Nomograms to Predict the Individual Survival of Patients with Solitary Hepatocellular Carcinoma after Hepatectomy

( Junyi Shen ),( Linye He ),( Chuan Li ),( Tianfu Wen ),( Weixia Chen ),( Changli Lu ),( Lvnan Yan ),( Bo Li ),( Jiayin Yang ) 대한간학회 2017 Gut and Liver Vol.11 No.5

Background/Aims: Solitary hepatocellular carcinoma (HCC) is a subgroup of HCCs. We aimed to establish nomograms for predicting the survival of solitary HCC patients after hepatectomy. Methods: A total of 538 solitary HCC patients were randomly classified into training and validation sets. A Cox model was used to identify predictors of overall survival (OS) in the training set. A nomogram was generated based on these predictors and was validated using the validation set. Results: Tumor size, microvascular invasion, and major vascular invasion were significantly associated with OS in the training set. Nomograms were developed based on these predictors in the multivariate analysis. The C-index was 0.75 for the OS nomogram and 0.72 for the recurrence-free sur-vival nomogram. Compared to the index of conventional stag-ing systems for predicting survival (0.71 for Barcelona Clinic Liver Cancer, 0.66 for the seventh American Joint Committee on Cancer, 0.68 for Cancer of the Liver Italian Program, and 0.70 for Hong Kong Liver Cancer), the index of the OS nomo-gram was significantly higher. Moreover, the calibration curve fitted well between the predicted and observed survival rate. Similarly, in the validation set, the nomogram discrimination was superior to those of the four staging systems (p<0.001). Conclusions: The nomograms demonstrated good discrimi-nation performance in predicting 3- and 5-year survival rates for solitary HCCs after hepatectomy. (Gut Liver 2017;11:684- 692)

Experiences of Body Image Changes in Chinese Patients Living with Inflammatory Bowel Disease: A Descriptive Qualitative Study

Jiayin Ruan,Linye Wu,Yunxian Zhou 한국간호과학회 2020 Asian Nursing Research Vol.14 No.4

Purpose: Body image changes are common among patients living with inflammatory bowel disease (IBD)because of the illness and related treatments. Currently, there is little known about how those patientsexperience and perceive their altered body image in the literature. The aim of this study was to explorethe experiences of body image changes in patients with IBD in China and to describe how those changesinfluence patients’ perception of body and self. Methods: This study used a descriptive qualitative approach. A total of 16 participants from three tertiaryhospitals in southeast China were recruited through purposive sampling combined with maximumvariation strategy. Data were collected through semistructured interviews and analyzed using conventionalcontent analysis method. Results: The following six themes were extracted: (1) “being a constrained person,” (2) “being a flawedperson,” (3) “being a disliked person,” (4) “being an alienated person,” (5) “being a reconciled person,”and (6) “being a blessed person.”Conclusion: With the diagnosis of IBD and its side effects of treatments, patients’ life changed significantlyand they were struggling to reinterpret their body and self. As a result, negative self-evaluations and/or positive self-evaluations towards themselves generated. Further studies are required to explore theunderlying mechanism and related influencing factors about how those different images were produced.

Student perspectives on fabrication methods and design outcomes

Young Mi Choi,Linye Zhang 한국디자인학회 2015 디자인학연구 Vol.28 No.4

Musca domestica Pupae Lectin Improves the Immunomodulatory Activity of Macrophages by Activating Nuclear Factor-jB

Xiaohong Cao,Minghui Zhou,Chunling Wang,Lihua Hou,Yuanyuan Li,Linye Chen 한국식품영양과학회 2012 Journal of medicinal food Vol.15 No.2

In this study, Musca domestica pupae lectin (MPL) was screened for its immunomodulatory effect on macrophages. The phagocytosis of macrophages was improved significantly when they were treated with MPL: remarkable changes were observed in the morphology of the cells, the metabolic abilities of DNA and RNA were enhanced, and the production of hepatin was increased. Meanwhile, compared with the control group, not only the mRNA expressions of tumor necrosis factor-a (TNF-a), interleukin-6 (IL-6), and interferon-c (IFN-c) in macrophages, but also the productions of proteins,were strongly induced by MPL; these effects were inhibited by pyrrolidine dithiocarbamate. Further study suggested that MPL could increase the nuclear factor-jB (NF-jB) p65 level in the nucleus. Overall, these results indicate that the improving immunomodulatory activity induced by MPL is mainly due to the increasing productions of TNF-a, IL-6, and IFN-c and that the activation of macrophage by MPL is partly mediated via the NF-jB pathway.

