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The Role of Pentraxin 3 in Aspergillosis: Reality and Prospects
( Yuening Kang ),( Yuetian Yu ),( Liangjing Lu ) 한국균학회 2020 Mycobiology Vol.48 No.1
Pentraxin 3 (PTX3) is a soluble pattern recognition receptor (PRR), which is produced by several kinds of cells, such as neutrophils, dendritic cells, macrophages, and epithelial cells. PTX3 is known to play an important protective effect against Aspergillus. Genetic linkage in gene-targeted mice and human PTX3 plays a non-redundant role in the immune protection against specific pathogens, especially Aspergillus. Recent studies have shown that the polymorphism of PTX3 is associated with increased susceptibility to invasive aspergillosis (IA). In this review, we provide an overview of these studies that underline the potential of PTX3 in diagnosis and therapy of IA.
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Study on preparation of inorganic binder stabilized material with large dosage of phosphogypsum
Sun Qiqi,Tao Liangjing,Li Xin,Xu Wei,Yao Shuo,Li Jinpeng,Ren Qi-Fang,Chen Yue’e,Xu Chunshan,Wu Zilong,Zhu Yuelei,Ding Yi,오원춘 한국세라믹학회 2023 한국세라믹학회지 Vol.60 No.6
With the rapid development of the phosphorus chemical industry, a large amount of phosphogypsum (PG) is discharged. The impurities in PG pollute the surrounding soil, the groundwater and the air in the long-term storage. In this paper, PG as the main raw material is used to study the stable material of inorganic binder in the condition of large dosage of PG. With PG and graded gravel as stabilized materials, and cement and fly ash as binder, materials are mixed to determine the influence of PG ratio and the amount of activator on the mixture. The results show that the mechanical strength of the mixture increased first and then decreased with the increase in the proportion of PG replacing graded gravel in the mixture. The activator significantly improves the properties of the material system and makes a significant contribution to the curing of PG. The best ratio of pretreated PG: cement: fly ash: aggregate is 50:6:5:39. The amount of activator added by the external mixing method is 0.3%, which can make the unconfined compressive strength reach 4.1 MPa after 7d. Finally, water-soluble phosphorus leaching experiment is conducted for all the samples. The results show that phosphorus leaching is so little that no secondary pollution of the environment is caused.
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THE IMPACT OF COMPARATIVE PRICE ON CONSUMER TOLERANCE FOR SERVICE FAILURE
Hailong Yang,Yuanyu Zhang,Liangjing Che 글로벌지식마케팅경영학회 2018 Global Marketing Conference Vol.2018 No.07
This research was conducted in order to examine the effect of comparative price on consumers’ reactions to service failure in the loyalty program. The current study finds that under condition of lower level of persuasion knowledge, compared to single retail price, comparative price would mitigate consumers’ negative emotion in the context of service failure, which in turn improves customers’ tolerance. The authors test this prediction in two experiments. Experiment 1 aimed to provide an initial exploration of hypothesis by employing a between-subjects design. This experiment recruited undergraduate students at Suzhou University to complete an online survey. After reading the scenario of service failure, participants were asked to answer a series of questions about their intension of spreading negative word of mouth (NWOM). A one-way ANOVA on intention of spreading NWOM suggested that the NWOM activity was significantly lower in the group of comparative prices than in the group of single retail price. In experiment 2, the authors measured angry and intension to complain when participants finished reading the scenario of service failure. Furthermore, one week later the authors measured price tactic persuasion knowledge of participants. The bootstrap method (number of bootstrap samples = 5000, level of confidence = .95) was used. The results showed that customers’ angry level mediated the effect of comparative price on intension of complaint. The authors further conducted a mediated moderation analysis with the participants in the high- and low-persuasive-knowledge conditions. The results indicated the indirect effect of the comparative price on intention to complain was mediated by customers’ angry when they have low persuasive knowledge, whereas the mediation effect of customer’s angry level was no longer significant in the higher persuasive-knowledge condition. To summarize, this research suggested that comparative price would exert a marked impact on the tolerance of members of loyalty program in the context of service failure. The present paper adds to the existing comparative price literatures by confirming its impact on consumers’ judgment in the context of service failure even if they are all members of loyalty program and informed with information of discounted size in advance. Given the special meaning of NWOM and complaint, current paper provides implications for marketing practices.
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Li Shuang,Guo Dongyang,Sun Qiang,Zhang Lu,Cui Yun,Liu Min,Ma Xixi,Liu Yiman,Cui Wenyu,Sun Leimin,Teng Lisong,Wang Liangjing,Lin Aifu,Liu Wei,Zhuo Wei,Zhou Tianhua 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-
Liver metastasis is a major cause of death in gastric cancer patients, but the underlying mechanisms are poorly understood. Through a combination of in vivo screening and transcriptome profiling followed by quantitative RT-PCR and tissue array analyses, we found that mitogen-activated protein kinase 4 (MAPK4) downregulation in gastric cancer tissues from patients is significantly associated with liver metastasis and poor prognosis. The knockdown of MAPK4 in gastric cancer cells promotes liver metastasis in orthotopic mouse models. MAPK4 depletion in gastric cancer cells induces the secretion of macrophage migration inhibitory factor (MIF) to polarize tumor-associated macrophages (TAMs) in orthotopic xenograft tumors. Moreover, TAMs activate epithelial–mesenchymal transition of gastric cancer cells to suppress MAPK4 expression, which further increases MIF secretion to polarize TAMs. Taken together, our results suggest a previously undescribed positive feedback loop between cancer cells and macrophages mediated by MAPK4 silencing that facilitates gastric cancer liver metastasis.
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