Production and immunogenicity of chimeric virus-like particles containing the spike glycoprotein of infectious bronchitis virus

Lishan Lv,Xiaoming Li,Genmei Liu,Ran Li,Qiliang Liu,Huifang Shen,Wei Wang,Chunyi Xue,Yongchang Cao 대한수의학회 2014 JOURNAL OF VETERINARY SCIENCE Vol.15 No.2

Infectious bronchitis virus (IBV) poses a severe threat to thepoultry industry and causes heavy economic losses worldwide. Vaccination is the most effective method of preventing infectionand controlling the spread of IBV, but currently availableinactivated and attenuated virus vaccines have somedisadvantages. We developed a chimeric virus-like particle(VLP)-based candidate vaccine for IBV protection. The chimericVLP was composed of matrix 1 protein from avian influenzaH5N1 virus and a fusion protein neuraminidase (NA)/spike 1 (S1)that was generated by fusing IBV S1 protein to the cytoplasmicand transmembrane domains of NA protein of avian influenzaH5N1 virus. The chimeric VLPs elicited significantly higherS1-specific antibody responses in intramuscularly immunizedmice and chickens than inactivated IBV viruses. Furthermore,the chimeric VLPs induced significantly higher neutralizationantibody levels than inactivated H120 virus in SPF chickens. Finally, the chimeric VLPs induced significantly higher IL-4production in mice. These results demonstrate that chimericVLPs have the potential for use in vaccines against IBV infection.

Backhaul transmission scheme for UAV based on improved Nash equilibrium strategy

Lishan Liu,Duanpo Wu,Xinyu Jin,Shuwei Cen,Fang Dong 한국인터넷정보학회 2022 KSII Transactions on Internet and Information Syst Vol.16 No.8

As a new alternative communication scheme in 5G, unmanned aerial vehicle (UAV) is used as a relay in the remote base station (BS) for assistant communication. In order to ameliorate the quality of the backhaul link, a UAV backhaul transmission scheme based on improved Nash equilibrium (NE) strategy is proposed. First, the capacity of air-to-ground (A2G) channel by the link preprocess is maximized. Then, the maximum utility function of each UAV is used as the basis of obtaining NE point according to the backhaul channel and the backhaul congestion. Finally, the improved NE strategy is applied in multiple iterations until maximum utility functions of all the UAVs are reached, and the UAVs which are rejected by air-to-air (A2A) link during the process would participate in the source recovery process to construct a multi-hop backhaul network. Simulation results show that average effective backhaul rate, minimum effective backhaul rate increases by 10%, 28.5% respectively in ideal A2G channel, and 11.8%, 42.3% respectively in fading channel, comparing to pure NE strategy. And the average number of iterations is decreased by 5%.

DERIVED FROM INTERACTION: DEVELOPING A CUSTOMER ENGAGEMENT MODEL IN WELLNESS TOURISM

Lishan Xie,Xinhua Guan,Yingxin He,Tzung-Cheng (TC) Huan 글로벌지식마케팅경영학회 2018 Global Marketing Conference Vol.2018 No.07

To investigate the value co-creation process in wellness tourism, this study constructed a structural equation model of customer interactions with (1) the environment, (2) service employees, and (3) other customers relating to customer-perceived value and customer engagement. Empirical data were collected from 528 survey respondents who were at wellness tourism resorts. The results reveal that all three types of interaction have positive effects on customer-perceived value, and that perceived value positively affects customer engagement. Based on this finding, management recommendations for wellness tourism service enterprises are given.

Estimating functional brain networks by incorporating a modularity prior

Qiao, Lishan,Zhang, Han,Kim, Minjeong,Teng, Shenghua,Zhang, Limei,Shen, Dinggang ACADEMIC PRESS 2016 NEUROIMAGE Vol.141 No.-

<P><B>Abstract</B></P> <P>Functional brain network analysis has become one principled way of revealing informative organization architectures in healthy brains, and providing sensitive biomarkers for diagnosis of neurological disorders. Prior to any post hoc analysis, however, a natural issue is how to construct “ideal” brain networks given, for example, a set of functional magnetic resonance imaging (fMRI) time series associated with different brain regions. Although many methods have been developed, it is currently still an open field to estimate biologically meaningful and statistically robust brain networks due to our limited understanding of the human brain as well as complex noises in the observed data. Motivated by the fact that the brain is organized with <I>modular</I> structures, in this paper, we propose a novel functional brain network modeling scheme by encoding a <I>modularity prior</I> under a <I>matrix-regularized</I> network learning framework, and further formulate it as a sparse low-rank graph learning problem, which can be solved by an efficient optimization algorithm. Then, we apply the learned brain networks to identify patients with mild cognitive impairment (MCI) from normal controls. We achieved 89.01% classification accuracy even with a simple feature selection and classification pipeline, which significantly outperforms the conventional brain network construction methods. Moreover, we further explore brain network features that contributed to MCI identification, and discovered potential biomarkers for personalized diagnosis.</P>

