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Early Life Factors Influencing the Risk of Obesity
Lifschitz, Carlos The Korean Society of Pediatric Gastroenterology 2015 Pediatric gastroenterology, hepatology & nutrition Vol.18 No.4
The obesity epidemic is a worldwide problem. Factors predisposing to obesity include genetics, race, socioeconomic conditions, birth by cesarean section, and perinatal antibiotic use. High protein (HP) content in infant formulas has been identified as a potential culprit predisposing to rapid weight gain in the first few months of life and leading to later obesity. In a large multicountry study the effects of lower protein (LP) formula (1.77 and 2.2 g protein/100 kcal, before and after the 5th month, respectively) were compared to those of higher protein (2.9 and 4.4 g protein/100 kcal, respectively). Results indicated that at 24 months, the weight-for-length z score of infants in the LP formula group was 0.20 (0.06, 0.34) lower than that of the HP group and was similar to that of the breastfed reference group. The authors concluded that a HP content of infant formula is associated with higher weight in the first 2 years of life but has no effect on length. LP intake in infancy might diminish the later risk of overweight and obesity. At 6 years of age HP children had a significantly higher body mass index (by 0.51; 95% confidence interval [CI], 0.13-0.90; p=0.009) and a 2.43 (95% CI, 1.12-5.27; p=0.024) fold greater risk of becoming obese than those who received the LP. In conclusion, several factors may influence development of metabolic syndrome and obesity. Breastfeeding should always be encouraged. An overall reduction of protein intake in formula non breastfed infants seems to be an additional way to prevent obesity.
Early Life Factors Influencing the Risk of Obesity
Carlos Lifschitz 대한소아소화기영양학회 2015 Pediatric gastroenterology, hepatology & nutrition Vol.18 No.4
The obesity epidemic is a worldwide problem. Factors predisposing to obesity include genetics, race, socioeconomic conditions, birth by cesarean section, and perinatal antibiotic use. High protein (HP) content in infant formulas has been identified as a potential culprit predisposing to rapid weight gain in the first few months of life and leading to later obesity. In a large multicountry study the effects of lower protein (LP) formula (1.77 and 2.2 g protein/100 kcal, before and after the 5th month, respectively) were compared to those of higher protein (2.9 and 4.4 g protein/100 kcal, respectively). Results indicated that at 24 months, the weight-for-length z score of infants in the LP formula group was 0.20 (0.06, 0.34) lower than that of the HP group and was similar to that of the breastfed reference group. The authors concluded that a HP content of infant formula is associated with higher weight in the first 2 years of life but has no effect on length. LP intake in infancy might diminish the later risk of overweight and obesity. At 6 years of age HP children had a significantly higher body mass index (by 0.51; 95% confidence interval [CI], 0.13-0.90; p=0.009) and a 2.43 (95% CI, 1.12-5.27; p=0.024) fold greater risk of becoming obese than those who received the LP. In conclusion, several factors may influence development of metabolic syndrome and obesity. Breastfeeding should always be encouraged. An overall reduction of protein intake in formula non breastfed infants seems to be an additional way to prevent obesity.
Shin, Junghun,Kim, Hyung Taek,Pathak, V B,Hojbota, Calin,Lee, Seong Ku,Sung, Jae Hee,Lee, Hwang Woon,Yoon, Jin Woo,Jeon, Cheonha,Nakajima, Kazuhisa,Sylla, F,Lifschitz, A,Guillaume, E,Thaury, C,Malka, IOP 2018 Plasma physics and controlled fusion Vol.60 No.6
<P>Generation of high-quality electron beams from laser wakefield acceleration requires optimization of initial experimental parameters. We present here the dependence of accelerated electron beams on the temporal profile of a driving PW laser, the density, and length of an interacting medium. We have optimized the initial parameters to obtain 2.8 GeV quasi-monoenergetic electrons which can be applied further to the development of compact electron accelerators and radiations sources.</P>
Toward compact and ultra-intense laser-based soft x-ray lasers
Sebban, S,Depresseux, A,Oliva, E,Gautier, J,Tissandier, F,Nejdl, J,Kozlova, M,Maynard, G,Goddet, J P,Tafzi, A,Lifschitz, A,Kim, H T,Jacquemot, S,Rousseau, P,Zeitoun, P,Rousse, A IOP 2018 Plasma physics and controlled fusion Vol.60 No.1
<P>We report here recent work on an optical field ionized (OFI), high-order harmonic-seeded EUV laser. The amplifying medium is a plasma of nickel-like krypton obtained by OFI when focusing a 1 J, 30 fs, circularly-polarized, infrared pulse into a krypton-filled gas cell or krypton gas jet. The lasing transition is the 3d<SUP>9</SUP>4d (<I>J</I>?=?0)?→?3d<SUP>9</SUP>4p (<I>J</I>?=?1) transition of Ni-like krypton ions at 32.8 nm and is pumped by collisions with hot electrons. The gain dynamics was probed by seeding the amplifier with a high-order harmonic pulse at different delays. The gain duration monotonically decreased from 7 ps to an unprecedented shortness of 450 fs full width at half-maximum as the amplification peak rose from 150 to 1200 with an increase of the plasma density from 3?×?10<SUP>18</SUP> to 1.2?×?10<SUP>20</SUP> cm<SUP>−3</SUP>. The integrated energy of the EUV laser pulse was also measured, and found to be around 2 <I>μ</I>J. It is to be noted that in the ASE mode, longer amplifiers were achieved (up to 2 cm), yielding EUV outputs up to 14 <I>μ</I>J.</P>