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이수현(Su Hyoun Lee), 김강산(Kang San Kim), 윤종민(Jong Min Yun), 고하늘(Ha Neal Ko), 김래희(Lae Hee Kim), 이윤진(Yun Jin Rhee), 손영진(Yung Chen Sun), 김광혁(Kwang Hyuk Kim), 이선엽(Seon Yeop Lee), 이시형(Si Hyeong Lee) 한의병리학회 2012 동의생리병리학회지 Vol.26 No.5
This study reported a clinical effect of Gamisoyo-san focussing on improvement of postoperative pain in thyroid cancer patients. Three thyroid cancer patients hospitalized at Wonkwang hospital were enrolled this study. These patients complained postoperative pain after thyroidectomy due to thyroid cancer. All patients was prescribed Gamisoyo-san. Subjective degree of pain in each patient was investigated daily. Postoperative pain of all patients were gradually relieved after treatment. In one of three case, postoperative pain relieved completely. These results suggest potential of Gamisoyo-san as effective medicine of postoperative pain after thyroidectomy in thyroid cancer patients.
Acute pancreatitis due to impaction of Ascaris lumbricoides into the pancreatic duct is very rare. Authors hnve experienced one case of pancreatic ascariasis. Patient was a 62-year-old female with epigastric pain. Abdominal USG and endoscopic retrograde cholangiopancreatography showed characteristic finding of pancreatic ascariasis. Ascaris was removed with palypectomy snare and acute pancreatitis was resolved completely.
<P>Magnetic sponges (MSs) and magnetic threads with hydrophilic and hydrophobic characteristics that can perform remote-controlled oil/water separation in a confined space and anaerobic reactions were prepared. For large amounts of water or oil, trainlike hydrophilic or hydrophobic MSs composed of more than three sponge balls moved as a group and quickly absorbed the water or oil droplets in oil or water by magnetic manipulation from outside of the tube. For the removal of heavy oils below the water in three-liquid multiphase solutions, the hydrophobic MS balls were moved to the heavy oil below the water, absorbed some of the heavy oil, and returned to the light oil layer to deliver the heavy oil by means of an external magnetic field. The mixed oils floating on the water were easily removed by a suction pump once the heavy oil had been completely delivered to the light oil layer via the round-trip process. Furthermore, our approach was demonstrated for use in an anaerobic reaction system due to the strong magnetic property that transfers the reactants/products, the porous structure providing a reaction site, and the prewetting ability containing the reactants/products of the MSs and the oil layer prohibiting oxygen contact.</P> [FIG OMISSION]</BR>
<P>AgBr nanostructures with unified shapes and sizes were prepared using simple polyelectrolyte (PE) coatings on various AgBr microstructures that were prepared by mixing silver precursors with hexadecyltrimethylammonium bromide (CTAB) under controlled conditions. The AgBr microstructures (plates, rods, and wires), regardless of initial structures or sizes, transformed into cubic AgBr nanoparticles (CNPs) after only three PE coatings. The electrostatic interactions between the PEs and the CTAB in the AgBr microstructures are the crucial factors that control the shapes and sizes of the AgBr microstructures. During the PE coating, the AgBr microstructures were transformed and rearranged into AgBr CNPs with favorable catalytic faces that enhanced the photocatalytic activity. The size- and shape-controlled AgBr CNPs showed excellent photocatalytic performance for the degradation of methylene orange (MO) dyes under visible-light irradiation without deterioration even after multiple uses.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/langd5/2014/langd5.2014.30.issue-31/la502378z/production/images/medium/la-2014-02378z_0009.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/la502378z'>ACS Electronic Supporting Info</A></P>
Lee,,Hyun-Jin,Lee,,Sang-Wook,Suh,,Cheol-Won,Huh,,Joo-Ryung,Yoon,,Sang-Min,Kim,,Young-Seok,Kim,,Su-San,Kim,,Jong-Hoon,Choi,,Eun-Kyung,Ahn,,Seung-Do The Korean Society for Radiation Oncology 2011 Radiation Oncology Journal Vol.29 No.3
Purpose: To evaluate the radiotherapy treatment outcome of patients in stage IE and IIE nasal natural killer/T-cell lymphoma. Materials and Methods: From August 1999 to August 2009, 46 patients with stage IE and IIE nasal natural killer/T-cell lymphoma were treated by definitive radiotherapy and chemotherapy. 33 patients were treated with chemotherapy followed by radiotherapy (CT + RT) and they received 50.4 Gy in 28 fractions. 13 patients were treated with concurrent chemoradiotherapy (CCRT) and they received 40 Gy in 20 fractions. Results: The median follow-up period was 4.6-137.6 months (median, 50.2 months) for all patients. The 4-year overall survival was 68.6% and 4-year disease free survival (DFS) was 61.9%. The 4-year locoregional recurrence free survival was 65.0%, and 4-year distant metastasis free survival (DMFS) was 66.2%. For patients treated with CT + RT, 15 patients (45.5%) achieved complete response after chemotherapy, and 13 patients (39.4%) achieved partial response. 13 patients (81.8%) achieved complete response after radiotherapy, and 6 patients (18.2%) achieved partial response. For patients treated with CCRT, 11 patients (84.6%) achieved complete response, and one patient (7.7%) achieved partial response. In univariate analysis, presence of cervical lymph node metastasis was only significant prognostic factor for DFS and DMFS. Conclusion: This study did not show satisfactory overall survival rate and disease free survival rate of definitive radiotherapy and chemotherapy for stage IE and IIE nasal natural killer/T-cell lymphoma. For patients with cervical lymph node metastasis, further investigation of new chemotherapy regimens is necessary to reduce the distant metastasis.