Citic Tower Construction Key Technology

Xu, Lishan Council on Tall Building and Urban Habitat Korea 2019 International journal of high-rise buildings Vol.8 No.3

Citic Tower is the first over-500 m-tall super highrise building in the world, located in the high seismic intensity area with paek ground acceleration over 0.2g in 475 years. This project is unique in its complexity, large volume, and challenging site conditions (zero site for construction). The traditional techniques can hardly meet safty, quality and schedule requirements of the construction. This article introduces the key construction technologies that are innovatively developed and applied in Citic Tower project construction, including intelligent super-high-rise building integrated construction platform system, independently developed by the CCTEB; Jump-Lift Elevator, which is the first of the kind with service height over 500 meters; combined temporary-and-permanent fire protection systems. The BIM technology is also applied in this project. Through technical innovation, and utilization of technologies, construction speed and safety had been greatly improved.

DOES CSR ALWAYS PROTECT FIRMS AGAINST NEGATIVE PUBLICITY?

Teng Gao,Lishan Xie,Patrick Poon 글로벌지식마케팅경영학회 2016 Global Marketing Conference Vol.2016 No.7

Previous research indicates that consumers may resist negative publicity when they perceive a firm to be socially responsible (Klein & Dawar, 2004; Chernev & Blair,2015). However, other research shows corporate social responsibility (CSR) may boomerang the damage of negative publicity (Sohn & Lariscy,2012). Firms may participate in CSR and it is important for market practitioners and researchers to understand the role of different types of CSR in minimizing the impact of negative publicity. This research aims to examine the moderating role of two types of CSR in the effect of negative publicity on consumer responses. An experiment with a 2 (negative publicity type: ability-related vs. morality-related) x 2 (CSR type: philanthropic donation vs. employee wellbeing) between-subjects factorial design was conducted in a major city of China. In the morality-related negative publicity and employee wellbeing condition, the participants were shown with employee wellbeing materials and a morality-related negatively publicized article about a fictitious hotel. Similar arrangements were setup for other different conditions. Then, consumer responses such as firm evaluation and patronage intention were measured. Results of two-way ANOVA revealed a significant interaction effect. The findings indicate that consumers’ patronage intention is lower when a morality-related negative publicity has happened to a firm having “philanthropic donation” type of CSR, and also when an ability-related negative publicity has happened to a firm having “employee wellbeing” type of CSR. Managerial

THE IMPACT OF NEGATIVE BRAND PUBLICITY ON HOTEL CONSUMERS IN CHINA

Patrick Poon,Lishan Xie,Teng Gao 글로벌지식마케팅경영학회 2014 Global Marketing Conference Vol.2014 No.11

Negative publicity can be defined as negative information about a product, a service, a brand, an organization or an individual that is circulated through mass media such as print media and broadcast media (Dean, 2004; O'Guinn, Allen, & Semenik, 2011). Indeed, there has been a growing interest in the marketing literature concerning the effects of negative brand publicity on consumer perceptions and evaluations (Cleeren, van Heerde, & Dekimpe, 2013; Dills & Hernández Julián, 2012; Pullig, Netemeyer & Biswas, 2006; Thirumalai & Sinha, 2011). Negatively publicized instances such as defective products/services or unethical business practices are likely to impair a brand’s image and its equity. However, previous literature has mainly focused on the effect of performance-related negative publicity on consumer responses and there are limited studies about the effect of value- or ethics-related negative publicity. Owing to the inherent characteristics of inseparability and intangibility, hospitality managers need to pay particular attention to ethical issues and the detrimental impact of value-related negative publicity. This study aims to examine the impact of negative brand publicity on hotel consumers for two types of negative publicity (namely, performance-related and value-related). A content analysis and a consumer survey were conducted in China so as to investigate the hotel recovery strategy and consumer responses toward negative publicity. The content analysis was performed on two largest local daily newspapers in China. It showed that the occurrence of value-related negative publicity (e.g., not keeping promises, or dishonesty) was much greater than performance-related negative publicity (e.g., untidy room, or equipment malfunction) in China’s hotel industry. Compensations appeared to be the most common method for hotel responses toward the two types of negative publicity. The consumer survey showed that consumer responses such as hotel evaluations and patronage intentions were negatively affected by negative brand publicity. Female consumers were found to be more sensitive to unethical issues than male consumers. In other words, females were more negatively affected by value-related publicity than performance-related publicity. Managerial implications for hospitality managers are discussed.

