White-Matter Hyperintensities and Lacunar Infarcts Are Associated with an Increased Risk of Alzheimer’s Disease in the Elderly in China

Shuai Ye,Shuyang Dong,Jun Tan,Le Chen,Hai Yang,Yang Chen,Zeyan Peng,Yingchao Huo,Juan Liu,Mingshan Tang,Yafei Li,Huadong Zhou,Yong Tao 대한신경과학회 2019 Journal of Clinical Neurology Vol.15 No.1

Background and Purpose This study investigated the contribution of white-matter hyperintensities (WMH) and lacunar infarcts (LI) to the risk of Alzheimer’s disease (AD) in an elderly cohort in China. Methods Older adults who were initially cognitively normal were examined with MRI at baseline, and followed for 5 years. WMH were classified as mild, moderate, or severe, and LI were classified into a few LI (1 to 3) or many LI (≥4). Cognitive function was assessed using the Mini Mental State Examination and the Activities of Daily Living scale. Results Among the 2,626 subjects, 357 developed AD by the end of the 5-year follow-up period. After adjusting for age and other potential confounders, having only WMH, having only LI, and having both WMH and LI were associated with an increased risk of developing AD compared with having neither WMH nor LI. Moderate and severe WMH were associated with an increased risk of developing AD compared with no WMH. Furthermore, patients with many LI had an increased risk of developing AD compared with no LI. Conclusions Having moderate or severe WMH and many LI were associated with an increased risk of developing AD, with this being particularly striking when both WMH and LI were present.

Influence of Particle Shape on the Density and Compressive Performance of Calcareous Sand

Shuai Wang,Xue-Wen Lei,Qing-Shan Meng,Jie-Li Xu,Ling-Feng Xie,Yu-Jie Li 대한토목학회 2020 KSCE Journal of Civil Engineering Vol.24 No.1

Particle shape influence the bearing capacity of calcareous sand foundations in island reef engineering. An improved Computer Image Analysis method that combined with mathematical statistics was proposed to categorize and sort different shapes of calcareous sand particles within the size range of 5 – 10 mm. Three single-shape calcareous sand specimens (granular ﾠ ﾠshape, dendritic shape, long strip shape) were obtained. A new self-developed vibration device was used measuring the maximum density of calcareous, the shape and content as the variables in the orthogonal test. On this basis, the lateral compression tests were carried out to assess the influence of particle shape on the density, compressive performance of calcareous sand. Test results showed that better discriminability was achieved by taking mean flatness (EL/B) as the quantification parameter of the particle shapes. The average flatness EL/B of specimens is approximately normally distributed in the statistical results. The shape and content of sand particles had an obvious influence on the density of calcareous sand. The compressive properties of calcareous sands with different particle shapes have obvious differences. After loaded, the particle size distribution of specimen improved, the average flatness EL/B of the granular-shaped specimens increased, while that of the dendritic-shaped and the long-strip-shaped specimens decreased, the average flatness EL/B of the specimens tended to be uniform. The relative fracture rate Br and the load value Pmax satisfied the exponential function fitting relationship. Therefore, it can be argued that particle shape should be taken into consideration when optimizing the foundation design in island reef engineering to achieve better compressive performance of the foundation.

An Improved Ant Colony Optimization for the Multi-Robot Path Planning with Timeliness

Shuai Zhou,GuangmingXiong,Yong Li,Xiaoyun Li 보안공학연구지원센터 2014 International Journal of Smart Home Vol.8 No.2

Coefficient of Restitution and Kinetic Energy Loss of Rockfall Impacts

Li-Ping Li,Shang-qu Sun,Shucai Li,Qian-qing Zhang,Cong Hu,Shao-shuai Shi 대한토목학회 2016 KSCE JOURNAL OF CIVIL ENGINEERING Vol.20 No.6

This paper presents the results of the coefficient of restitution and the kinetic energy loss rate obtained by lab experiment, two parameters that are crucial for rockfall impact. However, various definitions of coefficient of restitution exist and the most appropriate one is still not formed and obtained. In addition, the energy variation during the rockfall impacts has important significance in practical design. In this research, two kind shapes of blocks including plate and strip were adopted in the laboratory testing and the block material was tested before, indicating that the material has sufficient strength to prevent shattering during the impact. Furthermore, an apparatus specifically built for this study was established including a base, a slope and a releasing device. The falling testing was performed using plate and strip block while the falling height as well as the slope angle and releasing height were altered during the tests in order to estimate the effect of each parameter on the coefficients of restitution and energy loss rate. It was observed that collision reflection angle is less than impact angle for all, suggesting energy loss in collision. Impact angle decreases with increasing slope angle while there was no obvious effect of releasing height and releasing angle on impact angle. The relevant coefficient of restitution was found to decrease with impact angle, and the kinetic energy loss rate increased. Finally, the kinetic energy before and after the impact was found to significantly affect the COR and energy loss rate and the results can provide basis for mitigation measures.