Lee,,Beom,Suk,Cho,,Yong,Woo,Kim,,Gui,Chul,Lee,,Do,Hee,Kim,,Chang,Jin,Kil,,Hee,Seup,Chi,,Dae,Yoon,Byun,,Youngro,Yuk,,Soon,Hong,Kim,,Kwangmeyung,Kim,,In-San,Kwon,,Ick,Chan,Kim,,Sang,Yoon U.S. Dept. of Health, Education, and Welfare, Publ 2015 Journal of the National Cancer Institute Vol.107 No.2
<P><B>Background:</B></P><P>Tumor heterogeneity and evolutionary complexity may underlie treatment failure in spite of the development of many targeted agents. We suggest a novel strategy termed induced phenotype targeted therapy (IPTT) to simplify complicated targets because of tumor heterogeneity and overcome tumor evolutionary complexity.</P><P><B>Methods:</B></P><P>We designed a caspase-3 specific activatable prodrug, DEVD-S-DOX, containing doxorubicin linked to a peptide moiety (DEVD) cleavable by caspase-3 upon apoptosis. To induce apoptosis locally in the tumor, we used a gamma knife, which can irradiate a very small, defined target area. The in vivo antitumor activity of the caspase-3–specific activatable prodrug combined with radiation was investigated in C3H/HeN tumor-bearing mice (n = 5 per group) and analyzed with the Student’s <I>t</I> test or Mann-Whitney U test. All statistical tests were two-sided. We confirmed the basic principle using a caspase-sensitive nanoprobe (Apo-NP).</P><P><B>Results:</B></P><P>A single exposure of radiation was able to induce apoptosis in a small, defined region of the tumor, resulting in expression of caspase-3. Caspase-3 cleaved DEVD and activated the prodrug. The released free DOX further activated DEVD-S-DOX by exerting cytotoxic effects on neighboring tumor or supporting cells, which repetitively induced the expression of caspase-3 and the activation of DEVD-S-DOX. This sequential and repetitive process propagated the induction of apoptosis. This novel therapeutic strategy showed not only high efficacy in inhibiting tumor growth (14-day tumor volume [mm<SUP>3</SUP>] vs radiation alone: 848.21±143.24 vs 2511.50±441.89, <I>P</I> < .01) but also low toxicity to normal cells and tissues.</P><P><B>Conclusion:</B></P><P>Such a phenotype induction strategy represents a conceptually novel approach to overcome tumor heterogeneity and complexity as well as to substantially improve current conventional chemoradiotherapy with fewer sequelae and side effects.</P>
Although the saphenous flap has been used in reconstruction as a free flap, there has not yet been an anatomic study about the perforators of the saphenous artery. The aim of this study is to investigate the anatomy of the saphenous artery and the number and locations of its perforators. We dissected parts of 10 legs from 5 cadavers. Measurements of the positions of the dissected saphenous arteries and their perforators were taken from the medial epicondyle of the femur. We observed the origin, end point, and the diameter of each of the arteries, and we investigated the numbers and locations of both septocutaneous and musculocutaneous perforators. The average length of saphenous artery was 14.8 cm, and it was located 12.0 cm above the medial epicondyle of the femur. The average diameter was 1.63 mm. A median average of 4 perforators branched out from a single saphenous artery. There was a median average of 2 septocutaneous perforators and 2 musculocutaneous perforators from the saphenous artery. The perforators were mainly located at 7 cm proximal to the medial epicondyle of the femur. The saphenous artery has many perforators and is therefore useful as the pedicle of the perforator flap. The saphenous artery perforator flap can be designed within 7 cm proximal to the medial epicondyle of the femur. Our results may be helpful in the applications of the neurocutaneous flap using the saphenous artery or the perforator flap based on septocutaneous perforators.