes their preferences, especially when we compare owners and non-owners who have strong intentions of buying a product. Therefore, we develop following research hypotheses: H1: The SK level is positively associated with the product ownership experience. H2: The SK level is positively associated with purchase intention. H3: The relationship between purchase intention and SK level is moderated by the ownership of the product. H4: Preference heterogeneity for different types of brand attributes of the product between owners and non-owners is moderated by the SK level. The empirical context that illustrates the importance of this research is the Chinese car market where the majority of consumers are first time buyers. Our research shows that the SK level is positively associated with both car ownership and purchase intention. Furthermore, the segmentation analysis finds that purchase intention has a significant effect only on non-car owners’ SK level, while the effect on car owners’ SK level is insignificant. An interesting finding is that SK development, in turn, influences consumer’s preferences for different types of brand attributes of a product. We demonstrate the role of SK in forming consumer preference heterogeneity by comparing preferences for a tangible and a non-tangible brand attribute respectively across different consumer segments. We further show how this preference heterogeneity across two consumer segments (car owners versus non-car owners) depends on their SK level. The results of this study can be generalized beyond the specific context of the empirical study of the Chinese car market when marketers are considering new products launch or launching products where the majority of consumers may be unfamiliar with the product.

Research on the Innovation and Entrepreneurship of College Students’ Education Evaluation based on Analytic Hierarchy Process

LiXian Jing,Juan Li,Xue Zhang,Minghu Li 보안공학연구지원센터 2016 International Journal of Hybrid Information Techno Vol.9 No.1

Cultivation of innovative talents has already been the focus of education research, in this paper; we research the innovation and entrepreneurship education system, constructing the index system of innovation and entrepreneurship education for college students. Using the analytic hierarchy process and gray theory, we studied the quantitative evaluation of innovation and entrepreneurship education of college students. Taking North China University of science and engineering as an example, we put forward a set of countermeasures and suggestions on the cultivation of innovation and entrepreneurship education for college students.