艺术社会学语境下清代颜真卿书法接受现象探析

SHUAI WEN LI 한국서예학회 2018 서예학연구 Vol.33 No.-

The phenomenon that a school of calligraphists in Qin dynasty accepted Yan Zhenqing’s calligraphy widely is a dynamic process of artistic self-discipline and heteronomy which produced by Yan Zhengqing ,the subject and the society and culture of Qin dynasty. The style of seal characters and the acceptance of the unsophisticated style in Bei Qi’s tablets are the gene of epigraphy in Yan Zhenqing’s handwriting. The upright character of both handwriting and morality are the factors of habitude that Yan Zhenqing’s handwriting was widely accepted in Qin dynasty. In addition, the admiration of Yan’s handwriting in Qin dynasty is also affected by the communication with epigraphy and calligraphy and the independent choice made by a school of calligraphists in Qin dynasty because of politics and culture. 清代“文字狱”使得这一时期文人将研究领域转向金石考据,“乾嘉之风”使得传统帖学以“二王”为代表的书法审美范式受到了碑学的冲击,并出现了群体书家师法颜真卿书法的现象。本文基于阿诺德·豪泽尔的艺术社会学理论,以清代书家群体对颜真卿书法的推崇这一现象为论点,从艺术与社会的互动关系角度探讨清代书坛这一现象。碑学帖学转换、碑学地位提升是颜真卿书法在清代广被接受的影响因素之一,而颜真卿书法中碑与帖的基因同样也影响着清代书坛书家群体的选择。

Adaptive V1-MT model for motion perception

( Shuai Li ),( Xiaoguang Fan ),( Yuelei Xu ),( Jinke Huang ) 한국인터넷정보학회 2019 KSII Transactions on Internet and Information Syst Vol.13 No.1

Motion perception has been tremendously improved in neuroscience and computer vision. The baseline motion perception model is mediated by the dorsal visual pathway involving the cortex areas the primary visual cortex (V1) and the middle temporal (V5 or MT) visual area. However, few works have been done on the extension of neural models to improve the efficacy and robustness of motion perception of real sequences. To overcome shortcomings in situations, such as varying illumination and large displacement, an adaptive V1-MT motion perception (Ad-V1MTMP) algorithm enriched to deal with real sequences is proposed and analyzed. First, the total variation semi-norm model based on Gabor functions (TV-Gabor) for structure-texture decomposition is performed to manage the illumination and color changes. And then, we study the impact of image local context, which is processed in extra-striate visual areas II (V2), on spatial motion integration by MT neurons, and propose a V1-V2 method to extract the image contrast information at a given location. Furthermore, we take feedback inputs from V2 into account during the polling stage. To use the algorithm on natural scenes, finally, multi-scale approach has been used to handle the frequency range, and adaptive pyramidal decomposition and decomposed spatio-temporal filters have been used to diminish computational cost. Theoretical analysis and experimental results suggest the new Ad-V1MTMP algorithm which mimics human primary motion pathway has universal, effective and robust performance.

Genome-wide average DNA methylation is determined <i>in utero</i>

Li, Shuai,Wong, Ee Ming,Dugué,, Pierre-Antoine,McRae, Allan F,Kim, Eunae,Joo, Ji-Hoon Eric,Nguyen, Tuong L,Stone, Jennifer,Dite, Gillian S,Armstrong, Nicola J,Mather, Karen A,Thalamuthu, Anbupal Oxford University Press 2018 International journal of epidemiology Vol.47 No.3

<P><B>Abstract</B></P><P><B>Background</B></P><P>Investigating the genetic and environmental causes of variation in genome-wide average DNA methylation (GWAM), a global methylation measure from the HumanMethylation450 array, might give a better understanding of genetic and environmental influences on methylation.</P><P><B>Methods</B></P><P>We measured GWAM for 2299 individuals aged 0 to 90 years from seven twin and/or family studies. We estimated familial correlations, modelled correlations with cohabitation history and fitted variance components models for GWAM.</P><P><B>Results</B></P><P>The correlation in GWAM for twin pairs was ∼0.8 at birth, decreased with age during adolescence and was constant at ∼0.4 throughout adulthood, with no evidence that twin pair correlations differed by zygosity. Non-twin first-degree relatives were correlated, from 0.17 [95% confidence interval (CI): 0.05–0.30] to 0.28 (95% CI: 0.08–0.48), except for middle-aged siblings (0.01, 95% CI: −0.10–0.12), and the correlation increased with time living together and decreased with time living apart. Spouse pairs were correlated in all studies, from 0.23 (95% CI: 0.3–0.43) to 0.31 (95% CI: 0.05–0.52), and the correlation increased with time living together. The variance explained by environmental factors shared by twins alone was 90% (95% CI: 74–95%) at birth, decreased in early life and plateaued at 28% (95% CI: 17–39%) in middle age and beyond. There was a cohabitation-related environmental component of variance.</P><P><B>Conclusions</B></P><P>GWAM is determined <I>in utero</I> by prenatal environmental factors, the effects of which persist throughout life. The variation of GWAM is also influenced by environmental factors shared by family members, as well as by individual-specific environmental factors.</P>