A Newly Synthesized Flavone from Luteolin Escapes from COMT-Catalyzed Methylation and Inhibits Lipopolysaccharide-Induced Inflammation in RAW264.7 Macrophages via JNK, p38 and NF-κB Signaling Pathways

( Lin Ye ),( Yang Xin ),( Zhi-yuan Wu ),( Hai-jian Sun ),( De-jian Huang ),( Zhi-qin Sun ) 한국미생물 · 생명공학회 2022 Journal of microbiology and biotechnology Vol.32 No.1

Luteolin is a common dietary flavone possessing potent anti-inflammatory activities. However, when administrated in vivo, luteolin becomes methylated by catechol-O-methyltransferases (COMT) owing to the catechol ring in the chemical structure, which largely diminishes its anti-inflammatory effect. In this study, we made a modification on luteolin, named LUA, which was generated by the chemical reaction between luteolin and 2,2'-azobis(2-amidinopropane) dihydrochloride (AAPH). Without a catechol ring in the chemical structure, this new flavone could escape from the COMT-catalyzed methylation, thus affording the potential to exert its functions in the original form when administrated in the organism. Moreover, an LPS-stimulated RAW cell model was applied to detect the anti-inflammatory properties. LUA showed much more superior inhibitory effect on LPS-induced production of NO than diosmetin (a major methylated form of luteolin) and significantly suppressed upregulation of iNOS and COX-2 in macrophages. LUA treatment dramatically reduced LPS-stimulated reactive oxygen species (ROS) and mRNA levels of pro-inflammatory mediators such as IL-1β, IL-6, IL-8 and IFN-β. Furthermore, LUA significantly reduced the phosphorylation of JNK and p38 without affecting that of ERK. LUA also inhibited the activation of NF-κB through suppression of p65 phosphorylation and nuclear translocation.

THE ENVIRONMENT OF BARRED GALAXIES IN THE LOW-REDSHIFT UNIVERSE

Lin, Ye,Sodi, Bernardo Cervantes,Li, Cheng,Wang, Lixin,Wang, Enci IOP Publishing 2014 The Astrophysical journal Vol.796 No.2

<P>We present a study of the environment of barred galaxies using a volume-limited sample of over 30,000 galaxies drawn from the Sloan Digital Sky Survey. We use four different statistics to quantify the environment: the projected two-point cross-correlation function, the background-subtracted number count of neighbor galaxies, the overdensity of the local environment, and the membership of our galaxies to galaxy groups to segregate central and satellite systems. For barred galaxies as a whole, we find a very weak difference in all the quantities compared to unbarred galaxies of the control sample. When we split our sample into early- and late-type galaxies, we see a weak but significant trend for early-type galaxies with a bar to be more strongly clustered on scales from a few 100 kpc to 1 Mpc when compared to unbarred early-type galaxies. This indicates that the presence of a bar in early-type galaxies depends on the location within their host dark matter halos. This is confirmed by the group catalog in the sense that for early-types, the fraction of central galaxies is smaller if they have a bar. For late-type galaxies, we find fewer neighbors within similar to 50 kpc around the barred galaxies when compared to unbarred galaxies from the control sample, suggesting that tidal forces from close companions suppress the formation/growth of bars. Finally, we find no obvious correlation between overdensity and the bars in our sample, showing that galactic bars are not obviously linked to the large-scale structure of the universe.</P>

Assessment of Bacterial Wildfire Infection in Soybean Cultivars by Hyperspectral Imaging

Propey Then,Liny Lay,Amit Ghimire,Mohammad Shafiqul Islam,김윤하 강원대학교 농업생명과학연구원 2023 강원 농업생명환경연구 Vol.35 No.3

Soybean [Glycine max (L.) Merr.] is an economically important protein and oilseed legume. Bacterial wildfire, a major biotic stress caused by Pseudomonas syringae pv. tabaci (Pst), has steadily increased in occurrence and severity across several soybean cultivars, presenting a significant risk to soybean production. This study aimed to investigate and evaluate the effect of bacterial wildfires on selected soybean cultivars using imaging approaches, such as hyperspectral and digital imaging with red, green, and blue methods. A significant difference between the tolerance and sensitivity of the plants was observed in this study. In the present study, the disease incidence (DI) exhibited was observed in all soybean cultivars 2 days after inoculation (DAI). Taekwang (52.41%) showed more symptoms with a sensitive response to disease infection and showed a significant difference in DI compared with the other cultivars, whereas Daephung 2, Seunphung, and Soyun showed fewer symptoms on leaves (< 10%). Additionally, among the three vegetation indices (VIs), the normalized difference vegetation, photochemical reflectance, and anthocyanin reflectance indices were significantly correlated with DI at 3 DAI. Hence, these VIs can be used for the early detection of bacterial wildfires; however, further research is needed for more precise and accurate disease detection.

[PC-0006] Employing hyperspectral imaging for early detection of diseases in soybean

Rupesh Tayade(Rupesh Tayade ),Liny Lay(Liny Lay),Hogyun Kim(Hogyun Kim),Waleed Khan(Waleed Khan),Amit Ghimire(Amit Ghimire ),Mohammad Shafiqul(Mohammad Shafiqul ),Yoonha Kim(Yoonha Kim) 한국육종학회 2022 한국육종학회 공동학술발표집 Vol.2022 No.-