THE IMPACT OF NEGATIVE BRAND PUBLICITY ON HOTEL CONSUMERS IN CHINA

Patrick Poon,Lishan Xie,Teng Gao 글로벌지식마케팅경영학회 2014 Global Marketing Conference Vol.2014 No.7

Negative publicity can be defined as negative information about a product, a service, a brand, an organization or an individual that is circulated through mass media such as print media and broadcast media (Dean, 2004; O'Guinn, Allen, & Semenik, 2011). Indeed, there has been a growing interest in the marketing literature concerning the effects of negative brand publicity on consumer perceptions and evaluations (Cleeren, van Heerde, & Dekimpe, 2013; Dills & Hern?ndez Juli?n, 2012; Pullig, Netemeyer & Biswas, 2006; Thirumalai & Sinha, 2011). Negatively publicized instances such as defective products/services or unethical business practices are likely to impair a brand’s image and its equity. However, previous literature has mainly focused on the effect of performance-related negative publicity on consumer responses and there are limited studies about the effect of value- or ethics-related negative publicity. Owing to the inherent characteristics of inseparability and intangibility, hospitality managers need to pay particular attention to ethical issues and the detrimental impact of value-related negative publicity. This study aims to examine the impact of negative brand publicity on hotel consumers for two types of negative publicity (namely, performance-related and value-related). A content analysis and a consumer survey were conducted in China so as to investigate the hotel recovery strategy and consumer responses toward negative publicity. The content analysis was performed on two largest local daily newspapers in China. It showed that the occurrence of value-related negative publicity (e.g., not keeping promises, or dishonesty) was much greater than performance-related negative publicity (e.g., untidy room, or equipment malfunction) in China’s hotel industry. Compensations appeared to be the most common method for hotel responses toward the two types of negative publicity. The consumer survey showed that consumer responses such as hotel evaluations and patronage intentions were negatively affected by negative brand publicity. Female consumers were found to be more sensitive to unethical issues than male consumers. In other words, females were more negatively affected by value-related publicity than performance-related publicity. Managerial implications for hospitality managers are discussed.

Blow-up and global solutions for some parabolic systems under nonlinear boundary conditions

Limin Guo,Lishan Liu,Yonghong Wu,Yu-mei Zou 대한수학회 2019 대한수학회지 Vol.56 No.4

In this paper, blows-up and global solutions for a class of nonlinear divergence form parabolic equations with the abstract form of $(\varrho(u))_{t}$ and time dependent coefficients are considered. The conditions are established for the existence of a solution globally and also the conditions are established for the blow up of the solution at some finite time. Moreover, the lower bound and upper bound of the blow-up time are derived if blow-up occurs.

Feature fusion via hierarchical supervised local CCA for diagnosis of autism spectrum disorder

Zhao, Feng,Qiao, Lishan,Shi, Feng,Yap, Pew-Thian,Shen, Dinggang Springer-Verlag 2017 Brain imaging and behavior Vol.11 No.4

<P>Early diagnosis of autism spectrum disorder (ASD) is critical for timely medical intervention, for improving patient quality of life, and for reducing the financial burden borne by the society. A key issue in neuroimaging-based ASD diagnosis is the identification of discriminating features and then fusing them to produce accurate diagnosis. In this paper, we propose a novel framework for fusing complementary and discriminating features from different imaging modalities. Specifically, we integrate the Fisher discriminant criterion and local correlation information into the canonical correlation analysis (CCA) framework, giving a new feature fusion method, called Supervised Local CCA (SL-CCA), which caters specifically to local and global multimodal features. To alleviate the neighborhood selection problem associated with SL-CCA, we further propose a hierarchical SL-CCA (HSL-CCA), by performing SL-CCA with the gradually varying neighborhood sizes. Extensive experiments on the multimodal ABIDE database show that the proposed method achieves superior performance. In addition, based on feature weight analysis, we found that only a few specific brain regions play active roles in ASD diagnosis. These brain regions include the putamen, precuneus, and orbitofrontal cortex, which are highly associated with human emotional modulation and memory formation. These finding are consistent with the behavioral phenotype of ASD.</P>