Risk Factors for Work-Related Musculoskeletal Disorders Among Intensive Care Unit Nurses in China: A Structural Equation Model Approach

Shuai Yang,Li Li,Liqian Wang,Jiaqi Zeng,Yinglan Li 한국간호과학회 2020 Asian Nursing Research Vol.14 No.4

Purpose: This study explored the direct and indirect effects of risk factors of work-related musculoskeletaldisorders (WRMDs) in nurses working in intensive care units (ICUs). Methods: A cross-sectional study design was used. ICU nurses from 28 tertiary hospitals in the Hunanand Guangdong provinces participated in a survey conducted via a self-reported online questionnaire. Astructural equation model was used to fit the data and to evaluate associations among WRMDs and riskfactors. Results: Valid questionnaire samples were submitted by 984 ICU nurses. The prevalence of WRMDswithin the previous year among ICU nurses was 96.8%. A valid structural equation model was constructed,and a good fit was shown: Chi-square value/degrees of freedom ¼ 2.248; comparative fitindex ¼ .931; normal fit index ¼ .905; goodness-of-fit index ¼ .978; adjusted goodness-of-fit index ¼.966; and root mean square error of approximation ¼ .036. All regression coefficients for direct effectreached significant levels (critical ratio > 1.96 and p < .05). In the structural equation model, theoccurrence of WRMDs was directly affected by the following: physical factors, risk perception, and jobstress. Physical factors and a safe environment indirectly affected WRMDs through risk perception andjob stress. The strongest correlations with WRMDs were physical factors. Conclusion: The model provided a new perspective for understanding the associations among physicalfactors, workplace safety environment, risk perception, job stress, and WRMDs. To improve the practicesetting of the ICU, efforts should be made to help prevent WRMDs from physical, psychosocial, andenvironmental factors.

Use of autonomous maximal smile to evaluate dental and gingival exposure

Shuai Wang,Hengzhe Lin,Yan Yang,Xin Zhao,Li Mei,Wei Zheng,Yu Li,Zhihe Zhao 대한치과교정학회 2018 대한치과교정학회지 Vol.48 No.3

Objective: This study was performed to validate the autonomous maximal smile (AMS) as a new reference for evaluating dental and gingival exposure. Methods: Digital video clips of 100 volunteers showing posed smiles and AMS at different verbal directives were recorded for evaluation a total of three times at 1-week intervals. Lip-teeth relationship width (LTRW) and buccal corridor width (BCW) were measured. LTRW represented the vertical distance between the inferior border of the upper vermilion and the edge of the maxillary central incisors. Intraclass correlation coefficients (ICCs) for reproducibility, and the m-value (minimum number of repeated measurements required for an ICC level over 0.75), were calculated. Results: LTRW and BCW of the AMS were 1.41 and 2.04 mm, respectively, greater than those of the posed smile (p < 0.05), indicating significantly larger dental and gingival exposure in the AMS. The reproducibility of the AMS (0.74 to 0.77) was excellent, and higher than that of the posed smile (0.62 to 0.65), which had fair-to-good reproducibility. Moreover, the m-value of the AMS (0.88 to 1.05) was lower than that of the posed smile (1.59 to 1.85). Conclusions: Compared to the posed smile, the AMS shows significantly larger LTRW and BCW, with significantly higher reproducibility. The AMS might serve as an adjunctive reference, in addition to the posed smile, in orthodontic and other dentomaxillofacial treatments.

Study on the Anti-hypertension mechanism of Prunella Vulgaris based on entity grammar systems

Li Du,Man-man Li,Bai-Xia Zhang,Shuai-Bing He,Ya-Nam Hu,Yun Wang 셀메드 세포교정의약학회 2015 셀메드 (CellMed) Vol.5 No.4

Literatures and experimental studies have shown that Prunella has an effect on anti-hypertension, however, its components are complicated, so that it is still difficult to clear the specific roles of its various components in blood pressure regulation in. So we decide to systematically study the anti-hypertension mechanism of Prunella. We integrated multiple databases and constructed molecular interaction network between the chemical constituents of Prunella Vulgaris and hypertension based on entity grammar systems model. The network has 262 nodes and 802 edges. Then we infer the interactions between chemical compositions and disease targets to clarify the anti-hypertension mechanism. Finally, we found Prunella could influence hypertension by regulating apoptosis, cell proliferation, blood vessel development and vasoconstriction, etc. Thus this study provides reference for drug development and compatibility, and also gives guidance for health care at a certain extent.